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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling.

Ranran Dai, Qingping Jiang, You Zhou, Ruifeng Lin, Hai Lin, Yumin Zhang, Jinhu Zhang, Xingcheng Gao,

<h4>Background</h4>Epigenetic modulation by noncoding RNAs substantially contributes to human cancer development, but noncoding RNAs involvement in bladder cancer remains poorly understood. This study investigated the role of long noncoding RNA (lncRNA) lnc-STYK1-2 in tumorigenesis in cancerous bladder cells.<h4>Methods</h4>Differential lncRNA and mRNA profiles were characterized by high-throughput RNA sequencing combined with ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):408]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li, Dazhuo Shi,

Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear. This study was designed to determine the underlying mechanism by which ginsenoside Re protects from myocardial injury induced by H/R. HL-1 cells derived from AT-1 mouse atrial ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:532041]

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A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome.

Shiya Huang, Min Hu, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Yanhua Zheng, Qidan Wen, Cong Wang, Maohua Lai, Juan Li, Xingcheng Gao, Xinhua Wang, Zhenxing Hu, Tian Xia, Rongkui Hu, Jianping Liu, Xiaohui Wen, Shuna Li, Kewei Quan, Xingyan Liang, Hongcai Shang, Hongxia Ma, Jie Qiao,

<h4>Background</h4>Traditional Chinese medicine (TCM) usually involves syndrome differentiation and treatment. Acupuncture, one form of TCM, requires the selection of appropriate acupoints and needling techniques, but many clinical trials on acupuncture have used fixed acupuncture protocols without accounting for individual patient differences. We have designed a multicenter randomized controlled trial (RCT) ... Read more >>

Trials (Trials)
[2020, 21(1):239]

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MiR-200a Regulates Nasopharyngeal Carcinoma Cell Migration and Invasion by Targeting MYH10.

Wenya Liu, Tonghui Cai, Lingjun Li, Hui Chen, Ruichao Chen, Minfen Zhang, Wei Zhang, Li Zhao, Hanzhen Xiong, Ping Qin, Xingcheng Gao, Qingping Jiang,

Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. However, no ... Read more >>

J Cancer (Journal of Cancer)
[2020, 11(10):3052-3060]

Cited: 2 times

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome

Shiya Huang, Min Hu, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Yanhua Zheng, Qidan Wen, Cong Wang, Maohua Lai, Juan Li, Xingcheng Gao, Xinhua Wang, Zhenxing Hu, Tian Xia, Rongkui Hu, Jianping Liu, Xiaohui Wen, Shuna Li, Kewei Quan, Xingyan Liang, Hongcai Shang, Hongxia Ma, Jie Qiao,

BACKGROUND Traditional Chinese medicine (TCM) usually involves syndrome differentiation and treatment. Acupuncture, one form of TCM, requires the selection of appropriate acupoints points and needling techniques, but many clinical trials on acupuncture have used fixed acupuncture protocols without accounting for individual differences among patients. We have designed a multicenter randomized ... Read more >>

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Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer.

Ranran Dai, You Zhou, Zhishan Chen, Zihao Zou, Zhaojun Pan, Ping Liu, Xingcheng Gao,

The study aimed to investigate the expression and function of bladder cancer (BC) long noncoding RNAs (lncRNAs) using a high-throughput platform. High-throughput sequencing was used to compare the expression profiles of lncRNA in BC and adjacent normal tissues. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR), in situ hybridization, gene ontology, and ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2020, 121(10):4214-4225]

Cited: 2 times

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The mechanosensitive Piezo1 channel is required for bone formation.

Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li,

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 36 times

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Long Noncoding RNA PRRG4-4 Promotes Viability, Cell Cycle, Migration, and Invasion in Lung Cancer Cells.

Yuanyuan Wang, Wei Gong, Shiyu Zhou, Lei Yang, Fuman Qiu, Mingzhu Lin, Wenpeng Su, Wenjing Nie, Soham Datta, Boqi Rao, Jianfeng Xian, Yingyi Feng, Xin Zhang, Yifeng Zhou, Xingcheng Gao, Jiachun Lu,

There is a perception that long noncoding RNA (lncRNA) has relationship with carcinogenesis. Many studies have previously identified and validated that the section of chromosome 11p13 is associated with high incidence of tumor. In this study, we investigated a new lncRNA, named <i>lncPRRG4-4</i>, mapped to 11p13 and suspected that <i>lncPRRG4-4</i> ... Read more >>

DNA Cell Biol (DNA and cell biology)
[2018, 37(12):953-966]

Cited: 1 time

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Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Yang Li, Guohui Zhong, Ming Guo, Yuheng Li, Lin Yang, Jianpeng Du, Yuezhang Zhou, Jianwei Li, Shuai Liang, Yanqing Wang, Xingcheng Gao, Yating Zhang, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Zizhong Liu, Weijia Sun, Xiaorui Wu, Jinping Song, Yingxian Li, Dazhuo Shi,

<h4>Background</h4>Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca<sup>2+</sup>overload. However, whether PQS can ameliorate cardiac atrophy following ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 56:83-93]

Cited: 2 times

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Upregulation of LncRNA FEZF-AS1 is associated with advanced clinical stages and family history of cancer in patients with NSCLC.

Wei Gong, Yi Cao, Yuanyuan Wang, Lei Yang, Wenpeng Su, Fuman Qiu, Soham Datta, Boqi Rao, Jianfeng Xian, Mingzhu Lin, Yingyi Feng, Xin Zhang, Yifeng Zhou, Xingcheng Gao, Jiachun Lu,

Antisense RNA (AS) is a type of long non-coding RNAs that functions as a post-transcriptional regulatory element on regulating parental coding gene expression via directly binding to complementary mRNA sequences. We aimed to investigate the effect of the AS to FEZF1 gene on non-small cell lung cancer (NSCLC) development. The ... Read more >>

Pathol Res Pract (Pathology, research and practice)
[2018, 214(6):857-861]

Cited: 7 times

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Erratum to: Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing.

Xiangjin Kang, Wenyin He, Yuling Huang, Qian Yu, Yaoyong Chen, Xingcheng Gao, Xiaofang Sun, Yong Fan,

J Assist Reprod Genet (Journal of assisted reproduction and genetics)
[2017, 34(7):963]

Cited: 0 times

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Association of semen cytokines with reactive oxygen species and histone transition abnormalities.

Lu Jiang, Ting Zheng, Jun Huang, Jinhua Mo, Hua Zhou, Min Liu, Xingcheng Gao, Bolan Yu,

<h4>Purpose</h4>The aim of this study is to investigate the relationships among reactive oxygen species (ROS) elevation, histone transition, and seminal cytokine concentrations.<h4>Methods</h4>Total levels of ROS in semen samples from 6560 men were measured. From this sample, 118 cases with high ROS and 106 controls were recruited. Basic semen parameters and ... Read more >>

J Assist Reprod Genet (Journal of assisted reproduction and genetics)
[2016, 33(9):1239-1246]

Cited: 11 times

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Efficacy of Combined Laparoscopic and Hysteroscopic Repair of Post-Cesarean Section Uterine Diverticulum: A Retrospective Analysis.

Cuilan Li, Shiyan Tang, Xingcheng Gao, Wanping Lin, Dong Han, Jinguo Zhai, Xuetang Mo, Lee Jaden Gil Yu Kang Zhou,

<h4>Background</h4>Diverticulum, one of the long-term sequelae of cesarean section, can cause abnormal uterine bleeding and increase the risk of uterine scar rupture. In this study, we aimed to evaluate the efficacy of combined laparoscopic and hysteroscopic repair, a newly occurring method, treating post-cesarean section uterine scar diverticulum.<h4>Methods</h4>Data relating to 40 ... Read more >>

Biomed Res Int (BioMed research international)
[2016, 2016:1765624]

Cited: 7 times

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Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing.

Xiangjin Kang, Wenyin He, Yuling Huang, Qian Yu, Yaoyong Chen, Xingcheng Gao, Xiaofang Sun, Yong Fan,

<h4>Purpose</h4>As a powerful technology for genome engineering, the CRISPR/Cas system has been successfully applied to modify the genomes of various species. The purpose of this study was to evaluate the technology and establish principles for the introduction of precise genetic modifications in early human embryos.<h4>Methods</h4>3PN zygotes were injected with Cas9 ... Read more >>

J Assist Reprod Genet (Journal of assisted reproduction and genetics)
[2016, 33(5):581-588]

Cited: 100 times

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Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells.

Xiangjin Kang, Qian Yu, Yuling Huang, Bing Song, Yaoyong Chen, Xingcheng Gao, Wenyin He, Xiaofang Sun, Yong Fan,

Human-induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells using defined factors and provide a renewable source of autologous cells for cell therapy. Many reprogramming methods have been employed to generate human iPSCs, including the use of integrating vectors and non-integrating vectors. Maintenance of the genomic integrity of ... Read more >>

PLoS One (PloS one)
[2015, 10(7):e0131128]

Cited: 30 times

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Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm.

Bolan Yu, Yanbin Qi, Dan Liu, Xingcheng Gao, Hui Chen, Chuan Bai, Zhaofeng Huang,

<h4>Objective</h4>To investigate the association between smoking, semen quality, and the histone-to-protamine transition ratio in mature sperm.<h4>Design</h4>Biochemical and molecular analysis in human samples and a cell line.<h4>Setting</h4>Andrology laboratory in a university-affiliated hospital.<h4>Patient(s)</h4>Semen samples from 147 heavy smokers and 175 nonsmokers receiving infertility treatment.<h4>Intervention(s)</h4>None.<h4>Main outcome measure(s)</h4>Basic semen parameters, histone-to-protamine ratios, and number ... Read more >>

Fertil Steril (Fertility and sterility)
[2014, 101(1):51-57.e1]

Cited: 27 times

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An extraordinary T/NK lymphoma, nasal type, occurring primarily in the prostate gland with unusual CD30 positivity: case report and review of the literature.

QingPing Jiang, Shaoyan Liu, Juan Peng, Hanzhen Xiong, ZhongTang Xiong, Yuexin Yang, Xuexian Tan, Xingcheng Gao,

<h4>Unlabelled</h4>Extranodal NK/T cell lymphoma(NKTCL), nasal type, occurring primarily in the prostate gland, is extremely rare. We present a case of primarily prostatic NKTCL in a 59-year-old man suffering from dysuria. Histological examinations revealed that diffused, large-sized, pleomorphic lymphocytes were arranged in an angiocentric distribution with large areas of geographic necroses. ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2013, 8:94]

Cited: 8 times

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Low NRF2 mRNA expression in spermatozoa from men with low sperm motility.

Kang Chen, Zixin Mai, Yulin Zhou, Xingcheng Gao, Bolan Yu,

Antioxidant genes and enzymes play important roles in human spermatogenesis. Although low levels of antioxidant enzyme expression are associated with poor sperm quality, it is not clear whether mRNA expression of antioxidant genes is lower in these men than in normozoospermic men. In this study, 55 asthenozoospermic and ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2012, 228(3):259-266]

Cited: 23 times

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Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans.

Bolan Yu, Huanlan Lin, Lixia Yang, Kang Chen, Haihua Luo, Jianqiao Liu, Xingcheng Gao, Xuefeng Xia, Zhaofeng Huang,

Defective spermatogenesis, which severely impairs male fertility, can be caused by excessive reactive oxygen species (ROS). Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates transcription of genes encoding enzymes important for protection against ROS. In human seminal plasma and spermatozoa, superoxide dismutase isoenzymes (SOD) and glutathione S-transferases (GST) are key ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2012, 90(11):1333-1342]

Cited: 19 times

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