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Integrative analyses identify potential key genes and pathways in Keshan disease using whole-exome sequencing

Jichang Huang, Chenqing Zheng, Rong Luo, Mingjiang Liu, Qingquan Gu, Jinshu Li, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

Keshan disease (KD), an endemic heart disease with multifocal necrosis and replacement fibrosis of the myocardium,is still a nightmare situation for human health. However, molecular mechanism in the pathogenesis of KD remains unclear. Herein, blood samples were collected from 68 KD patients and 100 controls, and we systematically analyzed mutation ... Read more >>

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Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.

Li Lin, Wei Xu, Yongqing Li, Ping Zhu, Wuzhou Yuan, Ming Liu, Yan Shi, Yu Chen, Jifeng Liang, Jimei Chen, Boyu Yang, Wanwan Cai, Yao Wen, Xiaolan Zhu, Xiyang Peng, Zuoqiong Zhou, Xiaoyang Mo, Yongqi Wan, Haiyun Yuan, Fang Li, Xiangli Ye, Zhigang Jiang, Yuequn Wang, Jian Zhuang, Xiongwei Fan, Xiushan Wu,

Wnt/β-catenin signaling plays a key role in pathological cardiac remodeling in adults. The identification of a tissue-specific Wnt/β-catenin interaction factor may provide a tissue-specific clinical targeting strategy. <i>Drosophila Pygo</i> encodes the core interaction factor of Wnt/β-catenin. Two <i>Pygo</i> homologs (<i><i><i>Pygo1</i></i></i> and <i>Pygo2</i>) have been identified in mammals. Different from the ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2021, 320(4):H1634-H1645]

Cited: 1 time

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Master regulator genes and their impact on major diseases.

Wanwan Cai, Wanbang Zhou, Zhe Han, Junrong Lei, Jian Zhuang, Ping Zhu, Xiushan Wu, Wuzhou Yuan,

Master regulator genes (MRGs) have become a hot topic in recent decades. They not only affect the development of tissue and organ systems but also play a role in other signal pathways by regulating additional MRGs. Because a MRG can regulate the concurrent expression of several genes, its mutation often ... Read more >>

PeerJ (PeerJ)
[2020, 8:e9952]

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BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis.

Yan Shi, Yongqing Li, Yuequn Wang, Ping Zhu, Yu Chen, Heng Wang, Shusheng Yue, Xiaohui Xia, Jimei Chen, Zhigang Jiang, Chengbin Zhou, Wanwan Cai, Haiyun Yuan, Yueheng Wu, Yongqi Wan, Xiaohong Li, Xiaolan Zhu, Zuoqiong Zhou, Guo Dai, Fang Li, Xiaoyang Mo, Xiangli Ye, Xiongwei Fan, Jian Zhuang, Xiushan Wu, Wuzhou Yuan,

BVES is a transmembrane protein, our previous work demonstrated that single nucleotide mutations of BVES in tetralogy of fallot (TOF) patients cause a downregulation of BVES transcription. However, the relationship between BVES and the pathogenesis of TOF has not been determined. Here we reported our research results about the relationship between ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14167]

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Structure and function of Pygo in organ development dependent and independent Wnt signalling.

Yan Shi, Xiushan Wu, Shuoji Zhu, Huanlei Huang, Jian Zhuang, Haiyun Yuan, Wuzhou Yuan, Ping Zhu,

Pygo is a nuclear protein containing two conserved domains, NHD and PHD, which play important roles in embryonic development and carcinogenesis. Pygo was first identified as a core component of the Wnt/β-catenin signalling pathway. However, it has also been reported that the function of Pygo is not always Wnt/β-catenin signalling ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2020, 48(4):1781-1794]

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Solid phase drug-drug pharmaceutical co-crystal formed between pyrazinamide and diflunisal: Structural characterization based on terahertz/Raman spectroscopy combining with DFT calculation.

Xiushan Wu, Yaguo Wang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du,

Both pretty low solubility and high membrane permeability of diflunisal (DIF) would affect significantly its oral bioavailability as a typical non-steroidal anti-inflammatory substance. Meanwhile, pyrazinamide (PZA), known as one kind of important anti-tuberculosis drugs, has also several certain side effects. These deficiencies affect the large-scale clinical use of such drugs. ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2020, 234:118265]

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TRIM45 Suppresses the Development of Non-small Cell Lung Cancer.

Xiyang Peng, Yao Wen, Lagabaiyila Zha, Jian Zhuang, Li Lin, Xu Li, Yu Chen, Zhiqiang Liu, Shuangli Zhu, Jifeng Liang, Zuoqiong Zhou, Wuzhou Yuan, Yongqing Li, Yuequn Wang, Zhigang Jiang, Xiaoyang Mo, Yongqi Wan, Yan Shi, Ping Zhu, Lan Zheng, Changfa Tang, Xiushan Wu, Xiongwei Fan,

<h4>Background</h4>Previously, we first identified the human tripartite motifcontaining protein 45 (TRIM45) acts as a novel transcriptional repressor in mitogenactivated protein kinase (MAPK) signaling pathway. After that, the inhibitory role of TRIM45 in the development of tumor was gradually unveiled. However, the function of TRIM45 in the tumorigenesis of lung cancer ... Read more >>

Curr Mol Med (Current molecular medicine)
[2020, 20(4):299-306]

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Identification of potential candidate genes and pathways in atrioventricular nodal reentry tachycardia by whole-exome sequencing.

Rong Luo, Chenqing Zheng, Hao Yang, Xuepin Chen, Panpan Jiang, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

<h4>Background</h4>Atrioventricular nodal reentry tachycardia (AVNRT) is the most common manifestation of paroxysmal supraventricular tachycardia (PSVT). Increasing data have indicated familial clustering and participation of genetic factors in AVNRT, and no pathogenic genes related to AVNRT have been reported.<h4>Methods</h4>Whole-exome sequencing (WES) was performed in 82 patients with AVNRT and 100 controls. ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2020, 10(1):238-257]

Cited: 1 time

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FKBP51 induces p53-dependent apoptosis and enhances drug sensitivity of human non-small-cell lung cancer cells.

Yu Chen, Zhiqiang Liu, Yuequn Wang, Jian Zhuang, Yun Peng, Xiaoyang Mo, Jimei Chen, Yan Shi, Mengxiong Yu, Wanwan Cai, Yahuan Li, Xiaolan Zhu, Wuzhou Yuan, Yongqing Li, Fang Li, Zuoqiong Zhou, Guo Dai, Xiangli Ye, Yongqi Wan, Zhigang Jiang, Ping Zhu, Xiongwei Fan, Xiushan Wu,

Lung cancer is one of the most prevalent cancer types worldwide, and non-small-cell lung cancer (NSCLC) accounts for ~85% of all lung cancer cases. Despite the notable prevalence of NSCLC, the mechanisms underlying its progression remain unclear. The present study investigated the involvement of FK506-binding protein 51 (FKBP51) in NSCLC ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 19(3):2236-2242]

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Overexpression of Pygo2 Increases Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Cardiomyocyte-like Cells.

Lei Yang, Shuoji Zhu, Yongqing Li, Jian Zhuang, Jimei Chen, Huanlei Huang, Yu Chen, Yulin Wen, Yao Wen, Huiming Guo, Xiongwei Fan, Wuzhou Yuan, Zhigang Jiang, Yuequn Wang, Xiushan Wu, Ping Zhu,

<h4>Background</h4>Our previous studies have shown that Pygo (Pygopus) in Drosophila plays a critical role in adult heart function that is likely conserved in mammals. However, its role in the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into cardiomyocytes remains unknown.<h4>Objective</h4>To investigate the role of pygo2 in the differentiation ... Read more >>

Curr Mol Med (Current molecular medicine)
[2020, 20(4):318-324]

Cited: 1 time

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The Functional Polymorphism R129W in the BVES Gene Is Associated with Sporadic Tetralogy of Fallot in the Han Chinese Population.

Yan Shi, Yongqing Li, Yuequn Wang, Jian Zhuang, Heng Wang, Min Hu, Xiaoyang Mo, Shusheng Yue, Yu Chen, Xiongwei Fan, Jimei Chen, Wanwan Cai, Xiaolan Zhu, Yongqi Wan, Ying Zhong, Xiangli Ye, Fang Li, Zuoqiong Zhou, Guo Dai, Rong Luo, Karen Ocorr, Zhigang Jiang, Xiaoping Li, Ping Zhu, Xiushan Wu, Wuzhou Yuan,

<b><i>Background:</i></b> Tetralogy of Fallot (TOF) accounts for ∼10% of congenital heart disease cases. The blood vessel epicardial substance (<i>BVES</i>) gene has been reported to play a role in the function of adult hearts. However, whether allelic variants in <i>BVES</i> contribute to the risk of TOF and its possible mechanism remains ... Read more >>

Genet Test Mol Biomarkers (Genetic testing and molecular biomarkers)
[2019, 23(9):601-609]

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Using a Parallel Helical Sensing Cable for the Distributed Measurement of Ground Deformation.

Xiushan Wu, Renyuan Tong, Yanjie Wang, Congli Mei, Qing Li,

Surface and underground stretched deformation is one of the most important physical measurement quantities for geological-disaster monitoring. In this study, a parallel helical sensing cable (PHSC) based on the time⁻domain reflectometry (TDR) technique is proposed and used to monitor large ground stretched deformation. First, the PHSC structure and manufacturing process ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(6):]

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Study on an Online Detection Method for Ground Water Quality and Instrument Design.

Xiushan Wu, Renyuan Tong, Yanjie Wang, Congli Mei, Qing Li,

The online measurement of ground water quality, as one important area of water resource protection, can provide real-time measured water quality parameters and send out warning information in a timely manner when the water resource is polluted. Based on ultraviolet (UV) spectrophotometry, a remote online measurement method is proposed and ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(9):]

Cited: 1 time

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Association of CTLA-4 polymorphisms with increased risks of myasthenia gravis.

Fang Li, Wuzhou Yuan, Xiushan Wu,

Myasthenia gravis (MG) is considered to be a kind of autoimmune disorder resulting from dysfunction of neuromuscular transmission caused by autoantibodies against the nicotinic acetylcholine receptors. A number of studies have identified Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) as a candidate gene for MG. Several recent reports have indicated that single nucleotide ... Read more >>

Ann Hum Genet (Annals of human genetics)
[2018, 82(6):358-369]

Cited: 4 times

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Loss of the Nodal modulator Nomo results in chondrodysplasia in zebrafish.

Linghui Cao, Lingyu Li, Yongqing Li, Jian Zhuang, Yu Chen, Yuequn Wang, Yan Shi, Jimei Chen, Xiaolan Zhu, Yongqi Wan, Fang Li, Wuzhou Yuan, Xiaoyang Mo, Xiangli Ye, Zuoqiong Zhou, Guo Dai, Zhigang Jiang, Ping Zhu, Xiushan Wu, Xiongwei Fan,

<h4>Background</h4>Transforming growth factor-β (TGF-β)/nodal signaling is involved in early embryonic patterning in vertebrates. Nodal modulator (Nomo, also called pM5) is a negative regulator of nodal signaling. Currently, the role of nomo gene in cartilage development in vertebrates remains unknown.<h4>Methods</h4>Nomo mutants were generated in a knockout model of zebrafish by clustered ... Read more >>

Curr Mol Med (Current molecular medicine)
[2018, 18(7):448-458]

Cited: 2 times

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Prenatal diagnosis of monosomy 18p associated with holoprosencephaly: case report.

Zhaochu Yin, Kai Zhang, Bin Ni, Xiongwei Fan, Xiushan Wu,

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2017, 37(6):804-806]

Cited: 3 times

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Molecular mechanisms of heart failure: insights from Drosophila.

Shasha Zhu, Zhe Han, Yan Luo, Yulin Chen, Qun Zeng, Xiushan Wu, Wuzhou Yuan,

Heart failure places an enormous burden on health and economic systems worldwide. It is a complex disease that is profoundly influenced by both genetic and environmental factors. Neither the molecular mechanisms underlying heart failure nor effective prevention strategies are fully understood. Fortunately, relevant aspects of human heart failure can be ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2017, 22(1):91-98]

Cited: 8 times

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Identification of zebrafish magnetoreceptor and cryptochrome homologs.

Zuoqiong Zhou, Xiyang Peng, Jianbin Chen, Xiushan Wu, Yuequn Wang, Yunhan Hong,

Magnetoreception is essential for magnetic orientation in animal migration. The molecular basis for magnetoreception has recently been elucidated in fruitfly as complexes between the magnetic receptor magnetoreceptor (MagR) and its ligand cryptochrome (Cry). MagR and Cry are present in the animal kingdom. However, it is unknown whether they perform a ... Read more >>

Sci China Life Sci (Science China. Life sciences)
[2016, 59(12):1324-1331]

Cited: 4 times

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Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a single-center cohort study.

Xiaoping Li, Rong Luo, Wei Fang, Xiaolei Xu, Guodong Niu, Yixian Xu, Michael Fu, Wei Hua, Xiushan Wu,

<h4>Background</h4>Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. However, the prognostic implications of VCB patterns in dilated cardiomyopathy (DCM) patients need to be evaluated. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB.<h4>Methods</h4>This cohort study included ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2016, 16:136]

Cited: 3 times

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CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish.

Xiyang Peng, Guanming Li, Yuequn Wang, Jian Zhuang, Rong Luo, Jimei Chen, Fa Chen, Yan Shi, Jiani Li, Zuoqiong Zhou, Xiaoyang Mo, Xianchu Liu, Wuzhou Yuan, Qun Zeng, Yongqing Li, Zhigang Jiang, Yongqi Wan, Xiangli Ye, Wei Xu, Xijun Wang, Xiongwei Fan, Ping Zhu, Xiushan Wu, Yun Deng,

<h4>Background</h4>CXXC-type zinc-finger protein CXXC5 has been reported to be associated with the development of cardiovascular disease. Recently, through signaling pathway screening we found that CXXC5 activated Tgfβ and myocardial differentiation signaling pathways simultaneously. Although the physiological and pathological function of CXXC5 in many organs has been well elucidated, its function ... Read more >>

Int J Cardiol (International journal of cardiology)
[2016, 214:246-253]

Cited: 8 times

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SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis.

Xiangli Ye, Yu Qian, Qian Wang, Wuzhou Yuan, Xiaoyang Mo, Yongqing Li, Zhigang Jiang, Wei Xu, Yun Deng, Yongqi Wan, Xiongwei Fan, Xiushan Wu, Yuequn Wang,

Previous studies have demonstrated that Smyd1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization. In this study, we uncovered a novel function of Smyd1 in the regulation of endothelial cells (ECs). Our data showed that Smyd1 is expressed in vascular endothelial cells, and knockdown of SMYD1 ... Read more >>

PLoS One (PloS one)
[2016, 11(1):e0146468]

Cited: 5 times

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Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.

Jing Li, Li Zeng, Juan Xie, Zhiying Yue, Huayun Deng, Xueyun Ma, Chunbing Zheng, Xiushan Wu, Jian Luo, Mingyao Liu,

Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone loss and destruction. Therefore, targeting RANKL or its signaling pathway has been a promising and successful strategy for this osteoclast-related diseases. In this study, we examined the effects of xanthohumol (XN), an abundant ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:17605]

Cited: 17 times

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Atorvastatin treatment improves effects of implanted mesenchymal stem cells: meta-analysis of animal models with acute myocardial infarction.

Guo Dai, Qing Xu, Rong Luo, Jianfang Gao, Hui Chen, Yun Deng, Yongqing Li, Yuequn Wang, Wuzhou Yuan, Xiushan Wu,

<h4>Background</h4>Previous studies reported that Atorvastatin (ATOR) can improve the efficacy of Mesenchymal stem cells (MSCs) transplantation after acute myocardial infarction (AMI). However, the results of those studies were inconsistent. To clarify the beneficial effects of atorvastatin added to the cell therapy with MSCs in animal model of acute myocardial infarction ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2015, 15:170]

Cited: 4 times

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CXXC5 regulates differentiation of C2C12 myoblasts into myocytes.

Guangming Li, Xiangli Ye, Xiyang Peng, Yun Deng, Wuzhou Yuan, Yongqing Li, Xiaoyang Mo, Xijun Wang, Yongqi Wan, Xianchu Liu, Tingfang Chen, Zhigang Jiang, Xiongwei Fan, Xiushan Wu, Yuequn Wang,

CXXC5 is a member of the CXXC-type zinc-finger domain containing protein family, which is suggested to function in gene transcription, cell adhesion and cytoskeleton organization. Previous studies have revealed that CXXC5 is expressed in skeletal muscle, but whether it regulates skeletal myogenesis is yet unknown. Here, we screened for the ... Read more >>

J Muscle Res Cell Motil (Journal of muscle research and cell motility)
[2014, 35(5-6):259-265]

Cited: 8 times

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Expression and identification of a novel gene Spata34 in mouse spermatogenic cells.

Tingfang Chen, Zhigang Jiang, Wei Xu, Yuequn Wang, Yongqing Li, Yongqi Wan, Wuzhou Yuan, Xiaoyang Mo, Xiushan Wu, Yun Deng, Xiongwei Fan, Dongsong Nie,

Leucine-rich repeat (LRR) containing proteins play an essential role in signal transduction, cell adhesion, cell development, DNA repair and RNA processing. Here we cloned a novel gene, Spata34, encoding a LRR containing protein of 415 aa. Spata34 gene consisted of 9 exons and 8 introns and mapped to chromosome 3qA3. ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2014, 41(3):1683-1691]

Cited: 4 times

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