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Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

Lei Zhao, Zhongqi Li, Joaquim Vong, Xinyi Chen, Hei-Ming Lai, Leo Yan, Junzhe Huang, Samuel Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C.T. Mok, Ho Ko,

Abstract With advances in single-cell genomics, molecular signatures of cells comprising the brain vasculature are revealed in unprecedented detail 1,2 , yet the ageing-associated cell subtype transcriptomic changes which may contribute to neurovascular dysfunction in neurodegenerative diseases 3–7 remain elusive. Here, we performed single-cell transcriptomic profiling of brain endothelial cells ... Read more >>

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Changes of Serum IL-6, IL-17, and Complements in Systemic Lupus Erythematosus Patients.

Yamei Tang, Huai Tao, Yuji Gong, Fang Chen, Cunyan Li, Xiudeng Yang,

Cytokines activation and low complement levels are common in systemic lupus erythematosus (SLE) patients. This study is aimed to explore the relationship and clinical significance of cytokines and complements with SLE activity. Serum samples of 140 SLE patients and 36 age- and gender-matched healthy controls (HC) were collected. Serum interleukin ... Read more >>

J. Interferon Cytokine Res. (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2019, 39(7):410-415]

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Comparison between high-dose and low-dose intravenous methylprednisolone therapy in patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma.

Xiaohuang Zhuo, Xiaolong Huang, Maosheng Yan, Honghong Li, Yi Li, Xiaoming Rong, Jinpeng Lin, Jinhua Cai, Fukang Xie, Yongteng Xu, Keng Chen, Yamei Tang,

BACKGROUND:Radiotherapy is the standard radical treatment for nasopharyngeal carcinoma (NPC) and may cause radiation-induced brain necrosis (RN). Intravenous steroids have been considered as an effective treatment for RN. However, evidence concerning the efficacy of different doses of intravenous steroid therapy remains insufficient to establish the optimal regimen for NPC patients ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 137:16-23]

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Radiotherapy-induced dysphagia and its impact on quality of life in patients with nasopharyngeal carcinoma.

Honghong Li, Liting Li, Xiaolong Huang, Yi Li, Tangjie Zou, Xiaohuang Zhuo, Yan Chen, Yimin Liu, Yamei Tang,

PURPOSE:To investigate the swallowing status and its impact on quality of life (QOL) in patients who underwent radiotherapy for nasopharyngeal carcinoma (NPC). METHODS:In this study, 334 patients with NPC who underwent radiotherapy were reviewed. Clinical characteristics, videofluoroscopic swallowing studies (VFSSs), and scores of the World Health Organization quality of life-BREF (WHOQOL-BREF) ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2019, 195(6):457-467]

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Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial.

Jingru Jiang, Yi Li, Qingyu Shen, Xiaoming Rong, Xiaolong Huang, Honghong Li, Lizhi Zhou, Hai-Qiang Mai, Dong Zheng, Ming-Yuan Chen, Yongteng Xu, Jibin Li, Xuan Hui, Charles B Simone, Jan Gaertner, Andreas A Argyriou, Edward Chow, Pingyan Chen, Yamei Tang,

PURPOSE:Neuropathic pain is an unavoidable treatment-related adverse event among patients with head and neck cancer who are undergoing radiotherapy. We aimed to test the efficacy and safety of pregabalin versus placebo in the treatment of radiotherapy-related neuropathic pain. PATIENTS AND METHODS:This randomized, double-blind, placebo-controlled trial was conducted in four centers ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, 37(2):135-143]

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Efficacy and safety of prothrombin complex concentrate for vitamin K antagonist-associated intracranial hemorrhage: a systematic review and meta-analysis.

Rui Pan, Jinping Cheng, Kelin Lai, Qing Huang, Hui Wu, Yamei Tang,

BACKGROUND:Prothrombin complex concentrate (PCC) is the treatment of choice in vitamin K antagonist-associated intracranial hemorrhage (VKA-ICH). However, the efficiency and safety associated with their use remain unclear. AIMS:This study aimed to assess the current evidence of the clinical outcomes in patients with VKA-ICH treated with or without PCC. A meta-analysis ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2019, 40(4):813-827]

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A nomogram for the prediction of cerebrovascular disease among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma.

Jinhua Cai, Jinping Cheng, Honghong Li, Wei-Jye Lin, Yi Li, Xiaohuang Zhuo, Xiaolong Huang, Charles B Simone, Wilbert S Aronow, Edward L W Chow, Yamei Tang,

BACKGROUND AND PURPOSE:This study sought to develop and validate a nomogram to predict cerebrovascular disease (CVD) among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:A total of 346 eligible patients with brain necrosis after radiotherapy for NPC were divided into a training set (n = 231) and ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 132:34-41]

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Targeting pericytes for therapeutic approaches to neurological disorders.

Jinping Cheng, Nils Korte, Ross Nortley, Huma Sethi, Yamei Tang, David Attwell,

Many central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood-brain barrier. Pericytes, an under-studied cell type located on capillaries, ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2018, 136(4):507-523]

Cited: 12 times

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Intravenous Thrombolysis for Stroke Patients with G6PD Deficiency.

Xiaoyan Wu, Ruying Fu, Yamei Tang, Li Shi, Xiaoming Rong, Jianjun Guo, Jie Li, Qingyu Shen,

No reports regarding the safety of thrombolysis in acute stroke patients with a G6PD deficiency have been published to date. Here we aimed to evaluate the safety of intravenous thrombolysis for G6PD-deficient stroke patients.We enrolled each patient with acute ischemic stroke who arrived in our stroke unit within the therapeutic ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2018, 27(7):2026-2031]

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Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia.

Cunyan Li, Huai Tao, Xiudeng Yang, Xianghui Zhang, Yong Liu, Yamei Tang, Aiguo Tang,

Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential serum biomarkers during first-episode psychosis (FEP) is especially helpful to understand the onset and prognosis of this disorder. To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The expression levels of Neuregulin1 (NRG1), ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2018, 15(9):900-906]

Cited: 1 time

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Bevacizumab Monotherapy Reduces Radiation-induced Brain Necrosis in Nasopharyngeal Carcinoma Patients: A Randomized Controlled Trial.

Yongteng Xu, Xiaoming Rong, Weihan Hu, Xiaolong Huang, Yi Li, Dong Zheng, Zhaoxi Cai, Zhiyi Zuo, Yamei Tang,

PURPOSE:Studies have shown that addition of bevacizumab to corticosteroids improves outcome against radiation-induced brain necrosis (RN). Here, we aimed to evaluate the effectiveness and safety of bevacizumab monotherapy on RN in nasopharyngeal carcinoma (NPC) patients. METHODS AND MATERIALS:In this multicenter open-label study, patients with RN were randomly assigned (1:1) into ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, 101(5):1087-1095]

Cited: 5 times

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Clinical Variables for Prediction of the Therapeutic Effects of Bevacizumab Monotherapy in Nasopharyngeal Carcinoma Patients With Radiation-Induced Brain Necrosis.

Yi Li, Xiaolong Huang, Jingru Jiang, Weihan Hu, Jiang Hu, Jinhua Cai, Xiaoming Rong, Jinping Cheng, Yongteng Xu, Rong Wu, Jinjun Luo, Yamei Tang,

PURPOSE:To identify the predictive and prognostic factors for a decrease or recurrence of brain edema in patients who developed radiation-induced brain necrosis (RN) after radiation therapy for nasopharyngeal carcinoma (NPC) and who received bevacizumab monotherapy. METHODS AND MATERIALS:This was a retrospective study. The charts of 50 patients who were diagnosed with ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, 100(3):621-629]

Cited: 3 times

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The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions.

Ukpong B Eyo, Ukpong B Eyo, Ashley Bispo, Junting Liu, Sruchika Sabu, Rong Wu, Victoria L DiBona, Jiaying Zheng, Madhuvika Murugan, Huaye Zhang, Yamei Tang, Long-Jun Wu,

Microglia are known to engage in physical interactions with neurons. However, our understanding of the detailed mechanistic regulation of microglia-neuron interactions is incomplete. Here, using high resolution two photon imaging, we investigated the regulation of NMDA receptor-induced microglia-neuron physical interactions. We found that the GluN2A inhibitor NVPAAM007, but not the ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):828]

Cited: 2 times

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Up-regulated expression of oxytocin mRNA in peripheral blood lymphocytes from first-episode schizophrenia patients.

Xiudeng Yang, Yamei Tang, Qinling Wei, Bing Lang, Huai Tao, Xianghui Zhang, Yong Liu, Aiguo Tang,

Schizophrenia (SZ) is a severe neuropsychiatric disorder with significant social cognition impairment. Increasing evidence has suggested that neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are important mediators of complex social cognition and behavior associates with SZ. In the present study, forty-three first-episode schizophrenia (FES) patients and forty-seven healthy controls (HC) ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(45):78882-78889]

Cited: 1 time

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Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study.

Xiaoni Zhang, Yi Li, Xiangpen Li, Xiaoming Rong, Yamei Tang, Ying Peng,

To evaluate the neuroprotective effects of Dl-3-n-butylphthalide (NBP) on patients with radiation-induced brain injury, a hospital-based, clinical retrospective cohort study was conducted.Data were collected on patients diagnosed with radiation-induced brain injury from January 2009 to January 2015 in Department of Neurology, Sun Yat-Sen Memorial Hospital. All patients enrolled have received ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2017, 127(12):1059-1064]

Cited: 1 time

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TREM2 protects against cerebral ischemia/reperfusion injury.

Rong Wu, Xiangpen Li, Pengfei Xu, Likui Huang, Jinping Cheng, Xiaolong Huang, Jingru Jiang, Long-Jun Wu, Yamei Tang,

Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenesis of ischemic stroke remains to be elucidated. Here, we found that the transcriptional and post-transcriptional ... Read more >>

Mol Brain (Molecular Brain)
[2017, 10(1):20]

Cited: 14 times

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Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes).

J Donald Easton, Maria Aunes, Gregory W Albers, Pierre Amarenco, Sara Bokelund-Singh, Hans Denison, Scott R Evans, Peter Held, Marianne Jahreskog, Jenny Jonasson, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong, S Claiborne Johnston, ,

Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES ... Read more >>

Circulation (Circulation)
[2017, 136(10):907-916]

Cited: 3 times

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Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study.

Zhaoxi Cai, Yi Li, Zhen Hu, Ruying Fu, Xiaoming Rong, Rong Wu, Jinping Cheng, Xiaolong Huang, Jinjun Luo, Yamei Tang,

Radiation-induced brachial plexopathy (RIBP) is one of the late complications in nasopharyngeal carcinoma (NPC) patients who received radiotherapy. We conducted a retrospective study to investigate its clinical characteristics and risk factors.Thirty-onepatients with RIBP after radiotherapy for NPC were enrolled. Clinical manifestations of RIBP, electrophysiologic data, magnetic resonance imaging (MRI), and ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(14):18887-18895]

Cited: 5 times

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Sub-chronic Antipsychotic Drug Administration Reverses the Expression of Neuregulin 1 and ErbB4 in a Cultured MK801-Induced Mouse Primary Hippocampal Neuron or a Neurodevelopmental Schizophrenia Model.

Cunyan Li, Yamei Tang, Jingjing Yang, Xianghui Zhang, Yong Liu, Aiguo Tang,

It has been reported that specific environmental influences during the postpartum period might contribute to the development of schizophrenia (SZ). Administration of MK801 during early development led to persistent brain pathology. Glutamate decarboxylase 1 (GAD67) and parvalbumin (PV), and neuregulin 1 (NRG1)/ErbB4 signaling were closely associated with SZ pathology. We postulated ... Read more >>

Neurochem. Res. (Neurochemical research)
[2016, 41(8):2049-2064]

Cited: 3 times

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Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack.

S Claiborne Johnston, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Jenny Jonasson, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong, ,

Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia.We conducted an international double-blind, controlled trial in 674 centers in 33 countries, in which 13,199 patients with a nonsevere ischemic stroke or high-risk transient ischemic ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2016, 375(1):35-43]

Cited: 85 times

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Temporal Cerebral Microbleeds Are Associated With Radiation Necrosis and Cognitive Dysfunction in Patients Treated for Nasopharyngeal Carcinoma.

Qingyu Shen, Focai Lin, Xiaoming Rong, Wuyang Yang, Yi Li, Zhaoxi Cai, Pengfei Xu, Yongteng Xu, Yamei Tang,

PURPOSE:Radiation therapy for patients with nasopharyngeal carcinoma (NPC) may be complicated with radiation-induced brain necrosis (RN), resulting in deteriorated cognitive function. However, the underlying mechanism of this phenomenon remains unclear. This study attempts to elucidate the association between cerebral microbleeds (CMBs) and radiation necrosis and cognitive dysfunction in NPC patients ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2016, 94(5):1113-1120]

Cited: 8 times

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Dynorphin activation of kappa opioid receptor reduces neuronal excitability in the paraventricular nucleus of mouse thalamus.

Zhiheng Chen, Yamei Tang, Huai Tao, Cunyan Li, Xianghui Zhang, Yong Liu,

It has been reported that kappa opioid receptor (KOR) is expressed in the paraventricular nucleus of thalamus (PVT), a brain region associated with arousal, drug reward and stress. Although intra-PVT infusion of KOR agonist was found to inhibit drug-seeking behavior, it is still unclear whether endogenous KOR agonists directly regulate ... Read more >>

Neuropharmacology (Neuropharmacology)
[2015, 97:259-269]

Cited: 6 times

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Rhubarb extract has a protective role against radiation-induced brain injury and neuronal cell apoptosis.

Kui Lu, Cheng Zhang, Wenjun Wu, Min Zhou, Yamei Tang, Ying Peng,

Oxidative stress caused by ionizing radiation is involved in neuronal damage in a number of disorders, including trauma, stroke, Alzheimer's disease and amyotrophic lateral sclerosis. Ionizing radiation can lead to the formation of free radicals, which cause neuronal apoptosis and have important roles in the development of some types of ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2015, 12(2):2689-2694]

Cited: 10 times

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Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor.

Pengfei Xu, Yongteng Xu, Bin Hu, Jue Wang, Rui Pan, Madhuvika Murugan, Long-Jun Wu, Yamei Tang,

Activation of purinergic receptors by extracellular ATP (eATP) released from injured cells has been implicated in the pathogenesis of many neuronal disorders. The P2X7 receptor (P2X7R), an ion-selective purinergic receptor, is associated with microglial activation and paracrine signaling. However, whether ATP and P2X7R are involved in radiation-induced brain injury (RBI) ... Read more >>

Brain Behav. Immun. (Brain, behavior, and immunity)
[2015, 50:87-100]

Cited: 20 times

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BTH treatment caused physiological, biochemical and proteomic changes of muskmelon (Cucumis melo L.) fruit during ripening.

Xin Li, Yang Bi, Junjie Wang, Boyu Dong, Haijie Li, Di Gong, Ying Zhao, Yamei Tang, Xiaoyan Yu, Qi Shang,

Benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) is a chemical plant elicitor capable of inducing disease resistance in many crops. In this study, the climacteric fruit muskmelon (cv. Yujinxiang) was treated with BTH at 0.1g/L for assaying the changes in physiology, biochemistry and protein profile during ripening. The results showed that BTH ... Read more >>

J Proteomics (Journal of proteomics)
[2015, 120:179-193]

Cited: 2 times

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