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Clarifying the translational potential of B-I09.

Juan R Del Valle, Brian C Betts, Xue-Zhong Yu, Sophie Janssens, Bart N Lambrecht, M Celeste Simon, Chih-Chi Andrew Hu,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1152]

Cited: 0 times

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Morbidity and mortality risk factors in emergency department patients with Acinetobacter baumannii bacteremia.

Rui-Xue Sun, Priscilla Song, Joseph Walline, He Wang, Ying-Chun Xu, Hua-Dong Zhu, Xue-Zhong Yu, Jun Xu,

BACKGROUND:Acinetobacter baumannii (AB) bacteremia is an increasingly common and often fatal nosocomial infection. Identification of morbidity and mortality risk factors for AB bacteremia in emergency department (ED) patients may provide ways to improve the clinical outcomes of these patients. METHODS:The records for 51 patients with AB bacteremia and 51 patients ... Read more >>

World J Emerg Med (World journal of emergency medicine)
[2020, 11(3):164-168]

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Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.

Rebecca S Hesterberg, Matthew S Beatty, Ying Han, Mario R Fernandez, Afua A Akuffo, William E Goodheart, Chunying Yang, Shiun Chang, Christelle M Colin, Aileen Y Alontaga, Jessica M McDaniel, Adam W Mailloux, Julia M R Billington, Lanzhu Yue, Shonagh Russell, Robert J Gillies, Sang Y Yun, Muhammad Ayaz, Nicholas J Lawrence, Harshani R Lawrence, Xue-Zhong Yu, Jianing Fu, Lancia N Darville, John M Koomen, Xiubao Ren, Jane Messina, Kun Jiang, Timothy J Garrett, Anjali M Rajadhyaksha, John L Cleveland, Pearlie K Epling-Burnette,

Immunomodulatory drugs, such as thalidomide and related compounds, potentiate T-cell effector functions. Cereblon (CRBN), a substrate receptor of the DDB1-cullin-RING E3 ubiquitin ligase complex, is the only molecular target for this drug class, where drug-induced, ubiquitin-dependent degradation of known "neosubstrates," such as IKAROS, AIOLOS, and CK1α, accounts for their biological ... Read more >>

Blood (Blood)
[2020, 136(7):857-870]

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Association between anemia and outcome in patients hospitalized for acute heart failure syndromes: findings from Beijing Acute Heart Failure Registry (Beijing AHF Registry).

Shao-Dong Ye, Si-Jia Wang, Guo-Gan Wang, Lin Li, Zhi-Wei Huang, Jian Qin, Chun-Sheng Li, Xue-Zhong Yu, Hong Shen, Li-Pei Yang, Yan Fu, Ya-An Zheng, Bin Zhao, Dong-Min Yu, Fu-Jun Qin, De-Gui Zhou, Ying Li, Fu-Jun Liu,

Whether the anemia increases the risk of mortality in patients with acute heart failure (AHF) remains unclear. This study aims to explore the relationship between anemia and outcomes in patients with AHF including subgroup analysis. This study included 3279 patients with hemoglobin available from the Beijing Acute Heart Failure Registry ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2020, :]

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Clinical presentation and management of acquired thrombotic thrombocytopenic purpura: A case series of 55 patients.

Rui-Xue Sun, Jun Xu, Hua-Dong Zhu, Xue-Zhong Yu, Jing Yang,

The aim of this study was to explore the clinical characteristics and treatment of acquired thrombotic thrombocytopenic purpura (TTP). The clinical manifestations, laboratory findings, differential diagnoses, therapeutic methods, and prognosis of 55 patients with acquired TTP were retrospectively analyzed. Among the 55 TTP patients, 17 were males and 38 were ... Read more >>

Ther Apher Dial (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy)
[2020, :]

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Venous thromboembolism in the emergency department: A survey of current best practice awareness in physicians and nurses in China.

Wen-Hua Zhou, Jian-Qiang He, Shi-Gong Guo, Joseph Walline, Xiao-Ying Liu, Li-Yuan Tian, Hua-Dong Zhu, Xue-Zhong Yu, Yi Li,

BACKGROUND:For emergency department (ED) patients, risk assessment, prophylaxis, early diagnosis and appropriate treatment of venous thromboembolism (VTE) are essential for preventing morbidity and mortality. This study aimes to investigate knowledge amongst emergency medical staff in the management of VTE. METHODS:We designed a questionnaire based on multiple scales. The questionnaire was ... Read more >>

(World journal of emergency medicine)
[2019, 10(1):5-13]

Cited: 1 time

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Comparing the performance of SOFA, TPA combined with SOFA and APACHE-II for predicting ICU mortality in critically ill surgical patients: A secondary analysis.

Xiao-Ming Zhang, Wen-Wu Zhang, Xue-Zhong Yu, Qing-Li Dou, Andy Sk Cheng,

INTRODUCTION:Total psoas muscle area (TPA) can indicate the status of the entire human body's skeletal muscle mass. It has been reported that lower TPA can increase the risk of mortality in critically ill patients. The aim of our study was to evaluate the relationship between TPA and ICU mortality and ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2020, 39(9):2902-2909]

Cited: 1 time

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Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse.

Supinya Iamsawat, Linlu Tian, Anusara Daenthanasanmak, Yongxia Wu, Hung D Nguyen, David Bastian, Xue-Zhong Yu,

Adoptive transfer of induced regulatory T cells (iTregs) can ameliorate graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). CD4+ iTregs can effectively prevent GVHD but impair the graft-versus-leukemia (GVL) effect, whereas CD8+ iTregs preserve the GVL effect but have limited efficacy in GVHD control because of their instability under ... Read more >>

Blood Adv (Blood advances)
[2019, 3(24):4187-4201]

Cited: 1 time

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Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease.

Hung Nguyen, Ali Alawieh, David Bastian, Sandeepkumar Kuril, Min Dai, Anusara Daenthanasanmak, Mengmeng Zhang, Supinya Iamsawat, Steven D Schutt, Yongxia Wu, M Mahdi Sleiman, Akshay Shetty, Carl Atkinson, Shaoli Sun, Juan Carlos Varela, Stephen Tomlinson, Xue-Zhong Yu,

PURPOSE:Application of allogeneic hematopoietic cell transplantation (allo-HCT) for patients with hematologic disorders is limited by the development of GVHD. Separation of GVHD and graft-versus-leukemia (GVL) remains a great challenge in the field. We investigated the contribution of individual pathways involved in the complement cascade in GVH and GVL responses to ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(13):3481-3490]

Cited: 0 times

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Editorial: Pathogenesis and Therapy of Graft-versus-Host Disease.

Brian C Betts, Xue-Zhong Yu,

Front Immunol (Frontiers in immunology)
[2019, 10:1797]

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Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells.

Paramita Chakraborty, Shilpak Chatterjee, Pravin Kesarwani, Krishnamurthy Thyagarajan, Supinya Iamsawat, Annika Dalheim, Hung Nguyen, Shanmugam P Selvam, Patrick Nasarre, Gina Scurti, Gary Hardiman, Nilanjana Maulik, Lauren Ball, Vamsi Gangaraju, Mark P Rubinstein, Nancy Klauber-DeMore, Elizabeth G Hill, Besim Ogretmen, Xue-Zhong Yu, Michael I Nishimura, Shikhar Mehrotra,

Adoptive transfer of tumor epitope-reactive T cells has emerged as a promising strategy to control tumor growth. However, chronically-stimulated T cells expanded for adoptive cell transfer are susceptible to cell death in an oxidative tumor microenvironment. Because oxidation of cell-surface thiols also alters protein functionality, we hypothesized that increasing the ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2019, 294(23):9198-9212]

Cited: 1 time

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Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease.

M Hanief Sofi, Yongxia Wu, Steven D Schutt, Min Dai, Anusara Daenthanasanmak, Jessica Heinrichs Voss, Hung Nguyen, David Bastian, Supinya Iamsawat, Shanmugam Panneer Selvam, Chen Liu, Nilanjana Maulik, Besim Ogretmen, Junfei Jin, Shikhar Mehrotra, Xue-Zhong Yu,

Oxidative stress is elevated in the recipients of allogeneic hematopoietic transplantation (allo-HCT) and likely contributes to the development of graft-versus-host disease (GVHD). GVHD is characterized by activation, expansion, cytokine production and migration of alloreactive donor T cells, and remains a major cause of morbidity and mortality after allo-HCT. Hence, strategies ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2019, 129(7):2760-2774]

Cited: 0 times

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The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease.

David Bastian, Yongxia Wu, Brian C Betts, Xue-Zhong Yu,

Allogeneic hematopoietic cell transplantation (allo-HCT) is performed with curative intent for high- risk blood cancers and bone marrow failure syndromes; yet the development of acute and chronic graft-vs.-host disease (GVHD) remain preeminent causes of death and morbidity. The IL-12 family of cytokines is comprised of IL-12, IL-23, IL-27, IL-35, and ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:988]

Cited: 3 times

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Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.

Hung Nguyen, Sandeepkumar Kuril, David Bastian, Jisun Kim, Mengmeng Zhang, Silvia G Vaena, Mohammed Dany, Min Dai, Jessica Lauren Heinrichs, Anusara Daenthanasanmak, Supinya Iamsawat, Steven Schutt, Jianing Fu, Yongxia Wu, David P Fairlie, Carl Atkinson, Besim Ogretmen, Stephen Tomlinson, Xue-Zhong Yu,

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT). DCs play critical roles in GVHD induction. Modulating autophagy represents a promising therapeutic strategy for the treatment of immunological diseases. Complement receptors C3aR/C5aR expressed on DCs regulate immune responses by translating extracellular signals into intracellular activity. In ... Read more >>

JCI Insight (JCI insight)
[2018, 3(24):]

Cited: 1 time

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Modelling CAR-T therapy in humanized mice.

Yongxia Wu, Xue-Zhong Yu,

EBioMedicine (EBioMedicine)
[2019, 40:25-26]

Cited: 0 times

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Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice.

Anusara Daenthanasanmak, Supinya Iamsawat, Paramita Chakraborty, Hung D Nguyen, David Bastian, Chen Liu, Shikhar Mehrotra, Xue-Zhong Yu,

Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transcription factors that are important for modulating immune responses. In the current study, we ... Read more >>

Blood (Blood)
[2019, 133(3):266-279]

Cited: 9 times

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Continuous intravenous infusion of insulin and heparin vs plasma exchange in hypertriglyceridemia-induced acute pancreatitis.

Meng Jin, Jin Min Peng, Hua Dong Zhu, Hui Min Zhang, Bo Lu, Yi Li, Jia Ming Qian, Xue Zhong Yu, Hong Yang,

OBJECTIVE:Acute triglyceride-lowering therapy is crucial in the early treatment of hypertriglyceridemia-induced pancreatitis. This study aimed to compare the efficacy of continuous i.v. infusion of insulin and heparin therapy (IHT) and plasma exchange to lower triglyceride levels in the acute phase of hypertriglyceridemia-induced pancreatitis. METHODS:A retrospective observational study was conducted in ... Read more >>

J Dig Dis (Journal of digestive diseases)
[2018, 19(12):766-772]

Cited: 1 time

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Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.

Shilpak Chatterjee, Paramita Chakraborty, Anusara Daenthanasanmak, Supinya Iamsawat, Gabriela Andrejeva, Libia A Luevano, Melissa Wolf, Uday Baliga, Carsten Krieg, Craig C Beeson, Meenal Mehrotra, Elizabeth G Hill, Jeffery C Rathmell, Xue-Zhong Yu, Andrew S Kraft, Shikhar Mehrotra,

PURPOSE:Adoptive T-cell therapy (ACT) of cancer, which involves the infusion of ex vivo-engineered tumor epitope reactive autologous T cells into the tumor-bearing host, is a potential treatment modality for cancer. However, the durable antitumor response following ACT is hampered either by loss of effector function or survival of the antitumor ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(3):1036-1049]

Cited: 6 times

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Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease.

Supinya Iamsawat, Anusara Daenthanasanmak, Jessica Heinrichs Voss, Hung Nguyen, David Bastian, Chen Liu, Xue-Zhong Yu,

CD8+ induced regulatory T cells (iTregs) have been identified to suppress alloreactive immune responses and expressed regulatory T cell (Treg) ontological markers as similar as CD4+ iTregs. However, adoptive transfer of CD8+ iTreg-based therapy is hampered by the instability of Treg specific-transcription factor, Foxp3. As CD8+ iTregs were previously demonstrated ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2018, 201(9):2812-2823]

Cited: 8 times

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Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells.

Mengmeng Zhang, Yongxia Wu, David Bastian, Supinya Iamsawat, Jinsam Chang, Anusara Daenthanasanmak, Hung D Nguyen, Steven Schutt, Min Dai, Fangping Chen, Woong-Kyung Suh, Xue-Zhong Yu,

The incidence of chronic graft-versus-host disease (cGVHD) is on the rise and still the major cause of morbidity and mortality among patients after allogeneic hematopoietic stem cell transplantation (HCT). Both donor T and B cells contribute to the pathogenesis of cGVHD. Inducible T-cell co-stimulator (ICOS), a potent co-stimulatory receptor, plays ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:1461]

Cited: 5 times

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2050 Identifying the role and immunobiological mechanisms of Fli-1 mediated pathogenicity in graft Versus host disease.

Steven Schutt, Yongxia Wu, Anusara Daenthanasanmak, David Bastian, Carole Wilson, Lynn Schnapp, Xian Zhang, Xue-Zhong Yu, Hung Nguyen, Mohammed Hanief Sofi, Supinya Iamsuwat,

OBJECTIVES/SPECIFIC AIMS: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative procedure for hematological malignancies. Chronic graft Versus host disease (cGVHD) is a lethal complication that often develops after allo-HCT. Fli-1 is an aberrantly expressed protein in cancers including erythroleukemia and melanoma, while being implicated in pathogenesis of systemic lupus ... Read more >>

(Journal of clinical and translational science)
[2018, 2(Suppl 1):14-15]

Cited: 1 time

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IL-27 Receptor Signaling on T cells Augments GVHD Severity through Enhancing Th1 Responses.

David Bastian, Yuejun Liu, Yongxia Wu, Steven Schutt, Hung D Nguyen, Anusara Daenthanasanmak, M Hanief Sofi, Mengmeng Zhang, Supinya Iamsuwat, Xue-Zhong Yu,

IL-27 is a heterodimeric cytokine comprised of IL-27p28 and EBI3. As a relatively new member of the IL-12 family, the biological mechanisms associated with the role of IL-27 in the immune response are ambiguous, displaying both proinflammatory and suppressive functions that seem to be dependent on the disease model. A ... Read more >>

(Journal of immunology research and therapy)
[2018, 3(1):151-157]

Cited: 0 times

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T-Cell Metabolism in Hematopoietic Cell Transplantation.

Hung D Nguyen, Sandeepkumar Kuril, David Bastian, Xue-Zhong Yu,

Metabolism, including catabolism and anabolism, is a basic cellular process necessary for cell survival. T lymphocytes have a distinct metabolism that can determine both fate and function. T-cell activation depends on glycolysis to obtain materials and energy for proliferation and effector function. Importantly, T cells utilize different metabolic processes under ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:176]

Cited: 4 times

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MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice.

Yongxia Wu, Steven Schutt, Katelyn Paz, Mengmeng Zhang, Ryan P Flynn, David Bastian, M Hanief Sofi, Hung Nguyen, Min Dai, Chen Liu, Ying-Jun Chang, Bruce R Blazar, Xue-Zhong Yu,

Chronic graft-versus-host disease (cGVHD) is characterized as autoimmune-like fibrosis and antibody production mediated by pathogenic T cells and B cells. MicroRNA-17-92 (miR-17-92) influences the survival, differentiation, and function of lymphocytes in cancer, infections, and autoimmunity. To determine whether miR-17-92 regulates T- and B-cell responses in cGVHD, we generated mice conditionally ... Read more >>

Blood (Blood)
[2018, 131(17):1974-1986]

Cited: 4 times

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Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.

Steven D Schutt, Yongxia Wu, Chih-Hang Anthony Tang, David Bastian, Hung Nguyen, M Hanief Sofi, MengMeng Zhang, Chen Liu, Kris Helke, Carole Wilson, Lynn M Schnapp, Juan R Del Valle, Chih-Chi Andrew Hu, Xue-Zhong Yu,

Hematopoietic stem cell transplantation (HCT) is a curative procedure for hematological malignancies, but chronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic HCT. Because donor B cells are essential for cGVHD development and B cells are sensitive to endoplasmic reticulum (ER) stress, we hypothesized that the IRE-1α/XBP-1 pathway is ... Read more >>

Blood Adv (Blood advances)
[2018, 2(4):414-427]

Cited: 8 times

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