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The perceptions of anatomy teachers for different majors during the COVID-19 pandemic: a national Chinese survey.

Yu Yan, Xin Cheng, Changman Zhou, Xuesong Yang, Yun-Qing Li,

During the spring semester of 2020, medical school anatomists in China were forced by the COVID-19 pandemic to transition from face-to-face educators or part-time online educators to full-time online educators. This nationwide survey was conducted to assess online anatomy education during the pandemic for medical students from nonclinical medicine and ... Read more >>

Med Educ Online (Medical education online)
[2021, 26(1):1897267]

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Flexible porphyrin doped polymer optical fibers for rapid and remote detection of trace DNT vapor.

Huan Lin, Xin Cheng, Ming-Jie Yin, Zhouzhou Bao, Xunbin Wei, Bobo Gu,

With the rapid growth of anti-terrorist activities worldwide, it becomes an emerging requirement to rapidly and accurately detect hidden explosive threats. However, the safety issue during the explosive material detection, e.g. unexpected explosion, is still an insurmountable challenge. In this study, we design and mass-produce a novel kind of flexible ... Read more >>

Analyst (The Analyst)
[2020, 145(15):5307-5313]

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Hypermetabolic Unicentric Castleman Disease of Kidney on FDG PET/CT.

Peipei Wang, Guozhu Hou, Fang Li, Xin Cheng,

<h4>Abstract</h4>A 62-year-old man presented with a huge lesion of left kidney on ultrasound in a health examination 1 month ago. The mass showed hypervascularity on enhanced CT and intense FDG uptake on FDG PET/CT in the lower pole of kidney, which suggested renal malignancy. The histopathological result after surgical resection ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):510-511]

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Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing.

Rui Yan, Chan Gu, Di You, Zhongying Huang, Jingjing Qian, Qiuyun Yang, Xin Cheng, Lin Zhang, Hongmei Wang, Ping Wang, Fan Guo,

Developing female human germ cells undergo genome-wide epigenetic reprogramming, but de novo DNA methylation dynamics and their interplay with chromatin states and transcriptional activation in developing oocytes is poorly understood. Here, we developed a single-cell multi-omics sequencing method, scChaRM-seq, that enables simultaneous profiling of the DNA methylome, transcriptome, and chromatin ... Read more >>

Cell Stem Cell (Cell stem cell)
[2021, :]

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The effects of Methanococcus maripaludis on the corrosion behavior of EH40 steel in seawater.

Shiqiang Chen, Hao Deng, Yudi Zhao, Shihang Lu, Yao Zhao, Xin Cheng, Guangzhou Liu, Wenwen Dou, Jvna Chen,

The corrosion behavior of EH40 steel in seawater enriched with Methanococcus maripaludis was investigated through electrochemical methods and surface analysis techniques. The results revealed that the hydrogenotrophic M. maripaludis strain can utilize acetate as an alternative energy source. Corrosion of EH40 steel is initially inhibited, but prolonged exposure with the ... Read more >>

Bioelectrochemistry (Bioelectrochemistry (Amsterdam, Netherlands))
[2021, 140:107824]

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The relationships between the topological properties of the whole-brain white matter network and the severity of autism spectrum disorder: A study from monozygotic twins.

Chunyan Li, Yun Li, Linyan Fu, Yue Wang, Xin Cheng, Xiwen Cui, Jiying Jiang, Ting Xiao, Xiaoyan Ke, Hui Fang,

Twins provide a valuable perspective for exploring the pathological mechanism of autism spectrum disorder (ASD). We aim to analyze differences in the topological properties of the white matter (WM) network between monozygotic twins with ASD (MZCo-ASD) and children with typical development (TD). We enrolled 67 subjects aged 2-9 years. Twenty-three pairs ... Read more >>

Neuroscience (Neuroscience)
[2021, :]

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Responses of fungal communities along a chronosequence succession in soils of a tailing dam with reclamation by Heteropogon contortus.

Ying Yang, Yi Huang, Xue Tang, Ying Li, Jianing Liu, Hanyu Li, Xin Cheng, Xiangjun Pei, Haoran Duan,

Phytoremediation can obviously change the fungal communities in the soils, which will significantly impact carbon (C) and nitrogen (N) cycling in ecological system. So far, the relationship between soil fungal communities and environmental factors is still poorly understood along a long chronosequence. In this study, fungal communities in the surface ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 218:112270]

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Teaching NeuroImages: Parkinsonism Presenting With Watershed Pattern Lesions.

Yi Dong, Xin Cheng, Qiang Dong,

Neurology (Neurology)
[2021, :]

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Identification and application of a neutralizing epitope within alpha-hemolysin using human serum antibodies elicited by vaccination.

Jinning Wei, Xin Cheng, Yi Zhang, Chen Gao, Ying Wang, Qi Peng, Ping Luo, Liuyang Yang, Quanming Zou, Hao Zeng, Jiang Gu,

Staphylococcus aureus (SA), especially the methicillin-resistant variant (MRSA), is becoming a serious threat to human health in hospitals and communities, making the development of an effective vaccine urgent. Alpha-hemolysin (Hla) is a key virulence factor and also a good target for the development of SA vaccines. However, the epitopes in ... Read more >>

Mol Immunol (Molecular immunology)
[2021, 135:45-52]

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iT4SE-EP: Accurate Identification of Bacterial Type IV Secreted Effectors by Exploring Evolutionary Features from Two PSI-BLAST Profiles.

Haitao Han, Chenchen Ding, Xin Cheng, Xiuzhi Sang, Taigang Liu,

Many gram-negative bacteria use type IV secretion systems to deliver effector molecules to a wide range of target cells. These substrate proteins, which are called type IV secreted effectors (T4SE), manipulate host cell processes during infection, often resulting in severe diseases or even death of the host. Therefore, identification of ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(9):]

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Use of 18F-FDG PET/CT to differentiate ectopic adrenocorticotropic hormone-secreting lung tumors from tumor-like pulmonary infections in patients with ectopic Cushing syndrome

Guozhu Hou, Yuanyuan Jiang, Fang Li, Xin Cheng,

<h4>Background: </h4> Ectopic adrenocorticotropic hormone (ACTH)-secreting lung tumors represent the most common cause of ectopic Cushing syndrome (ECS). Pulmonary opportunistic infections are associated with ECS and occasionally difficult to differentiate from tumors by using computed tomography (CT) alone. The present study aimed to evaluate the usefulness of 18 F-fluorodeoxyglucose (FDG) ... Read more >>

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An early juvenile of Kunpengopterus sinensis (Pterosauria) from the Late Jurassic in China.

Shunxing Jiang, Xiaoli Wang, Xiaoting Zheng, Xin Cheng, Junqiang Zhang, Xiaolin Wang,

The Wukongopteridae is a transitional clade between the long- and short-tailed pterosaur groups, and at least ten specimens have been studied without a determined juvenile specimen. Here, we described a small-sized Kunpengopterus sinensis, less than half the size of the holotype, which is the smallest specimen in wukongopterids. Based on ... Read more >>

An Acad Bras Cienc (Anais da Academia Brasileira de Ciencias)
[2021, 93(suppl 2):e20200734]

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VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer in vivo.

Guangbo Kang, Min Hu, He Ren, Jiewen Wang, Xin Cheng, Ruowei Li, Bo Yuan, Yasmine Balan, Zixuan Bai, He Huang,

<h4>Objective</h4>We aimed to develop a novel anti-HIF-1α intrabody to decrease gemcitabine resistance in pancreatic cancer patients.<h4>Methods</h4>Surface plasmon resonance and glutathione S-transferase pull-down assays were conducted to identify the binding affinity and specificity of anti-HIF-1α VHH212 [a single-domain antibody (nanobody)]. Molecular dynamics simulation was used to determine the protein-protein interactions between ... Read more >>

Cancer Biol Med (Cancer biology & medicine)
[2021, :]

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MYB transcription factor GmMYBA2 and GmMYBR function in a feedback loop to control pigmentation of seed coat in soybean.

Ruifang Gao, Taotao Han, Hongwei Xun, Xiangsheng Zeng, Penghui Li, Yueqing Li, Yanan Wang, Yan Shao, Xin Cheng, Xianzhong Feng, Jian Zhao, Li Wang, Xiang Gao,

Soybean has undergone extensive selection pressures for seed nutrient compositions and seed color during domestication, but the major genetic loci controlling seed coat color have not been completely understood, and the transcriptional regulation relationship among the loci remains elusive. Here, two major regulators, GmMYBA2 and GmMYBR, were functionally characterized as ... Read more >>

J Exp Bot (Journal of experimental botany)
[2021, :]

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Flagella hook protein FlgE is a novel vaccine candidate of Pseudomonas aeruginosa identified by a genomic approach.

Chuang Wan, Chen Gao, Qin Xie, Yin Wang, Xin Cheng, Yao Fang, Zhiyong Liu, Weijun Zhang, Quanming Zou, Guangwen Lu, Jiang Gu,

Infections due to Pseudomonas aeruginosa (PA) are becoming a serious threat to patients in intensive care units. A PA vaccine is a practical and economical solution to solve the problems caused by PA infection successfully. In recent years, several antigen candidates have been tested in animal and human clinical trials, ... Read more >>

Vaccine (Vaccine)
[2021, 39(17):2386-2395]

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Ambient Ultraviolet B Signal Modulates Tea Flavor Characteristics via Shifting a Metabolic Flux in Flavonoid Biosynthesis.

Ning Lin, Xuyang Liu, Wenfeng Zhu, Xin Cheng, Xiaohui Wang, Xiaochun Wan, Linlin Liu,

Tea leaves contain an extraordinarily high level of flavonoids that contribute to tea health benefits and flavor characteristics, but the regulatory mechanism of ambient ultraviolet B (UV-B) on tea flavonoid enrichment remains unclear. Here, we report that ambient UV-B modulates tea quality by inducing a metabolic flux in flavonoid biosynthesis. ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2021, 69(11):3401-3414]

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Antibody-drug conjugate MORAb-202 exhibits long-lasting antitumor efficacy in TNBC PDx models.

Keiji Furuuchi, Katherine Rybinski, James Fulmer, Tomoyuki Moriyama, Brian Drozdowski, Allis Soto, Shawn Fernando, Kerrianne Wilson, Andrew Milinichik, Mary Lou Dula, Keigo Tanaka, Xin Cheng, Earl Albone, Toshimitsu Uenaka,

The antibody-drug conjugate (ADC) MORAb-202, consisting of farletuzumab paired with a cathepsin B-cleavable linker and eribulin, targets folate receptor alpha (FRA), which is frequently overexpressed in various tumor types. MORAb-202 was highly cytotoxic to FRA-positive cells in vitro, with limited off-target killing of FRA-negative cells. Furthermore, MORAb-202 showed a clear ... Read more >>

Cancer Sci (Cancer science)
[2021, :]

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Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors.

Nian Wu, Yingshi Li, Xiangyue He, Jiayi Lin, Denglu Long, Xin Cheng, Beate Brand-Saberi, Guang Wang, Xuesong Yang,

Whether or not the process of somitogenesis and myogenesis is affected by excessive caffeine intake still remains ambiguous. In this study, we first showed that caffeine treatment results in chest wall deformities and simultaneously reduced mRNA expressions of genes involved in myogenesis in the developing chicken embryos. We then used ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:586767]

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Gut-Lung Dysbiosis Accompanied by Diabetes Mellitus Leads to Pulmonary Fibrotic Change through the NF-κB Signaling Pathway.

Guang Wang, Yu-Xuan Hu, Mei-Yao He, Yun-Hai Xie, Wei Su, Denglu Long, Ran Zhao, Jingyun Wang, Chenyang Dai, Haiyang Li, Zhen-Peng Si, Xin Cheng, Rui-Man Li, Zhijie Li, Xuesong Yang,

Growing evidence shows that the lungs are an unavoidable target organ of diabetic complications. However, the pathologic mechanisms of diabetic lung injury are still controversial. This study demonstrated the dysbiosis of the gut and lung microbiome, pulmonary alveolar wall thickening, and fibrotic change in streptozotocin-induced diabetic mice and antibiotic-induced gut ... Read more >>

Am J Pathol (The American journal of pathology)
[2021, 191(5):838-856]

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In-Situ Intermolecular Interaction in Composite Polymer Electrolyte for Ultralong Life Quasi-Solid-State Lithium Metal Batteries.

Kangqiang He, Samson Ho-Sum Cheng, Jieying Hu, Yangqian Zhang, Huiwen Yang, Yingying Liu, Wenchao Liao, Dazhu Chen, Chengzhu Liao, Xin Cheng, Zhouguang Lu, Jun He, Jiaoning Tang, Robert K Y Li, Chen Liu,

Solid-state lithium metal batteries built with composite polymer electrolytes using cubic garnets as active fillers are particularly attractive owing to their high energy density, easy manufacturing and inherent safety. However, the uncontrollable formation of intractable contaminant on garnet surface usually aggravates poor interfacial contact with polymer matrix and deteriorates Li<sup>+</sup> ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :]

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The effects of long-term extracurricular scientific research on the medical students: Insight from Jinan University Medical School.

Guang Wang, Xin-Yue Ma, Xin Cheng, Chao-Hua Luo, Heng Wang, Xu Xu, Kenneth Ka Ho Lee, Xuesong Yang,

The benefits and long-term effects of extracurricular scientific research on undergraduate students in many countries have been intensively investigated, but it remains obscure for Chinese medical students. In this study, we investigated the outcome of 60 medical students who have participated in extracurricular scientific research at Jinan University Medical School ... Read more >>

Biochem Mol Biol Educ (Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology)
[2021, :]

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Endoplasmic reticulum stress-related calcium imbalance plays an important role on Zinc oxide nanoparticles-induced failure of neural tube closure during embryogenesis.

Yu Yan, Guang Wang, Xin Luo, Ping Zhang, Shuang Peng, Xin Cheng, Mengwei Wang, Xuesong Yang,

Zinc oxide nanoparticles (ZnO NPs) have been increasingly and widely utilized in various fields, such as agriculture, food and cosmetics. However, various levels of adverse impacts of ZnO NPs on the ecological environment and public health have been associated with each stage of their production, use and disposal. ZnO NPs ... Read more >>

Environ Int (Environment international)
[2021, 152:106495]

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Untargeted lipidomics reveals metabolic responses to different dietary n-3 PUFA in juvenile swimming crab (Portunus trituberculatus).

Ye Yuan, Fangmin Xu, Min Jin, Xuexi Wang, Xiaoying Hu, Mingming Zhao, Xin Cheng, Jiaxiang Luo, Lefei Jiao, Mónica B Betancor, Douglas R Tocher, Qicun Zhou,

While tissue fatty acid compositions reflect that of the dietary lipid source, little information is available on how dietary oils modify lipid class and molecular species profiles in hepatopancreas of crustacean. Herein, an 8-week nutritional trial and untargeted lipidomic analysis were used to investigate the impacts of dietary n-3 PUFA ... Read more >>

Food Chem (Food chemistry)
[2021, 354:129570]

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Cancer-associated fibroblasts: overview, progress, challenges, and directions.

Qinrong Ping, Ruping Yan, Xin Cheng, Wenju Wang, Yiming Zhong, Zongliu Hou, Yunqiang Shi, Chunhui Wang, Ruhong Li,

Tumors are one of the main causes of death in humans. The development of safe and effective methods for early diagnosis and treatment of tumors is a difficult problem that needs to be solved urgently. It is well established that the occurrence of tumors involves complex biological mechanisms, and the ... Read more >>

Cancer Gene Ther (Cancer gene therapy)
[2021, :]

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Experience of Ectopic Adrenocorticotropin Syndrome: 88 Cases With Identified Causes.

Hui Miao, Lin Lu, Huijuan Zhu, Hanze Du, Xiaoping Xing, Xiaobo Zhang, Lan Song, Wei Song, Qingxing Liu, Xin Cheng, Zhaohui Zhu, Shi Chen, Anli Tong, Hui Pan, Renzhi Wang, Zhaolin Lu,

<h4>Objective</h4>Ectopic adrenocorticotropic hormone syndrome (EAS) is a rare cause of Cushing's syndrome and diagnosis and management remain challenging. The aim of this study was to present the clinical spectrum of a group of EAS cases in a single center to explore better management strategies.<h4>Methods</h4>A retrospective study was conducted to identify ... Read more >>

Endocr Pract (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists)
[2021, :]

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