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A Multicentered Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended-Spectrum Beta-Lactamase Producing Enterobacterales Infections in Children.

Latania K Logan, Jared R Rispens, Rachel L Medernach, T Nicholas Domitrovic, Andrea M Hujer, Steven H Marshall, Susan D Rudin, Nadia K Qureshi, Xiaotian Zheng, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales-(Ent) infections are increasing in pediatrics. Before CTX-M ESBL emerged, the most common infection-associated ESBL genes were TEM and SHV-type ESBLs. We sought to define the current epidemiology of Ent infections in children due to blaTEM and blaSHV (TEM-SHV-Ent).<h4>Methods</h4>A retrospective case-control analysis of children with TEM-SHV-Ent infections ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):39-43]

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Comparison of Upper Respiratory Viral Load Distributions in Asymptomatic and Symptomatic Children Diagnosed with SARS-CoV-2 Infection in Pediatric Hospital Testing Programs.

Larry K Kociolek, William J Muller, Rebecca Yee, Jennifer Dien Bard, Cameron A Brown, Paula A Revell, Hanna Wardell, Timothy J Savage, Sarah Jung, Samuel Dominguez, Bijal A Parikh, Robert C Jerris, Sue C Kehl, Aaron Campigotto, Jeffrey M Bender, Xiaotian Zheng, Emily Muscat, Matthew Linam, Lisa Abuogi, Christiana Smith, Kelly Graff, Ariel Hernandez-Leyva, David Williams, Nira R Pollock,

The distribution of upper respiratory viral loads (VL) in asymptomatic children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We assessed PCR cycle threshold (Ct) values and estimated VL in infected asymptomatic children diagnosed in nine pediatric hospital testing programs. Records for asymptomatic and symptomatic patients with ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2020, 59(1):]

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1360. Variation in Duration of Antibiotic Therapy for Central-line Associated Blood Stream Infections Caused by Gram Negative Bacilli in Hospitalized Children

Grant R Whitmer, Tonya Scardina, Shan Sun, Xiaotian Zheng, Sameer Patel,

Abstract <h4>Background</h4> Central-line associated bloodstream infections (CLABSIs) are associated with increased morbidity, mortality, and duration of hospitalization in children. Existing guidelines recommend a broad range (7-14 days) for duration of antibiotic therapy. Unnecessarily prolonged therapy may be associated with emergence of antibiotic resistance and adverse events. <h4>Methods</h4> We performed a ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S691-S691]

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Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19).

Taylor Heald-Sargent, William J Muller, Xiaotian Zheng, Jason Rippe, Ami B Patel, Larry K Kociolek,

JAMA Pediatr (JAMA pediatrics)
[2020, 174(9):902-903]

Cited: 6 times

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Clinical Performance and Impact of Accelerate Pheno for Gram-negative Bacteremia in Hospitalized Children.

Michelle Lee, Tonya Scardina, Xiaotian Zheng, Sameer J Patel,

<h4>Purpose</h4>Accelerate Pheno provides rapid identification and antimicrobial susceptibility tests (ASTs) of pathogens that cause blood stream infections (BSIs). The study objective was to assess the accuracy of the Accelerate Pheno platform and its impact on antimicrobial modification in children with gram-negative BSIs.<h4>Methods</h4>A retrospective review was conducted of patients at a ... Read more >>

Clin Ther (Clinical therapeutics)
[2020, 42(9):1630-1636]

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Evaluation of Commercial Molecular Diagnostic Methods for Detection and Determination of Macrolide Resistance in Mycoplasma pneumoniae.

Sixto M Leal, Arthur H Totten, Li Xiao, Donna M Crabb, Amy Ratliff, Lynn B Duffy, Karen B Fowler, Emily Mixon, Jonas M Winchell, Maureen H Diaz, Alvaro J Benitez, Bernard J Wolff, Xuan Qin, Y-W Tang, Mark Gonzalez, Raj Selvarangan, Tao Hong, Edward Brooks, Steve Dallas, T Prescott Atkinson, Xiaotian Zheng, Jennifer Dien Bard, Ken B Waites,

We evaluated six commercial molecular tests targeting <i>Mycoplasma pneumoniae</i>, namely, the BioFire FilmArray respiratory panel (RP), the Meridian Alethia Mycoplasma Direct, the GenMark ePlex respiratory pathogen panel (RPP), the Luminex NxTAG RPP, the ELITech ELITe InGenius <i>Mycoplasma</i> MGB research use only (RUO) PCR, and the SpeeDx <i>Resistance Plus</i> MP assays. ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2020, 58(6):]

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Association Between Children's Hospital Visitor Restrictions and Healthcare-Associated Viral Respiratory Infections: A Quasi-Experimental Study.

Hawa Forkpa, Angela H Rupp, Stanford T Shulman, Sameer J Patel, Elizabeth L Gray, Xiaotian Zheng, Maria Bovee, Larry K Kociolek,

We investigated the effect of annual winter visitor restrictions on hospital respiratory virus transmission. The healthcare-associated (HA) viral respiratory infection (VRI) transmission index (number of HA VRIs per 100 inpatient community-associated VRIs) was 59% lower during the months in which visitor restrictions were implemented. These data prompt consideration for instituting ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, 9(2):240-243]

Cited: 1 time

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Detailed Phenotypic and Functional Characterization of a Rare, Antibody-Dependent SLAM-Associated Protein Expression Pattern.

Aaruni Khanolkar, Jeffrey D Wilks, Guorong Liu, Edward A Caparelli, Michelle De Moura, Kai Lee Yap, Asma Mustafa, Sabah Kadri, Wei Huang, Xiaotian T Zheng,

SLAM-associated protein (SAP) is an adaptor molecule that facilitates critical effector functions in immune cells, and its deficiency causes X-linked lymphoproliferative disease type 1 in which effector responses directed against EBV are severely compromised. The primary objective of this study was to phenotypically and functionally characterize a rare, CD8 T ... Read more >>

Immunohorizons (ImmunoHorizons)
[2020, 4(4):153-164]

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594. A Multi-Centered Study of the Clinical and Molecular Epidemiology of AmpC Cephalosporinase-Producing (AmpC) Enterobacteriaceae (Ent) Infections in Children

Rachel L Medernach, T Nicholas Domitrovic, Karen C Hayani, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Jared R Rispens, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

Abstract Background AmpC producing Ent are an important cause of multidrug-resistant (MDR) infections in pediatrics. Since most AmpC Ent studies have been conducted in adults, we characterized the molecular epidemiology of AmpC Ent strains with transmissible resistance and identified factors associated with AmpC Ent infections in children. Methods A case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S280-S280]

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Methods for Antimicrobial Susceptibility Testing for Human Mycoplasmas; Approved Guideline

Ken B. Waites, Donald J. Bade, Cecile Bébéar, Steven D. Brown, Maureen K. Davidson, Lynn B. Duffy, George Kenny, Anne Matlow, Dee Shortridge, Deborah Talkington, Patricia A. Totten, Jeffrey L. Watts, Xiaotian Zheng,

Antimicrobial susceptibility testing is indicated for any organism that contributes to an infectious process warranting antimicrobial chemotherapy, if its susceptibility cannot be reliably predicted from knowledge of the organism’s identity. Standardized in vitro antimicrobial susceptibility tests are also needed in order to evaluate new antimicrobials against specific groups of organisms ... Read more >>

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A Multi-Centered Case-Case-Control Study of Factors Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults.

Latania K Logan, David C Nguyen, Felicia A Scaggs Huang, Nadia K Qureshi, Angella Charnot-Katsikas, Allison H Bartlett, Xiaotian Zheng, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Robert A Bonomo, Robert A Weinstein,

<h4>Background</h4>Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae (KPC-CRE) are multidrug-resistant organisms causing morbidity and mortality worldwide. KPC-CRE prevalence is increasing in pediatric populations, though multi-centered data are lacking. Identifying risk factors for KPC-CRE infection in children and classifying genotypes is a priority in this vulnerable population.<h4>Methods</h4>A case-case-control study of patients (0-22 years) ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(5):490-495]

Cited: 3 times

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Laboratory Diagnosis of Neonatal Herpes Simplex Virus Infections.

William J Muller, Xiaotian Zheng,

Herpes simplex virus (HSV) is a common and often benign infection in humans; although it less commonly affects newborns, infection in this age group can be devastating. Newborns often present with nonspecific clinical findings, making timely and accurate diagnosis of infection critical. A wide variety of tests are available for ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2019, 57(5):]

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Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, Jared R Rispens, Steven H Marshall, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Sreenivas Konda, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(6):595-599]

Cited: 2 times

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The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Sreenivas Konda, Robert A Weinstein, Robert A Bonomo,

<h4>Introduction</h4>The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).<h4>Methods</h4>A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area ... Read more >>

Infect Dis Ther (Infectious diseases and therapy)
[2019, 8(2):243-254]

Cited: 2 times

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2336. Resistance Mechanisms and Factors Associated With CTX-M-9 Group Extended-Spectrum β-Lactamase (ESBL)-Producing Infections in Children.

Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundThere is an increasing incidence of extended-spectrum β-lactamase (ESBL) producing infections in children. However, most studies focus only on CTX-M-1 group (CTX-M-15). We sought to define the epidemiology of the CTX-M-9 group (CTX-M-9) producing infections in children to devise more effective treatment and prevention strategies.MethodsA case–control study of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S694-S694]

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Ideal and Actual Impact of Rapid Diagnostic Testing and Antibiotic Stewardship on Antibiotic Prescribing and Clinical Outcomes in Children With Positive Blood Cultures.

Caroline H Reuter, Hannah L Palac, Larry K Kociolek, Xiaotian T Zheng, Yusuf Y Chao, Rupal M Patel, Sameer J Patel,

BACKGROUND:Implementing matrix-assisted laser desorption ionization-time of flight and multiplex polymerase chain reaction has been associated with decreased mortality and hospital length of stay in adults, but the impact in pediatrics is less understood. METHODS:This pre-post quasi-experimental study compared antibiotic prescribing for positive blood cultures in patients ≤21 years of age ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(2):131-137]

Cited: 3 times

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Utilizing the electronic health record to construct antibiograms for previously healthy children with urinary tract infections.

Yusuf Y Chao, Larry K Kociolek, Xiaotian T Zheng, Tonya Scardina, Sameer J Patel,

Traditional antibiograms can guide empiric antibiotic therapy, but they may miss differences in resistance across patient subpopulations. In this retrospective descriptive study, we constructed and validated antibiograms using International Classification of Disease, Tenth Revision (ICD-10) codes and other discrete data elements to define a cohort of previously healthy children with ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2018, 39(12):1473-1475]

Cited: 0 times

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The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae infections in children

Latania Logan, Rachel Medernach, Nicholas Domitrovic, Jared Rispens, Andrea Hujer, Nadia Qureshi, Steven Marshall, David Nguyen, Susan Rudin, Xiaotian Zheng, Robert Weinstein, Robert Bonomo,

<h4>Background</h4> The pandemic of extended-spectrum-beta-lactamase (ESBL)-producing-Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent). <h4>Methods</h4> A multi-centered case-control analysis of Chicago children with CTX-M-9-grp-Ent infections was performed. Cases were defined as ... Read more >>

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Caution Needed: Molecular Diagnosis of Pediatric Group A Streptococcal Pharyngitis.

Robert R Tanz, Xiaotian T Zheng, Donna M Carter, Molly C Steele, Stanford T Shulman,

Among throat swabs processed in the microbiology laboratory as back-up for negative rapid antigen detection test results, we found a significant increase in the proportion that tested positive for group A streptococci after changing from throat culture to a molecular test.For group A streptococcus testing, our hospital laboratory replaced throat ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2018, 7(3):e145-e147]

Cited: 3 times

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Community origins and regional differences highlight risk of plasmid-mediated fluoroquinolone resistant Enterobacteriaceae infections in children

Latania Logan, Rachel Medernach, Jared Rispens, Steven Marshall, Andrea Hujer, Nicholas Domitrovic, Susan Rudin, Xiaotian Zheng, Nadia Qureshi, Sreenivas Konda, Mary Hayden, Robert Weinstein, Robert Bonomo,

<h4>Background:</h4> Fluoroquinolones (FQs) are uncommonly prescribed in children, yet pediatric multidrug-resistant (MDR)-Enterobacteriaceae (Ent) infections often reveal FQ resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children. <h4>Methods:</h4> A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children ... Read more >>

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Safety of Palivizumab Stewardship in Conjunction with Infection Prevention and Control Strategies for Healthcare-Associated Respiratory Syncytial Virus Infections.

Rupal M Patel, Larry K Kociolek, Emily Merrick, Caroline Reuter, Kenny Kronforst, Xiaotian Zheng, Sameer J Patel,

Transitioning from administration of monthly palivizumab to a single dose at discharge was associated with substantial pharmacy cost savings. With the concurrent adoption of private hospital rooms and visitor restriction policies, hospital-wide and neonatal intensive care unit healthcare-associated respiratory syncytial virus infections decreased following these changes. Infect Control Hosp Epidemiol ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2018, 39(4):485-487]

Cited: 0 times

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A Multicenter Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended- Spectrum β-Lactamase producing (ESBL) () Infections in Children.

Jared R Rispens, Rachel L Medernach, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Mary K Hayden, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundESBL infections are increasingly prevalent in the pediatric population; however, most ESBL studies have focused on adults and/or CTX-M-type strains. We sought to characterize the molecular epidemiology of ESBL strains and to identify factors associated with TEM- and SHV-type ESBL (TEMSHV ) infections in children.MethodsA case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S679-S679]

Cited: 0 times

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Impact of a Healthcare Provider Educational Intervention on Frequency of Clostridium difficile Polymerase Chain Reaction Testing in Children: A Segmented Regression Analysis.

Larry K Kociolek, Maria Bovee, Donna Carter, Jody D Ciolino, Rupal Patel, Anna O'Donnell, Angela H Rupp, Xiaotian Zheng, Stanford T Shulman, Sameer J Patel,

<h4>Background.</h4>Although Clostridium difficile infections (CDIs) are increasingly diagnosed in children, many children diagnosed with CDI lack classic risk factors. Frequent use of highly sensitive tcdB polymerase chain reaction (PCR) testing in low-risk patients leads to CDI misdiagnosis and unnecessary CDI antibiotic use in children with C difficile carriage.<h4>Methods.</h4>For this quasi-experimental ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2017, 6(2):142-148]

Cited: 7 times

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A Multicenter Case-Case–control Study of Factors Associated with Klebsiella pneumoniae Carbapenemase (KPC)-Producing Enterobacteriaceae (KPC-CRE) Infections in Children

David C Nguyen, Felicia Scaggs-Huang, Angella Charnot-Katsikas, Allison H Bartlett, Xiaotian Zheng, Nadia K Qureshi, Andrea M Hujer, T Nicholas Domitrovic, Robert A Bonomo, Robert A Weinstein, Latania K Logan,

Abstract <h4>Background</h4> KPC-CRE are multidrug-resistant organisms (MDRO) associated with morbidity and mortality worldwide. KPC-CRE infection prevalence is increasing in the pediatric population; however, multi-centered pediatric data are lacking. We sought to identify factors for KPC-CRE infections in children and to classify genotypes of infecting strains. <h4>Methods</h4> We conducted a case–case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S680-S680]

Cited: 0 times

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Differential recognition of the multiple banded antigen isoforms across Ureaplasma parvum and Ureaplasma urealyticum species by monoclonal antibodies.

Ali F Aboklaish, Shatha Ahmed, Douglas McAllister, Gail Cassell, Xiaotian T Zheng, Owen B Spiller,

Two separate species of Ureaplasma have been identified that infect humans: Ureaplasma parvum and Ureaplasma urealyticum. Most notably, these bacteria lack a cell wall and are the leading infectious organism associated with infection-related induction of preterm birth. Fourteen separate representative prototype bacterial strains, called serovars, are largely differentiated by the ... Read more >>

J Microbiol Methods (Journal of microbiological methods)
[2016, 127:13-19]

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