Full Text Journal Articles by
Author Xiaorong Zhang

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Redesign of protein nanocages: the way from 0D, 1D, 2D to 3D assembly.

Chenyan Lv, Xiaorong Zhang, Yu Liu, Tuo Zhang, Hai Chen, Jiachen Zang, Bowen Zheng, Guanghua Zhao,

Compartmentalization is a hallmark of living systems. Through compartmentalization, ubiquitous protein nanocages such as viral capsids, ferritin, small heat shock proteins, and DNA-binding proteins from starved cells fulfill a variety of functions, while their shell-like structures hold great promise for various applications in the field of nanomedicine and nanotechnology. However, ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2021, 50(6):3957-3989]

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MicroRNA-378 regulates adipogenic differentiation in bovine intramuscular preadipocytes by targeting CaMKK2.

Dongwei Li, Heng Wang, Yongmin Li, Changqing Qu, Yunhai Zhang, Hongyu Liu, Xiaorong Zhang,

Intramuscular fat, as one of the most important palatability attribute of beef carcase, is the primary determinant of beef quality. The research of adipogenesis mechanism would provide new insight into intramuscular fatty deposition. Here, the role of microRNA-378 was investigated during bovine adipogenic differentiation. It was revealed that miR-378 expression ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):483-492]

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Reversible structure transformation between protein nanocages and nanorods controlled by small molecules.

Xiaorong Zhang, Tuo Zhang, Yingjie Wang, Yu Liu, Jiachen Zang, Guanghua Zhao,

Constructing different protein nanostructures by using identical building blocks, while realizing their structural transformation in response to external stimuli, remains a challenge. Here, we fabricated protein nanocages and nanorods by using dimeric TmFtn as a building block and reacting with Mg<sup>2+</sup>/(α, L-lysine) with polymerization degrees of 9 (PLL<sub>9</sub>) and 15 ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, :]

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Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway.

Xumin Li, Haiyan Lin, Xiaorong Zhang, Richard T Jaspers, Qihao Yu, Yinghui Ji, Tim Forouzanfar, Dongyun Wang, Shengbin Huang, Gang Wu,

Oxidative stress (OS)-induced mitochondrial damage and the subsequent osteoblast dysfunction contributes to the initiation and progression of osteoporosis. Notoginsenoside R1 (NGR1), isolated from Panax notoginseng, has potent antioxidant effects and has been widely used in traditional Chinese medicine. This study aimed to investigate the protective property and mechanism of NGR1 ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

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Pathogenicity and innate response to Avibacterium paragallinarum in chickens.

Mengjiao Guo, Donghui Liu, Xiufang Chen, Yantao Wu, Xiaorong Zhang,

Infectious coryza (IC) is an acute infectious upper respiratory disease in chickens. Recently, the prevalence of IC has increased in China. In this study, to clarify the pathogenic mechanism and innate immune response of Avibacterium paragallinarum (A. paragallinarum), an infection experiment with A. paragallinarum was conducted. Our results showed that ... Read more >>

Poult Sci (Poultry science)
[2021, 101(1):101523]

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Patients with senile pruritus have a distinct skin microbiota and epidermal barrier in comparison with healthy controls.

Yaxin Huang, Jiexiong Liu, Xiaorong Zhang, Yujuan Li, Yong Xu, Xia Xiong, Yongqiong Deng,

Senile pruritus (SP) is a common skin disease in the elderly. The role of skin dysbacteriosis in the development of various skin diseases has been studied in recent years. However, the research about the skin microbiota of senile pruritus patients is lacking at present. The purpose of this cross-sectional study ... Read more >>

J Dermatol (The Journal of dermatology)
[2021, :]

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Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells.

Xiaorong Zhang, Yun Jiang, Jiajie Mao, Xuekun Ren, Yinghui Ji, Yixin Mao, Yang Chen, Xiaoyu Sun, Yihuai Pan, Jianfeng Ma, Shengbin Huang,

Reactive oxygen species (ROS) overproduction promotes the alveolar bone loss during the development of periodontitis. Mitochondria are the principal source of ROS. Hydroxytyrosol (HT), a natural phenolic compound present in olive oil, is well known for its antioxidant and mitochondrial-protective prosperities. Nonetheless, the impact of HT on periodontitis and its ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 176:298-311]

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Pathogenicity Comparison Between QX-Type And Mass-Type Infectious Bronchitis Virus To Different Segments of The Oviducts In Laying Phase

Xiaorong Zhang, Kun Yan, Chengcheng Zhang, Mengjiao Guo, Shuqin Chen, Kai Liao, Zongyi Bo, Yongzhong Cao, Yantao Wu,

<h4>Background: </h4> The QX-type infectious bronchitis virus (IBV) has become the predominant genotype worldwide in recent years and has caused serious economic losses to the chicken industry. The most significant feature of QX IBV is that its infection in the early growing stage can cause abnormal oviduct development, resulting in ... Read more >>

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Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization.

Zengjun Yang, Xiaohong Hu, Lina Zhou, Yaxiong He, Xiaorong Zhang, Jiacai Yang, Zhenyu Ju, Yih-Cherng Liou, Han-Ming Shen, Gaoxing Luo, Michael R Hamblin, Weifeng He, Rui Yin,

<h4>Background</h4>Epidermal stem cells (EpSCs) that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin homeostasis. Little is known about the effects of photochemical activation on EpSC differentiation, proliferation and migration during wound healing. The present study aimed to determine the ... Read more >>

Burns Trauma (Burns & trauma)
[2021, 9:tkab008]

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miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway.

Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu,

<h4>Background</h4>Atherosclerosis is a chronic process that takes place in the vascular wall and causes various cardiovascular diseases (CVDs). Micro-RNA-149 (miR-149) mediates many physiological and pathological processes, including atherosclerosis. However, it is unclear about the roles of miR-149 in endothelial injury. Here, we explored the protective effect and related mechanism of ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2021, 2021:9963258]

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Autophagy Induced by the N-Terminus of the Classic Swine Fever Virus Nonstructural Protein 5A Protein Promotes Viral Replication.

Chengcheng Zhang, Xiuling Wang, Jiahao Sun, Mengjiao Guo, Xiaorong Zhang, Yantao Wu,

Although classic swine fever virus (CSFV) infection has been reported to induce autophagy, the specific induced mechanism remains unrevealed. Nonstructural protein 5A (NS5A) of CSFV is a multiphosphorylated protein with multiple functions to regulate viral replication and the host cell immune responses. Herein, we demonstrated that CSFV NS5A could induce ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:733385]

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Interactive Web-based Annotation of Plant MicroRNAs with iwa-miRNA.

Ting Zhang, Jingjing Zhai, Xiaorong Zhang, Lei Ling, Menghan Li, Shang Xie, Minggui Song, Chuang Ma,

MicroRNAs (miRNAs) are important regulators of gene expression. The large-scale detection and profiling of miRNAs have accelerated with the development of high-throughput small RNA sequencing (sRNA-Seq) techniques and bioinformatics tools. However, generating high-quality comprehensive miRNA annotations remains challenging due to the intrinsic complexity of sRNA-Seq data and inherent limitations of ... Read more >>

Genomics Proteomics Bioinformatics (Genomics, proteomics & bioinformatics)
[2021, :]

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Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast.

Liuhanghang Cheng, Xiaoxuan Lei, Zengjun Yang, Yanan Kong, Pengcheng Xu, Shiya Peng, Jue Wang, Cheng Chen, Yunqing Dong, Xiaohong Hu, Xiaorong Zhang, Tymour Forouzanfar, Gang Wu, Xiaobing Fu,

<h4>Objectives</h4>Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulation of Hst 1 on the function of fibroblasts in the process of wound ... Read more >>

Cell Prolif (Cell proliferation)
[2021, 54(8):e13087]

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Author Correction: Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long.

Jinyang Zhang, Lingling Hou, Zhenqiang Zuo, Peifeng Ji, Xiaorong Zhang, Yuanchao Xue, Fangqing Zhao,

Nat Biotechnol (Nature biotechnology)
[2021, 39(7):893]

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Multi-locus sequence typing analysis of Mycoplasma synoviae isolates reveals unique sequence types in China.

Xiaorong Zhang, Yang Chen, Di Xie, Mengjiao Guo, Shuang Ma, Mengyao Chen, Dianfeng Chu, Yantao Wu,

Mycoplasma synoviae is a common pathogen affecting poultry and has important economic significance. Infectious synovitis is the most common clinical effect. Since 2010, the incidence of M. synoviae infection in China has rapidly risen, causing significant economic losses to the chicken industry; however, the cause of the disease outbreak remains ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 259:109101]

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Lacticaseibacillus rhamnosus Reduces the Pathogenicity of Escherichia coli in Chickens.

Mengjiao Guo, Congyue Zhang, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu,

<i>Lacticaseibacillus rhamnosus</i> is a recognized probiotic that is widely used in scientific research and clinical applications. This study found that the <i>Lacticaseibacillus rhamnosus</i> GG (LGG) strain can reduce the adhesion of <i>Escherichia coli</i> (<i>E. coli</i>) to primary chicken intestinal epithelial cells by 75.7% and inhibit 41.7% of the <i>E. coli</i> ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:664604]

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Crosstalk between reactive oxygen species and Dynamin-related protein 1 in periodontitis.

Lixi Shi, Yinghui Ji, Shufan Zhao, Houxuan Li, Yun Jiang, Jiajie Mao, Yang Chen, Xiaorong Zhang, Yixin Mao, Xiaoyu Sun, Panpan Wang, Jianfeng Ma, Shengbin Huang,

Excessive generation of reactive oxygen species (ROS) have great impacts on the development of periodontitis. Dynamin-related protein 1 (Drp1) mediated mitochondrial fission is the main reason and the result of excessive ROS generation. However, whether Drp1 and crosstalk between ROS and Drp1 contribute to the process of periodontitis remains elusive. ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 172:19-32]

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Vγ4 T cell-derived IL-17A is essential for amplification of inflammatory cascades in ischemic brain tissue after stroke.

Long Lu, Yangping Wang, Lina Zhou, Yashu Li, Xiaorong Zhang, Xiaohong Hu, Shugui Shi, Weifeng He,

<h4>Background</h4>Through amplifying inflammatory cascades, IL-17A produced by γδ T cells potently attracts neutrophils to the site of injury for exacerbating ischemic tissue damage. Our goal was to identify the precise role of γδ T cell subsets in ischemic brain tissue damage of stroke.<h4>Methods</h4>In a model of experimental stroke, we analyzed ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 96:107678]

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Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice.

Yunxia Chen, Xiaorong Zhang, Zhihui Liu, Jiacai Yang, Cheng Chen, Jue Wang, Zengjun Yang, Lei He, Pengcheng Xu, Xiaohong Hu, Gaoxing Luo, Weifeng He,

<h4>Background</h4>Delayed wound healing remains a common but challenging problem in patients with acute or chronic wound following accidental scald burn injury. However, the systematic and detailed evaluation of the scald burn injury, including second-degree deep scald (SDDS) and third-degree scald (TDS), is still unclear. The present study aims to analyze ... Read more >>

Burns Trauma (Burns & trauma)
[2021, 9:tkab004]

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Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration.

Xiao Zheng, Xiaorong Zhang, Yingting Wang, Yangxi Liu, Yining Pan, Yijia Li, Man Ji, Xueqin Zhao, Shengbin Huang, Qingqing Yao,

Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis. In present work, a nanoclay (Laponite, XLS)-functionalized 3D bioglass (BG) scaffold with hypoxia mimicking property was prepared by foam replication coupled with UV photopolymerization methods. Our data revealed that the incorporation of XLS can significantly promote the mechanical property ... Read more >>

Bioact Mater (Bioactive materials)
[2021, 6(10):3485-3495]

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Avian reovirus infection activate the cellular unfold protein response and induced apoptosis via ATF6-dependent mechanism.

Chengcheng Zhang, Jiashu Hu, Xiuling Wang, Yuyang Wang, Mengjiao Guo, Xiaorong Zhang, Yantao Wu,

Avian reovirus (ARV) infection induced apoptosis in vitro and vivo; nevertheless, the intracellular molecular mechanisms have not been sufficiently revealed. In the previous studies, there have been shown that cellular apoptosis caused by ARV were related with GRP78/IRE1/XBP1 pathway. Protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1) ... Read more >>

Virus Res (Virus research)
[2021, 297:198346]

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Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long.

Jinyang Zhang, Lingling Hou, Zhenqiang Zuo, Peifeng Ji, Xiaorong Zhang, Yuanchao Xue, Fangqing Zhao,

Reconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads has proved challenging given the similarity of circRNAs and their corresponding linear messenger RNAs. Previous sequencing methods were unable to achieve high-throughput detection of full-length circRNAs. Here we describe a protocol for enrichment and full-length sequencing of circRNA ... Read more >>

Nat Biotechnol (Nature biotechnology)
[2021, 39(7):836-845]

Cited: 10 times

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JNK-mediated blockage of autophagic flux exacerbates the triethylene glycol dimethacrylate-induced mitochondrial oxidative damage and apoptosis in preodontoblast.

Konghuai Wang, Qihao Yu, Danni Wu, Ruona Liu, Xuekun Ren, Hui Fu, Xiaorong Zhang, Yihuai Pan, Shengbin Huang,

Mitochondrial dependent oxidative stress (OS) and subsequent cell death are considered as the major cytotoxicity caused by Triethylene glycol dimethacrylate (TEGDMA), a commonly monomer of many resin-based dental composites. Under OS microenvironment, autophagy serves as a cell homeostatic mechanism and maintains redox balance through degradation or turnover of cellular components ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2021, 339:109432]

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Epidemiology and Outcome Analysis of Burns During Explosion Accident at a Major Center in Southwestern China From 2002 to 2016.

Yangping Wang, Xiaorong Zhang, Tengfei Liu, Menglong Liu, Haisheng Li, Yong Huang, Xiaohong Hu, Weifeng He, Gaoxing Luo, Wei Qian,

Explosions always lead to serious public health, social, and economic problems. We investigated the epidemiology, outcomes, and costs of burn patients caused by explosion accident in Southwest China to explore more effective prevention and treatment strategies. This retrospective study included 497 inpatients with burns during explosion accident admitted to the ... Read more >>

J Burn Care Res (Journal of burn care & research : official publication of the American Burn Association)
[2021, 42(1):49-62]

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Lactobacillus acidipiscis Induced Regulatory Gamma Delta T Cells and Attenuated Experimental Autoimmune Encephalomyelitis.

Saisai Ren, Xiaorong Zhang, Hongbing Guan, Lihong Wu, Miao Yu, Dan Hou, Yongyong Yan, Xuechun Fang,

Multiple sclerosis is a chronic autoimmune disease involving the central nervous system, and shows a high disability rate. Its pathogenesis is complicated, and there is no good treatment. In recent years, with in-depth studies on the regulation of gastrointestinal flora, the relationship between the mammalian immune system and the intestinal ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:623451]

Cited: 1 time

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