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Author Xingchen Li

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Diagnostic Model Incorporating Clinicopathological Characteristics of Delphian Lymph Node Metastasis Risk Profiles in Papillary Thyroid Cancer.

Xingchen Li, Yuansheng Duan, Dandan Liu, Hongwei Liu, Mengqian Zhou, Kai Yue, Yanjie Shuai, Yu Wang, Chenyan Ji, Chao Jing, Yansheng Wu, Xudong Wang,

The Delphian lymph node (DLN), also known as the prelaryngeal node, is one component of the central lymph node. The DLN has been well studied in laryngeal cancer, although its significance in papillary thyroid cancer (PTC) remains unclear. We retrospectively analyzed 936 patients with PTC who underwent thyroidectomy by a ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:591015]

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A comparative bibliometric analysis of Chinese and foreign articles in environmental footprint family (EFF) research.

Yezhu Wang, Yundong Xie, Rongting Zhou, Xiaoli Hu, Xingchen Li,

Research on environmental footprint family (EFF), including these studies of environmental footprints and footprint family, has been widely applied to environmental impact assessment and sustainability evaluation. Although some bibliometric studies have focused on footprint indicators, there is still the lack of the contrast of Chinese and foreign literature in the ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Identification of a Metabolism-Related Signature for the Prediction of Survival in Endometrial Cancer Patients.

Yuan Fan, Xingchen Li, Li Tian, Jianliu Wang,

<h4>Objective</h4>Endometrial cancer (EC) is one of the most common gynecologic malignancies. The present study aims to identify a metabolism-related biosignature for EC and explore the molecular immune-related mechanisms underlying the tumorigenesis of EC.<h4>Methods</h4>Transcriptomics and clinical data of EC were retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:630905]

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Preoperatively elevated RDW-SD and RDW-CV predict favorable survival in intrahepatic cholangiocarcinoma patients after curative resection.

Xingchen Li, Qichen Chen, Xinyu Bi, Jianjun Zhao, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Rui Mao, Hong Zhao, Jianqiang Cai,

<h4>Background</h4>Recent studies suggest red blood cell distribution width (RDW) was a prognostic factor in various types of cancer patients, although the results are controversial. The objective of this study was to investigate the significance of RDW in patients with intrahepatic cholangiocarcinoma (ICC) after radical resection.<h4>Method</h4>The relationship between the preoperative serum ... Read more >>

BMC Surg (BMC surgery)
[2021, 21(1):105]

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Anterior distal tibial plafond-plasty for the treatment of posttraumatic ankle osteoarthritis with anterior translation of the talus.

Xingchen Li, Yang Xu, Changjun Guo, Chonglin Yang, Yuan Zhu, Xiangyang Xu,

Posttraumatic ankle osteoarthritis (OA) represents a significant challenge to orthopedic surgeons, especially in cases of anterior talar translation and concomitant impaction of the anterior distal tibial plafond. The aim of this study was to evaluate the clinical outcomes of an intra-articular osteotomy for the management of these patients. A total ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4381]

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Identification of an immune-related risk signature and nomogram predicting the overall survival in patients with endometrial cancer.

Yuan Cheng, Xingchen Li, Yibo Dai, Yangyang Dong, Xiao Yang, Jianliu Wang,

<h4>Objective</h4>Aimed to construct an immune-related risk signature and nomogram predicting endometrial cancer (EC) prognosis.<h4>Methods</h4>An immune-related risk signature in EC was constructed using the least absolute shrinkage and selection operator regression analysis based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A nomogram integrating the immune-related genes ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e30]

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Establishment and validation of a prognostic nomogram based on a novel five-DNA methylation signature for survival in endometrial cancer patients.

Xingchen Li, Fufen Yin, Yuan Fan, Yuan Cheng, Yangyang Dong, Jingyi Zhou, Zhiqi Wang, Xiaoping Li, Jianliu Wang,

<h4>Background</h4>This study aimed to explore the prognostic role of DNA methylation pattern in endometrial cancer (EC) patients.<h4>Methods</h4>Differentially methylated genes (DMGs) of EC patients with distinct survival from The Cancer Genome Atlas (TCGA) database were analyzed to identify methylated genes as biomarkers for EC prognosis. The Least Absolute Shrinkage and Selection ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(2):693-708]

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Development and Validation of Nomograms Predicting the Overall and the Cancer-Specific Survival in Endometrial Cancer Patients.

Xingchen Li, Yuan Fan, Yangyang Dong, Yuan Cheng, Jingyi Zhou, Zhiqi Wang, Xiaoping Li, Jianliu Wang,

<b>Background:</b> The present study was aimed at developing nomograms estimating the overall survival (OS) and cancer-specific survival (CSS) of endometrial cancer (EC)-affected patients. <b>Patients and Methods:</b> We retrospectively collected 145,445 EC patients between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Independent prognostic factors were identified ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:614629]

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What is the optimal number of neoadjuvant chemotherapy cycles for resectable colorectal liver oligometastases?

Qichen Chen, Xingchen Li, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Hong Zhao, Jianqiang Cai,

<h4>Background</h4>The optimal number of neoadjuvant chemotherapy (NAC) cycles for resectable colorectal liver oligometastases (CLOM) remains unclear. The aim of this study was to investigate the optimal number of NAC cycles.<h4>Methods</h4>One hundred twenty-nine consecutive patients were included in this study. X-tile analysis was implemented to investigate the optimal cut-off point for ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(1):7]

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Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.

Chao Jing, Yuansheng Duan, Mengqian Zhou, Kai Yue, Shanshan Zhuo, Xingchen Li, Dandan Liu, Beibei Ye, Qingchuan Lai, Linqi Li, Xiaofeng Yao, Hui Wei, Wenchao Zhang, Yansheng Wu, Xudong Wang,

Increasing evidence reveals a close relationship between deubiquitinating enzymes (DUBs) and cancer progression. In this study, we attempted to identify the roles and mechanisms of critical DUBs in head and neck squamous cell carcinoma (HNSCC). <b>Methods:</b> Bioinformatics analysis was performed to screen differentially expressed novel DUBs in HNSCC. Immunohistochemistry assay ... Read more >>

Theranostics (Theranostics)
[2021, 11(6):2655-2669]

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Calcium and TRPV4 promote metastasis by regulating cytoskeleton through the RhoA/ROCK1 pathway in endometrial cancer.

Xingchen Li, Yuan Cheng, Zhiqi Wang, Jingyi Zhou, Yuanyuan Jia, Xiangjun He, Lijun Zhao, Yangyang Dong, Yuan Fan, Xiao Yang, Boqiang Shen, Xiaotong Wu, Jiaqi Wang, Chunyang Xiong, Lihui Wei, Xiaoping Li, Jianliu Wang,

Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that has been associated with several types of cancer. However, its biological significance, as well as its related mechanism in endometrial cancer (EC) still remains elusive. In this study, we examined the function of calcium in EC, with a ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(11):1009]

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Clinical Translation of Scarless 0.33mm Core Microbiopsy for Molecular Evaluation of Human Skin.

Mikaela Kislevitz, Christine Wamsley, Mason Bartels, Karen B Lu, Xingchen Li, Sydney Pinch, John Hoopman, Fritz Barton, Jeffrey Kenkel, Yucel Akgul,

<h4>Background</h4>Skin scarring can occur after punch biopsies, prohibiting their routine use especially in the central face.<h4>Objectives</h4>This paper describes a scarless 0.33mm in diameter skin microbiopsy for molecular analysis of skin.<h4>Methods</h4>This is a single center, randomized, prospective study with fifteen subjects receiving no biopsy, or biopsy on the left or right ... Read more >>

Aesthet Surg J (Aesthetic surgery journal)
[2020, :]

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Comparing less invasive plate fixation versus screw fixation of displaced intra-articular calcaneus fracture via sinus tarsi approach.

Changjun Guo, Yangbo Xu, Chunguang Li, Xingchen Li, Zhengxiang Wang, Ming Cai, Xiangyang Xu,

<h4>Purpose</h4>The purpose of this study was to compare the post-operative radiographic and clinical outcomes of less invasive plate fixation versus screw fixation of displaced intra-articular calcaneus fractures (DIACFs) via sinus tarsi approach.<h4>Methods</h4>A total of 165 consecutive DIACFs that underwent open reduction internal fixation via sinus tarsi approach from 2013 to ... Read more >>

Int Orthop (International orthopaedics)
[2020, :]

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A nomogram to predict prognosis after surgery for young patients with hepatocellular carcinoma

Xingchen Li, Xinyu Bi, Jianjun Zhao, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Hong Zhao, Jianqiang Cai,

<h4>Background: </h4> Only few studies have been evaluated the clinical characteristics and prognosis of hepatocellular carcinoma in young patients. The purpose of this study is to identify prognostic factors and develop an efficient and practical nomogram to predict cancer-specific survival in young patients with hepatocellular carcinoma. <h4>Methods: </h4> Four-hundred-and-forty-one young ... Read more >>

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Effects of multidisciplinary team on the outcomes of colorectal cancer patients with liver metastases.

Xingchen Li, Qichen Chen, Xinyu Bi, Jianjun Zhao, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Rui Mao, Hong Zhao, Jianqiang Cai,

<h4>Background</h4>To evaluate the effect of a multidisciplinary team (MDT) treatment modality on outcomes of patients with colorectal cancer with liver metastases (CRLMs) in China.<h4>Methods</h4>We retrospectively identified 236 (MDT: 46, non-MDT: 190) patients who underwent liver resection or simultaneous resection for primary colorectal cancer and liver metastases with a curative intent ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2020, 9(5):2741-2748]

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Sediment Bacterial Community Structure Under the Influence of Different Domestic Sewage Types.

Lei Zhang, Mengli Xu, Xingchen Li, Wenxuan Lu, Jing Li,

Sediment bacterial communities are critical to the biogeochemical cycle in river ecosystems, but our understanding of the relationship between sediment bacterial communities and their specific input streams in rivers remains insufficient. In this study, we analyzed the sediment bacterial community structure in a local river receiving discharge of urban domestic ... Read more >>

J Microbiol Biotechnol (Journal of microbiology and biotechnology)
[2020, 30(9):1355-1366]

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Development and Validation of Nomograms Predicting the Overall and the Cancer-Specific Survival in Endometrial Cancer Patients

Xingchen Li, Yangyang Dong, Yuan Cheng, Jingyi Zhou, Xiaotong Wu, Boqiang Shen, Xiao Yang, Zhiqi Wang, Xiaoping Li, Jianliu Wang,

<h4>Background: </h4> The present study was aimed at developing nomograms estimating the overall survival (OS) and cancer-specific survival (CSS) of endometrial cancer (EC)-affected patients. Patients and Methods: We retrospectively collected 145,445 EC patients between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Independent prognostic factors were ... Read more >>

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PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation.

Xiaojuan Wang, Fan Wu, Han Wang, Xiaoyuan Duan, Rong Huang, Amannisa Tuersuntuoheti, Luying Su, Shida Yan, Yuechao Zhao, Yan Lu, Kai Li, Jinjie Yao, Zhiwen Luo, Lei Guo, Jianmei Liu, Xiao Chen, Yalan Lu, Hanjie Hu, Xingchen Li, Mandula Bao, Xinyu Bi, Boyu Du, Shiying Miao, Jianqiang Cai, Linfang Wang, Haitao Zhou, Jianming Ying, Wei Song, Hong Zhao,

<h4>Background</h4>Colorectal cancer (CRC) is one of the most common malignancies, and it's expected that the CRC burden will substantially increase in the next two decades. New biomarkers for targeted treatment and associated molecular mechanism of tumorigenesis remain to be explored. In this study, we investigated whether PDCD6 plays an oncogenic ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):147]

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Preoperatively elevated RDW-SD and RDW-CV predict favorable survival in intrahepatic cholangiocarcinoma patients after curative resection

Xingchen Li, Qichen Chen, Xinyu Bi, Jianjun Zhao, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Rui Mao, Hong Zhao, Jianqiang Cai,

<h4>Background: </h4> Recent studies suggest red blood cell distribution width (RDW) was a prognostic factor in various types of cancer patients, although the results are controversial. The objective of this study was to investigate the significance of RDW in patients with Intrahepatic cholangiocarcinoma (ICC) after radical resection. Method: The ... Read more >>

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Diagnostic model incorporating clinicopathological characteristics of Delphian lymph node metastasis risk profiles in papillary thyroid cancer

Xingchen Li, Yuansheng Duan, Dandan Liu, Hongwei Liu, Mengqian Zhou, Kai Yue, Yanjie Shuai, Yu Wang, Chao Jing, Yansheng Wu, Xudong Wang,

<h4>Background: </h4> Delphian lymph node (DLN), also known as prelaryngeal node, is the component of central lymph node (Level VI). DLN has been well studied in laryngeal cancer while less in papillary thyroid cancer (PTC). However, increasing attention has been payed to its clinical value in PTC lymph node metastasis. ... Read more >>

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A New Minimally Invasive Surgery of Hallux Valgus: Technique and Preliminary Outcomes

Changjun Guo, Xingchen Li, Chunguang Li, Yang Xu, Ming Cai, Xiangyang Xu,

Purpose This study aimed to present a new minimally invasive surgery (MIS) technique and evaluate the safety and efficacy for correction of hallux valgus deformity at a preliminary follow-up. <h4>Methods: </h4> 48 consecutive feet that underwent a new MIS of hallux valgus with a mean 17.6 months follow-up (range 9 ... Read more >>

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Impact of long-term industrial contamination on the bacterial communities in urban river sediments

Lei Zhang, Demei Tu, Xingchen Li, Wenxuan Lu, Jing Li,

<h4>Background: </h4> The contamination of the aquatic environment of urban rivers with industrial wastewater has affected the abiotic conditions and biological activities of the trophic levels of the ecosystem, particularly sediments. However, most current research about microorganism in urban aquatic environments has focused on indicator bacteria related to feces and ... Read more >>

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Strong linkages between dissolved organic matter and the aquatic bacterial community in an urban river.

Lei Zhang, Wangkai Fang, Xingchen Li, Wenxuan Lu, Jing Li,

Aquatic bacterial communities play an important role in biogeochemical cycling in river ecosystems; however, knowledge of the linkages between bacterial communities and dissolved organic matter (DOM) in urban rivers is limited. Here, 16S rRNA amplicon sequencing and parallel factor (PARAFAC) modeling of excitation-emission fluorescence spectroscopy were used to analyze the ... Read more >>

Water Res (Water research)
[2020, 184:116089]

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Diagnosis of tibiofibular syndesmosis instability in Weber type B malleolar fractures.

Qiang Huang, Yongxing Cao, Chonglin Yang, Xingchen Li, Yangbo Xu, Xiangyang Xu,

<h4>Objective</h4>This study was performed to analyze the clinical value of X-ray, computed tomography (CT), and magnetic resonance imaging (MRI) examinations for the diagnosis of distal tibiofibular syndesmosis injuries in Weber type B ankle fractures with reference to the ankle arthroscopic findings.<h4>Methods</h4>This retrospective clinical study involved 52 patients with type B ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(7):300060520939752]

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Comprehensive Analysis of the Association Between the Glycolysis Prognostic Risk Signature and Immune Infiltration in Endometrial Cancer

Xiao Yang, Xingchen Li, Boqiang Shen, Jingyi Zhou, Yuan Cheng, Yuanyuan Jia, Jianliu Wang,

<h4>Background: </h4> Glycolysis is the primary mechanism of energy metabolism in tumor cells. The purpose of this study is to develop a glycolysis-related risk signature for endometrial cancer and analyze its relationship with immune function. <h4>Methods: </h4> The mRNA expression profiling and clinical information of endometrial cancer were downloaded from ... Read more >>

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