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Author Xiaoping Li

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A Bi-Objective Constrained Robust Gate Assignment Problem: Formulation, Instances and Algorithm.

Xinye Cai, Wenxue Sun, Mustafa Misir, Kay Chen Tan, Xiaoping Li, Tao Xu, Zhun Fan,

The gate assignment problem (GAP) aims at assigning gates to aircraft considering operational efficiency of airport and satisfaction of passengers. Unlike the existing works, we model the GAP as a bi-objective constrained optimization problem. The total walking distance of passengers and the total robust cost of the gate assignment are ... Read more >>

IEEE Trans Cybern (IEEE transactions on cybernetics)
[2021, 51(9):4488-4500]

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FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis

Hailong Li, Jin He, Ruotong Zhang, Yiying Wei, Shanshan Zhang, Xuefen Chen, Xiaoping Li, Rui Yu, Xiaohe Li, Xianfeng Zhang, Cheng Yang, Honggang Zhou,

Forkhead box protein O3 (FOXO3) has good inhibition ability toward fibroblast activation and extracellular matrix, especially for the treatment of idiopathic pulmonary fibrosis. How FOXO3 regulates pulmonary fibrosis remains unclear. In this study, we reported that FOXO3 had binding sequences with F-spondin 1 (SPON1) promoter, which can activate its transcription ... Read more >>

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Refractive index modulation in magnetophoresis of bioreaction induced self-assembled magnetic fluid.

Rende Ma, Xiaoping Li, Hongzhong Cao, Wendi Wu, Zhongxiao Man, Yunjie Xia,

We explore the refractive index (RI) modulation of bioreaction induced self-assembled magnetic fluid (SAMF) so as to facilitate the design of sensitive biosensors. Bovine serum albumin (BSA) is taken as a model protein to induce self-assembly of carboxylated magnetic nanoparticles (MNPs). A bidirectional magnetophoresis (BDMP) system is designed to generate ... Read more >>

Opt Lett (Optics letters)
[2021, 46(18):4658-4661]

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Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study.

Lin Zhang, Liu Yang, Congzhi Wang, Ting Yuan, Dongmei Zhang, Huanhuan Wei, Jing Li, Yunxiao Lei, Lu Sun, Xiaoping Li, Ying Hua, Hengying Che, Yuanzhen Li,

<h4>Background</h4>Malnutrition in early life may affect health in later life. The associations between malnutrition and serum uric acid (SUA) and hypertension were inconsistent. The present study aimed to investigate the individual and combined association between famine exposure and serum uric acid and hypertension in middle-aged and older Chinese.<h4>Methods</h4>Data were selected ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):420]

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Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice.

Xiaohe Li, Rui Liu, Yunyao Cui, Jingjing Liang, Zhun Bi, Shimeng Li, Yang Miao, Liang Zhang, Xiaoping Li, Honggang Zhou, Cheng Yang,

Pulmonary fibrosis is a known sequela of severe or persistent lung damage. Existing clinical, imaging and autopsy studies have shown that the lungs exhibit a pathological pulmonary fibrosis phenotype after infection with coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pulmonary fibrosis may be one of the most serious ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:692346]

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Characterization of the complete chloroplast genome of Salix linearistipularis (Franch.) Hao 1936.

Rongrong Ren, Xiaoping Li,

We characterized the complete chloroplast genome of a perennial woody plant species, <i>Salix linearistipularis</i>, based on high-throughput sequencing and <i>de novo</i> assembly technology for the first time. The complete chloroplast genome of <i>S. linearistipularis</i> is 155,564 bp in length, comprising one large single-copy region (LSC, 84,460 bp), one small single-copy region (SSC, ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[2021, 6(9):2764-2766]

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Capabilities and limitations of using DNA metabarcoding to study plant-pollinator interactions.

Katherine A Arstingstall, Sandra J DeBano, Xiaoping Li, David E Wooster, Mary M Rowland, Skyler Burrows, Kenneth Frost,

Many pollinator populations are experiencing declines, emphasizing the need for a better understanding of the complex relationship between bees and flowering plants. Using DNA metabarcoding to describe plant-pollinator interactions eliminates many challenges associated with traditional methods and has the potential to reveal a more comprehensive understanding of foraging behaviour and ... Read more >>

Mol Ecol (Molecular ecology)
[2021, :]

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The Correlation Between Nutrition and Frailty and the Predictive Value of Different Nutritional Indexes for Frailty

Hong Liang, Xiaoping Li, Xiaoye Lin, Yanmin Ju, Jiyan Leng,

<h4>Background: </h4> Frailty is a kind of geriatric syndrome, which is very common in the elderly. Patients with malnutrition are at higher risk of frailty. This study analyzes the risk factors of frailty and the predictive value of different indicators for the occurrence of frailty through a cross-sectional study. <h4>Results: ... Read more >>

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Zanubrutinib Attenuated Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-β1 Signaling Pathway

Xiaohe Li, Yuli Wei, Jinying Gu, Jingjing Liang, Shimeng Li, Yunyao Cui, Rui Liu, Xiaoping Li, Cheng Yang, Honggang Zhou,

<h4>Background: </h4> Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal interstitial lung disease with high mortality and limited treatment. So far, the only drugs approved for the treatment of IPF are Nintedanib and Pirfenidone. Zanubrutinib, a BTK small molecule inhibitor, is approved for the treatment of mantle cell ... Read more >>

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Characterization of the complete chloroplast genome of Salix gordejevii (Salicaceae).

Yinghao Wei, Xiaoping Li,

<i>Salix gordejevii</i> is an endemic species in northern China. The analysis of the complete chloroplast genome of <i>S. gordejevii</i> can offer a referential basis for identifying and utilizing <i>Salix</i> germplasm resources. In this study, we obtained chloroplast DNA from <i>S. gordejevii</i> and characterized it. The complete chloroplast genome of <i>S. ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[2021, 6(9):2510-2512]

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Physicochemical and in vitro digestibility properties on complexes of fermented wheat starches with konjac gum.

Xin Fan, Xiaoping Li, Jingwei Hu, Zhiyuan Cheng, Xiaolong Wang, Xinzhong Hu,

In this study, the wheat starch with natural fermentation for 72 h was combined with konjac gum (KGM) at different concentrations (0, 0.1, 0.3, 0.5%, w/w), and the changes in physicochemical and digestible characteristics of the complexes were investigated. The results showed that KGM clumped fermented starch (FS) granules together and ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 188:197-206]

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Efficacy of a Modified Training Program of Adaptive Biofeedback Therapy for Dyssynergic Defecation in Patients with Chronic Constipation.

Yuemei Xu, Xiaoping Li, Feizhen Xia, Feng Xu, Jiande D Z Chen,

<h4>Background</h4>Biofeedback therapy is highly effective and safe in treating dyssynergic defecation, which affects more than half of patients with chronic constipation. However, conventional biofeedback training has limitations.<h4>Aims</h4>This study aims to modify the adaptive biofeedback (ABF) previously established by the investigators and evaluate its efficacy for dyssynergic defecation.<h4>Methods</h4>A total of 42 ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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A more pronounced effect of type III resistant starch vs. type II resistant starch on ameliorating hyperlipidemia in high fat diet-fed mice is associated with its supramolecular structural characteristics.

Jiangbin Xu, Zhen Ma, Xiaoping Li, Liu Liu, Xinzhong Hu,

The anti-obesity effects of two categories of resistant starch (RS) including RS<sub>2</sub> (isolated from untreated lentil starch, URS) and RS<sub>3</sub> (isolated from autoclaved and retrograded lentil starch, ARS) on mice with high-fat (HF) diet-induced obesity and the supramolecular structure-in vivo physiological functionality relationship of RS were investigated. Following 6 consecutive ... Read more >>

Food Funct (Food & function)
[2020, 11(3):1982-1995]

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Beta-1 syntrophin (SNTB1) regulates colorectal cancer progression and stemness via regulation of the Wnt/β-catenin signaling pathway.

Yanfang Liang, Bin Wang, Shasha Chen, Ziyu Ye, Xingxing Chai, Ronggang Li, Xiaoping Li, Gang Kong, Yanyun Li, Xueying Zhang, Zhengping Che, Qi Xie, Jiachun Lian, Bihua Lin, Xin Zhang, Xueqin Huang, Weijuan Huang, Xianxiu Qiu, Jincheng Zeng,

<h4>Background</h4>Beta-1 syntrophin (SNTB1) is an intracellular scaffold protein that provides a platform for the formation of signal transduction complexes, thereby modulating and coordinating various intracellular signaling events and crucial cellular processes. However, the physiological role of SNTB1 is poorly understood. This study aims to explore the role of SNTB1 in ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(12):1016]

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Deinococcus radiodurans UWO298 Dependence on Background Radiation for Optimal Growth.

Hugo Castillo, Xiaoping Li, Geoffrey B Smith,

Ionizing radiation is a major environmental variable for cells on Earth, and so organisms have adapted to either prevent or to repair damages caused by it, primarily from the appearance and accumulation of reactive oxygen species (ROS). In this study, we measured the differential gene expression in <i>Deinococcus radiodurans UWO298</i> ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:644292]

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Comparative analysis of plastomes in Oxalidaceae: Phylogenetic relationships and potential molecular markers.

Xiaoping Li, Yamei Zhao, Xiongde Tu, Chengru Li, Yating Zhu, Hui Zhong, Zhong-Jian Liu, Shasha Wu, Junwen Zhai,

The wood sorrel family, Oxalidaceae, is mainly composed of annual or perennial herbs, a few shrubs, and trees distributed from temperate to tropical zones. Members of Oxalidaceae are of high medicinal, ornamental, and economic value. Despite the rich diversity and value of Oxalidaceae, few molecular markers or plastomes are available ... Read more >>

Plant Divers (Plant diversity)
[2021, 43(4):281-291]

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In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers.

Menglong Chen, Hui Shi, Shixue Gou, Xiaomin Wang, Lei Li, Qin Jin, Han Wu, Huili Zhang, Yaqin Li, Liang Wang, Huan Li, Jinfu Lin, Wenjing Guo, Zhiwu Jiang, Xiaoyu Yang, Anding Xu, Yuling Zhu, Cheng Zhang, Liangxue Lai, Xiaoping Li,

<h4>Background</h4>Mutations in the DMD gene encoding dystrophin-a critical structural element in muscle cells-cause Duchenne muscular dystrophy (DMD), which is the most common fatal genetic disease. Clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing is a promising strategy for permanently curing DMD.<h4>Methods</h4>In this study, we developed a novel strategy for ... Read more >>

Genome Med (Genome medicine)
[2021, 13(1):57]

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A ten-gene methylation signature as a novel biomarker for improving prediction of prognosis and indicating gene targets in endometrial cancer.

Xingchen Li, Xiao Yang, Yuan Fan, Yuan Cheng, Yangyang Dong, Jingyi Zhou, Zhiqi Wang, Xiaoping Li, Jianliu Wang,

Endometrial cancer (EC) is a common female reproductive tumor worldwide. Nonetheless, the pathogenesis of EC still remains ambiguous and associated epigenetic mechanism still to be explored. The goal of this study is to investigate whether gene methylation signature is associated with overall survival (OS) for EC patients. In this study, ... Read more >>

Genomics (Genomics)
[2021, 113(4):2032-2044]

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The impact of the spatial agglomeration of foreign direct investment on green total factor productivity of Chinese cities.

Dongsheng Yu, Xiaoping Li, Juanjuan Yu, Hui Li,

Based on data of 285 Chinese cities from 2003 to 2017, this paper mainly studies the impact of the spatial agglomeration of Foreign direct investment (FDI) on the green total factor productivity(TFP) of Chinese cities by SDM model. It is measured that China's urban green TFP generally has been developing ... Read more >>

J Environ Manage (Journal of environmental management)
[2021, 290:112666]

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The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population.

Li Zhang, Xiaoping Li, Jiang Lu, Yi Qian, Tao Qian, Xing Wu, Qinghua Xu,

<h4>Background</h4>Previous studies have shown that epidermal growth factor receptor (EGFR) promotes cell proliferation through the PI3K-Akt-mTOR signaling pathway and participates in the occurrence and development of hepatocellular carcinoma (HCC). Here, we focused on the functional polymorphism of EGFR in the 3'-untranslated region (UTR), aiming to reveal the potential mechanisms by ... Read more >>

Pharmgenomics Pers Med (Pharmacogenomics and personalized medicine)
[2021, 14:469-476]

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Early risk factors for extrapulmonary organ injury in adult COVID-19 patients.

Fang Huang, Wenxia Ma, Hui Zheng, Yan Ye, Hui Chen, Nan Su, Xiaoping Li, Xinyue Li, Yuyu Wang, Jun Jin, Zhengyuan Yu, Yongsheng Li, Jun Wang,

<h4>Background</h4>The novel 2019 coronavirus (COVID-19) has caused a global pandemic, and often leads to extrapulmonary organ injury. However, the risk factors for extrapulmonary organ injury are still unclear. We aim to explore the risk factors for extrapulmonary organ injury and the association between extrapulmonary organ injury and the prognosis in ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(8):701]

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Comprehensive screen the lead and other toxic metals in total environment from a coal-gas industrial city (NW, China): Based on integrated source-specific risks and site-specific blood lead levels of 0-6 aged children.

Yuhan Cao, Xiaoping Li, Feng He, Xuemeng Sun, Xu Zhang, Tao Yang, Jie Dong, Yu Gao, Qishang Zhou, Danqian Shi, Jiwen Wang, Hongtao Yu,

A new integrated source-specific risk model and site-specific blood lead levels (BLLs) of 0-6 children were introduced to comprehensive understand the status of the toxic metals in soil-dust-plant total environment from a Coal-Gas industrial city, NW China. 144 samples were collected and ten toxic metals (As, Ba, Co, Cr, Cu, ... Read more >>

Chemosphere (Chemosphere)
[2021, 278:130416]

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Integrative analyses identify potential key genes and pathways in Keshan disease using whole-exome sequencing

Jichang Huang, Chenqing Zheng, Rong Luo, Mingjiang Liu, Qingquan Gu, Jinshu Li, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

Keshan disease (KD), an endemic heart disease with multifocal necrosis and replacement fibrosis of the myocardium,is still a nightmare situation for human health. However, molecular mechanism in the pathogenesis of KD remains unclear. Herein, blood samples were collected from 68 KD patients and 100 controls, and we systematically analyzed mutation ... Read more >>

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Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway.

Xiaohe Li, Kai Huang, Xiaowei Liu, Hao Ruan, Ling Ma, Jingjing Liang, Yunyao Cui, Yanhua Wang, Shuyang Wu, Hailong Li, Yuli Wei, Zeping Li, Jingjing Gao, Bo Yang, Xiaoping Li, Guang Yang, Honggang Zhou, Cheng Yang,

Idiopathic pulmonary fibrosis is a progressive lung disease with high mortality and limited therapy that is characterized by epithelial cell damage and fibroblast activation. Ellagic acid is a natural polyphenol compound widely found in fruits and nuts that has multiple pharmacological activities. In this study, we explored the potential effects ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:639574]

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Development and validation of predictive model for lymph node metastasis in endometrial cancer: a SEER analysis.

Xingchen Li, Yuan Cheng, Yangyang Dong, Jingyi Zhou, Zhiqi Wang, Xiaoping Li, Jianliu Wang,

<h4>Background</h4>The purpose of this study was to develop a nomogram that can be used to predict lymph node metastasis (LNM) in patients with endometrial cancer (EC).<h4>Methods</h4>The clinical data of EC patients diagnosed between 2004 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results Program (SEER) registry. The nomogram ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(7):538]

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