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Author Xueyi Yang

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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miR-934 promotes breast cancer metastasis by regulation of PTEN and epithelial-mesenchymal transition.

Yexia Lu, Xiuxiu Hu, Xueyi Yang,

Breast cancer (BC) is the most commonly diagnosed malignancy and the leading cause of cancer-related mortality among females. Over 90 % of the cases of death in BC patients are attributed to tumor cell metastasis. Therefore, it is urgently needed to investigate the molecular mechanisms of BC metastasis. The expression ... Read more >>

Tissue Cell (Tissue & cell)
[2021, 71:101581]

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Chemical Editing of Proteoglycan Architecture

Timothy O’Leary, Meg Critcher, Tesia Stephenson, Xueyi Yang, Noah Bartfield, Richard Hawkins, Mia Huang,

Proteoglycans are heterogeneous macromolecular glycoconjugates that orchestrate many important cellular processes. While much attention has focused on the poly-sulfated glycosaminoglycan chains that decorate proteoglycans, other important elements of proteoglycan architecture, such as their core proteins and cell surface localization, have garnered less emphasis. Hence, comprehensive structure-function relationships that consider the ... Read more >>

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Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells.

Huijuan Wu, Yuanyuan Yu, Huanwei Huang, Yucheng Hu, Siling Fu, Zheng Wang, Mengting Shi, Xi Zhao, Jie Yuan, Jiao Li, Xueyi Yang, Ennan Bin, Dong Wei, Hongbin Zhang, Jin Zhang, Chun Yang, Tao Cai, Huaping Dai, Jingyu Chen, Nan Tang,

Cell (Cell)
[2021, 184(3):845-846]

Cited: 1 time

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Chemical screening identifies ROCK1 as a regulator of migrasome formation.

Puzhong Lu, Rui Liu, Di Lu, Yue Xu, Xueyi Yang, Zheng Jiang, Chun Yang, Li Yu, Xiaoguang Lei, Yang Chen,

Cell Discov (Cell discovery)
[2020, 6(1):51]

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Chemical screening identifies ROCK1 as a regulator of migrasome formation.

Puzhong Lu, Rui Liu, Di Lu, Yue Xu, Xueyi Yang, Zheng Jiang, Chun Yang, Li Yu, Xiaoguang Lei, Yang Chen,

Cell Discov (Cell discovery)
[2020, 6:51]

Cited: 0 times

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Optimal Gestational Weight Gain for Tibetans Based on Prepregnancy Body Mass Index.

Dajie Chen, Xianxian Zhou, Shijiao Yan, Wenzhen Li, Xueyi Yang, Chuanzhu Lv, Zuxun Lu,

We aimed to estimate the optimal gestational weight gain (GWG) in Tibetan women and to evaluate the appropriateness of the Institute of Medicine (IOM) GWG recommendations for Tibetan women. We analyzed data from 1474 Tibetan women from a cross-sectional study conducted in 2019. According to the three different body mass ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):10690]

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Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells.

Huijuan Wu, Yuanyuan Yu, Huanwei Huang, Yucheng Hu, Siling Fu, Zheng Wang, Mengting Shi, Xi Zhao, Jie Yuan, Jiao Li, Xueyi Yang, Ennan Bin, Dong Wei, Hongbin Zhang, Jin Zhang, Chun Yang, Tao Cai, Huaping Dai, Jingyu Chen, Nan Tang,

Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung periphery and then progresses toward the lung center, eventually causing respiratory failure. Little is known about the mechanisms underlying the ... Read more >>

Cell (Cell)
[2020, 180(1):107-121.e17]

Cited: 37 times

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Comparative gene expression profiling reveals key pathways and genes different in skin epidermal stem cells and corneal epithelial cells.

Yanjie Guo, Weini Wu, Xiya Ma, Mingyan Shi, Xueyi Yang,

<h4>Background</h4>Corneal epithelial cells (CECs) are required for corneal transparency and visual function, and corneal injuries may cause corneal blindness. Skin epidermal stem cells (SESCs), which share the same origin with CECs and have the potential of multi-directional differentiation are ideal seed cells for tissue engineered corneal construction to treat corneal ... Read more >>

Genes Genomics (Genes & genomics)
[2019, 41(6):679-688]

Cited: 1 time

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Continuous hypergravity alters the cytoplasmic elasticity of MC3T3-E1 osteoblasts via actin filaments.

Shuai Zhou, Xueyi Yang, Jiliang Hu, Chi Mo, Yanping Cao, Chun Yang,

Osteoblasts are sensitive to altered gravity conditions, displaying changes in RNA and protein expression, proliferation, and differentiation; however, the effect of hypergravity on the mechanical properties of osteoblasts remains unclear. In this study, atomic force microscopy (AFM) was used to evaluate the effect of hypergravity on the elasticity of osteoblasts. ... Read more >>

J Biomech (Journal of biomechanics)
[2018, 72:222-227]

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Potential tumor suppressing role of microRNA-545 in epithelial ovarian cancer.

Xibiao Jia, Xiaogang Liu, Ming Li, Yu Zeng, Zaoming Feng, Xian Su, Yan Huang, Maomao Chen, Xueyi Yang,

Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer, which exhibits invasive traits. MicroRNAs (miRNAs/miRs) have been demonstrated to serve important functions in the pathogenesis of EOC. However, the function of miR-545 in EOC remains unknown. In the present study, the function of miR-545 in EOC was ... Read more >>

Oncol Lett (Oncology letters)
[2018, 15(5):6386-6392]

Cited: 11 times

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Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells.

Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang,

Skin epidermal stem cells (SESCs), which share a single origin with corneal epithelial cells (CECs), are considered to be one of the most ideal seed cells for the construction of tissue engineered corneas. However, the mechanism underlying the transdifferentiation of SESCs to CECs has not been fully elucidated. In the ... Read more >>

Int J Mol Med (International journal of molecular medicine)
[2018, 41(2):877-887]

Cited: 1 time

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Reduced EphB6 protein in gastric carcinoma and associated lymph nodes suggests EphB6 as a gastric tumor and metastasis inhibitor.

Jiaxiu Liu, Bin Xu, Guoying Xu, Xiaolei Zhang, Xueyi Yang, Jiandong Wang,

<h4>Background</h4>Eph receptors comprise the largest group of the receptor tyrosine kinase (RTK) family, and Eph receptors interacting with their ligand ephrins play an important role in development and tumorigenesis. EphB6, a special Eph receptor that lacks tyrosine kinase activity, was reported to be expressed in some human cancers. The clinical ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2017, 19(3):241-248]

Cited: 3 times

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The four reprogramming factors and embryonic development in mice.

Xingrong Yan, Shumin Yu, Anmin Lei, Jinlian Hua, Fulin Chen, Liwen Li, Xin Xie, Xueyi Yang, Wenxin Geng, Zhongying Dou,

The transcription factors (Oct4, Sox2, c-Myc, and Klf4) play an important role in the generation of induced pluripotent stem cells. These factors are expressed in metaphase II oocytes and embryonic stem cells (ESCs). The mechanisms responsible for the reprogramming of ooplasm during nuclear transfer are expected to be associated with ... Read more >>

Cell Reprogram (Cellular reprogramming)
[2010, 12(5):565-570]

Cited: 6 times

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[Study on differentiation of embryonic stem cells into osteoblast in vitro inducing by 1,25(OH)2VD3].

Yadong Sun, Xueyi Yang, Fengtao Li, Zhongying Dou,

<h4>Objective</h4>To investigate the effect of 1,25(OH)2VD3 on differentiation of embryonic stem cells (ESCs) into osteoblasts.<h4>Methods</h4>Osteoblasts were isolated and cultured from calvarium of 2-day-old Kunming white mice, embryoid bodies (EBs) were prepared with modified zur Nieden method. EBs were divided into 4 groups according to different mediums: group A, as the ... Read more >>

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery)
[2008, 22(9):1117-1120]

Cited: 2 times

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Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a goat model.

Shengli Mi, Xueyi Yang, Qingmei Zhao, Lei Qu, Shuming Chen, Keith M Meek, Zhongying Dou,

We describe a procedure to construct an artificial corneal epithelium from cryopreserved limbal stem cells (LSCs) for corneal transplantation. The LSCs were separated from limbal tissue of male goats. The primary LSCs were identified by flow cytometry and were expanded. They were examined for stem cell-relevant properties and cryopreserved in ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2008, 75(11):1607-1616]

Cited: 13 times

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Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats.

Mei Xiao, LiLong An, XueYi Yang, Xin Ge, Hai Qiao, Ting Zhao, XiaoFei Ma, JingZhuang Fan, MengYang Zhu, ZhongYing Dou,

The major obstacle in using pancreatic islet transplantation to cure type I and some type II diabetes is the shortage of the donors. One of ways to overcome such obstacle is to isolate and clone pancreatic stem cells as "seed cells" and induce their differentiation into functional islets as an ... Read more >>

Sci China C Life Sci (Science in China. Series C, Life sciences)
[2008, 51(9):779-788]

Cited: 7 times

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Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells.

Xueyi Yang, Nicanor I Moldovan, Qingmei Zhao, Shengli Mi, Zhenhui Zhou, Dan Chen, Zhimin Gao, Dewen Tong, Zhongying Dou,

<h4>Purpose</h4>It is crucial for the treatment of severe ocular surface diseases such as Stevens-Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP) to find strategies that avoid the risks of allograft rejection and immunosuppression. Here, we report a new strategy for reconstructing the damaged corneal surface in a goat model of ... Read more >>

Mol Vis (Molecular vision)
[2008, 14:1064-1070]

Cited: 32 times

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Targeting the exogenous htPAm gene on goat somatic cell beta-casein locus for transgenic goat production.

Wei Shen, Guocheng Lan, Xueyi Yang, Lan Li, Lingjiang Min, Zhengtian Yang, Liyuan Tian, Xiaojie Wu, Yujiang Sun, Hong Chen, Jinghe Tan, Jixian Deng, Qingjie Pan,

Combining gene targeting of animal somatic cells with nuclear transfer technique has provided a powerful method to produce transgenic animal mammary gland bioreactor. The objective of this study is to make an efficient and reproducible gene targeting in goat fetal fibroblasts by inserting the exogenous htPAm cDNA into the beta-casein ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2007, 74(4):428-434]

Cited: 9 times

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Plasticity of epidermal adult stem cells derived from adult goat ear skin.

Xueyi Yang, Lei Qu, Xin Wang, Ming Zhao, Wei Li, Jinlian Hua, Mingyan Shi, Nicanor Moldovan, Hongfeng Wang, Zhongying Dou,

Here we report the isolation and characterization of pluripotent stem cells from adult goat skin. We found that these primary cells have the properties of embryonic stem cells (ESC), including the expression of appropriate immunological markers and the capability of forming embryoid bodies. The subcultured cells also show the characteristics ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2007, 74(3):386-396]

Cited: 26 times

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Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a rabbit model.

Lei Qu, Xueyi Yang, Xin Wang, Ming Zhao, Shengli Mi, Zhongying Dou, Huayan Wang,

The integrity and transparency of the cornea plays a key role in preserving vision. This paper reports a procedure to create an artificial sheet of corneal epithelium from cryopreserved limbal stem cells (LSCs) and to use this for corneal transplantation. Corneal LSCs were isolated from biopsy specimens of rabbit limbal ... Read more >>

Vet J (Veterinary journal (London, England : 1997))
[2009, 179(3):392-400]

Cited: 12 times

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