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LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis.

Xuewen Wang, Ziwei Liang, Hong Xiang, Yanqiu Li, Shuhua Chen, Hongwei Lu,

Liver kinase B1 (LKB1) is known to shape the regulation of macrophage function by participating in multiple processes including cell metabolism, growth, and polarization. However, whether LKB1 also affects the functional plasticity of macrophages in atherosclerosis has not attracted much attention. Abnormal macrophage function is a pathophysiological hallmark of atherosclerosis, ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:810224]

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Monolayer MoS2 Synaptic Transistors for High-Temperature Neuromorphic Applications.

Bolun Wang, Xuewen Wang, Enze Wang, Chenyu Li, Ruixuan Peng, Yonghuang Wu, Zeqin Xin, Yufei Sun, Jing Guo, Shoushan Fan, Chen Wang, Jianshi Tang, Kai Liu,

As essential units in an artificial neural network (ANN), artificial synapses have to adapt to various environments. In particular, the development of synaptic transistors that can work above 125 °C is desirable. However, it is challenging due to the failure of materials or mechanisms at high temperatures. Here, we report ... Read more >>

Nano Lett (Nano letters)
[2021, 21(24):10400-10408]

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Development of the temporomandibular joint in miniature pig embryos.

Lei Xiang, Xuewen Wang, Yongfeng Li, Hua Wei Liu, Xianhua Zhang, Xiaodan Mu, Changkui Liu, Min Hu,

The temporomandibular joint (TMJ) is a synovial joint involved in sliding and hinge movements of lower jaw in mammals. Studies on TMJ development in embryos have been mainly performed using rodents. However, the TMJ structure in rodents differs in several aspects from that in humans. There are few studies on ... Read more >>

J Morphol (Journal of morphology)
[2022, 283(1):134-143]

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Protection of Ang1-7 througth MKK/P38MAPKs inflammatory signal pathway on TNF-α stimulated mouse HL-1 cells

Xuewen Wang, Yuan Cao, Pradeep depark, Deepark Sharma, Guangping Li, Yanmin Xu,

<h4>Background: </h4> to explore the effect of Ang1-7 througth MKK/P38MAPKs inflammatory signaling pathway on TNF-α-stimulated mouse HL-1 cells. Methods Using TNF-α (100 µg/ml) to establish an inflammatory atrial fibrillation model in HL-1 cell, which derived from mouse atrial myocyte. treated HL-1 cells with different concentrations of Ang 1-7 (0.1, ... Read more >>

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Disclosing targets and pharmacological mechanisms of total bioflavonoids extracted from Selaginella doederleinii against non-small cell lung cancer by combination of network pharmacology and proteomics.

Dafen Xu, Xuewen Wang, Dandan Huang, Bing Chen, Xinhua Lin, Ailin Liu, Jianyong Huang,

<h4>Ethnopharmacological relevance</h4>Previously, the total bioflavonoids extract from Selaginella doederleinii (SDTBE) presented favorable in vitro and in vivo activities against non-small cell lung cancer (NSCLC), hinting at its medicinal potential. However, up to nowadays, targets and integrative action mechanisms of SDTBE are still not very clear, which presents an obstacle to ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2022, 286:114836]

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Quaternized carbon quantum dots with broad-spectrum antibacterial activity for the treatment of wounds infected with mixed bacteria.

Chengfei Zhao, Xuewen Wang, Luying Yu, Lina Wu, Xiaoli Hao, Qicai Liu, Liqing Lin, Zhengjun Huang, Zhipeng Ruan, Shaohuang Weng, Ailin Liu, Xinhua Lin,

Bacterial resistance to antibiotics have become one of the most severe threats in global public health, so the development of new-style antimicrobial agents is urgent. In this work, quaternized carbon quantum dots (qCQDs) with broad-spectrum antibacterial activity were synthesized by a simple green "one-pot" method using dimethyl diallyl ammonium chloride ... Read more >>

Acta Biomater (Acta biomaterialia)
[2022, 138:528-544]

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Inversion symmetry broken in 2H phase vanadium-doped molybdenum disulfide.

Hanjun Jiang, Lu Zheng, Jing Wang, Manzhang Xu, Xuetao Gan, Xuewen Wang, Wei Huang,

Two-dimensional (2D) layered transition metal dichalcogenides (TMDs) have received much attention in nonlinear optical applications due to their unique crystal structures and second harmonic generation (SHG) efficiency. However, SHG signals in TMDs show a layer-dependent behavior, consistent with the presence (absence) of inversion symmetry in even-layer (odd-layer) of TMDs. Herein, ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(43):18103-18111]

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Femtosecond laser induced in-situ crystallization of Tb-based luminescent metal organic framework.

Yanan Liu, Nianyao Chai, Xuewen Wang, Zhijun Luo, Junjie Zhao, Changsheng Xie, Zongsong Gan,

Luminescent metal-organic frameworks (LMOFs) are a class of interesting and well-investigated MOF materials, which have shown remarkable prospects in the past and have been widely applied in different fields. However, due to their organic hybrid aspect, micro-/nano-patterning LMOFs in devices via a conventional semiconductor process is very challenging. In this ... Read more >>

Opt Express (Optics express)
[2021, 29(24):39304-39311]

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Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics.

Wenhui Ji, Jingyu Zhu, Wanxia Wu, Nanxiang Wang, Jiqing Wang, Jiansheng Wu, Qiong Wu, Xuewen Wang, Changmin Yu, Gaofeng Wei, Lin Li, Fengwei Huo,

Sweat contains a broad range of critical biomarkers including ions, small molecules, and macromolecules that may indirectly or directly reflect the health status of the human body and thereby help track disease progression. Wearable sweat biosensors enable the collection and analysis of sweat <i>in situ</i>, achieving real-time, continuous, and noninvasive ... Read more >>

Research (Wash D C) (Research (Washington, D.C.))
[2021, 2021:9757126]

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Programmable patterned MoS2 film by direct laser writing for health-related signals monitoring.

Manzhang Xu, Jiuwei Gao, Juncai Song, Hanxin Wang, Lu Zheng, Yuan Wei, Yongmin He, Xuewen Wang, Wei Huang,

The two-dimensional (2D) transition metal dichalcogenides (TMDs) are promising flexible electronic materials for strategic flexible information devices. Large-area and high-quality patterned materials were usually required by flexible electronics due to the limitation from the process of manufacturing and integration. However, the synthesis of large-area patterned 2D TMDs with high quality ... Read more >>

iScience (iScience)
[2021, 24(11):103313]

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Distinguishing early patterns of physical activity goal attainment and weight loss in online behavioral obesity treatment using latent class analysis.

Melissa L Stansbury, Jean R Harvey, Rebecca A Krukowski, Christine A Pellegrini, Xuewen Wang, Delia S West,

Physical activity (PA) goal adherence is consistently associated with greater weight loss during behavioral obesity treatment, and early weight loss response predicts future weight loss success. However, it remains unclear which behaviors during the initial weeks of treatment distinguish responders from nonresponders and might be effective targets for improving treatment ... Read more >>

Transl Behav Med (Translational behavioral medicine)
[2021, :]

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The Expression of LIMK1 is Related to the Poor Prognosis and Immune Function of Hepatocellular Carcinoma

Yisheng Peng, Jun Fan, Gang Zhu, Shunde Tan, Jianfei Chen, Xuewen Wang, Haoxian Gou, Song Su, Xiaoli Yang, Bo Li,

<h4>Background: </h4> According to reports, LIMK1 may have the effect of promoting tumor progression. However, the effect of the expression of LIMK1 on the healing of patients with hepatocellular carcinoma and its effect on the immune function are still not clear. Therefore, we analyzed the effect of LIMK1 on the ... Read more >>

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Dynamic single-cell intracellular pH sensing using a SERS-active nanopipette.

Jing Guo, Alberto Sesena Rubfiaro, Yanhao Lai, Joseph Moscoso, Feng Chen, Yuan Liu, Xuewen Wang, Jin He,

Glass nanopipettes have shown promise for applications in single-cell manipulation, analysis, and imaging. In recent years, plasmonic nanopipettes have been developed to enable surface-enhanced Raman spectroscopy (SERS) measurements for single-cell analysis. In this work, we developed a SERS-active nanopipette that can be used to perform long-term and reliable intracellular analysis ... Read more >>

Analyst (The Analyst)
[2020, 145(14):4852-4859]

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Machine Learning Driven Synthesis of Few-Layered WTe2 with Geometrical Control.

Manzhang Xu, Bijun Tang, Yuhao Lu, Chao Zhu, Qianbo Lu, Chao Zhu, Lu Zheng, Jingyu Zhang, Nannan Han, Weidong Fang, Yuxi Guo, Jun Di, Pin Song, Yongmin He, Lixing Kang, Zhiyong Zhang, Wu Zhao, Cuntai Guan, Xuewen Wang, Zheng Liu,

Reducing the lateral scale of two-dimensional (2D) materials to one-dimensional (1D) has attracted substantial research interest not only to achieve competitive electronic applications but also for the exploration of fundamental physical properties. Controllable synthesis of high-quality 1D nanoribbons (NRs) is thus highly desirable and essential for further study. Here, we ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(43):18103-18113]

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Itaconate regulates macrophage function through stressful iron-sulfur cluster disrupting and iron metabolism rebalancing.

Xing Liu, Bingshuo Shi, Rong Suo, Shenglin Xiong, Xuewen Wang, Xue Liang, Xinjian Li, Guangping Li,

Lipopolysaccharide (LPS)-stimulated macrophages express an aconitate decarboxylase (IRG1, also called ACOD1), leading to accumulation of the endogenous metabolite itaconate. However, the precise mechanisms by which elevated itaconate levels alter macrophage function are not clear. Our hypothesis is itaconate affects macrophage function through some uncertain mechanism. Based on this, we established a transcriptional ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21936]

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Heterologous prime-boost immunization with CoronaVac and Convidecia

Jingxin Li, Lihua Hou, Xiling Guo, Pengfei Jin, Shipo Wu, Jiahong Zhu, Hongxing Pan, Xue Wang, Zhizhou Song, Jingxuan Wan, Lunbiao Cui, Junqiang Li, Xuewen Wang, Lairun Jin, Jingxian Liu, Fengjuan Shi, Xiaoyu Xu, Yin Chen, Tao Zhu, Wei Chen, Fengcai Zhu,

<h4>ABSTRACT</h4> <h4>Background</h4> The safety and immunogenicity of heterologous prime-boost COVID-19 vaccine regimens with one shot of a recombinant adenovirus type-5-vectored COVID-19 vaccine Convidecia has not been reported. <h4>Methods</h4> We conducted a randomized, controlled, observer-blinded trial of heterologous prime-boost immunization with CoronaVac and Convidecia in healthy adults 18-59 years of age. ... Read more >>

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Impact of prior cancer on the overall survival of patients with nasopharyngeal carcinoma.

Xuewen Wang, Zhiping Wang, Yaying Chen, Qin Lin, Hong Chen, Yihong Lin, Linbin Lu, Peichan Zheng, Xiong Chen,

<h4>Purpose</h4>Prior cancer history is an important exclusion criterion from clinical trials and may decrease their generalizability. This study aimed to investigate the impact of prior cancer on the prognosis of patients with nasopharyngeal carcinoma and to describe their characteristics.<h4>Materials and methods</h4>Data of patients with nasopharyngeal carcinoma diagnosed between 2010 and ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2022, 43(1):103235]

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Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus neoadjuvant chemotherapy plus concurrent chemoradiotherapy for ascending or descending types of nasopharyngeal carcinoma: A retrospective study.

Qin Lin, Linbin Lu, Xuewen Wang, Yihong Lin, Yaying Chen, Hong Chen, Shuyi Chen, Shaoqin Lin, Yan Zhang, Peichan Zheng, Xiong Chen,

<h4>Purpose</h4>This study aimed to compare the efficacy between neoadjuvant chemotherapy (NACT) plus intensity-modulated radiotherapy (IMRT) and NACT plus concurrent chemoradiotherapy (CCRT) in patients with nasopharyngeal carcinoma (NPC).<h4>Materials and methods</h4>Data from 603 patients with ascending (T4 and N0-1) or descending (T1-2&N3) NPC who were treated at Sun Yat-sen University Cancer Center ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2022, 43(1):103193]

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Genetic variance and transcriptional regulation modulate terpenoid biosynthesis in trichomes of Nicotiana tabacum under drought

Jing Wang, Hongyan Wang, Yunpeng Fu, Tingting Huang, Yuanbo Liu, Xuewen Wang,

Drought affects aromatic terpenoids biosynthesis in plant, but the associated regulatory mechanism is unknown. We investigated large-scale dynamic changes in trichomes, terpenoids, and transcriptomes in leaves of Nicotiana tabacum varieties K326 and Basma Xanthi with three replicates over five time-courses with or without drought treatment. We found drought affects trichome ... Read more >>

(Industrial crops and products.)
[2021, 167:Not Available]

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Renal microvascular damaged in diabetes mellitus with hyperlipidemia through the regulation of MAMs by PACS2 in endothelial cell

Zhihao Shu, Shuhua Chen, Hong Xiang, Ruoru Wu, Shaoli Zhao, Jie Xiao, Hengdao Liu, Yulan Liu, Xuewen Wang, Wenfang Xiong, Jie Ouyang, Jing Zhang, Huiqin Liu, Alex Chen, Hongwei Lu,

<h4>Background: </h4> The prevalence of diabetic vascular complications is rapidly increasing, especially in the diabetes mellitus with hyperlipidemia. Consistent hyperglycemia and hyperlipidemia impairs microvascular, but lack of effective intervention target to prevention or reduced the risk of serious bad ending. <h4>Methods:</h4> A mouse model of diabetes combined with hyperlipidemia were ... Read more >>

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Rational Design of Embedded CoTe2 Nanoparticles in Freestanding N-Doped Multichannel Carbon Fibers for Sodium-Ion Batteries with Ultralong Cycle Lifespan.

Wei Zhang, Xuewen Wang, Ka Wai Wong, Wang Zhang, Tong Chen, Weiming Zhao, Shaoming Huang,

Although sodium-ion batteries (SIBs) have high potential for applications in large-scale energy storage, their limited cycle life and unsatisfactory energy density hinder their commercial applications. Here, a superior stable CoTe<sub>2</sub>/carbon anode, in which CoTe<sub>2</sub> nanoparticles are embedded in freestanding N-doped multichannel carbon fiber (CoTe<sub>2</sub>@NMCNFs), with ultralong cycle life for SIBs, ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(29):34134-34144]

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Grain-Boundary Engineering of Monolayer MoS2 for Energy-Efficient Lateral Synaptic Devices.

Xuewen Wang, Bolun Wang, Qinghua Zhang, Yufei Sun, Enze Wang, Hao Luo, Yonghuang Wu, Lin Gu, Huanglong Li, Kai Liu,

Synaptic devices based on 2D-layered materials have emerged as high-efficiency electronic synapses and neurons for neuromorphic computing. Lateral 2D synaptic devices have the advantages of multiple functionalities by responding to diverse stimuli, but they consume large amounts of energy, far more than the human brain. Moreover, current lateral devices employ ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, 33(32):e2102435]

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Conservative production of galactosaminogalactan in Metarhizium is responsible for appressorium mucilage production and topical infection of insect hosts.

Lijuan Mei, Xuewen Wang, Ying Yin, Guirong Tang, Chengshu Wang,

The exopolysaccharide galactosaminogalactan (GAG) has been well characterized in Aspergilli, especially the human pathogen Aspergillus fumigatus. It has been found that a five-gene cluster is responsible for GAG biosynthesis in Aspergilli to mediate fungal adherence, biofilm formation, immunosuppression or induction of host immune defences. Herein, we report the presence of ... Read more >>

PLoS Pathog (PLoS pathogens)
[2021, 17(6):e1009656]

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Ultrafast, Kinetically Limited, Ambient Synthesis of Vanadium Dioxides through Laser Direct Writing on Ultrathin Chalcogenide Matrix.

Bolun Wang, Ruixuan Peng, Xuewen Wang, Yueyang Yang, Enze Wang, Zeqin Xin, Yufei Sun, Chenyu Li, Yonghuang Wu, Jinquan Wei, Jingbo Sun, Kai Liu,

Vanadium dioxide (VO<sub>2</sub>) is a strongly correlated electronic material and has attracted significant attention due to its metal-to-insulator transition and diverse smart applications. Traditional synthesis of VO<sub>2</sub> usually requires minutes or hours of global heating and low oxygen partial pressure to achieve thermodynamic control of the valence state. Further patterning ... Read more >>

ACS Nano (ACS nano)
[2021, 15(6):10502-10513]

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Two-Dimensional Lateral Heterostructures Made by Selective Reaction on a Patterned Monolayer MoS2 Matrix.

Xuewen Wang, Bolun Wang, Yonghuang Wu, Enze Wang, Hao Luo, Yufei Sun, Deyi Fu, Yinghui Sun, Kai Liu,

Two-dimensional (2D) heterostructures have attracted widespread attention for their promising prospects in the fields of electronics and optoelectronics. However, in order to truly realize 2D-material-based integrated circuits, precisely controllable fabrication of 2D heterostructures is crucial and urgently needed. Here, we demonstrate an <i>ex situ</i> growth method of MoSe<sub>2</sub>/MoS<sub>2</sub> lateral heterostructures ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(22):26143-26151]

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