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cAMP sensitive nanochannels driven by conformational transition of a tripeptide-based smart polymer.

Shengyan Ji, Yuting Xiong, Wenqi Lu, Minmin Li, Xue Wang, Cunli Wang, Dongdong Wang, Jie Xiao, Zhichao Zhu, Lihua Chen, Yahui Zhang, Guangyan Qing,

Inspired by biological nanochannels, a novel cyclic 3',5'-adenosine monophosphate (cAMP)-regulated artificial nanochannel based on a tripeptide Arg-Thr-Ala (RTA) design is developed. Highly specific binding between the tripeptide and cAMP triggers an obvious conformational transition of a smart polymer chain from a contracted state to a swollen one, which leads to ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(23):3425-3428]

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Profiling Chromatin Landscape at High Resolution and Throughput with 2C-ChIP.

Xue Qing David Wang, Christopher J F Cameron, Dana Segal, Denis Paquette, Mathieu Blanchette, Josée Dostie,

Chromatin immunoprecipitation (ChIP) is used to probe the presence of proteins and/or their posttranslational modifications on genomic DNA. This method is often used alongside chromosome conformation capture approaches to obtain a better-rounded view of the functional relationship between chromatin architecture and its landscape. Since the inception of ChIP, its protocol ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2021, 2157:127-157]

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Determination of steroid hydroxylation specificity of an industrial strain Aspergillus ochraceus TCCC41060 by cytochrome P450 gene CYP68J5

Xue Wang, Xingwei Yang, Xi Jia, Peng Jin, Zhengxiang Wang, Fuping Lu, Xiaoguang Liu,

PURPOSE: The use of Aspergillus ochraceus TCCC41060 for synthesis of 11α-OH-ethylgonendione, an important intermediate for synthesis of desogestrel-a major ingredient of the “third-generation” oral contraceptives, is hampered by its low regioselectivity of hydroxylation. In the present study, we sought to characterize gene(s) involved in steroid hydroxylation specificity in strain TCCC41060. ... Read more >>

Ann. Microbiol. (Annals of microbiology.)
[2020, 70(1):45]

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Effects of Continuous Cropping on Bacterial Community Structure in Rhizospheric Soil of Sweet Potato 

Zhiyuan Gao, Yaya Hu, Meikun Han, Junjie Xu, Xue Wang, Lanfu Liu, Zhonghou Tang, Weijing Jiao, Rong Jin, Ming Liu, Zhengjun Guan, Zhimin Ma,

Abstract Background: Continuous cropping obstacles from sweet potato are widespread, which seriously reduce the yield and quality, cause certain economic losses. Bacteria of Rhizospheric soil are the richest and are associated with obstacles to continuous cropping. However, few studies on how continuous sweet potato cropping affects the rhizospheric soil bacterial ... Read more >>

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Expression profiles of long noncoding RNAs in retinopathy of prematurity.

Yue Wang, Xue Wang, Yuan Ma, Yue-Xia Wang, Yu Di,

Long noncoding RNA (lncRNA) regulates the proliferation and migration of human retinal endothelial cells, as well as retinal neovascularization in diabetic retinopathy. Based on similarities between the pathogenesis of retinopathy of prematurity (ROP) and diabetic retinopathy, lncRNA may also play a role in ROP. Seven-day-old mice were administered 75 ± ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1962-1968]

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Prognostic Significance of Ambulatory BP Monitoring in CKD: A Report from the Chronic Renal Insufficiency Cohort (CRIC) Study.

Mahboob Rahman, Xue Wang, Joshua D Bundy, Jeanne Charleston, Debbie Cohen, Jordana Cohen, Paul E Drawz, Lama Ghazi, Edward Horowitz, James P Lash, Sarah Schrauben, Matthew R Weir, Dawei Xie, Raymond R Townsend, ,

BACKGROUND:Whether ambulatory BP monitoring is of value in evaluating risk for outcomes in patients with CKD is not clear. METHODS:We followed 1502 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study for a mean of 6.72 years. We evaluated, as exposures, ambulatory BP monitoring profiles (masked uncontrolled hypertension, white-coat effect, ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2020, :]

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IFN-g-induced Jmjd3-Zeb1 axis contributes to an aggressive phenotype in lung adenocarcinoma

Jianjian Yang, Xue Wang, Bing Huang, Rong Liu, Hui Xiong, Fan Ye, Chenxi Zeng, Xiangning Fu, Lequn Li,

Abstract Background Active IFN-γ signaling is a common feature of tumors responding to PD-1 checkpoint blockade. IFN-γ exhibits both anti- and pro-tumor activities. Therefore, identifying the pro-tumor effects of IFN-γ and their underlying molecular mechanisms could be a critical step for developing therapeutic strategies to maximize the anti-tumor efficacy ... Read more >>

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The Transcription Factor NIGT1.2 Modulates Both Phosphate Uptake and Nitrate Influx during Phosphate Starvation in Arabidopsis and Maize.

Xue Wang, Hai-Feng Wang, Yun Chen, Mi-Mi Sun, Yi Wang, Yi-Fang Chen,

Phosphorus and nitrogen are essential macronutrients for plant growth and crop production. During phosphate (Pi) starvation, plants enhanced Pi but reduced nitrate (NO3-) uptake capacity, and the mechanism is unclear. Here, we show that a GARP-type transcription factor NITRATE-INDUCIBLE, GARP-TYPE TRANSCRIPTIOANL REPRESSOR1.2 (NIGT1.2) coordinately modulates Pi and NO3- uptake in ... Read more >>

Plant Cell (The Plant cell)
[2020, :]

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Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess.

Yue Wang, Xue Wang, Yu Di,

BACKGROUNDS:Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused by liver abscess. METHODS:Between April 2014 and April 2019, the clinical data of 16 ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):661]

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3D Cage COFs: A Dynamic Three-Dimensional Covalent Organic Framework with High-Connectivity Organic Cage Nodes.

Qiang Zhu, Xue Wang, Rob Clowes, Peng Cui, Linjiang Chen, Marc A Little, Andrew I Cooper,

Three-dimensional (3D) covalent organic frameworks (COFs) are rare because there is a limited choice of organic building blocks that offer multiple reactive sites in a polyhedral geometry. Here, we synthesized an organic cage molecule (Cage-6-NH2) that was used as a triangular prism node to yield the first cage-based 3D COF, ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, :]

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Uniformly distributed ruthenium nanocrystals as highly efficient peroxidase for hydrogen peroxide colorimetric detection and nitroreductase for 4-nitroaniline reduction.

Shiya Feng, Mei Ming, Mingzhu Wang, Xue Wang, Daiping He, Ping Jiang, Yuyun Chen,

Here, we report highly dispersed small ruthenium nanoparticles (NPs) anchored onto a porous carbon (Ru/PC) with a clean catalytic surface and explore their excellent peroxidase-like activity for 3,3',5,5'-tetramethylbenzidine oxidation mediated by H2O2, which allows sensitive colorimetric detection of H2O2 with a low detection limit of 3.8 μM. Moreover, it is ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, :]

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Application of ultrasound artificial intelligence in the differential diagnosis between benign and malignant breast lesions of BI-RADS 4A

Sihua Niu, Jianhua Huang, Jia Li, Xueling Liu, Dan Wang, Ruifang Zhang, Yingyan Wang, Huiming Shen, Min Qi, Yi Xiao, Mengyao Guan, Haiyan Liu, Diancheng Li, Feifei Liu, Xiuming Wang, Yu Xiong, Siqi Gao, Xue Wang, Jiaan Zhu,

Abstract Background: The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the ultrasonic morphological and ... Read more >>

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Functional Nanochannels for Sensing Tyrosine Phosphorylation.

Minmin Li, Yuting Xiong, Wenqi Lu, Xue Wang, Yunhai Liu, Bing Na, Haijuan Qin, Mingliang Tang, Hongqiang Qin, Mingliang Ye, Xinmiao Liang, Guangyan Qing,

Tyrosine phosphorylation (pTyr), much of which occurred on localized multiple sites, initiates cellular signaling, governs cellular functions, and its dysregulation is implicated in many diseases, especially cancers. pTyr-specific sensing is of great significance for understanding disease states and developing targeted anticancer drugs, however, it is very challenging due to the ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(38):16324-16333]

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Correction to: Deciphering cellular transcriptional alterations in Alzheimer's disease brains.

Xue Wang, Mariet Allen, Shaoyu Li, Zachary S Quicksall, Tulsi A Patel, Troy P Carnwath, Joseph S Reddy, Minerva M Carrasquillo, Sarah J Lincoln, Thuy T Nguyen, Kimberly G Malphrus, Dennis W Dickson, Julia E Crook, Yan W Asmann, Nilüfer Ertekin-Taner,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

Mol Neurodegener (Molecular neurodegeneration)
[2020, 15(1):54]

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Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease in School-Age Children and Adolescents in Shenyang, China

Guan Lin, Zhang Xinhe, Tian Haoyu, Jin Xing, Li Dan, Wang Ningning, Sun Jing, Xue Wang, Zeng Zilu, Yiling Li,

Abstract Background : Metabolic-associated fatty liver disease (MAFLD) refers to abnormal accumulation of fat in the liver for metabolic dysfunction. With modern socioeconomic conditions and changes in dietary patterns, the prevalence of MAFLD is increasing, to the detrimental of children’s learning and quality of life. We investigated the prevalence and ... Read more >>

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FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages.

Dongxue Wang, Fei Liu, Liyun Zhu, Ping Lin, Fanyi Han, Xue Wang, Xianxi Tan, Li Lin, Ye Xiong,

BACKGROUND:Resident microglia and macrophages are the predominant contributors to neuroinflammation and immune reactions, which play a critical role in the pathogenesis of ischemic brain injury. Controlling inflammatory responses is considered a promising therapeutic approach for stroke. Recombinant human fibroblast growth factor 21 (rhFGF21) presents anti-inflammatory properties by modulating microglia and ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17(1):257]

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Ratios of neutrophil-to-lymphocyte and platelet-to-lymphocyte predict all-cause mortality in inpatients with coronavirus disease 2019 (COVID-19): a retrospective cohort study in a single medical centre.

Xue Wang, Xincheng Li, Yu Shang, Junwei Wang, Xiaona Zhang, Dongju Su, Shuai Zhao, Qin Wang, Lei Liu, Yupeng Li, Hong Chen,

The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern. The current study aims to explore whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the development of death in patients with COVID-19. A total ... Read more >>

Epidemiol. Infect. (Epidemiology and infection)
[2020, 148:e211]

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Cognitive Rehabilitation Interventions After Stroke: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials

Qing Zhao, Xue Wang, Tao Wang, Adam Dmytriw, Xiao Zhang, Kun Yang, Jichang Luo, Xuesong Bai, Nan Jiang, Bin Yang, Yan Ma, Liqun Jiao, Yunyan Xie,

Abstract Background: Stroke is the second leading cause of deaths worldwide, and 53.4% of the stroke survivors suffer from post-stroke cognitive impairment. Post-stroke cognitive impairment can increase hospitalization rate and cost of care, and decrease the quality of life of stroke patients. To date, multiple cognitive rehabilitation interventions have been ... Read more >>

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Biomarkers of postmenopausal osteoporosis and interventive mechanism of catgut embedding in acupoints

Guizhen Chen, Hongyuan Liu, Xiaofeng Wu, Xue Wang, Junquan Liang, Yunxiang Xu,

Abstract Introduction: Postmenopausal osteoporosis (PMOP), which is a common and frequently occurring age-related metabolic bone disease in perimenopausal women, severely affects patients living quality. Modern medicine therapies for PMOP have several problems such as side reactions, low compliance, and high costs. Thus, nonpharmacological modality is urgently needed. Although acupoint thread ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(37):]

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Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by live abscess

Yue Wang, Xue Wang, Yu Di,

Abstract Backgrounds: Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused by liver abscess. Methods: Between April 2014 and April 2019, the clinical ... Read more >>

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Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.

Xuejiao Leng, Jianfeng Wang, Na An, Xue Wang, Yile Sun, Zhiwei Chen,

Aberrations in epigenetic modulation dysregulate transcription, playing a critical role in the developmental process of tumors, including lung cancer. Aberrant levels of the histone 3 lysine-27 demethylase KDM6A have been found in cancer and are either positively or negatively associated with tumorigenesis and prognosis. However, the clinical relevance and functional ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Effect of MR Field Strength on the Texture Features of Cerebral T2-FLAIR Images: A Pilot Study.

Xue Dan Wang, Shi Wei Wang, Bo Tao Wang, Zhi Ye Chen,

Objective To investigate effect of MR field strength on texture features of cerebral T2 fluid attenuated inversion recovery (T2-FLAIR) images. Methods We acquired cerebral 3D T2-FLAIR images of thirty patients who were diagnosed with ischemic white matter lesion (WML) with MR-1.5T and MR-3.0T scanners. Histogram texture features which included mean ... Read more >>

Chin. Med. Sci. J. (Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih)
[2020, 35(3):248-253]

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Biomarkers of postmenopausal osteoporosis and interventive mechanism of catgut embedding in acupoints.

Guizhen Chen, Hongyuan Liu, Xiaofeng Wu, Xue Wang, Junquan Liang, Yunxiang Xu,

INTRODUCTION:Postmenopausal osteoporosis (PMOP), which is a common and frequently occurring age-related metabolic bone disease in perimenopausal women, severely affects patients living quality. Modern medicine therapies for PMOP have several problems such as side reactions, low compliance, and high costs. Thus, nonpharmacological modality is urgently needed. Although acupoint thread embedding treatment ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(37):e22178]

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Evaluation of Coat Color Inheritance and Production Performance for Cossbreed from Chinese Indigenous Chenghua Pig Crossbred with Berkshire

Xue Wang, Zhengyin Gong, Qin Zou, Li Zhu, Guoqing Tang, Mingzhou Li, Xuewei Li, Zhailin Zhang, Zhiyong Xu, Yanjun Sun, Yanzhi Jiang,

Abstract Background: Crossbreeding programs have been used extensively to improve the native pig’s overall production performance while maintaining superior meat quality. Chenghua (CH) pig is a traditional Chinese indigenous breed with superior meat quality characteristic but poor growth and carcass traits. In recent years, we implemented Berkshire × Chenghua (BC) ... Read more >>

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StackPDB: predicting DNA-binding proteins based on XGB-RFE feature optimization and stacked ensemble classifier

Qingmei Zhang, Peishun Liu, Yu Han, Yaqun Zhang, Xue Wang, Bin Yu,

ABSTRACT DNA binding proteins (DBPs) not only play an important role in all aspects of genetic activities such as DNA replication, recombination, repair, and modification but also are used as key components of antibiotics, steroids, and anticancer drugs in the field of drug discovery. Identifying DBPs becomes one of the ... Read more >>

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