Full Text Journal Articles by
Author Xisheng Fang

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Neuron Specific Enolase Promotes Metastasis by Activating the Wnt/β-catenin Pathway in Small Cell Lung Cancer

Zhiqiang Zha, Dailing Li, Peiling Zhang, Peipei Wang, Xisheng Fang, Xia Liu, Chengyin Weng, Baoxiu Li, Yong Wu, Haibo Mao, Lina Wang, Lin Xu, Jiaming Dong, Mingmei Guan, Lin Lu, Guolong Liu,

<h4>Background: </h4> Neuron-specific enolase (NSE) has been used as a specific biomarker for small cell lung cancer (SCLC) patients. Nevertheless, the biological function and mechanism of NSE in SCLC are still unclear. <h4>Methods: </h4> We conducted an investigation in SCLC patients and then analyzed the association between NSE concentration and ... Read more >>

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Construction and Validation of a Protein Prognostic Model for Lung Squamous Cell Carcinoma.

Xisheng Fang, Xia Liu, Chengyin Weng, Yong Wu, Baoxiu Li, Haibo Mao, Mingmei Guan, Lin Lu, Guolong Liu,

Lung squamous cell carcinoma (LUSCC), as the major type of lung cancer, has high morbidity and mortality rates. The prognostic markers for LUSCC are much fewer than lung adenocarcinoma. Besides, protein biomarkers have advantages of economy, accuracy and stability. The aim of this study was to construct a protein prognostic ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(17):2718-2727]

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Using Artificial Intelligence to Detect COVID-19 and Community-acquired Pneumonia Based on Pulmonary CT: Evaluation of the Diagnostic Accuracy.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease 2019 (COVID-19) has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performance. Materials and ... Read more >>

Radiology (Radiology)
[2020, 296(2):E65-E71]

Cited: 57 times

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CCR9 Promotes Migration and Invasion of Lung Adenocarcinoma Cancer Stem Cells.

Lin Lu, Huan Du, Haowei Huang, Chenxi Wang, Peipei Wang, Zhiqiang Zha, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Haibo Mao, Lina Wang, Mingmei Guan, Guolong Liu,

Aim: CC chemokine receptor 9 (CCR9) interacts with its exclusive ligand CCL25, resulting in promoting tumor progression and metastasis. However, the effect and mechanisms of CCR9 on lung adenocarcinoma distant metastasis remain largely unknown. To preliminary clarify the underlying mechanisms, we investigate the correlation between CCR9 and ALDH1A1+cancer stem cells ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(7):912-920]

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Knockdown of neuron-specific enolase suppresses the proliferation and migration of NCI-H209 cells.

Xia Liu, Shousheng Liu, Juan Fu, Jinsheng Huang, Chengyin Weng, Xisheng Fang, Mingmei Guan, Yong Wu, Lin Yang, Guolong Liu,

Neuron-specific enolase (NSE) is generally considered as a marker for diagnosis and evaluation of the response to therapy in small cell lung cancer (SCLC). However, the role of NSE in the progression of SCLC remains to be elucidated. In the present study, the functions of NSE in SCLC, in addition ... Read more >>

Oncol Lett (Oncology letters)
[2019, 18(5):4809-4815]

Cited: 2 times

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Regulation of BTG3 by microRNA-20b-5p in non-small cell lung cancer.

Lijun Peng, Shaobin Li, Yuchan Li, Minghui Wan, Xisheng Fang, Yongxin Zhao, Wei Zuo, De Long, Yiwen Xuan,

The present study aimed to evaluate microRNA- 20b-5p (miR-20b-5p) expression in non-small cell lung cancer (NSCLC), and investigate the effects of miR-20b-5p expression on NSCLC cell proliferation and migration. Reverse transcription-quantitative polymerase chain reaction was performed to measure the expression level of miR-20b-5p in NSCLC tissues and cell lines. Cell ... Read more >>

Oncol Lett (Oncology letters)
[2019, 18(1):137-144]

Cited: 3 times

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Silencing UBE4B induces nasopharyngeal carcinoma apoptosis through the activation of caspase3 and p53.

Chengyin Weng, Yong Chen, Yong Wu, Xia Liu, Haibo Mao, Xisheng Fang, Baoxiu Li, Lina Wang, Mingmei Guan, Guolong Liu, Lin Lu, Yawei Yuan,

<h4>Aim</h4>The human ubiquitination factor E4B (UBE4B) gene is frequently amplified in some solid cancers. However, the role of UBE4B in nasopharyngeal carcinoma (NPC) has not yet been investigated.<h4>Methods</h4>Firstly, we analyzed the expression of UBE4B in NPC samples using real-time quantitative PCR and Western blot analysis. After knocking down UBE4B using ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:2553-2561]

Cited: 1 time

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MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway.

Lin Lu, Qiyao Liu, Peipei Wang, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Xiaofei Cao, Haibo Mao, Lina Wang, Mingmei Guan, Wei Wang, Guolong Liu,

<h4>Background</h4>MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulating tumor progression remain ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):209]

Cited: 4 times

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Clinical significance of aberrant mammalian target of rapamycin expression in stage IIIB colon cancer.

Meiling Wen, Baoxiu Li, Xiaofei Cao, Chengyin Weng, Yong Wu, Xisheng Fang, Xiaoshi Zhang, Guolong Liu,

The aim of the present study was to investigate the significance of aberrant expression of mammalian target of rapamycin (mTOR) and the activated form of mTOR kinase, phosphorylated mTOR (pmTOR), in human stage IIIB colon cancer. The expression of mTOR and pmTOR was detected by immunohistochemistry in the tumor tissue ... Read more >>

Oncol Lett (Oncology letters)
[2014, 8(3):1080-1086]

Cited: 3 times

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Diversity and distribution of catechol 2, 3-dioxygenase genes in surface sediments of the Bohai Sea.

Peiqing He, Li Li, Jihua Liu, Yazhi Bai, Xisheng Fang,

Catechol 2, 3-dioxygenase (C23O) is the key enzyme for aerobic aromatic degradation. Based on clone libraries and quantitative real-time polymerase chain reaction, we characterized diversity and distribution patterns of C23O genes in surface sediments of the Bohai Sea. The results showed that sediments of the Bohai Sea were dominated by ... Read more >>

FEMS Microbiol Lett (FEMS microbiology letters)
[2016, 363(10):]

Cited: 3 times

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IL-17A promotes migration and tumor killing capability of B cells in esophageal squamous cell carcinoma.

Lin Lu, Chengyin Weng, Haibo Mao, Xisheng Fang, Xia Liu, Yong Wu, Xiaofei Cao, Baoxiu Li, Xiaojun Chen, Qinquan Gan, Jianchuan Xia, Guolong Liu,

We have previously reported that the accumulation of IL-17-producing cells could mediate tumor protective immunity by promoting the migration of NK cells, T cells and dendritic cells in esophageal squamous cell carcinoma (ESCC) patients. However, there were no reports concerning the effect of IL-17A on tumor infiltrating B cells. In ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(16):21853-21864]

Cited: 9 times

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HoxA10 induces proliferation in human prostate carcinoma PC-3 cell line.

Baoxiu Li, Xiaofei Cao, Chengyin Weng, Yong Wu, Xisheng Fang, Xiaoshi Zhang, Guolong Liu,

The objectives of this study were to examine the expression levels of Homeobox A10 (HoxA10) in prostate cancer cells and to study the molecular mechanism of HoxA10-mediated regulation of prostate cancer cell growth and development. We investigated the effect of HoxA10 on cell proliferation by stably overexpressing or silencing HoxA10 ... Read more >>

Cell Biochem Biophys (Cell biochemistry and biophysics)
[2014, 70(2):1363-1368]

Cited: 8 times

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