Full Text Journal Articles by
Author Xueting Gao

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Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity.

Xueting Gao, Shuai Yu, Yi Guan, Yunli Shen, Liang Xu,

Emerging evidence has demonstrated that nucleoporins (Nups) play a pivotal role in cell-type-specific gene regulation, but how they control the expression and activity of ion channel genes in the heart remains unclear. Here, we show that Nup50, which is localized in the nucleus of cardiomyocytes, selectively induces an increase in ... Read more >>

J Cell Sci (Journal of cell science)
[2021, 134(18):]

Cited: 0 times

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Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes.

Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qiang Ji, Qicheng Zou, Lingling Wang, Yi Liu, Dandan Liang, Jinfeng Xue, Luxin Wang, Xueting Gao, Xingdong Gu, Hongyu Liu, Xiaoyu He, Li Li, Jian Yang, Youming Lu, Luying Peng, Yi-Han Chen,

As an excitatory transmitter system, the glutamatergic transmitter system controls excitability and conductivity of neurons. Since both cardiomyocytes and neurons are excitable cells, we hypothesized that cardiomyocytes may also be regulated by a similar system. Here, we have demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulates ... Read more >>

Cell Res (Cell research)
[2021, 31(9):951-964]

Cited: 2 times

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Using epidemiological data to identify needs for child-rearing support among Chinese parents: a cross-sectional survey of parents of children aged 6 to 35 months in 15 Chinese cities.

Yue Zhang, Matthew Sanders, Weiwei Feng, He Tang, Huishan Wang, Xi Jin, Jieling Wu, Guangwen Huang, Jin Sun, Yan Luo, Lanqiu Lv, Shuangqin Yan, Dongmei Zhao, Lijuan Mu, Dongmei Yan, Hong Wang, Xueting Gao, Jing Yang, Hong Wang, Nianrong Wang, Jie Shao, Jinliuxing Yang, Divna Haslam,

BACKGROUND:The quality of the family environment-in particular, the kind of parenting children receive in their early years-plays a critical role in influencing children's growth and development. To facilitate the development and delivery of appropriate parenting and family interventions for Chinese parents, this study explores the prevalence of the difficulties that ... Read more >>

BMC Public Health (BMC public health)
[2019, 19(1):1470]

Cited: 1 time

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Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.

Yi Guan, Xueting Gao, Qiuyu Tang, Lin Huang, Siyun Gao, Shuai Yu, Jiale Huang, Jun Li, Daizhan Zhou, Yangyang Zhang, Dan Shi, Dandan Liang, Yi Liu, Li Li, Yingyu Cui, Liang Xu, Yi-Han Chen,

Nucleoporins (Nups) are known to be functional in nucleo-cytoplasmic transport, but the roles of nucleoporins in nonproliferating cells, such as cardiac myocytes, are still poorly understood. In this study, we report that Nup107 regulates cardiac bioelectricity by controlling the nucleo-cytoplasmic trafficking of Scn5a mRNA. Overexpression of Nup107 induced the protein ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2019, 23(2):1448-1457]

Cited: 2 times

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Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.

Xueting Gao, Siyun Gao, Yi Guan, Lin Huang, Jiale Huang, Li Lin, Yuan Liu, Hong Zhao, Bijun Huang, Tianyou Yuan, Yi Liu, Dandan Liang, Yangyang Zhang, Xiue Ma, Li Li, Jun Li, Daizhan Zhou, Dan Shi, Liang Xu, Yi-Han Chen,

TLRs have been proven to be essential mediators for the early innate immune response. Overactivation of TLR-mediated immune signaling promotes deterioration of cardiovascular diseases; however, the role of TLRs in the heart under physiologic conditions remains neglected. Here, we show that Tlr3 deficiency induced the endoplasmic reticulum (ER) retention of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(5):6197-6208]

Cited: 2 times

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