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Author Xiaoping Zhang

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Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats.

Shuping Sun, Shengli Li, Yunyan Du, Chenguang Wu, Mengyuan Zhang, Jiarong Li, Xiaoping Zhang,

Context: Chloranthus serratus [(Thunb.) Roem. et Schult, (Chloranthaceae)] is a folk medicine used for the treatment of rheumatoid arthritis.Objective: The aim of this study was to investigate anti-arthritic effects of the ethanol extracts of the roots (ER), stems (ES) and leaves (EL) of C. serratus on adjuvant arthritis rats and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):528-537]

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Protective effect of Bacillus amyloliquefaciens against Salmonella via polarizing macrophages to M1 phenotype directly and to M2 depended on microbiota.

Aikun Fu, Qiufen Mo, Yanping Wu, Baikui Wang, Rongrong Liu, Li Tang, Zhonghua Zeng, Xiaoping Zhang, Weifen Li,

Bacillus amyloliquefaciens SC06 (BaSC06), a potential probiotic, plays a positive role in animal growth performance and immune function. The aim of the present study was to investigate the protective effect of BaSC06 against Salmonella infection and its association with macrophage polarization. C57BL/6 mice were fed with or without a BaSC06-containing ... Read more >>

Food Funct (Food & function)
[2019, 10(12):7653-7666]

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Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrants

Jing Guo, Xiaoping Zhang, Aarti Saiganesh, Christopher Peacock, Shu Chen, Gary Dykes, Belinda Hales, Peter Le Souëf, Guicheng(Brad) Zhang,

Abstract Background: Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese immigrants, which fails to prime the immune system. Here, we investigated how differences in composition of oropharyngeal microbiome ... Read more >>

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Correction to: Phase 3 Multicenter Study of Revusiran in Patients with Hereditary Transthyretin-Mediated (hATTR) Amyloidosis with Cardiomyopathy (ENDEAVOUR).

Daniel P Judge, Arnt V Kristen, Martha Grogan, Mathew S Maurer, Rodney H Falk, Mazen Hanna, Julian Gillmore, Pushkal Garg, Akshay K Vaishnaw, Jamie Harrop, Christine Powell, Verena Karsten, Xiaoping Zhang, Marianne T Sweetser, John Vest, Philip N Hawkins,

The original article contained incorrect terminology for one of the cardiac measures; throughout the manuscript and supplementary information 'intraventricular septum wall thickness' should have been given as 'interventricular septum wall thickness'. Corrections should also be noted for Tables 1 and 4: in the Table 1 legend 'Low risk - Neither ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2020, :]

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TUG1 enhances high gluose impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling

Yang Li, Kangkang Zhi, Shilong Han, Xue Li, Maoquan Li, Weishuai Lian, Haijun Zhang, Xiaoping Zhang,

Abstract Background Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. LncRNA plays an essential role in microvascular dysfunction and signaling pathways in patients with diabetes. LncRNA taurine upregulated gene 1 ... Read more >>

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Changes in soil microbial communities at Jinsha earthen site are associated with earthen site deterioration

Jing Li, Xiaoyue Zhang, Lin Xiao, Ke Liu, Yue Li, Ziwei Zhang, Qiang Chen, Xiaolin Ao, Decong Liao, Yunfu Gu, Menggen Ma, Xiumei Yu, Quanju Xiang, Ji Chen, Xiaoping Zhang, Tao Yang, Petri Penttinen, Ke Zhao,

Abstract Background: Earthen sites are immobile cultural relics and an important part of cultural heritage with historical, artistic and scientific values. The deterioration of features in earthen sites result in permanent loss of cultural information, causing immeasurable damage to the study of history and culture. Most research on the deterioration ... Read more >>

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Epidemiology of varicella and effectiveness of varicella vaccine in Hangzhou, China, 2019.

Yuyang Xu, Yan Liu, Xiaoping Zhang, Xuechao Zhang, Jian Du, Yuxin Cai, Jun Wang, Xinren Che, Wenwen Gu, Wei Jiang, Junfang Chen,

BACKGROUND:The varicella vaccine (VarV) is not included in the national childhood immunization schedules in China, although 2-dose VarV (VarV2) were recommended for children at 1 and 4 years of age in Hangzhou since 2014. However, the reported incremental vaccine effectiveness (VE) of VarV2 varies widely among studies. We described the epidemiological ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2020, :1-6]

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Vaccination pattern of the 23-valent pneumococcal polysaccharide vaccine (PPV23) in Hangzhou, China: a coverage and adverse events following immunization of different age groups.

Yan Liu, Yuyang Xu, Jun Wang, Xinren Che, Wenwen Gu, Jian Du, Xiaoping Zhang, Xuechao Zhang, Wei Jiang, Junfang Chen, Zhijie An,

BACKGROUND:23-valent pneumococcal polysaccharide vaccine (PPSV23) has been used to prevent pneumococcal disease, and PPSV23 became available in 2003 in Hangzhou, China as a private-sector, vaccinee-chosen vaccine. No national guidelines for PPSV23 have been developed. We analyzed PPSV23 coverage and utilization in Hangzhou to determine patterns of PPSV23 use and the ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2020, :1-5]

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Pivotal biomarker expression and drug screening in advanced ccRCC.

Wen Xiao, Ke Chen, Xiaoping Zhang,

Clin Transl Med (Clinical and translational medicine)
[2020, :]

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Knockdown of H19 Inhibits the Pathogenesis of Acne Vulgaris by Targeting the miR-196a/TLR2/NF-κB Axis.

Shuyun Yang, Fumin Fang, Xiuqin Yu, Changzhi Yang, Xiaoping Zhang, Lu Wang, Liping Zhu, Kai Shao, Tingting Zhu,

Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit, and Propionibacterium acnes (P. acnes) has been implicated in acne inflammation. Numerous studies have shown that non-coding RNAs play important roles in regulating the pathophysiological processes of acne. In addition, the first imprinted long non-coding RNA (lncRNA) identified, ... Read more >>

Inflammation (Inflammation)
[2020, :]

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Changes in soil microbial communities at Jinsha earthen site are associated with earthen site deterioration.

Jing Li, Xiaoyue Zhang, Lin Xiao, Ke Liu, Yue Li, Ziwei Zhang, Qiang Chen, Xiaolin Ao, Decong Liao, Yunfu Gu, Menggen Ma, Xiumei Yu, Quanju Xiang, Ji Chen, Xiaoping Zhang, Tao Yang, Petri Penttinen, Ke Zhao,

BACKGROUND:Earthen sites are immobile cultural relics and an important part of cultural heritage with historical, artistic and scientific values. The deterioration of features in earthen sites result in permanent loss of cultural information, causing immeasurable damage to the study of history and culture. Most research on the deterioration of earthen ... Read more >>

BMC Microbiol. (BMC microbiology)
[2020, 20(1):147]

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Colonization by Tuber melanosporum and Tuber indicum affects the growth of Pinus armandii and phoD alkaline phosphatase encoding bacterial community in the rhizosphere.

Xiaoping Zhang, Xiaolin Li, Lei Ye, Yue Huang, Zongjing Kang, Bo Zhang, Xiaoping Zhang,

The synthesis of truffle ectomycorrhizae and the ecology of truffle-colonized seedlings in the early symbiotic stage are important for the successful truffle cultivation. In this study, two black truffle species, Tuber melanosporum and Tuber indicum, were selected to colonize Pinus armandii seedlings. 2, 4, 6 and 8 months after inoculation, ... Read more >>

Microbiol. Res. (Microbiological research)
[2020, 239:126520]

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Phase 3 Multicenter Study of Revusiran in Patients with Hereditary Transthyretin-Mediated (hATTR) Amyloidosis with Cardiomyopathy (ENDEAVOUR).

Daniel P Judge, Arnt V Kristen, Martha Grogan, Mathew S Maurer, Rodney H Falk, Mazen Hanna, Julian Gillmore, Pushkal Garg, Akshay K Vaishnaw, Jamie Harrop, Christine Powell, Verena Karsten, Xiaoping Zhang, Marianne T Sweetser, John Vest, Philip N Hawkins,

PURPOSE:The Phase 3 ENDEAVOUR study evaluated revusiran, an investigational RNA interference therapeutic targeting hepatic transthyretin (TTR) production, for treating cardiomyopathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis. METHODS:Patients with hATTR amyloidosis with cardiomyopathy were randomized 2:1 to receive subcutaneous daily revusiran 500 mg (n = 140) or placebo (n = 66) for 5 days over a week ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2020, 34(3):357-370]

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RNA-seq Profiling Showed Divergent Carbohydrate-Active Enzymes (CAZymes) Expression Patterns in Lentinula edodes at Brown Film Formation Stage Under Blue Light Induction.

Xiying Huang, Runji Zhang, Yijie Qiu, Haibing Wu, Quanju Xiang, Xiumei Yu, Ke Zhao, Xiaoping Zhang, Qiang Chen, Petri Penttinen, Yunfu Gu,

Lentinula edodes (shiitake mushroom) is one of the most important edible mushrooms worldwide. The L. edodes cultivation cycle includes a unique developing stage called brown film formation that directly affects the development of primordium and the quality of fruiting body. Brown film formation is induced by light, especially blue light. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1044]

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Seroepidemiology of tetanus in Hangzhou from 2009 to 2018.

Yuyang Xu, Yan Liu, Jian Du, Wei Zheng, Shijun Liu, Xuechao Zhang, Xiaoping Zhang, Jun Wang, Xinren Che, Wenwen Gu, Wei Jiang,

OBJECTIVE:The seroepidemiologic study aimed to delineate the immune status against tetanus in Hangzhou and its influential factors to provide evidence on strategies for tetanus prevention. METHODS:We used a multi-stage stratified random sampling method to recruit participants from several Community Health Centers in Hangzhou during 2009-2018. Demographic data and vaccination histories ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2020, :1-7]

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Unfavorable outcomes in pregnant patients with COVID-19.

Wenhui Huang, Zhiwei Zhao, Zicong He, Shuyi Liu, Qingxia Wu, Xiaoping Zhang, Xiaoming Qiu, Huanchu Yuan, Ke Yang, Xiaomei Tang, Shuixing Zhang,

J. Infect. (The Journal of infection)
[2020, :]

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Efficacy of Eutectic Mixture of Local Anesthetics on Pain Control During Extracorporeal Shock Wave Lithotripsy: A Systematic Review and Meta-Analysis.

Yu Huang, Shuaishuai Chai, Decai Wang, Wencheng Li, Xiaoping Zhang,

BACKGROUND The efficacy of a eutectic mixture of local anesthetics (EMLA) for pain control in extracorporeal shock wave lithotripsy is unclear. The aim of this study was to assess the effect of EMLA cream on pain control during extracorporeal shock wave lithotripsy. MATERIAL AND METHODS We searched Medline, EMBASE, and ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921063]

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Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway.

Yuanyuan Zheng, Chuanyong Guo, Xiaoping Zhang, Xiaoli Wang, A'Huo Ma,

Gastric cancer (GC) is one of the most common malignancies worldwide; however, treatment options other than surgery remain limited. Neoadjuvant chemotherapy has the potential to suppress of gastric tumorigenesis. Garcinol has been reported to exert inhibitory effects on the progression of numerous carcinomas. However, its effects in GC remain unclear. ... Read more >>

Oncol Lett (Oncology letters)
[2020, 20(1):667-676]

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No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019.

Feng Pan, Xingyuan Xiao, Jingtao Guo, Yarong Song, Honggang Li, Darshan P Patel, Adam M Spivak, Joseph P Alukal, Xiaoping Zhang, Chengliang Xiong, Philip S Li, James M Hotaling,

OBJECTIVE:To describe detection of severe acute respiratory syndrome (SARS)-coronavirus 2 (CoV-2) in seminal fluid of patients recovering from coronavirus disease 2019 (COVID-19) and to describe the expression profile of angiotensin-converting enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) within the testicle. DESIGN:Observational, cross-sectional study. SETTING:Tertiary referral center. PATIENT(S):Thirty-four adult ... Read more >>

Fertil. Steril. (Fertility and sterility)
[2020, 113(6):1135-1139]

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Cellular Analysis and Comparative Transcriptomics Reveal the Tolerance Mechanisms of Candida tropicalis Toward Phenol.

Hanyu Wang, Qian Li, Yuanyuan Peng, Zhengyue Zhang, Xiaolin Kuang, Xiangdong Hu, Ellen Ayepa, Xuebing Han, Getachew Tafere Abrha, Quanju Xiang, Xiumei Yu, Ke Zhao, Likou Zou, Yunfu Gu, Xi Li, Xiaoying Li, Qiang Chen, Xiaoping Zhang, Beidong Liu, Menggen Ma,

Phenol is a ubiquitous pollutant and can contaminate natural water resources. Hence, the removal of phenol from wastewater is of significant importance. A series of biological methods were used to remove phenol based on the natural ability of microorganisms to degrade phenol, but the tolerance mechanism of phenol-degraded strains to ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:544]

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Complete genome sequence data of multidrug-resistant Stenotrophomonas sp. strain SXG-1.

Xiaoping Zhang, Baodi Shang, Xiaoyi Li, Zhengyou Li, Sha Tao,

Objectives A multidrug-resistant bacterium, Stenotrophomonas sp. SXG-1, was isolated from the liver of diseased hybrid sturgeon from Guizhou province, China. Methods Whole-genome sequencing was performed on the Illumina HiSeq 2500-PE125 platform with MPS (massively parallel sequencing) Illumina technology. All good quality paired reads were assembled using the SOAPdenovo into a ... Read more >>

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2020, 22:206-209]

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Clinical and immunological features of severe and moderate coronavirus disease 2019.

Guang Chen, Di Wu, Wei Guo, Yong Cao, Da Huang, Hongwu Wang, Tao Wang, Xiaoyun Zhang, Huilong Chen, Haijing Yu, Xiaoping Zhang, Minxia Zhang, Shiji Wu, Jianxin Song, Tao Chen, Meifang Han, Shusheng Li, Xiaoping Luo, Jianping Zhao, Qin Ning,

BACKGROUNDSince December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODSIn this retrospective study, the clinical and immunological ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(5):2620-2629]

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Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury.

Yingchuan Li, Yongmei Cao, Jian Xiao, Jiawei Shang, Qin Tan, Feng Ping, Weifeng Huang, Fang Wu, Haijun Zhang, Xiaoping Zhang,

Acute lung injury (ALI) is a life-threatening disorder with high rates of morbidity and mortality. Reactive oxygen species and epithelial apoptosis are involved in the pathogenesis of acute lung injury. Ferroptosis, an iron-dependent non-apoptotic form of cell death, mediates its effects in part by promoting the accumulation of reactive oxygen ... Read more >>

Cell Death Differ. (Cell death and differentiation)
[2020, :]

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AgInS2 and graphene co-sensitized TiO2 photoanodes for photocathodic protection of Q235 carbon steel under visible light.

Hong Li, Weizhe Song, Xingqiang Cui, Yanhui Li, Baorong Hou, Xiaoping Zhang, Yuqi Wang, Lianjun Cheng, Pengfei Zhang, Junru Li,

AgInS2 nanoparticle and graphene nanosheet co-sensitized anatase TiO2 nanotube array films were fabricated by a combination of hydrothermal reaction and electrochemical anodization on titanium sheets. The results showed that the co-sensitization of AgInS2 nanoparticles and graphene nanosheets extended the photoresponse of TiO2 nanotubes into the visible-light region, and improved the ... Read more >>

Nanotechnology (Nanotechnology)
[2020, 31(30):305704]

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Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Bin Zhang, Shuyi Liu, Tan Tan, Wenhui Huang, Yuhao Dong, Luyan Chen, Qiuying Chen, Lu Zhang, Qingyang Zhong, Xiaoping Zhang, Yujian Zou, Shuixing Zhang,

As of March 24, 2020, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for 379,661 infection cases with 16,428 deaths globally, and the number is still increasing rapidly. Herein, we present four critically ill patients with SARS-CoV-2 infection who received supportive care and convalescent plasma. Although all ... Read more >>

Chest (Chest)
[2020, :]

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