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Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.

Xu Guo, Haozhe Piao, Ye Zhang, Peixin Sun, Bing Yao,

Glioblastoma multiforme (GBM) is a highly invasive cancer with a high recurrence rate. The prognosis of GBM patients remains poor, even after standard surgical resection combined with chemoradiotherapy. Thus, there is an urgent need for new therapeutic targets in GBM. In recent years, microRNAs have received considerable attention due to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):459-470]

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The feasibility of recruiting and retaining men who have sex with men and transgender women in a multinational prospective HIV prevention research cohort study in sub-Saharan Africa (HPTN 075).

Theodorus Gm Sandfort, Erica L Hamilton, Anita Marais, Xu Guo, Jeremy Sugarman, Ying Q Chen, Vanessa Cummings, Sufia Dadabhai, Karen Dominguez, Ravindre Panchia, David Schnabel, Fatima Zulu, Doerieyah Reynolds, Oscar Radebe, Calvin Mbeda, Dunker Kamba, Brian Kanyemba, Arthur Ogendo, Michael Stirratt, Wairimu Chege, Jonathan Lucas, Maria Fawzy, Laura A McKinstry, Susan H Eshleman,

INTRODUCTION:Men who have sex with men (MSM) and transgender women (TGW) in sub-Saharan Africa (SSA) are profoundly affected by HIV with high HIV prevalence and incidence. This population also faces strong social stigma and legal barriers, potentially impeding participation in research. To date, few multi-country longitudinal HIV research studies with ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23 Suppl 6:e25600]

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Dual-roadmap guidance for endovascular recanalization of medically refractory non-acute intracranial arterial occlusions: consecutive multicenter series and technical review.

Feng Gao, Xu Guo, Xuan Sun, Yan Liu, Yingchun Wu, Zhongrong Miao,

BACKGROUND:The optimal treatment for medically refractory non-acute intracranial artery occlusion is uncertain, and endovascular recanalization remains a technical challenge. Here, a multicenter clinical experience of dual-roadmap guidance for endovascular recanalization of non-acute intracranial artery occlusion is reported, focusing on the technical feasibility and safety. METHODS:From January 2014 to December 2019, ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2020, :]

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Genetic and phylogenetic analysis of canine bufavirus from Anhui Province, Eastern China.

Yong Wang, Xu Guo, Da Zhang, Jianfei Sun, Wei Li, Ziteng Fu, Guangqing Liu, Yongdong Li, Shudong Jiang,

Bufavirus is a novel virus associated with canine gastroenteritis. Three strains of bufavirus were first detected in dog feces collected from Anhui province in Eastern China. The near-complete genome sequences were amplified. Sequence alignment showed 98.3-99.5% homology between the three bufavirus strains and reference strains. Phylogenetic analysis showed the distributed ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2020, :104600]

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Deep learning radiomics of ultrasonography: Identifying the risk of axillary non-sentinel lymph node involvement in primary breast cancer.

Xu Guo, Zhenyu Liu, Caixia Sun, Lei Zhang, Ying Wang, Ziyao Li, Jiaxin Shi, Tong Wu, Hao Cui, Jing Zhang, Jie Tian, Jiawei Tian,

BACKGROUND:Completion axillary lymph node dissection is overtreatment for patients with sentinel lymph node (SLN) metastasis in whom the metastatic risk of residual non-SLN (NSLN) is low. However, the National Comprehensive Cancer Network panel posits that none of the previous studies has successfully identified such subset patients. Here, we develop a ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 60:103018]

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The feasibility of recruiting and retaining men who have sex with men and transgender women in a multinational prospective HIV prevention research cohort study in sub‐Saharan Africa (HPTN 075)

Theodorus GM Sandfort, Erica L Hamilton, Anita Marais, Xu Guo, Jeremy Sugarman, Ying Q Chen, Vanessa Cummings, Sufia Dadabhai, Karen Dominguez, Ravindre Panchia, David Schnabel, Fatima Zulu, Doerieyah Reynolds, Oscar Radebe, Calvin Mbeda, Dunker Kamba, Brian Kanyemba, Arthur Ogendo, Michael Stirratt, Wairimu Chege, Jonathan Lucas, Maria Fawzy, Laura A McKinstry, Susan H Eshleman,

Abstract Introduction Men who have sex with men (MSM) and transgender women (TGW) in sub‐Saharan Africa (SSA) are profoundly affected by HIV with high HIV prevalence and incidence. This population also faces strong social stigma and legal barriers, potentially impeding participation in research. To date, few multi‐country longitudinal HIV research ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(Suppl 6):]

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A Novel Next-Generation Sequencing-Based Approach for Concurrent Detection of Mitochondrial DNA Copy Number and Mutation.

Kaixiang Zhou, Qinqin Mo, Shanshan Guo, Yang Liu, Chun Yin, Xiaoying Ji, Xu Guo, Jinliang Xing,

Numerous studies have identified essential contributions of altered mitochondrial DNA (mtDNA) copy number and mutations in many common disorders including cancer. To date, capture-based next-generation sequencing (NGS) has been widely applied to detect mtDNA mutations, although it lacks the ability to assess mtDNA copy number. The current strategy for quantifying ... Read more >>

J Mol Diagn (The Journal of molecular diagnostics : JMD)
[2020, :]

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Integrated Z-Scheme Nanosystem Based on Metal Sulfide Nanorods for Efficient Photocatalytic Pure Water Splitting.

Zhixiao Qin, Xiangjiu Guan, Xu Guo, Penghui Guo, Menglong Wang, Zhenxiong Huang, Yubin Chen,

Developing efficient metal sulfides for pure water splitting is a challenging topic in the field of photocatalysis. Herein, inspired by natural photosynthesis, an all-solid-state Z-scheme photocatalyst is constructed with Cd 0.9 Zn 0.1 S (CZS) for water reduction, red phosphorus (RP) for water oxidation, and metallic CoP as the electron ... Read more >>

ChemSusChem (ChemSusChem)
[2020, :]

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Enhanced Light-Driven Charge Separation and H2 Generation Efficiency in WSe2 Nanosheet-Semiconductor Nanocrystal Heterostructures.

Xu Guo, Qiuyang Li, Yawei Liu, Tao Jin, Yubin Chen, Liejin Guo, Tianquan Lian,

Semiconductor-catalyst heterostructures have shown promising performances for light-driven H2 generation, although further development of these materials is hindered by the lack of cost-effective and efficient catalysts. In this paper, we adopt a colloidal method to prepare few-layer WSe2 nanosheets without exfoliation and apply them as catalysts for forming heterostructures with ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(40):44769-44776]

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Impact of Nischarin on EMT regulators in breast cancer cell lines.

Yuan-Jie Cai, Bo Ma, Mei-Li Wang, Jie Chen, Fu-Guang Zhao, Juan-Di Zhou, Xu Guo, Lei Zheng, Chun-Jing Xu, Yi Wang, Yi-Bo He, Jian Liu, Shang-Nao Xie,

Nischarin is an integrin-binding protein, which is well known as a novel tumor suppressor. In breast cancer, Nischarin serves a critical role in breast cancer cell migration and invasion. However, the molecular mechanism underlying the role of Nischarin remains unclear. Recent findings have demonstrated that epithelial-mesenchymal transition (EMT) increases the ... Read more >>

Oncol Lett (Oncology letters)
[2020, 20(6):291]

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Impact of Nischarin on EMT regulators in breast cancer cell lines

Yuan-Jie Cai, Bo Ma, Mei-Li Wang, Jie Chen, Fu-Guang Zhao, Juan-Di Zhou, Xu Guo, Lei Zheng, Chun-Jing Xu, Yi Wang, Yi-Bo He, Jian Liu, Shang-Nao Xie,

Nischarin is an integrin-binding protein, which is well known as a novel tumor suppressor. In breast cancer, Nischarin serves a critical role in breast cancer cell migration and invasion. However, the molecular mechanism underlying the role of Nischarin remains unclear. Recent findings have demonstrated that epithelial-mesenchymal transition (EMT) increases the ... Read more >>

(Oncology Letters)
[2020, 20(6):]

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Multiple-level copy number variations in circulating cell-free DNA for prognostic prediction of hepatocellular carcinoma with radical treatments

Yang Wang, Xiangxu Wang, Kaixiang Zhou, Yang Liu, Zhenyuan Bian, Dongna Guo, Liping Su, Kun Liu, Xiwen Gu, Xu Guo, Kaishan Tao, Jinliang Xing,

Abstract Background Copy number variations (CNVs) in circulating free DNA (cfDNA) are emerging as minimally invasive prognostic biomarkers for various cancers. However, little has been reported on the multiple-level analysis of cfDNA CNVs for hepatocellular carcinoma (HCC) patients with radical treatments. Methods Here, CNVs at genome-wide, chromosomal-arm and ... Read more >>

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Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis.

Yuanda Zhang, Binbin Bi, Xu Guo, Shaohui Zhang,

Objective:To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis. Methods:A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children's Hospital ... Read more >>

(Pakistan journal of medical sciences)
[2020, 36(6):1377-1381]

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Association Between Serum High-Density Lipoprotein Cholesterol Concentration and Mortality in Critically Ill Patients: A Retrospective Cohort Study

Xu Guo, Zhiyu Xu, Hengxing Qu, Ryan Charles Woods, Eunice Njobvu, Zhongyi Zhou, Xiaohong Xie, Jia Tian,

Abstract Background This research aims to explore the association between serum high-density lipoprotein cholesterol (HDL-C) and mortality in patients who are critically ill. MethodsThis was a retrospective cohort study. Data were extracted from an online database named ‘Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC III)’. 3384 patients were included, ... Read more >>

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Pan-metastatic cancer analysis of prognostic factors and a prognosis-based metastatic cancer classification system.

Chao Zhang, Guijun Xu, Yao Xu, Haixiao Wu, Xu Guo, Min Mao, Vladimir P Baklaushev, Vladimir P Chekhonin, Karl Peltzer, Ye Bai, Guowen Wang, Wenjuan Ma, Xin Wang,

We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at admission and overall survival were determined. A ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(16):16046-16061]

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Non-Collinear Orbital-induced Planar Quantum Anomalous Hall Effect.

Xu Guo, Zhao Liu, Bing Liu, Qunxiang Li, Zhengfei Wang,

Based on the 2D star lattice with noncollinear orbital, we present an intriguing six-band tight-binding model for planar quantum anomalous Hall effect (PQAHE) with in-plane magnetization. Depending on the orientation of the noncollinear orbital, the characterized Dirac-, Kagome-, and Four-band are all realizable. Moreover, including the intrinsic spin-orbital coupling, a ... Read more >>

Nano Lett (Nano letters)
[2020, 20(10):7606-7612]

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LMX1B-associated gankyrin expression predicts poor prognosis in glioma patients.

Xu Guo, Haozhe Piao, Yixue Xue, Yunhui Liu, Hongyu Zhao,

OBJECTIVE:To explore the potential of the transcription factor LMX1B and downstream gankyrin as prognostic biomarkers of glioma. METHODS:The expression levels of gankyrin and LMX1B were detected in 52 normal brain specimens and 339 glioma specimens. Correlations of gankyrin and LMX1B expression levels with pathological stages and clinical characteristics were statistically ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(9):300060520954764]

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TaqMan-based real-time polymerase chain reaction assay for specific detection of bocavirus-1 in domestic cats.

Yong Wang, Jianfei Sun, Xu Guo, Da Zhang, Yongqiu Cui, Wei Li, Guangqing Liu, Yongdong Li, Shudong Jiang,

Feline bocavirus-1 (FBoV-1) was first discovered in Hong Kong in 2012, and studies have indicated that the virus may cause feline hemorrhagic enteritis. Currently, there is a lack of an effective and quantitative method for FBoV-1 detection. In this study, a TaqMan-based quantitative real-time PCR (qPCR) for FBoV-1 detection was ... Read more >>

Mol. Cell. Probes (Molecular and cellular probes)
[2020, 53:101647]

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HIV drug resistance, phylogenetic analysis, and superinfection among men who have sex with men and transgender women in sub-Saharan Africa: HPTN 075.

Mariya V Sivay, Philip J Palumbo, Yinfeng Zhang, Vanessa Cummings, Xu Guo, Erica L Hamilton, Laura McKinstry, Arthur Ogendo, Noel Kayange, Ravindre Panchia, Karen Dominguez, Ying Q Chen, Theodorus G M Sandfort, Susan H Eshleman,

BACKGROUND:The HIV Prevention Trials Network (HPTN) 075 study evaluated the feasibility of enrolling and retaining men who have sex with men (MSM) and transgender women (TWG) from Kenya, Malawi, and South Africa. Twenty-one participants acquired HIV during study follow-up (seroconverters). We analyzed HIV subtype diversity, drug resistance, transmission dynamics, and ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Genetic characterization and phylogenetic analysis of feline astrovirus from Anhui province in eastern China.

Yong Wang, Xu Guo, Yongqiu Cui, Yu Zhou, Kankan Yang, Ziteng Fu, Jianfei Sun, Guangqing Liu, Bangzhao Cheng, Shudong Jiang, Yongdong Li,

This study aimed to explore the phylogenetic and molecular characteristics of feline astrovirus. A total of 33 fecal samples of domestic cats with or without diarrhea were collected from the Anhui province, and two positive samples were detected. The complete genome and ORF2 of the two strains were sequenced and ... Read more >>

3 Biotech (3 Biotech)
[2020, 10(8):354]

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An Innovative Data Analysis Strategy For Accurate NGS Detection of Tumor mtDNA Mutations

Shanshan Guo, Kaixiang Zhou, Qing Yuan, Liping Su, Xiaoying Ji, Xiwen Gu, Xu Guo, Jinliang Xing,

Abstract Background: Next generation sequencing (NGS) technology has been commonly applied to detect mtDNA mutations, which are reported to be strongly associated with cancers. However, several key challenges still exist in the bioinformatic analysis of mtDNA sequencing data, which greatly affect the detection accuracy of mtDNA mutations. Methods: Here, we ... Read more >>

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HIV drug resistance, phylogenetic analysis, and superinfection among men who have sex with men and transgender women in sub-Saharan Africa: HPTN 075.

Mariya V Sivay, Philip J Palumbo, Yinfeng Zhang, Vanessa Cummings, Xu Guo, Erica L Hamilton, Laura McKinstry, Arthur Ogendo, Noel Kayange, Ravindre Panchia, Karen Dominguez, Ying Q Chen, Theodorus G M Sandfort, Susan H Eshleman,

BACKGROUND:The HIV Prevention Trials Network (HPTN) 075 study evaluated the feasibility of enrolling and retaining men who have sex with men (MSM) and transgender women (TWG) from Kenya, Malawi, and South Africa. Twenty-one participants acquired HIV during study follow-up (seroconverters). We analyzed HIV subtype diversity, drug resistance, transmission dynamics, and ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Development of an SYBR Green I-based real-time PCR assay for the rapid detection of canine kobuvirus.

Yong Wang, Yongqiu Cui, Yeqiu Li, Da Zhang, Jianfei Sun, Xu Guo, Guangqing Liu, Shudong Jiang, Yongdong Li,

Canine kobuvirus (CaKoV) is a causative agent of gastroenteritis in dogs. Rapid detection of CaKoV is important for preventing and controlling this condition. In this study, an SYBR Green I-based quantitative real-time PCR assay was established for CaKoV detection. Specific primers targeting a highly conserved region of the CaKoV 3D ... Read more >>

J Virol Methods (Journal of virological methods)
[2020, 285:113944]

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PDB-1 from Potentilla discolor Bunge induces apoptosis and autophagy by downregulating the PI3K/Akt/mTOR signaling pathway in A549 cells.

Rui-Rui Zhang, Na-Na Meng, Chao Liu, Kui-Lin Li, Mu-Xuan Wang, Zhi-Bo Lv, Shu-Ya Chen, Xu Guo, Xin-Kun Wang, Qing Wang, Jin-Yue Sun,

PDB-1 is a new C-27-carboxylated-lupane-triterpenoid derivative isolated from Potentilla discolor Bunge. In our previous research, PDB-1 was suggested to have an obvious selectivity for tumor cells. This study focused on clarifying PDB-1's anticancer mechanism in the inhibition of proliferation and in the induction of apoptosis and autophagy in A549 cells. ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 129:110378]

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Healthcare-related stigma among men who have sex with men and transgender women in sub-Saharan Africa participating in HIV Prevention Trials Network (HPTN) 075 study.

Calvin Mbeda, Arthur Ogendo, Richard Lando, David Schnabel, Deborah A Gust, Xu Guo, Victor Akelo, Karen Dominguez, Ravindre Panchia, Yamikani Mbilizi, Ying Chen, Wairimu Chege, ,

ABSTRACT The inability to access health services when needed is a critical barrier to HIV prevention, treatment and care among men who have sex with men (MSM) and transgender women (TGW). Using data collected in HPTN 075, we explored factors associated with any experienced healthcare-related stigma. HPTN 075 was a ... Read more >>

AIDS Care (AIDS care)
[2020, 32(8):1052-1060]

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