Full Text Journal Articles by
Author Xuedong Zhou

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The regulation of hyphae growth in Candida albicans.

Hui Chen, Xuedong Zhou, Biao Ren, Lei Cheng,

In the last decades, Candida albicans has served as the leading causal agent of life-threatening invasive infections with mortality rates approaching 40% despite treatment. Candida albicans (C. albicans) exists in three biological phases: yeast, pseudohyphae, and hyphae. Hyphae, which represent an important phase in the disease process, can cause tissue ... Read more >>

Virulence (Virulence)
[2020, 11(1):337-348]

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Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation.

Yujia Cui, Jing Xie, Yujie Fu, Chuwen Li, Liwei Zheng, Dingming Huang, Changchun Zhou, Jianxun Sun, Xuedong Zhou,

Once pulp necrosis or apical periodontitis occurs on immature teeth, the weak root and open root apex are challenging to clinicians. Berberine (BBR) is a potential medicine for bone disorders, therefore, we proposed to apply BBR in root canals to enhance root repair in immature teeth. An in vivo model ... Read more >>

Int J Oral Sci (International journal of oral science)
[2020, 12(1):18]

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Porphyromonas gingivalis Promotes Immunoevasion of Oral Cancer by Protecting Cancer from Macrophage Attack.

Shiyu Liu, Xuedong Zhou, Xian Peng, Mingyun Li, Biao Ren, Guo Cheng, Lei Cheng,

The relationship of Porphyromonas gingivalis and oral squamous cell carcinoma (OSCC) has been studied for several years. Previous studies have focused on the direct effect of P. gingivalis on the activities of primary epithelial cells and OSCC cells. However, the immune system is responsible for mediating cancer development, whether P. ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2020, 205(1):282-289]

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The effect of disaggregated nano-hydroxyapatite on oral biofilm in vitro.

Weidan Luo, Yannan Huang, Xuedong Zhou, Qi Han, Xian Peng, Biao Ren, Jiyao Li, Mingyun Li, Lei Cheng,

OBJECTIVE:Agglomeration is a common problem facing the preparation and application of nanomaterials, and whether nano-hydroxyapatite (nano HA) can modulate oral microecology left to be unclear. In this study, nano HA was disaggregated by sodium hexametaphosphate (SHMP) and ultrasonic cavitation to observe whether agglomeration would affect its effect on oral bacterial ... Read more >>

Dent Mater (Dental materials : official publication of the Academy of Dental Materials)
[2020, 36(7):e207-e216]

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IL-1α regulates osteogenic differentiation and osteoclastic activity of dental follicle cells via JNK and p38 MAPK pathways

mingmei meng, Yandi Chen, Xinlei Chen, Qiong Zhang, Weihua Guo, Xuedong Zhou, Jing Zou,

Abstract Background The expression of interleukin-1α (IL-1α) is increased in tooth with periapical lesion and the eruption of the permanent successor is accelerated in the presence of an infected deciduous tooth with abscess formation. Dental follicle (DF) plays a central role in tooth eruption through regulating alveolar bone resorption ... Read more >>

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Anti-caries effect of resin infiltrant modified by quaternary ammonium monomers.

Jinzhao Yu, Xiaoyu Huang, Xuedong Zhou, Qi Han, Wen Zhou, Jingou Liang, Hockin H K Xu, Biao Ren, Xian Peng, Michael D Weir, Mingyun Li, Lei Cheng,

OBJECTIVES:Resin infiltrant is used in early enamel caries. However, commercial resin infiltrant lacks persistent antibacterial activity. Dimethylaminododecyl methacrylate (DMADDM) was added to resin infiltrant to give it sustainable antibacterial properties and inhibit demineralization. METHODS:After the application of resin infiltrant to bovine enamel, cytotoxicity, surface roughness, and aesthetics were assessed. A ... Read more >>

J Dent (Journal of dentistry)
[2020, 97:103355]

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Antibiotic-induced dysbiosis of the rat oral and gut microbiota and resistance to Salmonella.

Hongle Wu, Yue Ma, Xian Peng, Wei Qiu, Lixin Kong, Biao Ren, Mingyun Li, Guo Cheng, Xuedong Zhou, Lei Cheng,

OBJECTIVES:Antibiotics play a great role in the treatment of infectious diseases, but meantime, they cause great disturbances to host microbiota. Studies on different antibiotic-induced changes in host microbiota are relatively scarce. This study aimed to investigate the changes in oral and gut microbiota and possible alterations of gut resistance to ... Read more >>

Arch. Oral Biol. (Archives of oral biology)
[2020, 114:104730]

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Targeting tumor-associated macrophages in head and neck squamous cell carcinoma.

Bolei Li, Min Ren, Xuedong Zhou, Qi Han, Lei Cheng,

In head and neck squamous cell carcinoma (HNSCC), tumor-associated macrophages (TAMs) are associated with a poorer prognosis. TAMs, derived from inflammatory monocyte, play a critical role in regulating tumor progression. Generally, TAMs promote tumor progression and suppress immune response via both innate and adaptive immune mechanisms. However, as the double-blade ... Read more >>

Oral Oncol. (Oral oncology)
[2020, 106:104723]

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Antibacterial and remineralizing nanocomposite inhibit root caries biofilms and protect root dentin hardness at the margins.

Wen Zhou, Xuedong Zhou, Xiaoyu Huang, Chenyu Zhu, Michael D Weir, Mary A S Melo, Andrea Bonavente, Christopher D Lynch, Satoshi Imazato, Thomas W Oates, Lei Cheng, Hockin H K Xu,

OBJECTIVES:Senior patients have a high incidence of tooth root caries. The objectives of this study were to: (1) develop a bioactive composite with calcium (Ca) and phosphate (P) ion-release and antibacterial capabilities via nanoparticles of amorphous calcium phosphate (NACP) and dimethylaminohexadecyl methacrylate (DMAHDM); (2) inhibit root biofilms of Streptococcus mutans, ... Read more >>

J Dent (Journal of dentistry)
[2020, 97:103344]

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Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.

ZeYu Huang, Jing Chen, BoLei Li, Benhua Zeng, Ching-Heng Chou, Xin Zheng, JingWei Xie, Hao Li, Yu Hao, Guo Chen, FuXing Pei, Bin Shen, Virginia B Kraus, Hong Wei, Xuedong Zhou, Lei Cheng,

OBJECTIVES:Emerging evidence suggests that the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which one 'hit' is provided by an adverse gut microbiome that activates innate immunity; the other 'hit' is underlying joint damage. ... Read more >>

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2020, 79(5):646-656]

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Traumatic compressive stress inhibits osteoblast differentiation through long chain non-coding RNA Dancr.

Qian Lu, Weizhe Xu, Linyi Liu, Xuedong Zhou, Ling Ye, Dongzhe Song, Lan Zhang, Dingming Huang,

BACKGROUND:Occlusal trauma is an important local contributing factor aggravating periodontal pocket and alveolar bone absorption in periodontal diseases. Our previous studies have found that occlusal trauma inhibited osteogenic differentiation through nuclear factor (NF)-κB signaling. To further investigate the underlying mechanism, the aim of this study was to explore the role ... Read more >>

J. Periodontol. (Journal of periodontology)
[2020, :]

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Publisher Correction: Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study.

Hongle Wu, Benhua Zeng, Bolei Li, Biao Ren, Jianhua Zhao, Mingyun Li, Xian Peng, Mingye Feng, Jiyao Li, Hong Wei, Lei Cheng, Xuedong Zhou,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4728]

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Dimethylaminododecyl methacrylate inhibits Candida albicans and oropharyngeal candidiasis in a pH-dependent manner.

Hui Chen, Yujie Zhou, Xuedong Zhou, Binyou Liao, Hockin H K Xu, Chun-Hung Chu, Lei Cheng, Biao Ren,

The prevalence of stomatitis, especially that caused by Candida albicans, has highlighted the need for new antifungal agents. We previously found that a type of quaternary ammonium salts, dimethylaminododecyl methacrylate (DMADDM), incorporated in dental materials inhibited the growth and hyphal development of C. albicans. However, how the quaternary ammonium salts ... Read more >>

Appl. Microbiol. Biotechnol. (Applied microbiology and biotechnology)
[2020, 104(8):3585-3595]

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Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.

Chen Cui, Liwei Zheng, Yi Fan, Jun Zhang, Ruoshi Xu, Jing Xie, Xuedong Zhou,

OBJECTIVES:Ageing could be a contributing factor to the progression of temporomandibular joint osteoarthritis (TMJ OA), whereas its pathogenesis and potential therapeutic strategy have not been comprehensively investigated. MATERIALS AND METHODS:We generated ageing mouse models (45-week and 60-week; 12-week mice as control) and intermittently injected 45-week mice with parathyroid hormone (PTH(1-34)) ... Read more >>

Cell Prolif. (Cell proliferation)
[2020, 53(4):e12755]

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Sucrose promotes caries progression by disrupting the microecological balance in oral biofilms: an in vitro study.

Qian Du, Min Fu, Yuan Zhou, Yangpei Cao, Tingwei Guo, Zhou Zhou, Mingyun Li, Xian Peng, Xin Zheng, Yan Li, Xin Xu, Jinzhi He, Xuedong Zhou,

Sucrose has long been regarded as the most cariogenic carbohydrate. However, why sucrose causes severer dental caries than other sugars is largely unknown. Considering that caries is a polymicrobial infection resulting from dysbiosis of oral biofilms, we hypothesized that sucrose can introduce a microbiota imbalance favoring caries to a greater ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2961]

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Comparison between Fissure Sealant and Fluoride Varnish on Caries Prevention for First Permanent Molars: a Systematic Review and Meta-analysis.

Feifei Li, Peipei Jiang, Fanyuan Yu, Chunjie Li, Si Wu, Jing Zou, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng,

The high prevalence and heavy socio-economic burden for caries of first permanent molars (FPMs) make the prevention of this disease a major public health goal. Current guidelines recommend a preference of fissure sealant (FS) over fluoride varnish (FV) based on two recent systematic reviews. However, evidences of these two studies ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2578]

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Highly Proliferative Immortalized Human Dental Pulp Cells Retain the Odontogenic Phenotype when Combined with a Beta-Tricalcium Phosphate Scaffold and BMP2.

Xiangfen Li, Liu Wang, Qin Su, Ling Ye, Xuedong Zhou, Dongzhe Song, Dingming Huang,

Human dental pulp cells (HDPCs) play a vital role in dentin formation and reparative dentinogenesis, which indicated their potential application in regenerative medicine. However, HDPCs, which can only be obtained from scarce human pulp tissues, also have a limited lifespan in vitro, and stem cells usually lose their original characteristics ... Read more >>

Stem Cells Int (Stem cells international)
[2020, 2020:4534128]

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CRISPR-Cas systems in oral microbiome: From immune defense to physiological regulation.

Tao Gong, Jumei Zeng, Boyu Tang, Xuedong Zhou, Yuqing Li,

The clustered regularly interspaced short palindromic repeats with CRISPR-associated proteins (CRISPR-Cas) system, found in bacteria and archaea, provides sequence-based adaptive immunity against mobile genetic elements, including phages and plasmids. The oral cavity contains approximately 700 prokaryote species harboring known CRISPR-Cas systems, including type I, type II, type III, type V, ... Read more >>

Mol Oral Microbiol (Molecular oral microbiology)
[2020, 35(2):41-48]

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Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling.

Bomiao Cui, Jiao Chen, Min Luo, Liwei Wang, Hongli Chen, Yingzhu Kang, Jingnan Wang, Xuedong Zhou, Yun Feng, Ping Zhang,

Oral squamous cell carcinoma (OSCC) is capable of constructing a favorable immune escape environment through interactions of cells with cells and of cells with the environment. Programmed death ligand‑1 (PD‑L1) is a well‑recognized inhibitor of anti‑tumor immunity that plays an important role in tumor immune escape. However, the molecular mechanisms ... Read more >>

Int. J. Oncol. (International journal of oncology)
[2020, 56(4):909-920]

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The Impact of Smoking on Subgingival Microflora: From Periodontal Health to Disease.

Yaling Jiang, Xuedong Zhou, Lei Cheng, Mingyun Li,

Periodontal disease is one of the most common diseases of the oral cavity affecting up to 90% of the worldwide population. Smoking has been identified as a major risk factor in the development and progression of periodontal disease. It is essential to assess the influence of smoking on subgingival microflora ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:66]

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Antibacterial Activity of Fruiting Body Extracts from Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes) against Oral Pathogen Streptococcus mutans.

Chen Cui, Hui Xu, Hua Yang, Rui Wang, Yu Xiang, Bingxuan Li, Xuedong Zhou, Ruijie Huang, Shujie Cheng,

The edible medicinal mushroom Flammulina velutipes (enokitake) has many applications as food and medicine, but its application in dentistry is unknown. This study aims to investigate the inhibitory effect of fruiting body extracts from F. velutipes on the growth and adhesion of Streptococcus mutans, the main cause of human caries, ... Read more >>

Int J Med Mushrooms (International journal of medicinal mushrooms)
[2020, 22(2):115-124]

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Influence of bio-aging on corrosion behavior of different implant materials.

Wen Zhou, Xian Peng, Xuedong Zhou, Mingyun Li, Biao Ren, Lei Cheng,

BACKGROUND:Dental implants and abutments are exposed to challenging oral environment. Corrosion of these materials can affect the overall performance of titanium implants. PURPOSE:To investigate the effects of biofilm-induced bio-aging on corrosion behavior of different implant materials surface. MATERIALS AND METHODS:Commercial polished titanium (Polish), sand-blasted, large grit, acid-etched surface treated titanium ... Read more >>

Clin Implant Dent Relat Res (Clinical implant dentistry and related research)
[2019, :]

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Remineralization effectiveness of the PAMAM dendrimer with different terminal groups on artificial initial enamel caries in vitro.

Menglin Fan, Min Zhang, Hockin H K Xu, Siying Tao, Zhaohan Yu, Jiaojiao Yang, He Yuan, Xuedong Zhou, Kunneng Liang, Jiyao Li,

OBJECTIVE:Disruption of the demineralization-remineralization balance could trigger the development of dental caries, making it challenging for enamel to "self-heal". Thus, extrinsic assistance is needed to restore enamel lesions and stop undermining progression. The aim of this study was to investigate enamel remineralization in a simulated oral environment via poly (amino ... Read more >>

Dent Mater (Dental materials : official publication of the Academy of Dental Materials)
[2020, 36(2):210-220]

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The alteration of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in the knee joints of osteoarthritis mice

Luling Wang, Demao Zhang, Jianxun Sun, Yujia Cui, Linyi Cai, Chen Cui, Yuanchen Lan, Jinning Gu, Linfeng Liu, Geru Zhang, Liwei Zheng, Caixia Pi, Jing Xie, Xuedong Zhou,

Abstract Background: To clarify the expression and distribution of ADAMTS1, ADAMTS2 and ADAMTS5 in knee joints of osteoarthritis (OA) mice. Methods: OA was established via anterior cruciate ligament transection (ACLT) on the knee joints of C57BL/6J mice. The morphology change of OA was analyzed by Micro-CT. Histologic analysis was used ... Read more >>

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TGF-β1 facilitates cell-cell communication in osteocytes via connexin43- and pannexin1-dependent gap junctions.

Wenjing Liu, Demao Zhang, Xin Li, Liwei Zheng, Chen Cui, Yujia Cui, Jianxun Sun, Jing Xie, Xuedong Zhou,

Connexins and pannexins are two families of channel forming proteins that are able to pass small molecules to achieve communication between cells. While connexins have been recognized to mediate gap junctional intercellular communication (GJIC), pannexins are far less known. Our previous study reported the potential role of TGF-β1 in mediating ... Read more >>

Cell Death Discov (Cell death discovery)
[2019, 5:141]

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