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Author Xiaoqing Wu

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Chromosomal Microarray Analysis of Fetuses with Nasal Bone Anomaly

Xiaorui Xie, Xiaoqing Wu, Linjuan Su, Meiying Cai, Ying Li, Hailong Huang, Liangpu Xu,

Abstract Objective: To explore the significance and value of fetal nasal bone anomaly (absence or hypoplasia) as indications of prenatal diagnosis. Methods: A total of 102 fetuses diagnosed with nasal bone absence or hypoplasia by ultrasonography underwent chorionic, amniotic, or umbilical cord blood puncture. Single nucleotide polymorphism microarray (SNP-array) was ... Read more >>

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Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis.

Xiaoqing Wu, Gulhumay Gardashova, Lan Lan, Shuang Han, Cuncong Zhong, Rebecca T Marquez, Lanjing Wei, Spencer Wood, Sudeshna Roy, Ragul Gowthaman, John Karanicolas, Fei P Gao, Dan A Dixon, Danny R Welch, Ling Li, Min Ji, Jeffrey Aubé, Liang Xu,

Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorigenesis by regulating numerous proto-oncogenes, growth ... Read more >>

Commun Biol (Communications biology)
[2020, 3(1):193]

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Radiological findings and clinical characteristics of pregnant women with COVID-19 pneumonia.

Xiaoqing Wu, Ruihong Sun, Jianpu Chen, Yuanliang Xie, Shutong Zhang, Xiang Wang,

To study chest CT images and clinical characteristics of COVID-19 pneumonia in pregnant patients to examine any correlation. Between December 31, 2019 and March 7, 2020, 23 hospitalized pregnant patients with confirmed COVID-19 were enrolled in the study. Clinical presentations were collected retrospectively from records, including laboratory testing, chest CT ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, :]

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Adaptive niche-genetic algorithm based on backpropagation neural network for atmospheric turbulence forecasting.

Changdong Su, Xiaoqing Wu, Tao Luo, Su Wu, Chun Qing,

Because systematic direct measurements of the refractive index structure constant ($C_n^2$Cn2) are not available for many climates and seasons, we developed an indirect method to forecast optical turbulence. The $C_n^2$Cn2 was estimated from a backpropagation neural network optimized by an adaptive niche-genetic algorithm. The estimated result was validated against the ... Read more >>

Appl Opt (Applied optics)
[2020, 59(12):3699-3705]

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Copy number variations associated with fetal congenital kidney malformations.

Meiying Cai, Na Lin, Linjuan Su, Xiaoqing Wu, Xiaorui Xie, Ying Li, Xuemei Chen, Yuan Lin, Hailong Huang, Liangpu Xu,

Background:Congenital anomalies of the kidney and urinary tract (CAKUT) constitute 20-30% of all congenital malformations. Within the CAKUT phenotypic spectrum, renal hypodysplasia (RHD) is particularly severe. This study aimed to evaluate the applicability of single-nucleotide polymorphism (SNP) array test in prenatal diagnosis of RHD for improving prenatal genetic counseling and ... Read more >>

Mol Cytogenet (Molecular cytogenetics)
[2020, 13:11]

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Complex Interaction of Hb Q-Thailand with α and β Thalassemia in a Hakka Family

Lin Zheng, Hailong Huang, Xiaoqing Wu, Qingmei Shen, Meihuan Chen, Meiying Wang, Linjuan Su, Liangpu Xu,

Abstract Background HbQ-Thailand is an α-globin chain variant that results from a point mutation at codon 74 of the α1-globin gene on chromosome 16p. It commonly appears with a leftward single α-globin gene deletion (-α 4.2 ). There have been few reports regarding the interaction between HbQ-Thailand and other globin ... Read more >>

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Modified NUTRIC score: a predictor for mortality in patients with septic shock-a single center retrospective study

Jiatong Hou, Wentao Liu, Yina Wu, Xiaoqing Wu, Jun Duan,

Abstract Objective to evaluate the modified NUTRIC score in identifying nutritional risk patients and predicting mortality in septic shock patients. Methods A retrospective study was performed with septic shock patients admitted to the intensive care unit (ICU) from January 2018 to December 2019. A receiver operating characteristic ... Read more >>

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Bisphenol A affects ovarian development in adolescent mice caused by genes expression change.

Fengrui Wu, Jing Zhao, Enyu Zhang, Qingqing Wu, Xiaoqing Wu, Di Zhang, Yong Liu, Rong Wang, Wenyong Li,

Many human epidemiology and animal model studies have reported that bisphenol A (BPA) exerts adverse effects on reproduction through different regulatory mechanisms and signaling pathways in adults. In recent years, the exposure risk has increased for the general population, and little is known about how BPA affects ovarian development in ... Read more >>

Gene (Gene)
[2020, 740:144535]

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Abstracts from Frontiers Research Day.

Kans J Med (Kansas journal of medicine)
[2020, 13(Suppl 2):30-60]

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Mesoscale optical turbulence simulations above Tibetan Plateau: first attempt.

Chun Qing, Xiaoqing Wu, Xuebin Li, Tao Luo, Changdong Su, Wenyue Zhu,

The vertical distributions of optical turbulence (C n2 profiles) are a major factor in defining the capabilities of ground-based telescopes and interferometers. As site-testing campaigns are extremely expensive and instruments only provide the local atmospheric parameter, atmospheric modeling might represent an advance prediction result in astronomical sites. The key meteorological ... Read more >>

Opt Express (Optics express)
[2020, 28(4):4571-4586]

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Mismatch repair status between primary colorectal tumor and metastatic tumor, a retrospective consistent study.

Zheng Wang, Xiaoli Tang, Xiaoqing Wu, Meiyuan Yang, Daorong Wang,

Objectives Mismatch repair (MMR) and Microsatellite instability (MSI) are critical when considering immunotherapy and chemotherapeutic drugs an option for patients with colorectal cancer (CRC). We investigated the consistence of MMR status as well as MSI between primary CRC and metastatic tumor to see if the expression of four MMR proteins ... Read more >>

Biosci. Rep. (Bioscience reports)
[2019, 39(12):]

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miR-125 inhibits colorectal cancer proliferation and invasion by targeting TAZ.

Meiyuan Yang, Xiaoli Tang, Zheng Wang, Xiaoqing Wu, Dong Tang, Daorong Wang,

Colorectal cancer (CRC) is the third most common malignant tumor worldwide and is a serious threat to human health. MicroRNAs (miRNAs) play a key role in oncogenesis and cancer progression. MiRNA-125 (miR-125) is an important miRNA that is dysregulated in several kinds of cancers. Thus, we investigated the expression and ... Read more >>

Biosci. Rep. (Bioscience reports)
[2019, 39(12):]

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Intra-articular Injection of Chloramphenicol Reduces Articular Cartilage Degeneration in a Rabbit Model of Osteoarthritis.

Xiaoqing Wu, Yongsong Cai, Shemin Lu, Ke Xu, Xuanren Shi, Le Yang, Zhenjian Huang, Peng Xu,

BACKGROUND:Osteoarthritis (OA) is characterized by degeneration of articular cartilage. Studies have found that enhancement of autophagy, an intracellular catabolic process, may limit the pathologic progression of OA. Chloramphenicol is a potent activator of autophagy; however, the effects of chloramphenicol on articular cartilage are unknown. QUESTIONS/PURPOSES:Using human OA knee chondrocytes in ... Read more >>

Clin. Orthop. Relat. Res. (Clinical orthopaedics and related research)
[2019, 477(12):2785-2797]

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Applicability of long-term satellite-based precipitation products for drought indices considering global warming.

Xiaoyan Bai, Wen Shen, Xiaoqing Wu, Peng Wang,

This study evaluates the applicability of using long-term satellite rainfall estimate (SRE) precipitation products in drought monitoring over mainland China under global warming conditions. Two widely used drought indices, the self-calibrating Palmer Drought Severity Index (scPDSI) and the Standardized Precipitation Evapotranspiration Index (SPEI), were selected as study cases; both indices ... Read more >>

J. Environ. Manage. (Journal of environmental management)
[2020, 255:109846]

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Chromosomal microarray analysis for pregnancies with or without ultrasound abnormalities in women of advanced maternal age.

Xiaoqing Wu, Gang An, Xiaorui Xie, Linjuan Su, Meiying Cai, Xuemei Chen, Ying Li, Na Lin, Deqin He, Meiying Wang, Hailong Huang, Liangpu Xu,

BACKGROUND:Chromosomal microarray analysis (CMA) has been suggested to be routinely conducted for fetuses with ultrasound abnormalities (UA), especially with ultrasound structural anomalies (USA). Whether to routinely offer CMA to women of advanced maternal age (AMA) without UA when undergoing invasive prenatal testing is inconclusive. OBJECTIVE:This study aimed to evaluate the ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(4):e23117]

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circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer.

Sen Wang, Dong Tang, Wei Wang, Yining Yang, Xiaoqing Wu, Liuhua Wang, Daorong Wang,

BACKGROUND:As a novel class of non-coding RNAs, circular RNAs (circRNAs) are key regulators of the development and progression of different cancers. However, little is known about the function and biological mechanism of circLMTK2, also named hsa_circ_0001725, in gastric cancer (GC) tumourigenesis. METHODS:circLMTK2 was identified in ten paired cancer specimens and ... Read more >>

Mol. Cancer (Molecular cancer)
[2019, 18(1):162]

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Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria.

Yanping Du, Xiaodong Wang, Hua Xie, Songbai Zheng, Xiaoqing Wu, Xiaoying Zhu, Xuemei Zhang, Sihong Xue, Huilin Li, Wei Hong, Wenjing Tang, Minmin Chen, Qun Cheng, Jianqin Sun,

BACKGROUND:Sarcopenia and sarcopenic obesity (SO) have a greater impact on the elderly. This study aimed to explore whether there were sex differences in the prevalence and adverse outcomes of sarcopenia and SO in community-dwelling elderly individuals in East China. METHODS:This was a cross-sectional study that enrolled 213 males and 418 ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2019, 19(1):109]

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Patient experience of treatment decision making for wet age-related macular degeneration disease: a qualitative study in China.

Wei Bian, Junli Wan, Mingqiong Tan, Xiaoqing Wu, Jun Su, Lihua Wang,

OBJECTIVES:This study aimed to investigate the experience of patients with wet age-related macular degeneration (wAMD) in treatment decision-making process. DESIGN:A descriptive qualitative study was designed by using semistructured interviews, and the data analysis was conducted with the thematic analysis approach. PARTICIPANTS AND SETTING:A convenient and purposive sample of 21 participants ... Read more >>

BMJ Open (BMJ open)
[2019, 9(9):e031020]

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Detection of copy number disorders associated with congenital anomalies of the kidney and urinary tract in fetuses via single nucleotide polymorphism arrays.

Meiying Cai, Na Lin, Linjuan Su, Xiaoqing Wu, Xiaorui Xie, Ying Li, Xuemei Chen, Yifang Dai, Yuan Lin, Hailong Huang, Liangpu Xu,

BACKGROUND:While congenital anomalies of the kidney and urinary tract (CAKUT) constitute one-third of all congenital malformations, the mechanisms underlying their development are poorly understood. Some studies have reported an association between CAKUT and copy number variations (CNVs) in children and adults, but few have focused on chromosomal microarray analysis (CMA) ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(1):e23025]

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Validation of Glacier Topographic Acquisitions from an Airborne Single-Pass Interferometer.

Delwyn Moller, Scott Hensley, Jeremie Mouginot, Joshua Willis, Xiaoqing Wu, Christopher Larsen, Eric Rignot, Ronald Muellerschoen, Ala Khazendar,

The airborne glacier and ice surface topography interferometer (GLISTIN-A) is a single-pass radar interferometer developed for accurate high-resolution swath mapping of dynamic ice surfaces. We present the first validation results of the operational sensor, collected in 2013 over glaciers in Alaska and followed by more exhaustive collections from Greenland in ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(17):]

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RNA-Binding Proteins MSI-1 (Musashi) and EXC-7 (HuR) Regulate Serotonin-Mediated Behaviors in C. elegans

Zhe Yang, Lan Lan, Xiaoqing Wu, Liang Xu, Matthew Buechner,

Abstract The evolutionarily conserved RNA-binding proteins HuR and MSI are essential for multiple developmental processes and are upregulated in many cancer tissues. The C. elegans homologues EXC-7 (HuR) and MSI-1 (MSI1 and MSI2) have been implicated in tubulogenesis, neural development, and specific behaviors that include male tail-curling to maintain contact ... Read more >>

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A non-intrusive evaluation method for tumor-targeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging.

Hao Liu, Rebecca T Marquez, Xiaoqing Wu, Ke Li, Shweta Vadlamani, Song Li, Ya Wang, Liang Xu, Daocheng Wu,

We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2019, 7(31):4751-4757]

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Submicroscopic aberrations of chromosome 16 in prenatal diagnosis.

Xiaoqing Wu, Liangpu Xu, Ying Li, Na Lin, Linjuan Su, Meiying Cai, Xiaorui Xie, Lin Zheng, Hailong Huang, Yuan Lin,

Background:Nearly 9.89% of chromosome 16 consists of segmental duplications, which makes it prone to non-homologous recombination. The present study aimed to investigate the incidence and perinatal characteristics of submicroscopic chromosome 16 aberrations in prenatal diagnosis. Results:A total of 2,414 consecutive fetuses that underwent prenatal chromosomal microarray analysis (CMA) between January ... Read more >>

Mol Cytogenet (Molecular cytogenetics)
[2019, 12:36]

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Bone metastases at initial diagnosed breast cancer — A retrospective study based on SEER database

Zheng Wang, Xiaoli Tang, Qi Zhang, Xiaoqing Wu, Meiyuan Yang, Zhixiang Jin, Daorong Wang,

Abstract Background To explore the features of incidence proportions and long-term survivals of breast cancer patients with bone metastasis when first diagnosed. Methods Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. Stratifications were made according to molecular subtype, ... Read more >>

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MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1.

Xiaoli Tang, Meiyuan Yang, Zheng Wang, Xiaoqing Wu, Daorong Wang,

The functional role of microRNA-23a in tumorigenesis has been investigated; however, the exact mechanism of microRNA-23a (miR-23a) in colorectal cancer development has not been fully explored. In the present study, we aimed to investigate the molecular functional role of miR-23a in colorectal carcinogenesis. Quantitative real-time polymerase chain reaction was conducted ... Read more >>

Acta Biochim. Biophys. Sin. (Shanghai) (Acta biochimica et biophysica Sinica)
[2019, 51(7):661-668]

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