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Author Xiaoyu Qu

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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song,

<h4>Context</h4>Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.<h4>Objective</h4>This study estimates the protective effect of HQH against CYP-induced nephrotoxicity in rats.<h4>Materials and methods</h4>Four groups of 10 Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1425-1431]

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Polypharmacy and potentially inappropriate medications among elderly patients in the geriatric department at a single-center in China: A retrospective cross-sectional study.

Lina Tao, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Yueming Zhang, Yanqing Song,

<h4>Abstract</h4>The aging of the population has become a worldwide concern, especially in China. Polypharmacy and potentially inappropriate medications (PIMs) are prominent issues in elderly patients. Therefore, the aim of this study was to investigate the prevalence of polypharmacy and PIMs in older inpatients and further to explore the factors associated ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(42):e27494]

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Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu,

The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP-induced nephrotoxicity. However, the mechanisms ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(11):e22896]

Cited: 1 time

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Mutational profiling in acute lymphoblastic leukemia by RNA sequencing and chromosomal genomic array testing.

Cecilia Yeung, Xiaoyu Qu, Olga Sala-Torra, David Woolston, Jerry Radich, Min Fang,

<h4>Background</h4>Comprehensive molecular and cytogenetic profiling of acute lymphoblastic leukemia (ALL) is important and critical to the current standard of care for patients with B-acute lymphoblastic leukemia (B-ALL). Here we propose a rapid process for detecting gene fusions whereby FusionPlex RNA next-generation sequencing (NGS) and DNA chromosome genomic array testing (CGAT) ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(16):5629-5642]

Cited: 1 time

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Uplift Resistance Capacity of Anchor Piles used in Marine Aquaculture

Fukun Gui, Jianqiao Kong, Dejun Feng, Xiaoyu Qu, Fang Zhu, Yang You,

Anchor piles are widely used in marine aquaculture, and their uplift resistance capacity largely determines their safety, especially in harsh ocean environments. However, a practical guide on its design and installation is wanting. Laboratory experiments were conducted to investigate the effect of the initial tension angle, pile diameter, embedded depth, ... Read more >>

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Genome-wide identification, and phylogenetic and expression profiling analyses, of XTH gene families in Brassica rapa L. and Brassica oleracea L.

Di Wu, Anqi Liu, Xiaoyu Qu, Jiayi Liang, Min Song,

<h4>Background: </h4> Xyloglucan endotransglucosylase/hydrolase genes ( XTHs ) are a multigene family and play key roles in regulating cell wall extensibility in plant growth and development. Brassica rapa and Brassica oleracea contain XTHs, but detailed identification and characterization of the XTH family in these species, and analysis of their tissue ... Read more >>

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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.

Yanqing Song, Tingting Hu, Huan Gao, Jinghui Zhai, Jiawei Gong, Yueming Zhang, Lina Tao, Jingmeng Sun, Zhiyuan Li, Xiaoyu Qu,

Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous study demonstrated that astragaloside IV (AS IV), an active compound of the traditional Chinese herb Astragalus membranaceus, alleviated CDDP-induced AKI. To explore the mechanism, we performed a metabolomics study to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 183:114299]

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Genome-wide identification, and phylogenetic and expression profiling analyses, of XTH gene families in Brassica rapa L. and Brassica oleracea L.

Di Wu, Anqi Liu, Xiaoyu Qu, Jiayi Liang, Min Song,

<h4>Background</h4>Xyloglucan endotransglucosylase/hydrolase genes (XTHs) are a multigene family and play key roles in regulating cell wall extensibility in plant growth and development. Brassica rapa and Brassica oleracea contain XTHs, but detailed identification and characterization of the XTH family in these species, and analysis of their tissue expression profiles, have not ... Read more >>

BMC Genomics (BMC genomics)
[2020, 21(1):782]

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Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway.

Huan Gao, Xiangfeng Wang, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Yueming Zhang, Yanqing Song, Wenrui Zhang,

Renal toxicity is the primary factor that limits clinical use of cisplatin (CP). A previous study showed that omeprazole (OME) protected against CP-induced toxicity in human renal tubular HK-2 cells and rat kidneys. However, the protective mechanisms of OME have not been characterized. We evaluated the ability of OME to ... Read more >>

Toxicology (Toxicology)
[2020, 440:152487]

Cited: 2 times

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Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.

Xiaoyu Qu, Huan Gao, Jinghui Zhai, Jingmeng Sun, Lina Tao, Yueming Zhang, Yanqing Song, Tingting Hu,

Decreased chemosensitivity among tumor cells is often an obstacle in cisplatin (Cis) chemotherapy. Overexpression of multidrug resistance-associated protein 2 (MRP2) is a key mechanism underlying decreased Cis chemosensitivity and resistance. Astragaloside IV (AS IV) is an important component derived from the well-known traditional Chinese herb Astragalus membranaceus. The aim of ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 148:105325]

Cited: 3 times

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Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway.

Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhang,

Severe hepatotoxicity greatly limits the clinical application of the first-line anti-tuberculosis drug isoniazid(INH). Quercetin(Que) has multiple pharmacological properties, and is regarded as a potential protective agent against a variety of organ injuries. However, the exact effect of quercetin on INH-induced hepatotoxicity and the underlying mechanisms are not yet completely understood. ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 85:106634]

Cited: 3 times

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Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats.

Xiaoyu Qu, Huan Gao, Jingmeng Sun, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Tingting Hu, Zhiyuan Li,

Kidney injury is a major adverse effect of cisplatin use. Metabolomics has been used to characterize physiological or pathological conditions through identification of metabolites and characterization of the metabolic pathway. Metabolomics profiling could allow for identification of nephrotoxic mechanisms of cisplatin and identification of biomarkers of cisplatin-induced injury. In this ... Read more >>

Toxicology (Toxicology)
[2020, 431:152366]

Cited: 3 times

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Comparison of four next generation sequencing platforms for fusion detection: Oncomine by ThermoFisher, AmpliSeq by illumina, FusionPlex by ArcherDX, and QIAseq by QIAGEN.

Xiaoyu Qu, Cecilia Yeung, Ilsa Coleman, Peter S Nelson, Min Fang,

As fusion detection NGS techniques are adopted by clinical labs, assay performance comparison is urgently needed. We compared four fusion-detection assay platforms on a pilot cohort of 24 prostate cancer samples: (1) Oncomine Comprehensive panel v3; (2) AmpliSeq comprehensive panel v3; (3) The solid tumor panel of FusionPlex; and (4) ... Read more >>

Cancer Genet (Cancer genetics)
[2020, 243:11-18]

Cited: 3 times

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Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.

Jinghui Zhai, Lina Tao, Sixi Zhang, Huan Gao, Yueming Zhang, Jingmeng Sun, Yanqing Song, Xiaoyu Qu,

The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA), an isoflavonoid that is the major active component in Radix astragali, has been reported in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(3):649-659]

Cited: 10 times

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Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway.

Yueming Zhang, Wenrui Zhang, Lina Tao, Jinghui Zhai, Huan Gao, Yanqing Song, Xiaoyu Qu,

Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH-induced hepatotoxicity using ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2019, 33(9):e22369]

Cited: 3 times

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Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney.

Xiaoyu Qu, Jinghui Zhai, Tingting Hu, Huan Gao, Lina Tao, Yueming Zhang, Yanqing Song, Sixi Zhang,

We aimed to investigate the drug-drug interaction (DDI) between doxorubicin (DOX) and <i>Dioscorea bulbifera L.</i> (DB) solution in mice, and to explore the effect of P-glycoprotein (P-gp) on this type of DDI. The toxicity of DOX in the liver, kidneys, and heart was assessed with alanine aminotransferase (ALT), aspartate aminotransferase ... Read more >>

Xenobiotica (Xenobiotica; the fate of foreign compounds in biological systems)
[2019, 49(9):1116-1125]

Cited: 1 time

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Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation.

Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang,

High glucose and high fat are important inducements for the development and progression of diabetic cardiopathy. Salvianolic acid B (SAB), which is the most abundant and bioactive compound in Danshen, attenuates oxidative stress-related disorders, such as cardiovascular diseases, cerebral ischemia, and diabetes. However, the effect of SAB on diabetic cardiopathy ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:9846325]

Cited: 4 times

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Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials.

Lina Tao, Xiaoyu Qu, Yue Zhang, Yanqing Song, Si-Xi Zhang,

<h4>Background</h4>Prophylactic therapy with silymarin to prevent the development of antituberculosis drug-induced liver injury (anti-TB DILI) has been under debate. We aimed to evaluate the effect of silymarin in the prevention of anti-TB DILI.<h4>Methods</h4>We searched MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to 30th November 2018. ... Read more >>

Can J Gastroenterol Hepatol (Canadian journal of gastroenterology & hepatology)
[2019, 2019:3192351]

Cited: 3 times

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A meta-analysis of naldemedine for the treatment of opioid-induced constipation.

Xuesong Song, Dunwei Wang, Xiaoyu Qu, Naifu Dong, Shiyong Teng,

<h4>Introduction</h4>Opioid-induced constipation (OIC) is a common adverse effect in patients under long-term opioid therapy. Naldemedine is a novel peripherally acting μ-opioid receptor antagonists being developed for the treatment of OIC without affecting central analgesia. This meta-analysis is to assess the current evidence for efficacy and safety of naldemedine for the ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2019, 12(2):121-128]

Cited: 5 times

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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Jingmeng Sun, Yanqing Song, Sixi Zhang,

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered ... Read more >>

J Toxicol Sci (The Journal of toxicological sciences)
[2019, 44(3):167-175]

Cited: 9 times

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Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cells.

Huan Gao, Sixi Zhang, Tingting Hu, Xiaoyu Qu, Jinghui Zhai, Yueming Zhang, Lina Tao, Jianyuan Yin, Yanqing Song,

The present study assessed the therapeutic potential of omeprazole (OME), the most commonly prescribed proton pump inhibitor (PPI) used to treat gastroesophageal hyperacidity, against cisplatin (CP)-induced toxicity in human renal tubular HK-2 cells and rat kidneys. Herein, we observed that exposure of HK-2 cells to OME reversed the injury caused by CP, ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2019, 297:130-140]

Cited: 3 times

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Genomic alterations important for the prognosis in patients with follicular lymphoma treated in SWOG study S0016.

Xiaoyu Qu, Hongli Li, Rita M Braziel, Verena Passerini, Lisa M Rimsza, Eric D Hsi, John P Leonard, Sonali M Smith, Robert Kridel, Oliver Press, Oliver Weigert, Michael LeBlanc, Jonathan W Friedberg, Min Fang,

Although recent advances in molecular genetics have enabled improved risk classification of follicular lymphoma (FL) using, for example, the m7-FLIPI score, the impact on treatment has been limited. We aimed to assess the prognostic significance of copy-number aberrations (CNAs) and copy-neutral loss of heterozygosity (cnLOH) identified by chromosome genomic-array testing ... Read more >>

Blood (Blood)
[2019, 133(1):81-93]

Cited: 5 times

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Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway.

Jinghui Zhai, Xiaoyu Qu, Yueming Zhang, Huan Gao, Lina Tao, Yanqing Song, Sixi Zhang,

Salvianolic acid (SA) is known for improving blood circulation, scavenging hydroxyl radicals, and preventing platelet aggregation. The research explored whether SA can protect against cardiovascular disease induced by high glucose conditions. Our results indicate that SA significantly increases cells viability and nitric oxide levels while decreasing reactive oxygen species generation. ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2019, 33(2):e22245]

Cited: 1 time

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Hyperspectral Remote Sensing Image Classification Based on Maximum Overlap Pooling Convolutional Neural Network.

Chenming Li, Simon X Yang, Yao Yang, Hongmin Gao, Jia Zhao, Xiaoyu Qu, Yongchang Wang, Dan Yao, Jianbing Gao,

In a traditional convolutional neural network structure, pooling layers generally use an average pooling method: a non-overlapping pooling. However, this condition results in similarities in the extracted image features, especially for the hyperspectral images of a continuous spectrum, which makes it more difficult to extract image features with differences, and ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2018, 18(10):]

Cited: 2 times

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Autophagy inhibition-enhanced assembly of the NLRP3 inflammasome is associated with cisplatin-induced acute injury to the liver and kidneys in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Sixi Zhang,

The nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome has a key role in the inflammatory response. We found that cisplatin (7.5, 15 mg/kg, IV) could induce acute injury to the liver and kidneys of rats. Western blot and immunohistochemical analyses showed that expression of NLRP3, caspase-1 and ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2018, :e22208]

Cited: 5 times

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