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Author Ya Chen Tina Shih

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Rising Economic Burden of Renal Cell Carcinoma among Elderly Patients in the USA: Part II-An Updated Analysis of SEER-Medicare Data.

Ya-Chen Tina Shih, Ying Xu, Chun-Ru Chien, Bumyang Kim, Yu Shen, Liang Li, Daniel M Geynisman,

BACKGROUND:The influx of new oncologic technologies has changed the treatment landscape of renal cell carcincoma (RCC) in the last decade. This study updated a previously published paper on the economic burden of RCC in the USA by using more recent data to examine the impact of various forms of new ... Read more >>

Pharmacoeconomics (PharmacoEconomics)
[2019, :]

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Post-Discharge Services for Different Diagnoses Than Index Hospitalization Predict Decreased 30-Day Readmissions Among Medicare Beneficiaries.

Hyo Jung Tak, Li-Wu Chen, Fernando A Wilson, Andrew M Goldsweig, Dmitry Oleynikov, Michael Hawking, Ya-Chen Tina Shih,

BACKGROUND:Efforts to reduce hospital readmissions include post-discharge interventions related to the illness treated during the index hospitalization (IH). These efforts may be inadequate because readmissions are precipitated by a wide range of health conditions unrelated to the primary diagnosis of the IH. OBJECTIVE:To investigate the relationship between post-discharge health services ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2019, :]

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Trends in Volume-Outcome Relationship in Gastrectomies in Texas.

Naruhiko Ikoma, Bumyang Kim, Linda S Elting, Ya-Chen Tina Shih, Brian D Badgwell, Paul Mansfield,

BACKGROUND:We previously reported a significant volume-outcome relationship in mortality rates after gastrectomies for gastric cancer patients in Texas (1999-2001). We aimed to identify whether changes in the volume distribution of gastrectomies occurred, whether volume-outcome relationships persisted, and potential changes in the factors influencing volume-outcome relationships. METHODS:We performed a population-based study ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(9):2694-2702]

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Treatment value of second-generation BCR-ABL1 tyrosine kinase inhibitors compared with imatinib to achieve treatment-free remission in patients with chronic myeloid leukaemia: a modelling study.

Ya-Chen Tina Shih, Jorge E Cortes, Hagop M Kantarjian,

BACKGROUND:Treatment-free remission in chronic myeloid leukaemia-ie, achievement of a sustained deep molecular response leading to discontinuation of BCR-ABL1 tyrosine kinase inhibitor (TKI) therapy-has become a potential aim of therapy. Highly priced second-generation TKIs might offer deep molecular response status more quickly and for more patients than imatinib; however, with the ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2019, 6(8):e398-e408]

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Simple Quasi-Bayes Approach for Modeling Mean Medical Costs.

Grace Yoon, Wenxin Jiang, Lei Liu, Ya-Chen Tina Shih,

AbstractSeveral statistical issues associated with health care costs, such as heteroscedasticity and severe skewness, make it challenging to estimate or predict medical costs. When the interest is modeling the mean cost, it is desirable to make no assumption on the density function or higher order moments. Another challenge in developing ... Read more >>

Int J Biostat (The international journal of biostatistics)
[2019, :]

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Complication Rates in a Study of Invasive Diagnostic Procedures for Lung Abnormalities-In Reply.

Jinhai Huo, Ya-Chen Tina Shih,

JAMA Intern Med (JAMA internal medicine)
[2019, 179(6):847]

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Smoking Cessation Treatment Needs of Low SES Cervical Cancer Survivors.

Diana S Hoover, Claire A Spears, Damon J Vidrine, Joan L Walker, Ya-Chen Tina Shih, David W Wetter,

Objectives: We investigated the treatment needs and preferences of low socioeconomic status cervical cancer survivors to inform the adaptation of a theoretically- and empirically-based Motivation and Problem-Solving approach to facilitate cessation in this at-risk population. Methods: Individual in-depth interviews were conducted with 12 female smokers with cervical cancer. Interviews were ... Read more >>

Am J Health Behav (American journal of health behavior)
[2019, 43(3):606-620]

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Trends in Radiation for Bone Metastasis During a Period of Multiple National Quality Improvement Initiatives.

Jennifer K Logan, Jing Jiang, Ya-Chen Tina Shih, Xiudong Lei, Ying Xu, Karen E Hoffman, Sharon H Giordano, Benjamin D Smith,

PURPOSE:To evaluate trends in fractionation and cost of radiation for bone metastasis during a time period of multiple national quality improvement initiatives that focused on reducing the number of fractions per radiation episode. METHODS:Using nationwide Medicare claims from 2011 to 2014, we identified radiation episodes for bone metastasis from prostate, ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2019, 15(4):e356-e368]

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Economic Burden of Renal Cell Carcinoma-Part I: An Updated Review.

Chun-Ru Chien, Daniel M Geynisman, Bumyang Kim, Ying Xu, Ya-Chen Tina Shih,

BACKGROUND:The economic burden of renal cell carcinoma (RCC) had been reported to be significant in a previous review published in 2011. OBJECTIVE:The objective of this study was to perform an updated review by synthesizing economic studies related to the treatment of RCC that have been published since the previous review. ... Read more >>

Pharmacoeconomics (PharmacoEconomics)
[2019, 37(3):301-331]

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Complication Rates and Downstream Medical Costs Associated With Invasive Diagnostic Procedures for Lung Abnormalities in the Community Setting.

Jinhai Huo, Ying Xu, Tommy Sheu, Robert J Volk, Ya-Chen Tina Shih,

Importance:The Centers for Medicare & Medicaid Services added lung cancer screening with low-dose computed tomography (LDCT) as a Medicare preventive service benefit in 2015 following findings from the National Lung Screening Trial (NLST) that showed a 16% reduction in lung cancer mortality associated with LDCT. A challenge in developing and ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2019, 179(3):324-332]

Cited: 2 times

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How much of US health care spending provides direct care or benefit to patients?

Morgan N Fredell, Hagop M Kantarjian, Ya-Chen Tina Shih, Vivian Ho, Binata Mukherjee,

Plans to optimize health care in the United States highlight the high cost but rarely explore opportunities for redirecting resources within the existing system to increase access to care while lowering spending. This analysis indicates that, of the total national health care expenditures of $3.21 trillion in 2015, only $1.4 ... Read more >>

Cancer (Cancer)
[2019, 125(9):1404-1409]

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Comparative Effectiveness of Medication Therapy Management Eligibility Criteria Across Racial/Ethnic Groups.

Christina A Spivey, Yanru Qiao, Junling Wang, Ya-Chen Tina Shih, Jim Y Wan, Samuel Dagogo-Jack, William C Cushman, Lisa E Hines, Marie A Chisholm-Burns,

BACKGROUND/OBJECTIVES:Previous research indicates that eligibility criteria for medication therapy management (MTM) services in Medicare prescription drug (Part D) plans, defined under the Medicare Modernization Act (MMA), are associated with racial/ethnic disparities and ineffective in identifying individuals with medication utilization issues. Our study's objective was to determine the comparative effectiveness of ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2019, 67(3):581-587]

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Cardiovascular health in young and middle adulthood and medical care utilization and costs at older age - The Chicago Heart Association Detection Project Industry (CHA).

Cuiping Schiman, Lei Liu, Ya-Chen Tina Shih, Lihui Zhao, Martha L Daviglus, Kiang Liu, James Fries, Daniel B Garside, Thanh-Huyen T Vu, Jeremiah Stamler, Donald M Lloyd-Jones, Norrina B Allen,

It is unclear how long-term medical utilization and costs from diverse care settings and their age-related patterns may differ by cardiovascular health (CVH) status earlier in adulthood. We followed 17,195 participants of the Chicago Heart Association Detection Project Industry (1967-1973) with linked Medicare claims (1992 to 2010). Baseline CVH is ... Read more >>

Prev Med (Preventive medicine)
[2019, 119:87-98]

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Favorable Cardiovascular Health at Young and Middle Ages and Dementia in Older Age-The CHA Study.

Thanh-Huyen T Vu, Lihui Zhao, Lei Liu, Cuiping Schiman, Donald M Lloyd-Jones, Martha L Daviglus, Kiang Liu, Daniel B Garside, Jeremiah Stamler, James F Fries, Ya-Chen Tina Shih, Norrina B Allen,

Background Data are sparse on the association of cardiovascular health ( CVH ) in younger/middle age with the incidence of dementia later in life. Methods and Results We linked the CHA (Chicago Heart Association Detection Project in Industry) study data, assessed in 1967 to 1973, with 1991 to 2010 Medicare ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(1):e009730]

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Comparative Effectiveness of Computed Tomography- Versus Ultrasound-Guided Percutaneous Radiofrequency Ablation Among Medicare Patients 65 Years of Age or Older With Hepatocellular Carcinoma.

Jinhai Huo, Thomas A Aloia, Ying Xu, Tong Han Chung, Tommy Sheu, Ya-Chen Tina Shih,

BACKGROUND:For patients with hepatocellular carcinoma (HCC) not eligible for surgical resection, radiofrequency ablation (RFA) is a promising technique that reduces the risk of disease progression. OBJECTIVES:To evaluate whether the trend of image guidance for RFA is moving toward the more expensive computed tomography (CT) technology and to determine the clinical ... Read more >>

Value Health (Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research)
[2019, 22(3):284-292]

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Insurance transitions and healthcare utilization for children with refractory epilepsy.

I-Wen Pan, Sandi Lam, Dave Fitzgerald Clarke, Ya-Chen Tina Shih,

OBJECTIVES:The objective of the study is to investigate the association between insurance transitions and healthcare utilization among children with refractory epilepsy. METHODS:We applied published algorithms to identify the study cohort of children with a diagnosis of refractory epilepsy who were treated between 10/1/2013 and 9/30/2014 at 36 children's hospitals in ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2018, 89:48-54]

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Assessing the Cost-Effectiveness of Updated Breast Cancer Screening Guidelines for Average-Risk Women.

Ya-Chen Tina Shih, Wenli Dong, Ying Xu, Yu Shen,

BACKGROUND:Several specialty societies have recently updated their breast cancer screening guidelines in late 2015/early 2016. OBJECTIVES:To evaluate the cost-effectiveness of US-based mammography screening guidelines. METHODS:We developed a microsimulation model to generate the natural history of invasive breast cancer and capture how screening and treatment modified the natural course of the disease. ... Read more >>

Value Health (Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research)
[2019, 22(2):185-193]

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Predictive Value Positive of MTM Eligibility Criteria under MMA and ACA in Identifying Individuals with Medication Utilization Issues.

Yanru Qiao, Christina A Spivey, Junling Wang, Ya-Chen Tina Shih, Jim Y Wan, Julie Kuhle, Samuel Dagogo-Jack, William C Cushman, Marie Chisholm-Burns,

Objectives:To compare the predictive value positives (PVP) of medication therapy management eligibility criteria under the Medicare Modernization Act (MMA) and Affordable Care Act (ACA) in identifying individuals with medication utilization issues (MUI). Methods:This is a retrospective analysis of Medicare database (2012-2013). MUI were determined based on medication utilization measures related ... Read more >>

J Pharm Health Serv Res (Journal of pharmaceutical health services research: an official journal of the Royal Pharmaceutical Society of Great Britain)
[2018, 9(4):393-401]

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Trends in breast cancer mortality by stage at diagnosis among young women in the United States.

Fangjian Guo, Yong-Fang Kuo, Ya Chen Tina Shih, Sharon H Giordano, Abbey B Berenson,

BACKGROUND:Assessing trends in breast cancer survival among young women who are largely unaffected by breast cancer screening will provide important information regarding improvements in the effectiveness of cancer care for breast cancer in the last few decades. METHODS:The cohort for this study consisted of women who were diagnosed with breast ... Read more >>

Cancer (Cancer)
[2018, 124(17):3500-3509]

Cited: 1 time

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Costs of Cancer Care for Elderly Patients with Neuroendocrine Tumors.

Chan Shen, Arvind Dasari, Dian Gu, Yiyi Chu, Shouhao Zhou, Ying Xu, Daniel Halperin, Shuangshuang Fu, James C Yao, Ya-Chen Tina Shih,

BACKGROUND:The incidence and prevalence of neuroendocrine tumors (NETs) have been steadily rising. NETs can arise in various parts of the body and have distinct pathogenesis, clinical manifestations, treatment, and survival compared to other neoplasms. The magnitude of the economic burden of NETs is largely unknown. This study aimed to estimate ... Read more >>

Pharmacoeconomics (PharmacoEconomics)
[2018, 36(8):1005-1013]

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Evaluating for Pseudoprogression in Colorectal and Pancreatic Tumors Treated With Immunotherapy.

Christine M Parseghian, Madhavi Patnana, Priya Bhosale, Kenneth R Hess, Ya-Chen Tina Shih, Bumyang Kim, Scott Kopetz, Michael J Overman, Gauri R Varadhachary, Milind Javle, Aung Naing, Sarina Piha-Paul, David Hong, Hung Le, Vivek Subbiah, Shubham Pant,

Pseudoprogression has been observed in patients with various tumor types treated with immunotherapy. However, the frequency of pseudoprogression is unknown in gastrointestinal malignancies. Metastatic colorectal cancer (mCRC) and advanced pancreatic ductal adenocarcinoma (PDAC) patients who progressed on treatment with immunotherapy beyond RECIST version 1.1 criteria were analyzed. Degree of progression, ... Read more >>

J. Immunother. (Journal of immunotherapy (Hagerstown, Md. : 1997))
[2018, 41(6):284-291]

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Cost and efficacy comparison of five prostate biopsy modalities: a platform for integrating cost into novel-platform comparative research.

Muammer Altok, Bumyang Kim, Bina B Patel, Ya-Chen Tina Shih, John F Ward, Stephen E McRae, Brian F Chapin, Louis L Pisters, Curtis A Pettaway, Jeri Kim, Huseyin C Demirel, John W Davis,

BACKGROUND:The cornerstone of prostate cancer diagnosis remains the transrectal ultrasound-guided biopsy (TRUS-BX), which most frequently occurs in the office setting under local anesthesia. However, there are now other techniques of prostate biopsy aimed at improving outcomes such as patient comfort, significant cancer detection, and infectious complications. The purpose of the ... Read more >>

Prostate Cancer Prostatic Dis. (Prostate cancer and prostatic diseases)
[2018, 21(4):524-532]

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Semiparametric Estimation of Longitudinal Medical Cost Trajectory.

Liang Li, Chih-Hsien Wu, Jing Ning, Xuelin Huang, Ya-Chen Tina Shih, Yu Shen,

Estimating the average monthly medical costs from disease diagnosis to a terminal event such as death for an incident cohort of patients is a topic of immense interest to researchers in health policy and health economics because patterns of average monthly costs over time reveal how medical costs vary across ... Read more >>

J Am Stat Assoc (Journal of the American Statistical Association)
[2018, 113(522):582-592]

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Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society.

Andrew M D Wolf, Elizabeth T H Fontham, Timothy R Church, Christopher R Flowers, Carmen E Guerra, Samuel J LaMonte, Ruth Etzioni, Matthew T McKenna, Kevin C Oeffinger, Ya-Chen Tina Shih, Louise C Walter, Kimberly S Andrews, Otis W Brawley, Durado Brooks, Stacey A Fedewa, Deana Manassaram-Baptiste, Rebecca L Siegel, Richard C Wender, Robert A Smith,

In the United States, colorectal cancer (CRC) is the fourth most common cancer diagnosed among adults and the second leading cause of death from cancer. For this guideline update, the American Cancer Society (ACS) used an existing systematic evidence review of the CRC screening literature and microsimulation modeling analyses, including ... Read more >>

CA Cancer J Clin (CA: a cancer journal for clinicians)
[2018, 68(4):250-281]

Cited: 23 times

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Impact on Oncology Practices of Including Drug Costs in Bundled Payments.

Jeffery C Ward, Laura A Levit, Ray D Page, John E Hennessy, John V Cox, Deborah Y Kamin, Suanna S Bruinooge, Ya-Chen Tina Shih, Blase N Polite,

INTRODUCTION:This analysis evaluates the impact of bundling drug costs into a hypothetic bundled payment. METHODS:An economic model was created for patient vignettes from: advanced-stage III colon cancer and metastatic non-small-cell lung cancer. First quarter 2016 Medicare reimbursement rates were used to calculate the average fee-for-service (FFS) reimbursement for these vignettes. ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2018, 14(5):e259-e268]

Cited: 2 times

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