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Author Xinwei Li

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Qingluoyin granules protect against adjuvant-induced arthritis in rats via downregulating the CXCL12/CXCR4-NF-κB signalling pathway.

Min Si, Zheng Ma, Jie Zhang, Xinwei Li, Rui Li, Chao Wang, Huiyu Jia, Shengyong Luo,

<h4>Context</h4>Qingluoyin (QLY) is a traditional Chinese medicine (TCM) formula which has been used in treating human rheumatoid arthritis (RA) for years in China.<h4>Objective</h4>This study investigates the effect of QLY granules on adjuvant arthritis (AA) and the possible mechanism.<h4>Materials and methods</h4>Sprague-Dawley (SD) rats were injected with Complete Freund's adjuvant (CFA) to ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1441-1451]

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Gene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer.

Yongfei Fan, Zhaojia Gao, Xinwei Li, Shuzhang Wei, Kai Yuan,

The X-ray repair cross-complementing gene (<i>XRCC</i>) family participates in DNA damage repair and its dysregulation is associated with the development and progression of a variety of cancers. However, <i>XRCCs</i> have not been systematically studied in non-small cell lung cancer (NSCLC). Using The Cancer Genome Atlas (TCGA) and Oncomine databases, we ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6210-6228]

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A Center of Mass Estimation and Control Strategy for Body-Weight-Support Treadmill Training.

Xinwei Li, Bingze He, Zhipeng Deng, Yixi Chen, Duojin Wang, Yuanjie Fan, Hao Su, Hongliu Yu,

Walking disorders are common in post-stroke. Body weight support (BWS) systems have been proposed and proven to enhance gait training systems for recovering in individuals with hemiplegia. However, the fixed weight support and walking speed increase the risk of falling and decrease the active participation of the subjects. This paper ... Read more >>

IEEE Trans Neural Syst Rehabil Eng (IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society)
[2021, 29:2388-2398]

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Design and Preliminary Validation of a Lightweight Powered Exoskeleton During Level Walking for Persons With Paraplegia.

Duojin Wang, Bingshan Hu, Wenming Chen, Qingyun Meng, Shiyu Liu, Suowen Ma, Xinwei Li, Hongliu Yu,

Upright-legged locomotion is a desirable ability for people with paraplegia. This paper introduces a newly developed lightweight powered exoskeleton (LIPE) for level walking and posture transfer of people with paraplegia using a user-centered design concept, which integrates the requirements of practical use, mechanical structure, and control system. The LIPE was ... Read more >>

IEEE Trans Neural Syst Rehabil Eng (IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society)
[2021, 29:2112-2123]

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β-Hydroxybutyrate impairs neutrophil migration distance through activation of a protein kinase C and myosin light chain 2 signaling pathway in ketotic cows.

Yuxiang Song, Yuchen Yang, Wen Zeng, Juan J Loor, Qianming Jiang, Zhicheng Peng, Yunfei Li, Shang Jiang, Xiancheng Feng, Xiliang Du, Xinwei Li, Guowen Liu,

Ketosis in dairy cows often occurs in the peripartal period and is accompanied by immune dysfunction. High concentrations of β-hydroxybutyrate (BHB) in peripheral blood during ketosis are closely related to the impairment of polymorphonuclear neutrophil (PMN) chemotaxis and contribute to immune dysfunction. The specific effect of BHB on PMN chemotaxis ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

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Autism spectrum disorder diagnosis using graph attention network based on spatial-constrained sparse functional brain networks.

Chunde Yang, Panyu Wang, Jia Tan, Qingshui Liu, Xinwei Li,

The accurate diagnosis of autism spectrum disorder (ASD), a common mental disease in children, has always been an important task in clinical practice. In recent years, the use of graph neural network (GNN) based on functional brain network (FBN) has shown powerful performance for disease diagnosis. The challenge to construct ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2021, 139:104963]

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Why are Individuals with Alexithymia Symptoms More Likely to Have Mobile Phone Addiction? The Multiple Mediating Roles of Social Interaction Anxiousness and Boredom Proneness.

Weilong Xiao, Hui Zhou, Xinwei Li, Xue Lin,

<h4>Purpose</h4>Previous studies have investigated the relationship between alexithymia and problematic mobile phone use (PMPU). However, yet gaps in identifying the internal mechanisms of this relationship remain. Hence, based on the Interaction of Person-Affect-Cognition-Execution model, the current research examined the mediating roles of college students' social interaction anxiousness (SIA) and boredom ... Read more >>

Psychol Res Behav Manag (Psychology research and behavior management)
[2021, 14:1631-1641]

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Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of αMβ2 Integrin in Dairy Cows With Fatty Liver.

Zhicheng Peng, Chenxu Zhao, Xiliang Du, Yuchen Yang, Yunfei Li, Yuxiang Song, Baochen Fang, Yuming Zhang, Xia Qin, Yuanyuan Zhang, Xiaobing Li, Zhe Wang, Xinwei Li, Guowen Liu,

β2 integrins are critical for neutrophil firm adhesion, trans-endothelial migration, and the recruitment to the inflamed tissue. Autophagy is implicated in cell migration and tumor metastasis through facilitating the turnover of β1 integrins; however, whether autophagy is able to control neutrophil migration by promoting the degradation of β2 integrins is ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:726829]

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Stable isotopes reveal intensive pig husbandry practices in the middle Yellow River region by the Yangshao period (7000-5000 BP).

Quan Zhang, Yanfeng Hou, Xinwei Li, Amy Styring, Julia Lee-Thorp,

It is well-known that pigs (Sus scrofa) were domesticated very early in Neolithic China, but far less is known about the processes by which pig husbandry intensified so that pork became the most important animal protein for humans are less clear. Here, we explore pig feeding practices using the carbon ... Read more >>

PLoS One (PloS one)
[2021, 16(10):e0257524]

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Additively Manufactured Deformation-Recoverable and Broadband Sound-Absorbing Microlattice Inspired by the Concept of Traditional Perforated Panels.

Xinwei Li, Xiang Yu, Wei Zhai,

Noise pollution is a highly detrimental daily health hazard. Sound absorbers, such as the traditionally used perforated panels, find widespread applications. Nonetheless, modern product designs call for material novelties with enhanced performance and multifunctionality. The advent of additive manufacturing has brought about the possibilities of functional materials design to be ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, 33(44):e2104552]

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Physics-Guided and Physics-Explainable Recurrent Neural Network for Time Dynamics in Optical Resonances

Yingheng Tang, Jichao Fan, Xinwei Li, Jianzhu Ma, Minghao Qi, Cunxi Yu, Weilu Gao,

Understanding the time evolution of physical systems is crucial to revealing fundamental characteristics that are hidden in frequency domain. In optical science, high-quality resonance cavities and enhanced interactions with matters are at the heart of modern quantum technologies. However, capturing their time dynamics in real-world scenarios suffers from long data ... Read more >>

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Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of β-hydroxybutyrate in bovine hepatocytes.

Lin Lei, Wenwen Gao, Juan J Loor, Ahmad Aboragah, Zhiyuan Fang, Xiliang Du, Min Zhang, Yuxiang Song, Guowen Liu, Xinwei Li,

Ketotic dairy cows exhibit a state of negative energy balance (NEB) characterized by elevated circulating levels of β-hydroxybutyrate (BHB) and fatty acids. Impaired hepatic insulin signaling in dairy cows occurs frequently during the transition into lactation, but its role on liver function during this period is not well known. In ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(12):12845-12858]

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A Chinese Han pedigree with Huntington disease mimicking spinocerebellar ataxia.

Chengyuan Mao, Yun Su, Huiyun Wang, Liyuan Fan, Huimin Zheng, Tai Wang, Xinwei Li, Shuo Zhang, Zhengwei Hu, Haiyang Luo, Jing Yang, Changhe Shi, Yuming Xu,

J Neurol Sci (Journal of the neurological sciences)
[2021, 430:119985]

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Aridity-driven shift in biodiversity-soil multifunctionality relationships.

Weigang Hu, Jinzhi Ran, Longwei Dong, Qiajun Du, Mingfei Ji, Shuran Yao, Yuan Sun, Chunmei Gong, Qingqing Hou, Haiyang Gong, Renfei Chen, Jingli Lu, Shubin Xie, Zhiqiang Wang, Heng Huang, Xiaowei Li, Junlan Xiong, Rui Xia, Maohong Wei, Dongmin Zhao, Yahui Zhang, Jinhui Li, Huixia Yang, Xiaoting Wang, Yan Deng, Ying Sun, Hailing Li, Liang Zhang, Qipeng Chu, Xinwei Li, Muhammad Aqeel, Abdul Manan, Muhammad Adnan Akram, Xianghan Liu, Rui Li, Fan Li, Chen Hou, Jianquan Liu, Jin-Sheng He, Lizhe An, Richard D Bardgett, Bernhard Schmid, Jianming Deng,

Relationships between biodiversity and multiple ecosystem functions (that is, ecosystem multifunctionality) are context-dependent. Both plant and soil microbial diversity have been reported to regulate ecosystem multifunctionality, but how their relative importance varies along environmental gradients remains poorly understood. Here, we relate plant and microbial diversity to soil multifunctionality across 130 ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5350]

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Sirtuin 3 inhibits nuclear factor-κB signaling activated by a fatty acid challenge in bovine mammary epithelial cells.

Lei Liu, Hong Lu, Juan J Loor, Ahmad Aboragah, Xiliang Du, Jianhua He, Tao Peng, Jianming Su, Zhe Wang, Guowen Liu, Xinwei Li,

Susceptibility to mastitis is highest during the peripartal (transition) period and is often concomitant with other comorbidities such as ketosis. Although infection with pathogenic microorganisms and immune-dysfunction around calving clearly play key roles in mastitis development, other metabolic factors also contribute. Sirtuin 3 (SIRT3), a mitochondrial deacetylase regulating energy and ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(12):12871-12880]

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Decisional Balance of Smoking and Planning to Quit Smoking: A Moderated Mediation Model among Chinese Male Smokers.

Ningmeng Cao, Xinwei Li, Haide Chen, Xinyu Li, Weijian Li,

Decisional balance in quitting smoking involves positive and negative attitudes toward smoking. This study explored the relationship between the decisional balance of smoking and planning to quit smoking, and examined the mediating role of willingness to quit smoking and the moderating role of social support. A questionnaire survey was conducted ... Read more >>

J Psychoactive Drugs (Journal of psychoactive drugs)
[2021, :1-9]

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Free fatty acids impair autophagic activity and activate nuclear factor kappa B signaling and NLR family pyrin domain containing 3 inflammasome in calf hepatocytes.

Taiyu Shen, Xinwei Li, Bo Jin, Juan J Loor, Ahmad Aboragah, Lingxue Ju, Zhiyuan Fang, Hao Yu, Meng Chen, Yiwei Zhu, Hongsheng Ouyang, Yuxiang Song, Zhe Wang, Xiliang Du, Guowen Liu,

Free fatty acids (FFA)-induced hepatic inflammation agravates liver injury and metabolic dysfunction in dairy cows with ketosis or fatty liver. Under stressful conditions, autophagy is generally considered as a cell protection mechanism, but whether the FFA-induced inflammatory and stress effect on hepatocytes involves an autophagy response is not well known. ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(11):11973-11982]

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PLXDC1 May Serve As A Target For Combining Antiangiogenic Therapy and Immunotherapy In Gastric Adenocarcinoma

Xinwei Li, Yonfei Fan, Fang Su, Zishu Wang,

<h4>Introduction: </h4> Based on the immunosuppression of traditional antiangiogenic agents in the treatment of tumors and the newly proposed concept of antiangiogenic therapy combined with immunotherapy, this paper will mainly explore the prospects of PLXDC1 in stomach adenocarcinoma (STAD) regarding antiangiogenic therapy and immunotherapy. <h4>Methods: </h4> First, the transcriptional and ... Read more >>

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Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus.

Lu Peng, Xinwei Li, Yu Li, Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin, Huina Zhang,

<h4>Background</h4>Inflammatory response plays a critical role in the initiation and progression of type 2 diabetes mellitus (T2DM). Myeloperoxidase (MPO), a leukocyte-derived protagonist, exerts its proinflammatory properties in many complications. We explored the associations between serum extracellular vesicle (EV)-derived MPO as well as serum MPO and T2DM.<h4>Methods</h4>We performed a cross-sectional study ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2021, 522:70-76]

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A Retrospective Study of 268 Patients with SARS-CoV-2 Infection to Evaluate the Association Between Blood Glucose and Severity of COVID-19 Pneumonia and Patient Mortality.

Yaoyao Sun, Nan Jiang, Zhijun Li, Xinwei Li, Bo Yang, Daoyuan Si, Piyong Ma, Jinnan Zhang, Ningning Jia, Mengdi Jin, Yang He, Xingyao Cui, Tianji Liu, Qiong Yu,

BACKGROUND Diabetes is one of the most commonly reported comorbidities among patients infected with SARS-CoV-2. This retrospective study of patients with SARS-CoV-2 infection was conducted to evaluate the association between blood glucose levels and the severity of COVID-19 pneumonia and patient mortality. MATERIAL AND METHODS A total of 268 patients ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2021, 27:e932156]

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Alterations in the Expression Levels of miR-9-5p and miR-4467 in Peripheral Blood of Patients with First-Episode Schizophrenia

Mengdi Jin, Xiaojing Zhu, Yaoyao Sun, Zhijun Li, Xinwei Li, Yang He, Yane Liu, Ningning Jia, Guoyan Hu, Xingyao Cui, Qiong Yu,

The diagnosis of schizophrenia (SCZ) patients largely rely on abnormal behavior and mental state examination, which is inevitably subjective and susceptible. Finding more stable and objective biomarkers has always been the vision of scholars. In this study, we aim to validate peripheral blood miRNA as potential biomarkers for patients with ... Read more >>

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Two novel nomograms based on inflammatory cytokines or lymphocyte subsets to differentially diagnose severe or critical and Non-Severe COVID-19.

Zhijun Li, Nan Jiang, Xinwei Li, Bo Yang, Mengdi Jin, Yaoyao Sun, Yang He, Yang Liu, Yueying Wang, Daoyuan Si, Piyong Ma, Jinnan Zhang, Tianji Liu, Qiong Yu,

We intend to evaluate the differences of the clinical characteristics, cytokine profiles and immunological features in patients with different severity of COVID-19, and to develop novel nomograms based on inflammatory cytokines or lymphocyte subsets for the differential diagnostics for severe or critical and non-severe COVID-19 patients. We retrospectively studied 254 ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(14):17961-17977]

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Methicillin-resistant Staphylococcus aureus of the clonal lineage ST5-SCCmecII-t2460 was associated with high mortality in a Wuhan hospital.

Xuehan Li, Jing Zhang, Yifan Zhang, Junying Zhou, Xinwei Li, Ruo Feng, Yirong Li,

Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that can cause serious infectious diseases. An emerging MRSA strain, ST5-SCCmecII spa-type-t2460 (SMRSA), has spread rapidly since its recent emergence in China, but little information is available about this lineage. In this study, 91 MRSA isolates were collected from patients treated ... Read more >>

Braz J Microbiol (Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology])
[2021, 52(4):1929-1936]

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The importance of future urban development in hourly extreme rainfall projections- comparing global warming and urbanization forcing over the Pearl River Delta region

Chenxi Hu, Chi-Yung Tam, Xinwei Li, Kangning Huang, Chao Ren, Kwun Yip Fung, Ziqian Wang,

The impacts of future urban development and global warming forcing on hourly extreme rainfall over the Pearl River Delta (PRD) area have been investigated, by dynamically downscaling General Circulation Model (GCM) outputs using the Weather Research and Forecasting Model (WRF) at convection-permitting resolution, coupled with an Urban Canopy Model (UCM). ... Read more >>

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Analysis of risk factors related to breast cancer metastasis: a retrospective nested case-control study.

Yang Liu, Bin Liu, Yang He, Zhijun Li, Xinwei Li, Duo Wang, Zongqiang Wang, Ying Xu, Qiong Yu,

<h4>Purpose</h4>To explore the laboratory indexes related to breast cancer metastasis, so as to provide scientific basis for the control of breast metastasis.<h4>Methods</h4>A retrospective cohort-based nested case-control study was used to screen 732 breast cancer patients recorded in the First and the Third Hospitals of Jilin University's electronic medical record system ... Read more >>

J BUON (Journal of B.U.ON. : official journal of the Balkan Union of Oncology)
[2021, 26(4):1415-1421]

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