Full Text Journal Articles by
Author Xiaoxian Wu


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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Very Strong, Super-Tough, Antibacterial, and Biodegradable Polymeric Materials with Excellent UV-Blocking Performance.

Xiao Zhang, Weifeng Liu, Danting Sun, Jinhao Huang, Xueqing Qiu, Zhixian Li, Xiaoxian Wu,

In this work, inspired by the dynamic sacrificial hydrogen bonds in biological materials, a very strong, super-tough, antibacterial, and cost-effective biodegradable poly(vinyl alcohol) (PVA) nanocomposite material was developed by incorporating the nanoscale antibacterial agent [email protected] [email protected] was prepared from the green biomass tannic acid (TA) and sodium lignosulfonate (LS), and ... Read more >>

ChemSusChem (ChemSusChem)
[2020, :]

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Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.

Ningning Zhuang, Hao Zhang, Lingting Li, Xiaoxian Wu, Chen Yang, Yu Zhang,

A recently discovered ornithine-ammonia cycle (OAC) serves as a conduit in the nitrogen storage and remobilization machinery in cyanobacteria. The OAC involves an arginine catabolic reaction catalyzed by the arginine dihydrolase ArgZ whose catalytic mechanism is unknown. Here we determined the crystal structures at 1.2-3.0 Å of unliganded ArgZ from ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2020, 295(7):2113-2124]

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Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.

Xiaoxian Wu, Diane L Haakonsen, Allen G Sanderlin, Yue J Liu, Liqiang Shen, Ningning Zhuang, Michael T Laub, Yu Zhang,

Canonical bacterial transcription activators bind to non-transcribed promoter elements to increase transcription of their target genes. Here we report crystal structures of binary complexes comprising domains of Caulobacter crescentus GcrA, a noncanonical bacterial transcription factor, that support a novel mechanism for transcription activation through the preferential binding of methylated cis-regulatory ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2018, 46(6):3245-3256]

Cited: 4 times

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Effect of Ganoderma Lucidum Preparation on the Behavior,Biochemistry,and Autoimmune Parameters of Mouse Models of APP/PS1 Double Transgenic Alzheimer's Disease.

Chuan Qin, Shanqiu Wu, Baosheng Chen, Xiaoxian Wu, Kunyao Qu, Junmin Liu, Guifang Zhang, Yanfeng Xu, Shunli Shu, Lihua Sun, Yanhong Li, Hua Zhu, Lan Huang, Chunmei Ma, Yuhuan Xu, Yunlin Han, Yaozeng Lu,

Objective To evaluate the efficacy of Ganoderma lucidum preparation on the behaviors,biochemistry,and autoimmunity parameters of mouse models of APP/PS-1 double transgenic Alzheimer's disease(AD).Methods A total of 44 4-month-old APP/PS-1 double transgenic AD mice were randomly divided into AD model group,Aricept group,Ganoderma lucidum middle-dose(LZ-M)group,and Ganoderma lucidum high-dose(LZ-H)group,with 11 mice in each ... Read more >>

Zhongguo Yi Xue Ke Xue Yuan Xue Bao (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae)
[2017, 39(3):330-335]

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Directional Selection from Host Plants Is a Major Force Driving Host Specificity in Magnaporthe Species.

Zhenhui Zhong, Justice Norvienyeku, Meilian Chen, Jiandong Bao, Lianyu Lin, Liqiong Chen, Yahong Lin, Xiaoxian Wu, Zena Cai, Qi Zhang, Xiaoye Lin, Yonghe Hong, Jun Huang, Linghong Xu, Honghong Zhang, Long Chen, Wei Tang, Huakun Zheng, Xiaofeng Chen, Yanli Wang, Bi Lian, Liangsheng Zhang, Haibao Tang, Guodong Lu, Daniel J Ebbole, Baohua Wang, Zonghua Wang,

One major threat to global food security that requires immediate attention, is the increasing incidence of host shift and host expansion in growing number of pathogenic fungi and emergence of new pathogens. The threat is more alarming because, yield quality and quantity improvement efforts are encouraging the cultivation of uniform ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:25591]

Cited: 9 times

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Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin.

Qiang Wei, Li Liu, Zhe Cong, Xiaoxian Wu, Hui Wang, Chuan Qin, Patricia Molina, Zhiwei Chen,

Delta9-tetrahydrocannabinol (Δ(9)-THC) is the major psychoactive component of the cannabis plant. Δ(9)-THC has been used in the active ingredient of Marinol as an appetite stimulant for AIDS patients. Its impact on progression of HIV-1 infection, however, remains debatable. Previous studies indicated that Δ(9)-THC administration enhanced HIV-1 infection in huPBL-SCID mice ... Read more >>

J Neuroimmune Pharmacol (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology)
[2016, 11(3):584-591]

Cited: 1 time

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Separation method of rhubarb-combined anthraquinone and rhubarb tannin


The invention discloses a separation method of rhubarb-combined anthraquinone and rhubarb tannin, belonging to the separation of anthraquinone. The method comprises the steps: one part of traditionalChinese medicine rhubarb sub cargo is weighted according to the weight parts, and then added into 4-15 parts of boiling water for decoction, and ... Read more >>

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Determination of phenolic preservatives in gelatin and vacant capsules for medicine use by ion-suppression reversed-phase high performance liquid chromatography.

Hongzhen Lian, Danli Li, Xiaoxian Wu, Liching Tian,

A reliable method for the simultaneous determination of phenolic preservatives parahydroxybenzoic acid, methyl, ethyl, propyl, butyl and pentyl parahydroxybenzoates in gelatin and vacant capsules for medical use has been developed by ion-suppression reversed-phase high performance liquid chromatography. Separation was carried out on a Kromasil C(18) column by isocratic elution using ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2005, 37(2):369-372]

Cited: 2 times

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Therapeutic dendritic-cell vaccine for simian AIDS.

Wei Lu, Xiaoxian Wu, Yaozeng Lu, Weizhong Guo, Jean-Marie Andrieu,

An effective immune response against human immunodeficiency virus or simian immunodeficiency virus (SIV) is critical in achieving control of viral replication. Here, we show in SIV-infected rhesus monkeys that an effective and durable SIV-specific cellular and humoral immunity is elicited by a vaccination with chemically inactivated SIV-pulsed dendritic cells. After ... Read more >>

Nat. Med. (Nature medicine)
[2003, 9(1):27-32]

Cited: 145 times

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