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The maturity in fetal pigs using a multi-fluid metabolomic approach

Gaëlle Lefort, Rémi Servien, Hélène Quesnel, Yvon Billon, Laurianne Canario, Nathalie Iannuccelli, Cécile Canlet, Alain Paris, Nathalie Vialaneix, Laurence Liaubet,

Abstract In mammalian species, the first days after birth are an important period for survival and the rates of mortality before weaning are high. In pigs, the perinatal deaths average 20% of the litter, with important economic and societal consequences. Among the factors influencing piglet survival at birth, the maturity ... Read more >>

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[Cystic fibrosis and pregnancy: Outcome, prognostic factors and obstetrical management].

A-L Fijean, M Chamagne, Y Billon, O Morel, S Dahlhoff,

As a result of improvements in life expectancy and therapies, increasing numbers of patients with cystic fibrosis become pregnant. The first studies were pessimistic and report adverse outcomes on the fetus and the mother. In the recent publications, long-term outcome for women with cystic fibrosis does not appear to be ... Read more >>

Gynecol Obstet Fertil Senol (Gynecologie, obstetrique, fertilite & senologie)
[2020, 48(5):428-435]

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Real-Life Safety and Effectiveness of Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis.

Pierre-Régis Burgel, Anne Munck, Isabelle Durieu, Raphaël Chiron, Laurent Mely, Anne Prevotat, Marlene Murris-Espin, Michele Porzio, Michel Abely, Philippe Reix, Christophe Marguet, Julie Macey, Isabelle Sermet-Gaudelus, Harriet Corvol, Stéphanie Bui, Lydie Lemonnier, Clémence Dehillotte, Jennifer Da Silva, Jean-Louis Paillasseur, Dominique Hubert, ,

Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and adults (≥18 yr) in a real-life postapproval setting.Methods: The study was conducted ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(2):188-197]

Cited: 1 time

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[Therapeutic strategies in advanced ALK positive non-small cell lung cancer].

A Tiotiu, Y Billon, P Vaillant, O Menard, P Hofman, C Mascaux,

Anaplastic lymphoma kinase (ALK) rearrangement is a therapeutically targetable oncogenic driver found in 5% of patients with non-small-cell lung cancer (NSCLC). The objective of this paper is to synthesise current knowledge on ALK rearrangement and its impact on the management of advanced NSCLC. Several inhibitors of the tyrosine kinase of ... Read more >>

Rev Mal Respir (Revue des maladies respiratoires)
[2019, 36(10):1107-1116]

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Effect of chronic and acute heat challenges on fecal microbiota composition, production, and thermoregulation traits in growing pigs1,2.

Mathilde Le Sciellour, Olivier Zemb, Isabelle Hochu, Juliette Riquet, Hélène Gilbert, Mario Giorgi, Yvon Billon, Jean-Luc Gourdine, David Renaudeau,

The present study aimed at investigating the impact of heat challenges on gut microbiota composition in growing pigs and its relationship with pigs' performance and thermoregulation responses. From a total of 10 F1 sire families, 558 and 564 backcross Large White × Créole pigs were raised and phenotyped from 11 ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2019, 97(9):3845-3858]

Cited: 1 time

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Genotype by environment interactions for performance and thermoregulation responses in growing pigs1,2.

Jean-Luc Gourdine, Juliette Riquet, Roseline Rosé, Nausicaa Poullet, Mario Giorgi, Yvon Billon, David Renaudeau, Hélène Gilbert,

Heat stress affects pig health, welfare, and production, and thus the economic viability of the pig sector in many countries. Breeding for heat tolerance is a complex issue, increasingly important due to climate change and the development of pig production in tropical areas. Characterizing genetic determinism of heat tolerance would ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2019, 97(9):3699-3713]

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Towards the quantitative characterisation of piglets' robustness to weaning: a modelling approach.

M Revilla, N C Friggens, L P Broudiscou, G Lemonnier, F Blanc, L Ravon, M J Mercat, Y Billon, C Rogel-Gaillard, N Le Floch, J Estellé, R Muñoz-Tamayo,

Weaning is a critical transition phase in swine production in which piglets must cope with different stressors that may affect their health. During this period, the prophylactic use of antibiotics is still frequent to limit piglet morbidity, which raises both economic and public health concerns such as the appearance of ... Read more >>

Animal (Animal : an international journal of animal bioscience)
[2019, 13(11):2536-2546]

Cited: 1 time

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Effects of divergent selection upon adrenocortical activity on immune traits in pig.

Julie Hervé, Elena Terenina, Karine Haurogné, Elodie Bacou, Elizaveta Kulikova, Marie Allard, Yvon Billon, Jean-Marie Bach, Pierre Mormède, Blandine Lieubeau,

BACKGROUND:The sustainability of farming and animal welfare requires the reconsideration of current selection schemes. In particular, implementation of new selection criteria related to animal health and welfare should help to produce more robust animals and to reduce anti-microbial use. The hypothalamo-pituitary-adrenocortical (HPA) axis plays a major role in metabolic regulation ... Read more >>

BMC Vet. Res. (BMC veterinary research)
[2019, 15(1):71]

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[The impact of the patient's age on the delay of the lung cancer treatment].

Arnaud Knoepfli, Pierre Vaillant, Yves Billon, Maeva Zysman, Olivier Menard, Angelica Tiotiu,

INTRODUCTION:The results from the medical literature regarding the influence of patient's age on the delay of treatment in lung cancer are controversial in the absence of a consensual definition. The aim of this study was to determine the impact of the patient's age on the delay of the lung cancer ... Read more >>

Bull Cancer (Bulletin du cancer)
[2019, 106(5):421-430]

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Responses to weaning in two pig lines divergently selected for residual feed intake depending on diet.

Hélène Gilbert, Julien Ruesche, Nelly Muller, Yvon Billon, Vincent Begos, Lucile Montagne,

Weaning is a stress every piglet has to face. It is a main cause of antibiotic uses due to digestive disorders. In this study, response to weaning was analyzed in pigs from two lines divergently selected for residual feed intake (RFI) during growth. A total of 132 pigs from each ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2019, 97(1):43-54]

Cited: 1 time

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Towards the quantitative characterization of piglets’ robustness to weaning: A modelling approach

Revilla, N.C. Friggens, L.-P. Broudiscou, Lemonnier, Blanc, Ravon, M.-J. Mercat, Billon, Rogel-Gaillard, Le Floch, Estellé, Muñoz-Tamayo,

Abstract Weaning is a critical transition phase in swine production in which piglets must cope with different stressors that may affect their health. During this period, the prophylactic use of antibiotics is still frequent to limit piglet morbidity, which raises both economic and public health concerns such as the appearance ... Read more >>

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Immunome differences between porcine ileal and jejunal Peyer's patches revealed by global transcriptome sequencing of gut-associated lymphoid tissues.

T Maroilley, M Berri, G Lemonnier, D Esquerré, C Chevaleyre, S Mélo, F Meurens, J L Coville, J J Leplat, A Rau, B Bed'hom, S Vincent-Naulleau, M J Mercat, Y Billon, P Lepage, C Rogel-Gaillard, J Estellé,

The epithelium of the intestinal mucosa and the gut-associated lymphoid tissues (GALT) constitute an essential physical and immunological barrier against pathogens. In order to study the specificities of the GALT transcriptome in pigs, we compared the transcriptome profiles of jejunal and ileal Peyer's patches (PPs), mesenteric lymph nodes (MLNs) and ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):9077]

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Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed.

F Gondret, B Guével, M C Père, H Quesnel, Y Billon, E Com, L Canario, I Louveau, L Liaubet,

The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows (a fat breed with excellent maternal ability) have a higher survival rate than piglets from Large White sows (a lean breed). To identify the main ... Read more >>

J Anim Sci Biotechnol (Journal of Animal Science and Biotechnology)
[2018, 9:28]

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1HNMR-Based metabolomic profiling method to develop plasma biomarkers for sensitivity to chronic heat stress in growing pigs.

Samir Dou, Nathalie Villa-Vialaneix, Laurence Liaubet, Yvon Billon, Mario Giorgi, Hélène Gilbert, Jean-Luc Gourdine, Juliette Riquet, David Renaudeau,

The negative impact of heat stress (HS) on the production performances in pig faming is of particular concern. Novel diagnostic methods are needed to predict the robustness of pigs to HS. Our study aimed to assess the reliability of blood metabolome to predict the sensitivity to chronic HS of 10 ... Read more >>

PLoS ONE (PloS one)
[2017, 12(11):e0188469]

Cited: 1 time

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Integrated Analysis of Proteomic and Transcriptomic Data Highlights Late Fetal Muscle Maturation Process.

Valentin Voillet, Magali San Cristobal, Marie-Christine Père, Yvon Billon, Laurianne Canario, Laurence Liaubet, Louis Lefaucheur,

In pigs, the perinatal period is the most critical time for survival. Piglet maturation, which occurs at the end of gestation, is an important determinant of early survival. Skeletal muscle plays a key role in adaptation to extra-uterine life, e.g. motor function and thermoregulation. Progeny from two breeds with extreme ... Read more >>

Mol. Cell Proteomics (Molecular & cellular proteomics : MCP)
[2018, 17(4):672-693]

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Time course study of the response to LPS targeting the pig immune gene networks.

Elena Terenina, Valérie Sautron, Caroline Ydier, Darya Bazovkina, Amélie Sevin-Pujol, Laure Gress, Yannick Lippi, Claire Naylies, Yvon Billon, Laurence Liaubet, Pierre Mormede, Nathalie Villa-Vialaneix,

Stress is a generic term used to describe non-specific responses of the body to all kinds of challenges. A very large variability in the response can be observed across individuals, depending on numerous conditioning factors like genetics, early influences and life history. As a result, there is a wide range ... Read more >>

BMC Genomics (BMC genomics)
[2017, 18(1):988]

Cited: 2 times

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Estimation of the effects of selection on French Large White sow and piglet performance during the suckling period.

P Silalahi, T Tribout, Y Billon, J Gogué, J P Bidanel,

The effects of 21 yr of selection were estimated for sow and piglet performance during the suckling period in a French Large White (LW) pig population using frozen semen. Two experimental groups (EXP = L77 and L98) were produced by inseminating LW sows with either stored frozen semen from 17 ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2017, 95(10):4333-4343]

Cited: 1 time

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Interactions between sire family and production environment (temperate vs. tropical) on performance and thermoregulation responses in growing pigs.

R Rosé, H Gilbert, T Loyau, M Giorgi, Y Billon, J Riquet, D Renaudeau, J-L Gourdine,

The aim of this study was to evaluate the effect of 2 climatic environments (temperate [TEMP] vs. tropical humid [TROP]) on production and thermoregulation traits in growing pigs. A backcross design involving Large White (LW; heat sensitive) and Creole (CR; heat tolerant) pigs was studied. The same 10 F LW ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2017, 95(11):4738-4751]

Cited: 3 times

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Comparing the intestinal transcriptome of Meishan and Large White piglets during late fetal development reveals genes involved in glucose and lipid metabolism and immunity as valuable clues of intestinal maturity.

Ying Yao, Valentin Voillet, Maeva Jegou, Magali SanCristobal, Samir Dou, Véronique Romé, Yannick Lippi, Yvon Billon, Marie-Christine Père, Gaëlle Boudry, Laure Gress, Nathalie Iannucelli, Pierre Mormède, Hélène Quesnel, Laurianne Canario, Laurence Liaubet, Isabelle Le Huërou-Luron,

Maturity of intestinal functions is critical for neonatal health and survival, but comprehensive description of mechanisms underlying intestinal maturation that occur during late gestation still remain poorly characterized. The aim of this study was to investigate biological processes specifically involved in intestinal maturation by comparing fetal jejunal transcriptomes of two ... Read more >>

BMC Genomics (BMC genomics)
[2017, 18(1):647]

Cited: 1 time

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Review: divergent selection for residual feed intake in the growing pig.

H Gilbert, Y Billon, L Brossard, J Faure, P Gatellier, F Gondret, E Labussière, B Lebret, L Lefaucheur, N Le Floch, I Louveau, E Merlot, M-C Meunier-Salaün, L Montagne, P Mormede, D Renaudeau, J Riquet, C Rogel-Gaillard, J van Milgen, A Vincent, J Noblet,

This review summarizes the results from the INRA (Institut National de la Recherche Agronomique) divergent selection experiment on residual feed intake (RFI) in growing Large White pigs during nine generations of selection. It discusses the remaining challenges and perspectives for the improvement of feed efficiency in growing pigs. The impacts ... Read more >>

Animal (Animal : an international journal of animal bioscience)
[2017, 11(9):1427-1439]

Cited: 18 times

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Acute social stress-induced immunomodulation in pigs high and low responders to ACTH.

Elodie Bacou, Karine Haurogné, Grégoire Mignot, Marie Allard, Laurence De Beaurepaire, Jordan Marchand, Elena Terenina, Yvon Billon, Julien Jacques, Jean-Marie Bach, Pierre Mormède, Julie Hervé, Blandine Lieubeau,

Pig husbandry is known as an intensive breeding system, piglets being submitted to multiple stressful events such as early weaning, successive mixing, crowding and shipping. These stressors are thought to impair immune defences and might contribute, at least partly, to the prophylactic use of antibiotics. Robustness was recently defined as ... Read more >>

Physiol. Behav. (Physiology & behavior)
[2017, 169:1-8]

Cited: 6 times

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Multiple-trait structured antedependence model to study the relationship between litter size and birth weight in pigs and rabbits.

Ingrid David, Hervé Garreau, Elodie Balmisse, Yvon Billon, Laurianne Canario,

Some genetic studies need to take into account correlations between traits that are repeatedly measured over time. Multiple-trait random regression models are commonly used to analyze repeated traits but suffer from several major drawbacks. In the present study, we developed a multiple-trait extension of the structured antedependence model (SAD) to ... Read more >>

Genet. Sel. Evol. (Genetics, selection, evolution : GSE)
[2017, 49(1):11]

Cited: 6 times

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Estimation of the effects of selection on French Large White reproductive performance using frozen semen.

P Silalahi, T Tribout, A Prunier, Y Billon, J Gogué, J P Bidanel,

Genetic trends for male and female sexual development and components of litter size and weight at birth (LB) as well as traits related to sow lifetime productivity were estimated in a French Large White (LW) pig population using frozen semen. Two experimental groups (EXP = L77 and L98) were produced ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2016, 94(9):3655-3662]

Cited: 3 times

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Phylogenetic network analysis applied to pig gut microbiota identifies an ecosystem structure linked with growth traits.

Yuliaxis Ramayo-Caldas, Nuria Mach, Patricia Lepage, Florence Levenez, Catherine Denis, Gaetan Lemonnier, Jean-Jacques Leplat, Yvon Billon, Mustapha Berri, Jöel Doré, Claire Rogel-Gaillard, Jordi Estellé,

The ecological interactions within the gut microbial communities are complex and far from being fully understood. Here we report the first study that aims at defining the interaction network of the gut microbiota in pigs and comparing it with the enterotype-like clustering analysis. Fecal microbiota of 518 healthy piglets was ... Read more >>

ISME J (The ISME journal)
[2016, 10(12):2973-2977]

Cited: 55 times

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Time course of the response to ACTH in pig: biological and transcriptomic study.

Valérie Sautron, Elena Terenina, Laure Gress, Yannick Lippi, Yvon Billon, Catherine Larzul, Laurence Liaubet, Nathalie Villa-Vialaneix, Pierre Mormède,

HPA axis plays a major role in physiological homeostasis. It is also involved in stress and adaptive response to the environment. In farm animals in general and specifically in pigs, breeding strategies have highly favored production traits such as lean growth rate, feed efficiency and prolificacy at the cost of ... Read more >>

BMC Genomics (BMC genomics)
[2015, 16:961]

Cited: 9 times

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