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Author Xinxing Liao

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Boosting two-photon photodynamic therapy with mitochondria-targeting ruthenium-glucose conjugates.

Jiangping Liu, Xinxing Liao, Kai Xiong, Shi Kuang, Chengzhi Jin, Liangnian Ji, Hui Chao,

Herein, we present a series of dual-targeted ruthenium-glucose conjugates that can function as two-photon absorption (TPA) PDT agents to effectively destroy tumors by preferentially targeting both tumor cells and mitochondria. The in vivo experiments revealed an excellent tumor inhibitory efficiency of the dual-targeted TPA PSs. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(43):5839-5842]

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The stepwise photodamage of organelles by two-photon luminescent ruthenium(ii) photosensitizers.

Kangqiang Qiu, Ya Wen, Cheng Ouyang, Xinxing Liao, Chaofeng Liu, Thomas W Rees, Qianling Zhang, Liangnian Ji, Hui Chao,

Ru(ii) polypyridyl complexes, containing a morpholine moiety, and possessing two-photon absorption properties and pH dependent singlet oxygen production were used for stepwise lysosomes-to-mitochondria photodamage of cancer cells. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(75):11235-11238]

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Mitochondria-targeted [email protected] as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy.

Libing Ke, Cheng Zhang, Xinxing Liao, Kangqiang Qiu, Thomas W Rees, Yu Chen, Zizhuo Zhao, Liangnian Ji, Hui Chao,

Ir(iii) complex modified gold nanorods, [email protected], were developed as mitochondria-targeted theranostic nanoagents. Their hypoxia imaging and photothermal therapeutic properties were demonstrated in vitro and in vivo. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(69):10273-10276]

Cited: 1 time

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An Ultrasmall RuO2 Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury.

Zhou Liu, Lina Xie, Kangqiang Qiu, Xinxing Liao, Thomas W Rees, Zizhuo Zhao, Liangnian Ji, Hui Chao,

Oxidative stress induced by reactive oxygen species (ROS) is one of the major pathological mechanisms of acute kidney injury (AKI). Inorganic nanomaterial-mediated antioxidant therapy is considered a promising method for the prevention of AKI; however, currently available antioxidants for AKI exhibit limited clinical efficacy due to the glomerular filtration threshold ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II.

Hui Chao, Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W Rees, Yu Chen, Jian Wan, Liangnian Ji,

Inducing necroptosis in cancer cells is an effective approach to circumvent drug-resistance. Metal-based triggers have, however, rarely been reported. Ruthenium(II) complexes containing 1,1-(pyrazin-2-yl)pyreno[4,5-e][1,2,4]triazine were developed with a series of different ancillary ligands ( Ru1 - 7 ). The combination of the main ligand with bipyridyl and phenylpyridyl ligands endows Ru7 ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging.

Chengzhi Jin, Fengyin Liang, Jinquan Wang, Lili Wang, Jiangping Liu, Xinxing Liao, Thomas W Rees, Bo Yuan, Hui Wang, Yong Shen, Zhong Pei, Liangnian Ji, Hui Chao,

Compared to 2PE (two-photon excitation) microscopy, 3PE microscopy has superior spatial resolution, deeper tissue penetration, and less defocused interference. The design of suitable agents with a large Stokes shift, good three-photon absorption (3PA), subcellular targeting, and fluorescence lifetime imaging (FLIM) properties, is challenging. Now, two IrIII complexes (3PAIr1 and 3PAIr2) ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Lysosome-Targeting Iridium(III) Probe with Near-Infrared Emission for the Visualization of NO/O2•- Crosstalk via In Vivo Peroxynitrite Imaging.

Weijun Wu, Cheng Zhang, Thomas W Rees, Xinxing Liao, Xu Yan, Yu Chen, Liangnian Ji, Hui Chao,

Nitric oxide (NO) and superoxide anions (O2•-) are two noteworthy reactive species implicated in various physiological and pathological processes, such as ROS-induced lysosomal cell death. The interaction ("crosstalk") between them may form a new mediator peroxynitrite (ONOO-) which has implications for cancer, diabetes, Alzheimer's disease, and liver-damage. It is therefore ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, 92(8):6003-6009]

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Correction: Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for phototherapy in the second near-infrared window.

Zhou Liu, Jinquan Wang, Kangqiang Qiu, Xinxing Liao, Thomas W Rees, Liangnian Ji, Hui Chao,

Correction for 'Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for phototherapy in the second near-infrared window' by Zhou Liu et al., Chem. Commun., 2019, 55, 6523-6526. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(25):3697]

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FerriIridium: A Lysosome-Targeting Iron(III)-Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells.

Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W Rees, Ruilin Guan, Kai Xiong, Yu Chen, Liangnian Ji, Hui Chao,

Reported is the FeIII -activated lysosome-targeting prodrug FerriIridium for gastric cancer theranostics. It contains a meta-imino catechol group that can selectively bond to, and be oxidized by, free FeIII inside the cell. Subsequent oxidative rearrangement releases FeII and hydrolyses the amine bond under acidic conditions, forming an aminobipyridyl Ir complex ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, 59(8):3315-3321]

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Correction: Mitochondria-targeted [email protected] as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy.

Libing Ke, Cheng Zhang, Xinxing Liao, Kangqiang Qiu, Thomas W Rees, Yu Chen, Zizhuo Zhao, Liangnian Ji, Hui Chao,

Correction for 'Mitochondria-targeted [email protected] as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy' by Libing Ke et al., Chem. Commun., 2019, 55, 10273-10276. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(25):3698]

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A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells.

Cheng Zhang, Ruilin Guan, Xinxing Liao, Cheng Ouyang, Thomas W Rees, Jiangping Liu, Yu Chen, Liangnian Ji, Hui Chao,

A mitochondria-targeting hetero-binuclear Ir(iii)-Ru(ii) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(83):12547-12550]

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Bimodal Visualization of Endogenous Nitric Oxide in Lysosomes with a Two-Photon Iridium(III) Phosphorescent Probe.

Weijun Wu, Ruilin Guan, Xinxing Liao, Xu Yan, Thomas W Rees, Liangnian Ji, Hui Chao,

Nitric oxide (NO) is a fundamental signaling molecule that shows complex effects on the catabolic autophagy process, which is closely linked with lysosomal function. In this study, a new lysosome-targeted, pH-independent, and two-photon phosphorescent iridium(III) complex, Ir-BPDA, has been investigated for endogenous NO detection and imaging. The rational design of ... Read more >>

Anal. Chem. (Analytical chemistry)
[2019, 91(15):10266-10272]

Cited: 1 time

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Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for phototherapy in the second near-infrared window.

Zhou Liu, Jinquan Wang, Kangqiang Qiu, Xinxing Liao, Thomas W Rees, Liangnian Ji, Hui Chao,

Cu2-xSe nanoparticles (Cu2-xSeNPs) were camouflaged with a red blood cell membrane (RBC) to create nanoparticles with improved biocompatibility, longer blood retention times, excellent absorption properties, superior photothermal conversion efficiency (67.2%) and singlet oxygen production capabilities for the synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR-II) window. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(46):6523-6526]

Cited: 0 times

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