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Author Xiuying Chen

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Facile Fabrication of N-Doped TiO₂ Nanoparticles/Carbon Composite with Excellent Electrochemical Properties for Lithium Ion Batteries.

Jinyan Cai, Lin Chen, Xiuying Chen,

A promising anode material for lithium-ion batteries (LIBs) consisting of ultrafine N-doped TiO₂ nanoparticles and N-doped carbon composite has been prepared by an effective sol-gel-calcined strategy. The synergetic effect between N-doped TiO₂ nanoparticles and N-doped carbon provides not only high conductivity paths and strong electron contact interface, but also supply ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2020, 20(4):2452-2459]

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Astragalin alleviates cerebral ischemia-reperfusion injury by improving anti-oxidant and anti-inflammatory activities and inhibiting apoptosis pathway in rats.

Xiuying Chen, Chang Cheng, Xuzheng Zuo, Wen Huang,

BACKGROUND:Astragalin (AG), a flavonoid from many traditional herbs and medicinal plants, has been described to exhibit in vitro anti-inflammatory activity. The paper aimed to study the effects of astragalin on anti-inflammatory, anti-oxidative ability and apoptosis signaling pathway in brain tissue of rats with cerebral ischemia-reperfusion injury, and to explore its ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2020, 20(1):120]

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PGC-1α inhibits polyamine metabolism in Cyclin E1-driven ovarian cancer.

Ting Guo, Bin Li, Chao Gu, Xiuying Chen, Mengxin Han, Xiaocheng Liu, Congjian Xu,

AIM:Cyclin E1-driven ovarian cancer (OvCa) is characterized with metabolic shift. In this study, we aim to pinpoint the metabolic pathway altered and assess its therapeutic potential. METHODS:In silico reproduction of TCGA ovarian cancer dataset and functional annotation using GSEA was performed. Candidate metabolic pathway was validated using in vitro and ... Read more >>

Cancer Med (Cancer medicine)
[2019, 8(18):7754-7761]

Cited: 1 time

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Extracorporeal treatment in children with acute severe poisoning.

Xiaomei Sun, Xiuying Chen, Jing Lu, Yuhong Tao, Lijuan Zhang, Liqun Dong,

Acute poisoning in children is a clinical emergency. Prompt and effective treatment is critical for life-threatening poisoning. Extracorporeal treatment (ECTR) is a practical option for enhancing the elimination of poisons.We conducted a retrospective observational study on 338 children with severe acute poisoning who received ECTR during hospitalization from January 2010 ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(47):e18086]

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Cyclodextrin based unimolecular micelles with targeting and biocleavable abilities as chemotherapeutic carrier to overcome drug resistance.

Wenqiang Li, Chenfang Xu, Shuxian Li, Xiuying Chen, Xiaoshan Fan, Zhiguo Hu, Yun-Long Wu, Zibiao Li,

An amphiphilic star-shaped copolymer β-CD-g-PCL-SS-PEG-FA, consisting of a β-cyclodextrin (β-CD) core as well as grafted with bioreducible disulfide linkage in PCL-SS-PEG multiarms and targeting folic acid (FA) as end moiety, is designed with unimolecular micelles formation ability for targeted transport of chemotherapeutics to drug resistant tumor cells. Firstly, β-CD was ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2019, 105:110047]

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Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate ameliorates pressure overload-induced cardiac hypertrophy and dysfunction through inhibiting autophagy.

Bo Wang, Deliang Shen, Junnan Tang, Jing Li, Yue Xiao, Xiuying Chen, Chang Cao, Dongjian Han, Erhe Gao, Wen Zhao, Jinying Zhang, Junbiao Chang,

Sodium (±)-5-bromo-2-(a-hydroxypentyl) benzoate (generic name: brozopine, BZP) has been reported to protect against stroke-induced brain injury and was approved for Phase II clinical trials for treatment of stroke-related brain damage by the China Food and Drug Administration (CFDA). However, the role of BZP in cardiac diseases, especially in pressure overload-induced ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(9):6048-6059]

Cited: 1 time

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GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer.

Ting Guo, Bin Li, Chao Gu, Xiuying Chen, Mengxin Han, Xiaocheng Liu, Congjian Xu,

AIM:We previously found Cyclin E1-driven high grade serous ovarian cancer (HGSOC) showed metabolic shift. In this study, we aimed to elucidate signaling pathway therein. METHODS:In silico reproduction of TCGA ovarian cancer dataset and pathway analysis were performed. Candidate metabolic pathway was validated using in vitro and in vivo assays. RESULTS:We ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(14):4890-4899]

Cited: 1 time

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Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a.

Qianqian Shi, Xiuying Chen, Guangli Sun, Lili Wang, Longjiang Cui,

AIMS:The therapeutic strategies for diabetic retinopathy (DR) are disappointing. Ginsenoside Rg1 (Rg1) extracted from Panax ginseng can induce glucose uptake and lower oxidative stress. We aimed to explore the effect of Rg1 on DR using human retinal pigment epithelium cells (ARPE-19). MAIN METHODS:ARPE-19 cells were grown in high glucose (HG) ... Read more >>

Life Sci. (Life sciences)
[2019, 221:152-158]

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Effect of Montmorillonite powder on intestinal mucosal barrier in children with abdominal Henoch-Schonlein purpura: A randomized controlled study.

Xiaolin Gao, Ruixue Miao, Yuhong Tao, Xiuying Chen, Chaomin Wan, Ruizhen Jia,

BACKGROUND:Our previous studies found that intestinal barrier function has been changed in children with abdominal Henoch-Schonlein purpura (HSP). Montmorillonite has been shown to be protective for digestive tract mucosa. OBJECTIVE:The present study aimed to investigate whether Montmorillonite powder could improve the intestinal mucosal barrier function in children with abdominal HSP. ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(39):e12577]

Cited: 1 time

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Design, synthesis, and antitumor evaluation of quinoline-imidazole derivatives.

Zhen Xiao, Fei Lei, Xiuying Chen, Xiaolei Wang, Lujie Cao, Kejun Ye, Wufu Zhu, Shan Xu,

A series of compounds bearing quinoline-imidazole (8a-e, 9a-e, 10a-e, 11a-e, and 12a-e) not reported previously were designed and synthesized. The target compounds were evaluated for antitumor activity against A549, PC-3, HepG2, and MCF-7 cells by the MTT method, with NVP-BEZ235 being the positive control. Most compounds showed moderate activity and ... Read more >>

Arch. Pharm. (Weinheim) (Archiv der Pharmazie)
[2018, 351(6):e1700407]

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18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.

Li Su, Zeng Wang, Fei Huang, Ruilong Lan, Xiuying Chen, Deping Han, Lurong Zhang, Weijian Zhang, Jinsheng Hong,

Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18β-GA treatment decreased the production of IL-1β, IL-6, PGE2 and ... Read more >>

Environ. Toxicol. Pharmacol. (Environmental toxicology and pharmacology)
[2018, 60:82-90]

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Discovery of thinopyrimidine-triazole conjugates as c-Met targeting and apoptosis inducing agents.

Linxiao Wang, Shan Xu, Xiaobo Liu, Xiuying Chen, Hehua Xiong, Shanshan Hou, Wensheng Zou, Qidong Tang, Pengwu Zheng, Wufu Zhu,

Five series of N-methylpicolinamide moiety and thienopyrimidine moiety bearing triazole (21-26, 27-34, 35-41, 42-47 and 48-54) were designed and synthesized. And all the target compounds were evaluated for the IC50 values against three cancer cell lines (A549, HepG2 and MCF-7) and some selected compounds (43, 49 and 52) were further ... Read more >>

Bioorg. Chem. (Bioorganic chemistry)
[2018, 77:370-380]

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An adenosine A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation.

Wen Huang, Shunjie Bai, Xuzheng Zuo, Weiju Tang, Pengfei Chen, Xiuying Chen, Gong Wang, Haoxiang Wang, Peng Xie,

Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the activation of microglia, however, the underlying mechanisms remain elusive. Thus, the present study used a microglia/oligodendrocyte co‑culture model exposed to ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2018, 41(6):3559-3569]

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Synthesis and bioevaluation study of novel N-methylpicolinamide and thienopyrimidine derivatives as selectivity c-Met kinase inhibitors.

Linxiao Wang, Shan Xu, Xiuying Chen, Xiaobo Liu, Yongli Duan, Dejia Kong, Dandan Zhao, Pengwu Zheng, Qidong Tang, Wufu Zhu,

Four series of N-methylpicolinamide moiety and thienopyrimidine moiety bearing pyridazinone were designed and synthesized and evaluated for the IC50 values against three cancer cell lines (A549, HepG2 and MCF-7) and some selected compounds were further evaluated for the activity against c-Met, Flt-3, VEGFR-2, c-Kit and EGFR kinases. Three compounds (35, ... Read more >>

Bioorg. Med. Chem. (Bioorganic & medicinal chemistry)
[2018, 26(1):245-256]

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Facile synthesis of fluorescence carbon dots from sweet potato for Fe3+ sensing and cell imaging.

Jie Shen, Shaoming Shang, Xiuying Chen, Dan Wang, Yan Cai,

In this study, a facile synthesis of fluorescence carbon dots (CDs) from sweet potato was performed through hydrothermal treatment. The obtained CDs with quantum yield of 8.64% have good dispersibility due to the soluble functional groups on their surfaces. The characterization of CDs was carried out and their possible formation ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2017, 76:856-864]

Cited: 10 times

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Determination of 16 mycotoxins in vegetable oils using a QuEChERS method combined with high-performance liquid chromatography-tandem mass spectrometry.

Hongxia Zhao, Xiuying Chen, Chen Shen, Baocheng Qu,

A simple and efficient method for determining multiple mycotoxins was developed using a QuEChERS (quick, easy, cheap, effective, rugged and safe)-based extraction procedure in vegetable oils. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used for the quantification and confirmation of 16 chemically diversified mycotoxins. Different extraction procedures were studied and ... Read more >>

Food Addit Contam Part A Chem Anal Control Expo Risk Assess (Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment)
[2017, 34(2):255-264]

Cited: 2 times

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Epidemiological characteristics of seven respiratory viruses among pediatric patients with acute respiratory tract infections from 2011 to 2015 in Dongguan, Southern China.

Mingyu Xie, Qiang Ma, Xiuying Chen, Xiaomei Lu, Baimao Zhong,

Braz J Infect Dis (The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases)
[2017, 21(4):486-488]

Cited: 0 times

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Adenosine A1-Receptors Modulate mTOR Signaling to Regulate White Matter Inflammatory Lesions Induced by Chronic Cerebral Hypoperfusion.

Pengfei Cheng, Xuzheng Zuo, Yifei Ren, Shunjie Bai, Weiju Tang, Xiuying Chen, Gong Wang, Haoxiang Wang, Wen Huang, Peng Xie,

We sought to investigate the role of the adenosine A1 receptors (A1ARs) in white matter lesions under chronic cerebral hypoperfusion (CCH) and explore the potential repair mechanisms by activation of the receptors. A right unilateral common carotid artery occlusion (rUCCAO) method was used to construct a CCH model. 2-chloro-N6-cyclopentyladenosine (CCPA), ... Read more >>

Neurochem. Res. (Neurochemical research)
[2016, 41(12):3272-3277]

Cited: 4 times

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IFN-τ Plays an Anti-Inflammatory Role in Staphylococcus aureus-Induced Endometritis in Mice Through the Suppression of NF-κB Pathway and MMP9 Expression.

Kangfeng Jiang, Xiuying Chen, Gan Zhao, Haichong Wu, Junxian Mi, Changwei Qiu, Xiuli Peng, Ganzhen Deng,

Interferon-tau (IFN-τ) is a type I interferon and considered as a pregnancy recognition signal in ruminants. Our previous reports have confirmed that IFN-τ has a potential anti-inflammatory effect in macrophage. However, the anti-inflammatory effect of IFN-τ on endometritis has never been reported. Thus, the aim of this study was to ... Read more >>

J. Interferon Cytokine Res. (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2017, 37(2):81-89]

Cited: 10 times

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IFN-τ Alleviates Lipopolysaccharide-Induced Inflammation by Suppressing NF-κB and MAPKs Pathway Activation in Mice.

Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Guangze Rui, Changwei Qiu, Mengyao Guo, Ganzhen Deng,

IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a lipopolysaccharide-stimulated ... Read more >>

Inflammation (Inflammation)
[2016, 39(3):1141-1150]

Cited: 12 times

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Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis.

Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Zhe Zhu, Changwei Qiu, Ganzhen Deng,

Mastitis is defined as the inflammation of the mammary gland. There is generally no effective treatment for mastitis in animals. Puerarin, extracted from Radix puerariae, has been proven to possess many biological activities. The present study aims to reveal the potential mechanism that is responsible for the antiinflammatory action of ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2016, 30(10):1658-1664]

Cited: 7 times

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Inhibition of succinate dehydrogenase sensitizes cyclin E-driven ovarian cancer to CDK inhibition.

Ting Guo, Chao Gu, Xiuying Chen, Yu Kang, Bin Li, Congjian Xu,

High-grade serous ovarian cancer (HGS-OvCa) is characterized by widespread CCNE1 amplification. Current treatments lack specificity to target Cyclin E-driven OvCa.By in silico analysis of the TCGA OvCa dataset we searched association between genes involved in glucose metabolism and cell cycle control. Metabolic shift was studied in Cyclin E-driven OvCa cells ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2016, 42(2):171-178]

Cited: 1 time

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Measurement of Temperature Dependence for Vapor Pressures of Seventeen OH-PBDEs and Eleven MeO-PBDEs by Gas Chromatographic Method.

Hongxia Zhao, Qing Xie, Xiuying Chen, Baocheng Qu, Jingqiu Jiang,

Hydroxylated polybromodiphenyl ethers (OH-PBDEs) and methoxylated polybrominated diphenyl ethers (MeO-PBDEs) are emerging organic pollutants. Supercooled liquid vapor pressures (p L) and enthalpies of vaporization (∆vap H) for seventeen OH-PBDEs and eleven MeO-PBDEs were determined by a gas chromatographic technique. p L at 298 K ranged from 0.0173 Pa for 2'-OH-BDE3 ... Read more >>

Bull Environ Contam Toxicol (Bulletin of environmental contamination and toxicology)
[2016, 96(5):657-663]

Cited: 0 times

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The Anti-Inflammatory Effects of Interferon Tau by Suppressing NF-κB/MMP9 in Macrophages Stimulated with Staphylococcus aureus.

Gan Zhao, Haichong Wu, Kangfeng Jiang, Xiuying Chen, Xiaoyan Wang, Changwei Qiu, Mengyao Guo, Ganzhen Deng,

Previous studies have reported that interferon tau (IFNT) significantly mitigates tissue inflammation. However, this effect and its regulating pathways have not been reported for Staphylococcus aureus-induced inflammation. In this study, RAW 264.7 cells stimulated with S. aureus were used to identify the anti-inflammatory effects and mechanism of IFNT. First, IFNT ... Read more >>

J. Interferon Cytokine Res. (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2016, 36(8):516-524]

Cited: 6 times

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Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation.

Haichong Wu, Gan Zhao, Kangfeng Jiang, Xiuying Chen, Zhe Zhu, Changwei Qiu, Chengye Li, Ganzhen Deng,

Despite developments in the knowledge and therapy of acute lung injury in recent decades, mortality remains high, and there is usually a lack of effective therapy. Plantamajoside, a major ingredient isolated from Plantago asiatica L. (Plantaginaceae), has been reported to have potent anti-inflammatory properties. However, the effect of plantamajoside on ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2016, 35:315-322]

Cited: 24 times

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