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Author Xuexin Lu

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Serum MMP-7 in the Diagnosis of Biliary Atresia.

Jingying Jiang, Junfeng Wang, Zhen Shen, Xuexin Lu, Gong Chen, Yanlei Huang, Rui Dong, Shan Zheng,

BACKGROUND:The overlapping features of biliary atresia (BA) and other neonatal cholestasis with alternative causes (non-BA) have posed challenges for diagnosis. Matrix metalloproteinase-7 (MMP-7) has been reported to be promising in diagnosing BA. We aimed to validate the diagnostic accuracy of MMP-7 for BA in a large population sample. METHODS:We enrolled ... Read more >>

Pediatrics (Pediatrics)
[2019, 144(5):]

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Intrahepatic cystic lesions in children with biliary atresia after Kasai procedure.

Jingying Jiang, Junfeng Wang, Xuexin Lu, Zhen Shen, Gong Chen, Yanlei Huang, Rui Dong, Shan Zheng,

BACKGROUND:Intrahepatic cystic lesion (ICL) is a common complication for biliary atresia post-Kasai portoenterostomy. The purpose of this study was to review the cases in our hospital and assess the correlation between characteristics of ICL and clinical outcomes. METHODS:We retrospectively analyzed 787 cases of biliary atresia from 2012 to 2016. Demographics, ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2019, 54(12):2565-2569]

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Endothelial-to-mesenchymal transition: Pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases.

Xuexin Lu, Jiannan Gong, Phyllis A Dennery, Hongwei Yao,

Endothelial-to-mesenchymal transition (EndoMT) is a process of transdifferentiation where endothelial cells gradually adopt the phenotypic characteristics of mesenchymal cells. This phenomenon was first discovered in embryonic heart development. The mechanisms underlying EndoMT are due to the activation of transforming growth factor-β, bone morphogenetic protein, Wingless/Integrated, or Notch signaling pathways. The ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2019, 168:100-107]

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Fatty Acid Oxidation Protects against Hyperoxia-induced Endothelial Cell Apoptosis and Lung Injury in Neonatal Mice.

Hongwei Yao, Jiannan Gong, Abigail L Peterson, Xuexin Lu, Peng Zhang, Phyllis A Dennery,

In neonates, hyperoxia or positive pressure ventilation causes continued lung injury characterized by simplified vascularization and alveolarization, which are the hallmarks of bronchopulmonary dysplasia. Although endothelial cells (ECs) have metabolic flexibility to maintain cell function under stress, it is unknown whether hyperoxia causes metabolic dysregulation in ECs, leading to lung ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2019, 60(6):667-677]

Cited: 3 times

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Triple A syndrome: two siblings with a novel mutation in the AAAS gene.

Athanasia Bouliari, Xuexin Lu, Rebecca W Persky, Constantine A Stratakis,

OBJECTIVE:Triple A syndrome is a rare autosomal recessive disorder caused by mutations in the AAAS gene on chromosome 12q13. Its main clinical features are alacrima, achalasia, and adrenal insufficiency, with most patients also having neurological symptoms and autonomic dysfunction. The neurologic manifestations are less well-understood, especially in children. Here, we ... Read more >>

Hormones (Athens) (Hormones (Athens, Greece))
[2019, 18(1):109-112]

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A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice.

Pengcheng Yu, Jianghong Yan, Weicheng Wu, Xiaoyan Tao, Xuexin Lu, Shuqing Liu, Wuyang Zhu,

BACKGROUND:Rabies is a fatal disease that is preventable when post exposure prophylaxis (PEP) is administered in a timely fashion. CpG oligodeoxynucleotides (ODNs) can trigger cells that express Toll-like receptor 9, and their immunopotentiation activity in an inactivated aluminum-adjuvanted rabies vaccine for dogs has been identified using mouse and dog models. ... Read more >>

Virol. J. (Virology journal)
[2018, 15(1):174]

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Clinical and pathological features of patients with biliary atresia who survived for more than 5 years with native liver.

Song Sun, Shan Zheng, Xuexin Lu, Gong Chen, Yangyang Ma, Lian Chen, Kuiran Dong,

The objective of this study was to determine the predictive index for prognosis in patients with biliary atresia (BA).A total of 71 patients were divided into two groups. Group A included 39 postoperative BA patients who survived for more than 5 years with normal liver function and did not present ... Read more >>

Pediatr. Surg. Int. (Pediatric surgery international)
[2018, 34(4):381-386]

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MiRNAs participate in the diagnosis, pathogenesis and therapy of Parkinson's disease.

Xuexin Lu, Zhijie Cui, Shuang Liu, Feng Yin,

MicroRNAs (miRNAs), one kind of post-transcriptional modification, mediate transcriptional silencing of various metabolic enzymes that are involved in various life processes, including Parkinson's disease. At present, the pathogenesis of Parkinson's disease is not clear, although many studies suggest that miRNAs play a very important role in the progress of Parkinsonism. ... Read more >>

Histol. Histopathol. (Histology and histopathology)
[2018, 33(5):447-453]

Cited: 1 time

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Role of systemic injection of rabies immunoglobulin in rabies vaccination.

Weichen Wu, Shuqing Liu, Pengcheng Yu, Xiaoyan Tao, Xuexin Lu, Jianghong Yan, Qian Wang, Zongshen Zhang, Wuyang Zhu,

To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably ... Read more >>

Arch. Virol. (Archives of virology)
[2017, 162(6):1701-1703]

Cited: 1 time

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[The Preparation of Epitope-based Recombinant Rubella Virus Diagnostic Antigen].

Qiudong Su, Minzhuo Guo, Feng Qiu, Zhiyuan Jia, Xuexin Lu, Qingling Meng, Ruiguang Tian, Shengli Bi, Yao Yi,

To prepare an epitope-based recombinant Rubella virus (RV) recombinant diagnostic antigen(designated ‘H29’) and preliminarily evaluate its antigenicity. With Glutathione S-Transferase (GST) located at the N-terminal, and the His tag at the C-terminal, the epitope-based RV recombinant diagnostic antigen (designated‘H29’) was expressed in Escherichia coli (E.coli) and purified by affinity and ... Read more >>

Bing Du Xue Bao (Bing du xue bao = Chinese journal of virology)
[2016, 32(3):249-255]

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Epitope-based recombinant diagnostic antigen to distinguish natural infection from vaccination with hepatitis A virus vaccines.

Qiudong Su, Minzhuo Guo, Zhiyuan Jia, Feng Qiu, Xuexin Lu, Yan Gao, Qingling Meng, Ruiguang Tian, Shengli Bi, Yao Yi,

Hepatitis A virus (HAV) infection can stimulate the production of antibodies to structural and non-structural proteins of the virus. However, vaccination with an inactivated or attenuated HAV vaccine produces antibodies mainly against structural proteins, whereas no or very limited antibodies are produced against the non-structural proteins. Current diagnostic assays to ... Read more >>

J. Virol. Methods (Journal of virological methods)
[2016, 233:41-45]

Cited: 1 time

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Enhanced mucosal immune responses induced by a combined candidate mucosal vaccine based on Hepatitis A virus and Hepatitis E virus structural proteins linked to tuftsin.

Yan Gao, Qiudong Su, Yao Yi, Zhiyuan Jia, Hao Wang, Xuexin Lu, Feng Qiu, Shengli Bi,

Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are the most common causes of infectious hepatitis. These viruses are spread largely by the fecal-oral route and lead to clinically important disease in developing countries. To evaluate the potential of targeting hepatitis A and E infection simultaneously, a combined mucosal ... Read more >>

PLoS ONE (PloS one)
[2015, 10(4):e0123400]

Cited: 10 times

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