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Author Xue Wang

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Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.

Wentao Zheng, Xue Wang, Haibo Zhou, Youming Zhang, Aiying Li, Xiaoying Bian,

The Burkholderiales are an emerging source of bioactive natural products. Their genomes contain a large number of cryptic biosynthetic gene clusters (BGCs), indicating great potential for novel structures. However, the lack of genetic tools for the most of Burkholderiales strains restricts the mining of these cryptic BGCs. We previously discovered ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2020, 13(2):397-405]

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Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats.

Xue Wang, Yuhai Zhu, Shuanglin Wang, Zhuoqun Wang, Haonan Sun, Yujie He, Wei Yao,

Evidence indicates that renin-angiotensin-aldosterone system (RAS) inhibitors can protect the brain in Alzheimer's disease and Parkinson's disease. The current study evaluated the relationship between aldosterone and tissue damage in the brains of spontaneously hypertensive rats (SHRs) and whether the RAS inhibitor eplerenone can mitigate the damage seen in these rats.SHRs ... Read more >>

Clin. Exp. Hypertens. (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2020, :1-8]

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The effect of human gene therapy for RPE65-associated Leber's congenital amaurosis on visual function: a systematic review and meta-analysis.

Xue Wang, Chaofeng Yu, Radouil T Tzekov, Yihua Zhu, Wensheng Li,

BACKGROUND:RPE65-associated LCA (RPE65-LCA) is an inherited retinal degeneration caused by the mutations of RPE65 gene and gene therapy has been developed to be a promising treatment. This study aims to evaluate the association between changes in visual function and application of gene therapy in patients with RPE65-LCA. METHODS:Several databases (PubMed, ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):49]

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Exogenous GM1 Ganglioside Attenuates Ketamine-Induced Neurocognitive Impairment in the Developing Rat Brain.

Chen Meng, Xue-Qin Yao, Rui-Jie Chang, Si-Lu Wang, Xue Wang, Da-Qing Ma, Qing Li, Xian-Yu Wang,

BACKGROUND:A prolonged exposure to ketamine triggers significant neurodegeneration and long-term neurocognitive deficits in the developing brain. Monosialotetrahexosylganglioside (GM1) can limit the neuronal damage from necrosis and apoptosis in neurodegenerative conditions. We aimed to assess whether GM1 can prevent ketamine-induced developmental neurotoxicity. METHODS:Postnatal day 7 (P7) rat pups received 5 doses ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2020, 130(2):505-517]

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High Cell Selectivity and Bactericidal Mechanism of Symmetric Peptides Centered on d-Pro-Gly Pairs.

Bo-Yan Jia, Yi-Ming Wang, Ying Zhang, Zi Wang, Xue Wang, Inam Muhammad, Ling-Cong Kong, Zhi-Hua Pei, Hong-Xia Ma, Xiu-Yun Jiang,

Antimicrobial peptides (AMPs) have a unique action mechanism that can help to solve global problems in antibiotic resistance. However, their low therapeutic index and poor stability seriously hamper their development as therapeutic agents. In order to overcome these problems, we designed peptides based on the sequence template XXRXXRRzzRRXXRXX-NH2, where X ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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Promoter Screening Facilitates Heterologous Production of Complex Secondary Metabolites in Burkholderiales Strains.

Qing Ouyang, Xue Wang, Na Zhang, Lin Zhong, Jiaqi Liu, Xiaoming Ding, Youming Zhang, Xiaoying Bian,

Burkholderiales are an emerging source of bioactive secondary metabolites and have the potential to be a robust chassis for metabolites from Gram-negative bacteria. However, only a few constitutive promoters can be utilized in Burkholderiales. Herein, we described the screening of strong constitutive promoters from Burkholderiales strain DSM 7029, and 37 ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2020, :]

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Ulinastatin ameliorates acute kidney injury induced by crush syndrome inflammation by modulating Th17/Treg cells.

Xin-Yue Yang, Jie Song, Shi-Ke Hou, Hao-Jun Fan, Qi Lv, Zi-Quan Liu, Hui Ding, Yong-Zhong Zhang, Jin-Yang Liu, Wen-Long Dong, Xue Wang,

BACKGROUND:Acute kidney injury (AKI) is the main complication of crush syndrome (CS), and it is also a cause of lethality in CS. However, effective treatments for AKI are still lacking. Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor extracted from human urine that reportedly modulates innate immunity and pro-inflammatory responses ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2020, 81:106265]

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Wilms' tumour 1 (WT1) negatively regulates the expression of connexin 43 via a non-canonical Wnt signalling pathway in cultured bovine Sertoli cells.

Xue Wang, Ziming Wang, S O Adeniran, Fushuo Huang, Mingjun Ma, Han Zhang, Xiaoyu Li, Peng Zheng, Guixue Zhang,

The gap junction protein connexin (Cx) 43 between adjacent Sertoli cells (SCs) is the main testicular factor regulating the growth and development of SCs, and plays a vital role in controlling cell differentiation and maturation. However, the endogenous testicular factors that regulate Cx43 and the downstream signalling pathways that mediate ... Read more >>

Reprod. Fertil. Dev. (Reproduction, fertility, and development)
[2020, :]

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Impact of spatiotemporal change of cultivated land on food-water relations in China during 1990-2015.

Xue Wang, Liangjie Xin, Minghong Tan, Xiubin Li, Jiayue Wang,

The spatiotemporal change of cultivated land can exert significant effects on food production and the associated water consumption. The quantification of these effects is meaningful for guiding relevant policies. However, few studies have explored systematic methods assessing changes of food production and water consumption and the relations between them, caused ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 716:137119]

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Efficacy and safety of corticosteroids for septic shock in immunocompromised patients: A cohort study from MIMIC.

Xin Lu, Xue Wang, Yanxia Gao, Shiyuan Yu, Lina Zhao, Zhongheng Zhang, Huadong Zhu, Yi Li,

BACKGROUND:Corticosteroids have been widely used as adjunct therapy for septic shock for many decades, but both the efficacy and safety remain unclear. The study was designed to investigate overall benefits and potential risks of corticosteroids in immunocompromised patients with septic shock. METHODS:The Medical Information Mart for Intensive Care III (MIMIC-III) ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2020, :]

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Survival comparison of Three histological subtypes of lung squamous cell carcinoma: A population-based propensity score matching analysis.

Na An, Xuejiao Leng, Xue Wang, Yile Sun, Zhiwei Chen,

OBJECTIVES:This study is aimed to analyze the survival differences among patients with lung basaloid squamous cell carcinoma (BSCC), keratinizing squamous cell carcinoma (KSCC), and nonkeratinizing squamous cell carcinoma (NKSCC), and explore the prognostic factors of patients with lung BSCC. MATERIALS AND METHODS:We searched the information of 4743 patients with lung ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2020, 142:13-19]

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Efficacy of prebiotics and probiotics for functional dyspepsia: A systematic review and meta-analysis.

Jiaqi Zhang, Hao Meng Wu, Xue Wang, Jingyi Xie, Xia Li, Jinxin Ma, Fengyun Wang, Xudong Tang,

BACKGROUND:Functional dyspepsia (FD) is a functional gastrointestinal disorder. Evidence suggests that disturbance of the gastrointestinal microbiota may be implicated in FD. We performed a systematic review and meta-analysis to examine the efficacy of prebiotics and probiotics for FD. METHODS:MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (through September ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(7):e19107]

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CO2 electrolysis to multicarbon products at activities greater than 1 A cm-2.

F Pelayo García de Arquer, Cao-Thang Dinh, Adnan Ozden, Joshua Wicks, Christopher McCallum, Ahmad R Kirmani, Dae-Hyun Nam, Christine Gabardo, Ali Seifitokaldani, Xue Wang, Yuguang C Li, Fengwang Li, Jonathan Edwards, Lee J Richter, Steven J Thorpe, David Sinton, Edward H Sargent,

Electrolysis offers an attractive route to upgrade greenhouse gases such as carbon dioxide (CO2) to valuable fuels and feedstocks; however, productivity is often limited by gas diffusion through a liquid electrolyte to the surface of the catalyst. Here, we present a catalyst:ionomer bulk heterojunction (CIBH) architecture that decouples gas, ion, ... Read more >>

Science (Science (New York, N.Y.))
[2020, 367(6478):661-666]

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Liquid-liquid phase equilibrium and the effect of a water-soluble polymer on the interaction between droplets in water-in-oil microemulsions.

Xue Wang, Doudou Liu, Mingjie Wang, Zhiyun Chen, Tianxiang Yin, Weiguo Shen,

The liquid-liquid phase equilibria of {water/PEG200/sodium bis(2-ethylhexyl)sulfosuccinate (AOT)/n-decane} with the molar ratio of water to AOT being 37.9 and various concentrations cPEG of PEG in water were measured in this study. The critical exponent β corresponding to the width of the coexistence curve was determined, which showed good agreement with ... Read more >>

Soft Matter (Soft matter)
[2018, 14(48):9950-9958]

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Detecting a single nanoparticle by imaging the localized enhancement and interference of surface plasmon polaritons: erratum.

Xuqing Sun, Hongyao Liu, Liwen Jiang, Ruxue Wei, Xue Wang, Chang Wang, Xinchao Lu, Chengjun Huang,

In this erratum, the function ${\lambda _{{\rm SPP}}}$λSPP in the third page of Opt. Lett.44, 5707 (2019)OPLEDP0146-959210.1364/OL.44.005707 has been corrected. ... Read more >>

Opt Lett (Optics letters)
[2020, 45(4):917]

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A solvent-assisted active loading technology to prepare gambogic acid and all-trans retinoic acid co-encapsulated liposomes for synergistic anticancer therapy.

Kexin Na, Kai Liu, Jiang Yu, Xue Wang, Meng Li, Chutong Tian, Haixia He, Yuan He, Yongjun Wang,

Liposomal drug delivery has become an established technology platform to deliver dual drugs to produce synergistic effects and reduce the adverse effects of traditional chemotherapy. Gambogic acid (GA) and retinoic acid (RA) are both effective anticancer components, but their low water-solubility (gambogic acid < 0.0050 mg/mL, retinoic acid 0.0048 < mg/mL) makes it difficult ... Read more >>

Drug Deliv Transl Res (Drug delivery and translational research)
[2020, 10(1):146-158]

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Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.

Xue Wang, Haibo Xu, Chaping Cheng, Zhongzhong Ji, Huifang Zhao, Yaru Sheng, Xiaoxia Li, Jinming Wang, Yu Shu, Yuman He, Liancheng Fan, Baijun Dong, Wei Xue, Chee Wai Chua, Dongdong Wu, Wei-Qiang Gao, Helen He Zhu,

The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells. However, basal cells are heterogenous and the stem cell subpopulation within basal cells is not well elucidated. Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):706]

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Porcine CXCR1/2 antagonist CXCL8(3-72)G31P inhibits lung inflammation in LPS-challenged mice.

Xue Wang, Yanchuan Li, Lintao Li, Zhe Jiao, Xiaoli Liu, Guofu Cheng, Changqin Gu, Xueying Hu, Wanpo Zhang,

Swine pneumonia is a great threat for pig industry around the world, which is usually accompanied with neutrophils infiltration in the airway. Although interleukin-8 (CXCL8) and its receptors, CXC chemokine receptor 1 and 2 (CXCR1/2) in human have been well documented, the expression and function of CXCR1/2 is still unknown ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1210]

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Efficient methane electrosynthesis enabled by tuning local CO2 availability.

Xue Wang, Aoni Xu, Fengwang Li, Sung-Fu Hung, Dae-Hyun Nam, Christine M Gabardo, Ziyun Wang, Yi Xu, Adnan Ozden, Armin Sedighian Rasouli, Alexander H Ip, David Sinton, Edward H Sargent,

The electroreduction of carbon dioxide (CO2RR) to valuable chemicals is a promising avenue to store intermittent renewable electricity. Renewable methane - obtained via CO2RR using renewable electricity as energy input - has the potential to serve as a carbon-neutral fuel or chemical feedstock, and it is of particular interest in ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, :]

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Nitrate partially inhibits lipopolysaccharide-induced inflammation by maintaining mitochondrial function.

Yang Yang, Shaoqing Li, Yi Qu, Xue Wang, Wei An, Zhilin Li, Zhengxue Han, Lizheng Qin,

J. Int. Med. Res. (The Journal of international medical research)
[2020, 48(2):300060520902605]

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Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma.

Chen Hao Jiang, Xin Yuan, Jiang Fen Li, Yu Fang Xie, An Zhi Zhang, Xue Li Wang, Lan Yang, Chun Xia Liu, Wei Hua Liang, Li Juan Pang, Hong Zou, Xiao Bin Cui, Xi Hua Shen, Yan Qi, Jin Fang Jiang, Wen Yi Gu, Feng Li, Jian Ming Hu,

BACKGROUND:Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and is closely related to liver cirrhosis. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but the molecular mechanism remains unclear. The aims of the present study were to identify key genes related to ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):40]

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Zinc is essential for the transcription function of PGC-1α/Nrf2 signal pathway in human primary endometrial stromal cells.

Xiaodan Lu, Qiang Zhang, Li Xu, Xiuying Lin, Jianhua Fu, Xue Wang, Yinong Liu, Yifan Lin, Bing Li, Ruobing Wang, Lei Liu, Xuguang Mi, Haifeng Wei, Yan Tan, Yanqiu Fang,

Zinc (Zn) has antioxidant effect in different types of organs and is closely associated with human health. The endometrial receptivity is one of the most important factors in the embryo implantation and development. However, the regulatory mechanism of Zn in endometrium tissue is still unclear. In the study, we found ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2020, :]

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Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae.

Xue Wang, Xue-Liang Yang, Ke-Chun Liu, Wen-Long Sheng, Qing Xia, Rong-Chun Wang, Xi-Qiang Chen, Yun Zhang,

Type 1 diabetes is characterized by an increase in blood glucose levels resulting from damage to β cells in pancreatic islets and the consequent absolute insufficiency of insulin. Animal models of type 1 diabetes were usually established using drugs toxic to β cells, such as streptozotocin (STZ). To assess the ... Read more >>

Fish Physiol. Biochem. (Fish physiology and biochemistry)
[2020, :]

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The application of pseudotargeted metabolomics method for fruit juices discrimination.

Lei Xu, Zhenzhen Xu, Xue Wang, Bingfeng Wang, Xiaojun Liao,

To optimize and evaluate the pseudotargeted metabolomics for juice discrimination and authentication, five widely consumed fruit (apple, orange, pear, purple grape and mandarin) juices were selected. SWATH-MS data was acquired by various windows being calculated based on total ion current, and then 2310 and 2292 MRM transitions were generated. Most ... Read more >>

Food Chem (Food chemistry)
[2020, 316:126278]

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Autophagy and Hsp70 activation alleviate oral epithelial cell death induced by food-derived hypertonicity.

Ji Yang, Huijie Zhang, Sujiao Sun, Xue Wang, Ying Guan, Qili Mi, Wanli Zeng, Haiying Xiang, Huadong Zhu, Xin Zou, Yunfei You, Yang Xiang, Qian Gao,

Stable intracellular and intercellular osmolarity is vital for all physiological processes. Although it is the first organ that receives food, the osmolarity around the mouth epithelium has never been systematically investigated. We found that oral epithelial cells are a population of ignored cells routinely exposed to hypertonic environments mainly composed ... Read more >>

Cell Stress Chaperones (Cell stress & chaperones)
[2020, :]

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