Full Text Journal Articles by
Author Yan Chen

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Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy.

Yue Qin, Tingting Liu, Mengfei Guo, Yuping Liu, Congyan Liu, Yan Chen, Ding Qu,

Increasing evidence indicates that the tumor microenvironment (TME) imposes various obstacles in response to chemotherapies. Sodium tanshinone IIA sulfonate (STS) has a validated ability to repair the unfavorable TME, providing a suitable environment for celastrol-based chemotherapy. However, remodeling TME still possesses enormous challenges for STS due to the difficulty in ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(14):3916-3925]

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Exploring the structure-property relationship of three-dimensional hexagonal boron nitride aerogels with gyroid surfaces.

Yan Chen, Huasong Qin, Juzheng Song, Zeming Liu, Yilun Liu, Qing-Xiang Pei,

Three-dimensional hexagonal boron nitride aerogels (hBNAGs) are novel porous materials with many promising applications such as energy storage, thermal insulation and sensing. However, the structure-property relationships of hBNAGs in complicated thermo-mechanical coupled environments are still not clear. In this study, we employed a binary phase-field crystal (PFC) model to construct ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(18):10180-10188]

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Sarcodon aspratus polysaccharides ameliorated obesity-induced metabolic disorders and modulated gut microbiota dysbiosis in mice fed a high-fat diet.

Juan Chen, Jiaojiao Liu, Chenchen Yan, Chan Zhang, Wenjuan Pan, Wenna Zhang, Yongming Lu, Lei Chen, Yan Chen,

Sarcodon aspratus is a popular edible fungus that has commonly been used as a functional food in China and other Asian countries. This study is conducted to examine the potential health benefits of Sarcodon aspratus polysaccharides (SATPs), on obesity and related metabolism disorders. C57BL/6J mice were fed with a high-fat ... Read more >>

Food Funct (Food & function)
[2020, 11(3):2588-2602]

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A label-free protamine-assisted colorimetric sensor for highly sensitive detection of S1 nuclease activity.

Jiahui Wen, Yongming Liu, Jingwen Li, Hao Lin, Yiran Zheng, Yan Chen, Xiuli Fu, Lingxin Chen,

A label-free, sensitive, simple and general colorimetric method was reported to monitor S1 nuclease activity based on protamine-assisted aggregation of gold nanoparticles (AuNPs). Here, protamine, a linear polycation, was used as a medium for causing the aggregation of negatively charged AuNPs by electrostatic interactions, resulting in changes in the surface ... Read more >>

Analyst (The Analyst)
[2020, 145(7):2774-2778]

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Organic-inorganic hybrid (CH3NH3)2FeCuI4Cl2 and (CH3NH3)2InCuI6 for ultraviolet light photodetectors.

Siwen Tao, Yan Chen, Jiawen Cui, Huawei Zhou, Ning Yu, Xiaorui Gao, Shuting Cui, Cang Yuan, Meiqian Liu, Miaomiao Wang, Xiaojun Wang, Haoyu Gong, Yanmin Li, Tian Liu, Xun Sun, Jie Yin, Xianxi Zhang, Mingxing Wu,

Photodetectors play a key role in the military, aerospace, communications, bio-imaging, etc. In this study, we fabricate photodetector devices based on (CH3NH3)2FeCuI4Cl2 (MA2FeCuI4Cl2) and (CH3NH3)2InCuI6 (MA2InCuI6) for the first time. We find that the device based on MA2InCuI6 is highly selective for ultraviolet light (880 nA mW-1) and shows high ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(12):1875-1878]

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Improving single-cell transcriptome sequencing efficiency with a microfluidic phase-switch device.

Baoyue Zhang, Hong Xu, Yuqing Huang, Weiliang Shu, Hongtao Feng, Jin Cai, Jiang F Zhong, Yan Chen,

In this paper, we present a novel method to improve the efficiency of single-cell transcriptome sequencing for analyzing valuable cell samples. The microfluidic device we designed integrates multiple single-cell isolation chambers with hydrodynamic traps and achieves a nearly 100% single-cell capture rate and minimal cell loss, making it particularly suitable ... Read more >>

Analyst (The Analyst)
[2019, 144(24):7185-7191]

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Sr5TeO2(BO3)4 and NaSr5(BO3)(SiO4)2: two inorganic metal borate derivatives with diverse zero dimensional anions.

Ruling Tang, Chunli Hu, Jianghe Feng, Zhi Fang, Yan Chen, Fang Kong, Jianggao Mao,

Two new inorganic metal borate derivatives, Sr5TeO2(BO3)4 and NaSr5(BO3)(SiO4)2, have been obtained through a high temperature solid reaction method. Sr5TeO2(BO3)4 crystallizes in a tetragonal space group of P4/mnc featuring a three-dimensional (3D) structure composed of a porous 3D strontium framework stabilized by the unique zero-dimensional (0D) [TeO2(BO3)4]10- anions. NaSr5(BO3)(SiO4)2 crystallizes ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(12):3743-3749]

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Synergistic effect of supercritical CO2 and organic solvent on exfoliation of graphene: experiment and atomistic simulation studies.

Lixi Liu, Yan Chen, Fei Dang, Yilun Liu, Xiaogeng Tian, Xi Chen,

In this work, experiments and molecular dynamics (MD) simulations are carried out to explore the synergistic effect of supercritical CO2 (scCO2) and organic solvent on intercalation and exfoliation of graphene. Experimental characterizations via transmission electron microscopy, atomic force microscopy and Raman spectroscopy indicate that by combining scCO2 and organic solvent ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(39):22149-22157]

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Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS)

Dengyong Liu, Lu Bai, Xi Feng, Yan Ping Chen, Danni Zhang, Wensheng Yao, Hao Zhang, Gaole Chen, Yuan Liu,

A rapid method for analyzing of Jinhua ham samples in different aging time was created based on gas chromatography-ion mobility spectrometry (GC-IMS). The GC-IMS chromatograph provided information regarding the identities and intensities of 37 volatile flavor compounds, including both monomers and dimers. Principal component analysis (PCA) effectively distinguished the variation ... Read more >>

Meat Sci. (Meat science)
[2020, 168:Not Available]

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Defective Fe3+ self-doped spinel ZnFe2O4 with oxygen vacancies for highly efficient photoelectrochemical water splitting.

Jianmin Wang, Yunan Wang, Xinchao Xv, Yan Chen, Xi Yang, Jun Zhou, Song Li, Feng Cao, Gaowu Qin,

Defective Fe3+ self-doped spinel ZnFe2O4 with abundant oxygen vacancies, (Zn1-xFex)Fe2O4-y, was successfully synthesized via a simple spin-coating method and subsequent hydrogen reduction treatment. It displays a photocurrent density of 0.22 mA cm-2 at 1.23 (V vs. RHE), which is 11 times higher than that of pure ZnFe2O4. The largely enhanced ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(31):11934-11940]

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Correction: Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2.

Yan Chen, Lin Chen, Duanyang Hong, Zongyue Chen, Jingyu Zhang, Lingyun Fu, Di Pan, Yanyan Zhang, Yini Xu, Shiquan Gan, Chaoda Xiao, Ling Tao, Xiangchun Shen,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(7):532]

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Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets.

Matt R Paul, Tien-Chi Pan, Dhruv K Pant, Natalie Nc Shih, Yan Chen, Kyra L Harvey, Aaron Solomon, David Lieberman, Jennifer Jd Morrissette, Danielle Soucier-Ernst, Noah G Goodman, S William Stavropoulos, Kara N Maxwell, Candace Clark, George K Belka, Michael Feldman, Angela DeMichele, Lewis A Chodosh,

Nearly all breast cancer deaths result from metastatic disease. Despite this, the genomic events that drive metastatic recurrence are poorly understood. We performed whole-exome and shallow whole-genome sequencing to identify genes and pathways preferentially mutated or copy-number altered in metastases compared with the paired primary tumors from which they arose. ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, :]

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Construction of multifunctional nano-architecture in one-step on a composite fuel catalyst through in situ exsolution of La0.5Sr0.5Fe0.8Ni0.1Nb0.1O3-δ.

Xing Wu, Yan Yu, Yan Chen, Linsen Li, Zi-Feng Ma, Yimei Yin,

Multifunctional nano-architecture (MNA) on catalysts have attracted great attention because of their capability to improve the performance, durability and resistance to unwanted side reactions. Such structures, however, are conventionally prepared by deposition methods, which inherently suffer from costly and time-consuming drawbacks. Here we report a simple one-step process to successfully ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells.

Shihao Du, Xiaoyu Song, Yuan Li, Yalei Cao, Fuhao Chu, Olanrewaju Ayodeji Durojaye, Zeqi Su, Xiaoguang Shi, Jing Wang, Juan Cheng, Tangshun Wang, Xiang Gao, Yan Chen, Wuzhekai Zeng, Fengsong Wang, DongMei Wang, Xing Liu, Xia Ding,

Progression of hepatocellular carcinoma involves multiple genetic and epigenetic alterations that promote cancer invasion and metastasis. Our recent study revealed that hyperphosphorylation of ezrin promotes intrahepatic metastasis in vivo and cell migration in vitro. Celastrol is a natural product from traditional Chinese medicine which has been used in treating liver ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):11273]

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Correlation between monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 and coronary plaque characteristics.

Meng Li, Yan Chen, Yan Zhang, Danna Li, Jun Liu,

IMPACT STATEMENT:Vulnerable plaques are plaques which are susceptible to rupture or thrombosis and trigger a series of adverse events such as coronary disorders. CCL2 is a soluble basic protein belonging to the CC subfamily. Previous studies have been investigated on the correlation between inflammatory factors and clinical events, but there ... Read more >>

Exp. Biol. Med. (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2020, :1535370220941424]

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Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment.

Ding Qu, Yue Qin, Yuping Liu, Tingting Liu, Congyan Liu, Tao Han, Yan Chen, Chengyao Ma, Xiaoqi Li,

A fever-mimic response capable of recruiting reprogrammed macrophages holds great potential in the engineering of the tumor microenvironment (TME). Low-temperature photothermal therapy (LT-PTT) can maintain tumors at a fever-like temperature (<45 °C) temporarily; however, it still faces several challenges in efficient regulation of TME because of reciprocal cross-talk between the ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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The health effect of perceived built environment on depression of elderly people in rural China: Moderation by income.

Haimin Pan, Yixi Liu, Yan Chen,

This study explored the health effect of perceived built environment on depression of the Chinese elderly people in rural areas. A multifaceted approach in examining perceived built environment was used. A sample of 670 older residents in rural area of China were interviewed, and data were collected mainly for exploratory ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2020, :]

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Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer.

Rui Peng, Yan Chen, Liangnian Wei, Gang Li, Dongju Feng, Siru Liu, Runqiu Jiang, Shaojiang Zheng, Yun Chen,

BACKGROUND:Fibroblast growth factor receptor 1 (FGFR1) is frequently dysregulated in various tumors. FGFR inhibitors have shown promising therapeutic value in several preclinical models. However, tumors resistant to FGFR inhibitors have emerged, compromising therapeutic outcomes by demonstrating markedly aggressive metastatic progression; however, the underlying signaling mechanism of resistance remains unknown. METHODS:We ... Read more >>

Gastric Cancer (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association)
[2020, :]

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Simple nomogram based on initial laboratory data for predicting the probability of ICU transfer of COVID-19 patients: Multicenter retrospective study.

Zihang Zeng, Yiming Ma, Huihui Zeng, Peng Huang, Wenlong Liu, Mingyan Jiang, Xudong Xiang, Dingding Deng, Xin Liao, Ping Chen, Yan Chen,

This retrospective, multicenter study investigated risk factors associated with intensive care unit (ICU) admission and transfer in 461 adult patients with confirmed coronavirus disease 2019 (COVID-19) hospitalized from January 22 to March 14, 2020 in Hunan Province, China. Outcomes of ICU and non-ICU patients were compared, and a simple nomogram ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy.

Wen-Xuan Zhu, Yan Chen, Deng-Gao Liu, Guang-Yan Yu,

OBJECTIVES:To investigate the clinical, laboratory, radiological, histopathological, and immunohistochemical features, and the expression of allergy-related cytokines in eosinophilic sialodochitis (ES). METHODS:Thirty-eight patients diagnosed with chronic obstructive sialadenitis (COS) who had undergone glandular excision or incisional biopsy were enrolled. Seventeen patients with comorbid atopic disease and increased ductal tissue eosinophils comprised ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Prognostic significance of serum lactate dehydrogenase in patients undergoing radical cystectomy for bladder cancer.

Shiqiang Su, Lizhe Liu, Chao Sun, Lijun Yang, Yanhua Nie, Yan Chen, Jin Zhang, Shen Li,

BACKGROUND:To investigate the prognostic significance of preoperative serum lactate dehydrogenase (LDH) in patients undergoing radical cystectomy for bladder cancer (BCa). PATIENTS AND METHODS:A cohort of 263 patients undergoing open or laparoscopic radical cystectomy between 2011 and 2016 was studied. Baseline characteristics, hematological variables, follow-up data were collected. Kaplan-Meier curves and ... Read more >>

Urol. Oncol. (Urologic oncology)
[2020, :]

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Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis.

Weiqian Wang, Xiao Yang, Yan Chen, Xuanling Ye, Kaiyuan Jiang, Aizhen Xiong, Li Yang, Zhengtao Wang,

Herbal drug-induced liver injury has been reported worldwide and gained global attention. Thousands of hepatic sinusoidal obstruction syndrome (HSOS) cases have been reported after consumption of herbal medicines and preparations containing pyrrolizidine alkaloids (PAs), which are natural phytotoxins globally distributed. And herbal medicines, such as Gynura japonica, are the current ... Read more >>

J Appl Toxicol (Journal of applied toxicology : JAT)
[2020, :]

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Community-Acquired Methicillin-Resistant Staphylococcus aureus ST59 in a Chinese Adult with Meningitis: A Case Report from China.

Fayu Chen, Yan Chen, Xiaofei Zhao, Jianfeng Wang,

AbstractCommunity-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are reported worldwide and are associated with serious outcomes. The majority of CA-MRSA infections are soft tissue and skin infections, and cases with meningitis caused by CA-MRSA are rare. Here, we reported a 53-year-old male patient with meningitis due to CA-MRSA infection, as confirmed ... Read more >>

Infect Drug Resist (Infection and Drug Resistance)
[2020, 13:2011-2016]

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A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.

Shalender Bhasin, Thomas M Gill, David B Reuben, Nancy K Latham, David A Ganz, Erich J Greene, James Dziura, Shehzad Basaria, Jerry H Gurwitz, Patricia C Dykes, Siobhan McMahon, Thomas W Storer, Priscilla Gazarian, Michael E Miller, Thomas G Travison, Denise Esserman, Martha B Carnie, Lori Goehring, Maureen Fagan, Susan L Greenspan, Neil Alexander, Jocelyn Wiggins, Fred Ko, Albert L Siu, Elena Volpi, Albert W Wu, Jeremy Rich, Stephen C Waring, Robert B Wallace, Carri Casteel, Neil M Resnick, Jay Magaziner, Peter Charpentier, Charles Lu, Katy Araujo, Haseena Rajeevan, Can Meng, Heather Allore, Brooke F Brawley, Rich Eder, Joanne M McGloin, Eleni A Skokos, Pamela W Duncan, Dorothy Baker, Chad Boult, Rosaly Correa-de-Araujo, Peter Peduzzi, ,

BACKGROUND:Injuries from falls are major contributors to complications and death in older adults. Despite evidence from efficacy trials that many falls can be prevented, rates of falls resulting in injury have not declined. METHODS:We conducted a pragmatic, cluster-randomized trial to evaluate the effectiveness of a multifactorial intervention that included risk ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2020, 383(2):129-140]

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Are COVID-19 patients with hypertension at higher risk in China?

Siqi Wang, Yan Chen, Lu Wang, Huan Liu, Ping Han,

J. Hypertens. (Journal of hypertension)
[2020, 38(7):1384-1385]

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