Full Text Journal Articles by
Author Xun Ming Ji

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Inflammatory Biomarkers May Predict Poor Outcome in Patients with Chronic Cerebrospinal Venous Insufficiency.

Siying Song, Duo Lan, Xiao qin Wu, Yu chuan Ding, Xun ming Ji, Ran Meng,

Abstract Background and purpose Chronic cerebrospinal venous insufficiency (CCSVI) related inflammatory process is still unclear. This study aimed to evaluate peripheral inflammatory biomarkers in both intracranial CCSVI and the extracranial CCSVI group, as well as the relationship between the inflammatory state and prognosis of CCSVI. Methods Patients with CCSVI were ... Read more >>

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Stroke prevention and control system in China: CSPPC-Stroke Program.

Bao-Hua Chao, Feng Yan, Yang Hua, Jian-Min Liu, Yi Yang, Xun-Ming Ji, Bin Peng, Guo-Guang Zhao, Yong-Jun Wang, De-Zhi Kang, Yi-Long Wang, Jin-Sheng Zeng, Lan Chu, Tian-Xiao Li, Yu-Ming Xu, Ming Liu, Li He, Yun Xu, Jian Wu, Min Lou, Wei Yue, Lei Cao, Wen-Jun Tu, Long-De Wang,

In China, stroke is a major cause of mortality, and long-term physical and cognitive impairment. To meet this challenge, the Ministry of Health China Stroke Prevention Project Committee (CSPPC) was established in April 2011. This committee actively promotes stroke prevention and control in China. With government financial support of 838.4 ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, :1747493020913557]

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Long-term outcomes of axillary to carotid bypass for symptomatic patients with chronic common carotid artery occlusion.

Li Po Song, Yong Quan Gu, Heng Xi Yu, Xun Ming Ji, Chun Mei Wang, Jian Zhang,

OBJECTIVE:Relatively little is known about the natural history of atherosclerotic common carotid artery occlusion and optimal treatment of these patients is still unclear. The aim of this retrospective study was to evaluate the immediate- and long-term outcomes of axillary to carotid bypass with polytetrafluoroethylene graft for symptomatic patients with chronic ... Read more >>

J. Vasc. Surg. (Journal of vascular surgery)
[2019, :]

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Remote ischemic conditioning for the treatment of ischemic moyamoya disease.

Jia-Yue Ding, Shu-Ling Shang, Zhi-Shan Sun, Karam Asmaro, Wei-Li Li, Qi Yang, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng,

AIMS:This study investigated the safety and efficacy of remote ischemic conditioning (RIC) on ameliorating the sequelae of ischemic moyamoya disease (iMMD). METHODS:A total of 30 iMMD patients underwent long-term RIC and were followed up at 0.5, 1, and 2 years for clinical outcomes, including frequency of stroke recurrence, Patient Global Impression ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2020, 26(5):549-557]

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Antiphospholipid syndrome may induce non-thrombus internal jugular vein stenosis - Two cases report and literature review

Song Si-ying, Rajah Gary, Ding Yu-chuan, Ji Xun-ming, Ran Meng,

Abstract Background: Antiphospholipid syndrome (APS) is associated with artery or venous thrombosis. However, non-thrombus venous stenosis is rarely reported. Case presentation: This study described two young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literatures on this issue, including clinical features, diagnosis and treatment. Conclusions: IJVS is ... Read more >>

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Collagen-chitosan scaffold impregnated with bone marrow mesenchymal stem cells for treatment of traumatic brain injury.

Feng Yan, Ming Li, Hong-Qi Zhang, Gui-Lin Li, Yang Hua, Ying Shen, Xun-Ming Ji, Chuan-Jie Wu, Hong An, Ming Ren,

Combinations of biomaterials and cells can effectively target delivery of cells or other therapeutic factors to the brain to rebuild damaged nerve pathways after brain injury. Porous collagen-chitosan scaffolds were prepared by a freeze-drying method based on brain tissue engineering. The scaffolds were impregnated with rat bone marrow mesenchymal stem ... Read more >>

Neural Regen Res (Neural regeneration research)
[2019, 14(10):1780-1786]

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MicroRNA expression in the hippocampal CA1 region under deep hypothermic circulatory arrest.

Xiao-Hua Wang, Dong-Xu Yao, Xiu-Shu Luan, Yu Wang, Hai-Xia Liu, Bei Liu, Yang Liu, Lei Zhao, Xun-Ming Ji, Tian-Long Wang,

Using deep hypothermic circulatory arrest, thoracic aorta diseases and complex heart diseases can be subjected to corrective procedures. However, mechanisms underlying brain protection during deep hypothermic circulatory arrest are unclear. After piglet models underwent 60 minutes of deep hypothermic circulatory arrest at 14°C, expression of microRNAs (miRNAs) was analyzed in ... Read more >>

Neural Regen Res (Neural regeneration research)
[2019, 14(11):2003-2010]

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Cognitive improvement after carotid artery stenting in patients with symptomatic internal carotid artery near-occlusion.

Li Po Song, Wei Wei Zhang, Yong Quan Gu, Xun Ming Ji, Jian Zhang,

BACKGROUND AND PURPOSE:To investigate the influence of carotid artery stenting (CAS) with embolic protection device (EPD) on the cognitive function of patients with near-occlusion of the cervical internal carotid artery (ICA). METHODS:From February 2014 to December 2017, a total of 79 symptomatic patients were recruited in this study. Of these ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2019, 404:86-90]

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Cervical spondylotic internal jugular venous compression syndrome.

Jia-Yue Ding, Da Zhou, Li-Qun Pan, Jing-Yuan Ya, Cheng Liu, Feng Yan, Chun-Qiu Fan, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng,

AIMS:This study aimed to identify the clinical profiles of cervical spondylosis-related internal jugular vein stenosis (IJVS) comprehensively. METHODS:A total of 46 patients, who were diagnosed as IJVS induced by cervical spondylotic compression were recruited. The clinical manifestations and imaging features of IJVS were presented particularly in this study. RESULTS:Vascular stenosis ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2020, 26(1):47-54]

Cited: 3 times

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Batroxobin in combination with anticoagulation may promote venous sinus recanalization in cerebral venous thrombosis: A real-world experience.

Jia-Yue Ding, Li-Qun Pan, Yan-Yu Hu, Gary B Rajah, Da Zhou, Chao-Bo Bai, Jing-Yuan Ya, Zhong-Ao Wang, Ke-Xin Jin, Jing-Wei Guan, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng,

AIMS:The objective of this study was to evaluate cerebral venous recanalization with magnetic resonance black-blood thrombus imaging (MRBTI) in patients with cerebral venous thrombosis (CVT) who underwent batroxobin treatment in combination with anticoagulation. METHODS:A total of 31 CVT patients were enrolled in this real-world registry study. The patients were divided ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2019, 25(5):638-646]

Cited: 1 time

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Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice.

Li-Qiang Liu, Xiang-Rong Liu, Jing-Yan Zhao, Feng Yan, Rong-Liang Wang, Shao-Hong Wen, Lei Wang, Yu-Min Luo, Xun-Ming Ji,

INTRODUCTION:The neuroprotective effects of hypothermia in acute ischemic stroke are well documented. However, the mechanisms involved in the effects remain to be clearly elucidated and the role of hypothermia on long-term white matter integrity after acute ischemic stroke has yet to be investigated. AIMS:To investigate the role of mild focal ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2018, 24(12):1275-1285]

Cited: 5 times

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Severe Hyperhomocysteinemia with Two Novel Mutations of c.154T>C and c.457G>A in Cystathionine Beta-Synthase Gene.

Hong An, Chun-Qiu Fan, Jian-Gang Duan, Yi Ren, Kai Dong, Qian Zhang, Xun-Ming Ji, Xiao-Qin Huang,

Chin. Med. J. (Chinese medical journal)
[2018, 131(19):2368-2370]

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2-(2-Benzofuranyl)-2-imidazoline treatment within 5 hours after cerebral ischemia/reperfusion protects the brain.

Zheng Zhang, Jin-Long Yang, Lin-Lei Zhang, Zhen-Zhen Chen, Jia-Ou Chen, Yun-Gang Cao, Man Qu, Xin-Da Lin, Xun-Ming Ji, Zhao Han,

We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin (2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou ... Read more >>

Neural Regen Res (Neural regeneration research)
[2018, 13(12):2111-2118]

Cited: 1 time

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Understanding jugular venous outflow disturbance.

Da Zhou, Jia-Yue Ding, Jing-Yuan Ya, Li-Qun Pan, Feng Yan, Qi Yang, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng,

Extracranial venous abnormalities, especially jugular venous outflow disturbance, were originally viewed as nonpathological phenomena due to a lack of realization and exploration of their feature and clinical significance. The etiology and pathogenesis are still unclear, whereas a couple of causal factors have been conjectured. The clinical presentation of this condition ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2018, 24(6):473-482]

Cited: 3 times

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Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective.

Shu-Hai Shi, Zhi-Feng Qi, Yu-Min Luo, Xun-Ming Ji, Ke Jian Liu,

Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. ... Read more >>

Med Gas Res (Medical gas research)
[2016, 6(3):147-153]

Cited: 11 times

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Rationale and Study Design for a Single-Arm Phase IIa Study Investigating Feasibility of Preventing Ischemic Cerebrovascular Events in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events Using Remote Ischemic Conditioning.

Shi-Meng Liu, Wen-Le Zhao, Hai-Qing Song, Ran Meng, Si-Jie Li, Chang-Hong Ren, Bruce Ovbiagele, Xun-Ming Ji, Wu-Wei Feng,

BACKGROUND:Acute minor ischemic stroke (AMIS) or transient ischemic attack (TIA) is a common cerebrovascular event with a considerable high recurrence. Prior research demonstrated the effectiveness of regular long-term remote ischemic conditioning (RIC) in secondary stroke prevention in patients with intracranial stenosis. We hypothesized that RIC can serve as an effective ... Read more >>

Chin. Med. J. (Chinese medical journal)
[2018, 131(3):347-351]

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Advances in chronic cerebral circulation insufficiency.

Da Zhou, Ran Meng, Si-Jie Li, Jing-Yuan Ya, Jia-Yue Ding, Shu-Ling Shang, Yu-Chuan Ding, Xun-Ming Ji,

Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long-term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2018, 24(1):5-17]

Cited: 11 times

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Generalization of the Right Acute Stroke Prevention Strategies in Reducing in-Hospital Delays.

Qiang Huang, Hai-Qing Song, Xun-Ming Ji, Wei-Yang Cheng, Juan Feng, Jian Wu, Qing-Feng Ma,

The aim of this study was to reduce the door-to-needle (DTN) time of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) through a comprehensive, hospital-based implementation strategy. The intervention involved a systemic literature review, identifying barriers to rapid IVT treatment at our hospital, setting target DTN time intervals, and building ... Read more >>

PLoS ONE (PloS one)
[2016, 11(5):e0154972]

Cited: 5 times

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Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats.

Ning-Qun Wang, Li-Ye Wang, Hai-Ping Zhao, Ping Liu, Rong-Liang Wang, Jue-Xian Song, Li Gao, Xun-Ming Ji, Yu-Min Luo,

Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented and approved by the State Food and Drug Administration. In this retrospective validation study we investigated the ability of LYT to protect against cerebral ischemia-reperfusion injury in rats. Cerebral ischemia-reperfusion injury was induced ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2015, 2015:369021]

Cited: 2 times

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Cerebrospinal fluid from rats given hypoxic preconditioning protects neurons from oxygen-glucose deprivation-induced injury.

Yan-Bo Zhang, Zheng-Dong Guo, Mei-Yi Li, Si-Jie Li, Jing-Zhong Niu, Ming-Feng Yang, Xun-Ming Ji, Guo-Wei Lv,

Hypoxic preconditioning activates endogenous mechanisms that protect against cerebral ischemic and hypoxic injury. To better understand these protective mechanisms, adult rats were housed in a hypoxic environment (8% O2/92% N2) for 3 hours, and then in a normal oxygen environment for 12 hours. Their cerebrospinal fluid was obtained to culture ... Read more >>

Neural Regen Res (Neural regeneration research)
[2015, 10(9):1471-1476]

Cited: 1 time

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Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.

Yan-Bo Zhang, Zheng-Dong Guo, Mei-Yi Li, Peter Fong, Ji-Guo Zhang, Can-Wen Zhang, Ke-Rui Gong, Ming-Feng Yang, Jing-Zhong Niu, Xun-Ming Ji, Guo-Wei Lv,

Currently, the clinical management of visceral pain remains unsatisfactory for many patients suffering from this disease. While preliminary animal studies have suggested the effectiveness of gabapentin in successfully treating visceral pain, the mechanism underlying its analgesic effect remains unclear. Evidence from other studies has demonstrated the involvement of protein kinase ... Read more >>

PLoS ONE (PloS one)
[2015, 10(10):e0141142]

Cited: 7 times

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Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke.

Guo-Xiang Huang, Xun-Ming Ji, Yu-Chuan Ding, Huai-Yu Huang,

We sought to investigate whether serum cystatin C levels are correlated with either stroke severity or with potential risk factors of acute ischemic stroke.171 patients with acute ischemic stroke and 99 control subjects with minor, unrelated diseases with stroke were included in this retrospective study. Serum cystatin C levels were ... Read more >>

Neurol. Res. (Neurological research)
[2016, 38(6):518-523]

Cited: 2 times

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Coexistence of High Fibrinogen and Low High-density Lipoprotein Cholesterol Levels Predicts Recurrent Cerebral Venous Thrombosis.

Xin Ma, Xun-Ming Ji, Paul Fu, Yu-Chuan Ding, Qiang Xue, Yue Huang,

Cerebral venous thrombosis (CVT) may lead to serious neurological disorders; however, little is known about the risk factors for recurrent CVT. Our aim was to determine the association between elevated fibrinogen and decreased high-density lipoprotein cholesterol (HDL-C) levels with recurrent CVT.This retrospective cohort study included participants if they had a ... Read more >>

Chin. Med. J. (Chinese medical journal)
[2015, 128(13):1732-1737]

Cited: 3 times

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Remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke is Associated with Significant Alterations in Peripheral Immune Responses.

Zong-Jian Liu, Chen Chen, Xiao-Rong Li, Yuan-Yuan Ran, Tao Xu, Ying Zhang, Xiao-Kun Geng, Yu Zhang, Hui-Shan Du, Rehana K Leak, Xun-Ming Ji, Xiao-Ming Hu,

AIMS:Remote ischemic preconditioning (RIPC) of a limb is a clinically feasible strategy to protect against ischemia-reperfusion injury after stroke. However, the mechanism underlying RIPC remains elusive. METHODS:We generated a rat model of noninvasive RIPC by four repeated cycles of brief blood flow constriction (5 min) in the hindlimbs using a ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2016, 22(1):43-52]

Cited: 25 times

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Gender-linked stem cell alterations in stroke and postpartum depression.

Mibel M Pabón, Xun-Ming Ji, Jamie Winderbaum Fernandez, Cesar V Borlongan,

Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2015, 21(4):348-356]

Cited: 1 time

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