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Author Xiaomei Sun

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Ultrasensitive detection of prostate specific antigen using a personal glucose meter based on DNA-mediated immunoreaction.

Feifei Sun, Xiaomei Sun, Yijing Jia, Zhian Hu, Shenghao Xu, Lin Li, Na Na, Jin Ouyang,

With the increase in cancer risk, early immunodiagnosis is of great significance for timely therapy. In this work, a DNA-mediated immunosensor for the highly sensitive detection of prostate specific antigen (PSA) is proposed, which is mainly based on a portable personal glucose meter (PGM). Gold nanoparticles (AuNPs) functionalized with PSA ... Read more >>

Analyst (The Analyst)
[2019, 144(20):6019-6024]

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WGCNA analysis of the subcutaneous fat transcriptome in a novel tree shrew model.

Yuanyuan Han, Wenguang Wang, Jie Jia, Xiaomei Sun, Dexuan Kuang, Pinfen Tong, Na Li, Caixia Lu, Huatang Zhang, Jiejie Dai,

Exp. Biol. Med. (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2020, :1535370220915180]

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First Report of an Alternaria alternata Isolate That Causes Leaf Spot Disease on Ilex crenata var. convexa in China

Chunlin Song, Jinguang Huang, Xiaomei Sun, Yanxiang Zhao,

Ilex crenata var. convexa is an evergreen, obtuse-toothed, and cultivated shrub belonging to the Ilex family and is often used as a ground cover or hedge in landscape greening and as a potted plant. In three surveys conducted in 2019 in Qingdao city, Shandong Province, China, many I. crenata var. ... Read more >>

Plant Dis. (Plant disease)
[2020, 104(3):979]

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Comparative genomic analysis of Proteus spp. isolated from tree shrews indicated unexpectedly high genetic diversity.

Wenpeng Gu, Wenguang Wang, Pinfen Tong, Chenxiu Liu, Jie Jia, Caixia Lu, Yuanyuan Han, Xiaomei Sun, Dexuan Kuang, Na Li, Jiejie Dai,

Proteus spp. are commensal gastrointestinal bacteria in many hosts, but information regarding the mutual relationships between these bacteria and their hosts is limited. The tree shrew is an alternative laboratory animal widely used for human disease research. However, little is known about the relationship between Proteus spp. and tree shrews. ... Read more >>

PLoS ONE (PloS one)
[2020, 15(2):e0229125]

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mRNA profiling reveals response regulators of decreased fungal keratitis symptoms in a tree shrew model.

Jie Jia, WenGuang Wang, DeXuan Kuang, CaiXia Lu, Na Li, PinFen Tong, YuanYuan Han, XiaoMei Sun, JieJie Dai,

Fungal keratitis is a corneal disease with a high blindness rate caused by pathogenic fungal infections. The pathogenesis of fungal keratitis and the immune response after fungal infection are still unclear. Notably, the pathological features of fungal keratitis in tree shrews are similar to those in humans. In the present ... Read more >>

Gene (Gene)
[2020, 737:144450]

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Effects of mixed-species litter on bacterial and fungal lignocellulose degradation functions during litter decomposition

Wenbo Wang, Dongsheng Chen, Heribert Insam, Roger T Koide, Xiaomei Sun, Qian Zhang, Shougong Zhang,

Lignocellulose is the main component of forest litter. Due to the recalcitrance of coniferous litter, nutrient turnover is usually slower in coniferous plantations. Lignocellulose decomposition is reportedly rapid in mixed-species litter, but the underlying microbial metabolic pathways that may explain this rapid rate are not well-studied. We collected litter at ... Read more >>

Soil Biol. Biochem. (Soil biology & biochemistry)
[2020, 141:Not Available]

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Crystallographic analysis of Eisenia hydrolysis-enhancing protein using a long wavelength for native-SAD phasing.

Xiaomei Sun, Yuxin Ye, Naofumi Sakurai, Koji Kato, Keizo Yuasa, Akihiko Tsuji, Min Yao,

Eisenia hydrolysis-enhancing protein (EHEP), which is a novel protein that has been identified in Aplysia kurodai, protects β-glucosidases from phlorotannin inhibition to facilitate the production of glucose from the laminarin abundant in brown algae. Hence, EHEP has attracted attention for its potential applications in producing biofuel from brown algae. In ... Read more >>

Acta Crystallogr F Struct Biol Commun (Acta crystallographica. Section F, Structural biology communications)
[2020, 76(Pt 1):20-24]

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Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4.

Xian Lin, Shiman Yu, Peilei Ren, Xiaomei Sun, Meilin Jin,

Influenza A virus (IAV) has evolved multiple mechanisms to compromise type I interferon (IFN) responses. The antiviral function of IFN is mainly exerted by activating the JAK/STAT signalling and subsequently inducing IFN-stimulated gene (ISG) production. However, the mechanism by which IAV combat the type I IFN signalling pathway is not ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2020, 22(5):e13150]

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TKP, a serine protease extracted from Trichosanthes kirilowii, inhibits the migration and invasion of colorectal adenocarcinoma cells by targeting Wnt/β-catenin and Hedgehog/Gli1 signalings.

Xiaomei Sun, Xiaobo Xu, Li Song,

Trichosanthes kirilowii, which is a type of Liana from cucurbitaceous family, possesses many bioactive constituents and therefore has multifarious pharmacological functions. TKP, which is a serine protease extracted from the fruit of Trichosanthes kirilowii, has been reported to possess potential anticancer activity. However, the effects of TKP on cancer cell ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(4):867-878]

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Construction and preliminary identification of a prokaryotic expression single-chain antibody fragments library against Streptococcus pneumoniae from antibody-producing cells in human tonsil.

Jiaqi Luo, Lu Yang, Zhen Long, Zhiwen Xiao, Xiaomei Sun, Shimin Zhuang, Liangen Xie, Wei Wang, Guanping Zhang, Yue Qu, Tianrun Liu,

Tonsillitis is the inflammation of the tonsils due to infection, many patients ultimately have to undergo tonsillectomy. In order to improve the accuracy of diagnosis and even create a new treatment for tonsillitis, we constructed a prokaryotic expression single-chain antibody fragment library against Streptococcus pneumoniae with immunoglobulin heavy chain variable ... Read more >>

Bioengineered (Bioengineered)
[2019, 10(1):162-171]

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Identification of the Genes Involved in Anthocyanin Biosynthesis and Accumulation in Taxus chinensis.

Lisha Zhang, Xiaomei Sun, Iain W Wilson, Fenjuan Shao, Deyou Qiu,

Taxus chinensis is a precious woody species with significant economic value. Anthocyanin as flavonoid derivatives plays a crucial role in plant biology and human health. However, the genes involved in anthocyanin biosynthesis have not been identified in T. chinensis. In this study, twenty-five genes involved in anthocyanin biosynthesis were identified, ... Read more >>

Genes (Basel) (Genes)
[2019, 10(12):]

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HP1717 Contributes to Streptococcus suis Virulence by Inducing an Excessive Inflammatory Response and Influencing the Biosynthesis of the Capsule.

Liang Liu, Qiang Zhang, Zhongmin Xu, Jingjing Huang, Weifeng Zhu, Anding Zhang, Xiaomei Sun, Meilin Jin,

Streptococcus suis 2 (SS2) is an important zoonotic pathogen that substantially harms the swine industry and poses threats to human health. Excessive inflammation is considered to be a hallmark of SS2 infection because it is responsible for most clinical signs of SS2, especially streptococcal toxic shock-like syndrome. However, the current ... Read more >>

Microorganisms (Microorganisms)
[2019, 7(11):]

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Atypical manifestations of cardiomegaly and nephrotic syndrome in Kawasaki disease: Two case reports.

Liyuan Wang, Xiaomei Sun, Xiaotang Cai, Shunli Liu, Zhiling Wang, Yongmei Xie,

RATIONALE:To examine atypical manifestations of Kawasaki disease (KD) in children. BACKGROUND:Cardiovascular complications during acute KD are a major contributor to its mortality rate. It can involve the pericardium, the myocardium, the endocardium, and/or the coronary arteries; however, cardiomegaly and nephrotic syndrome (NS) during the acute stage of KD have seldom ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(48):e18117]

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Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo.

Cuixia Qiao, Jin'e Wan, Lize Zhang, Bo Luo, Penglin Liu, Aiting Di, Hairui Gao, Xiaomei Sun, Gang Zhao,

BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory intestinal disease, and its morbidity is rising worldwide. Previous study indicated that astragaloside II (AS II), a monomeric compound, was used to treat bowel disease. However, the effects of AS II on UC remains unclear. Thus, this study aimed to investigate the therapeutic ... Read more >>

Am J Transl Res (American journal of translational research)
[2019, 11(11):7074-7083]

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Extracorporeal treatment in children with acute severe poisoning.

Xiaomei Sun, Xiuying Chen, Jing Lu, Yuhong Tao, Lijuan Zhang, Liqun Dong,

Acute poisoning in children is a clinical emergency. Prompt and effective treatment is critical for life-threatening poisoning. Extracorporeal treatment (ECTR) is a practical option for enhancing the elimination of poisons.We conducted a retrospective observational study on 338 children with severe acute poisoning who received ECTR during hospitalization from January 2010 ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(47):e18086]

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Novel lncRNA lncFAM200B: Molecular Characteristics and Effects of Genetic Variants on Promoter Activity and Cattle Body Measurement Traits.

Sihuan Zhang, Zihong Kang, Xiaomei Sun, Xiukai Cao, Chuanying Pan, Ruihua Dang, Chuzhao Lei, Hong Chen, Xianyong Lan,

Skeletal muscle is one of the three major muscle types in an organism and has key roles in the motor system, metabolism, and homeostasis. RNA-Seq analysis showed that novel lncRNA, lncFAM200B, was differentially expressed in embryonic, neonatal, and adult cattle skeletal muscles. The main aim of this study was to ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:968]

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The characteristics of gut microbiota and commensal Enterobacteriaceae isolates in tree shrew (Tupaia belangeri).

Wenpeng Gu, Pinfen Tong, Chenxiu Liu, Wenguang Wang, Caixia Lu, Yuanyuan Han, Xiaomei Sun, De Xuan Kuang, Na Li, Jiejie Dai,

BACKGROUND:Tree shrew is a novel laboratory animal with specific characters for human disease researches in recent years. However, little is known about its characteristics of gut microbial community and intestinal commensal bacteria. In this study, 16S rRNA sequencing method was used to illustrate the gut microbiota structure and commensal Enterobacteriaceae ... Read more >>

BMC Microbiol. (BMC microbiology)
[2019, 19(1):203]

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Genome-Wide Identification and Expression Analysis of GA2ox, GA3ox, and GA20ox Are Related to Gibberellin Oxidase Genes in Grape (Vitis Vinifera L.).

Honghong He, Guoping Liang, Shixiong Lu, Pingping Wang, Tao Liu, Zonghuan Ma, Cunwu Zuo, Xiaomei Sun, Baihong Chen, Juan Mao,

Gibberellin (GAs) plays the important role in the regulation of grape developmental and growth processes. The bioinformatics analysis confirmed the differential expression of GA2, GA3, and GA20 gibberellin oxidase genes (VvGA2oxs, VvGA3oxs, and VvGA20oxs) in the grape genome, and laid a theoretical basis for exploring its role in grape. Based ... Read more >>

Genes (Basel) (Genes)
[2019, 10(9):]

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Functional regulation of human trophoblast cells by CSE1L.

Yu Zhou, Qian Zhou, Lei Li, Yongzhong Gu, Xiaomei Sun, Shan Wang, Xietong Wang,

Objectives: To investigate the effects of the human chromosomal segregation 1-like (CSE1L) gene on the biological behaviour of human placental cells. Study design: The CSE1L gene plays important roles in chromosome segregation during mitosis, cell proliferation and apoptosis. We used MTT, Cellomics, cell colony formation and flow cytometry assays in ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-8]

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Evidence for a novel mechanism of influenza A virus host adaptation modulated by PB2-627.

Xiaokun Liu, Cha Yang, Xiaomei Sun, Xian Lin, Lianzhong Zhao, Huanchun Chen, Meilin Jin,

Influenza virus cross-species transmission is restricted by the host, but viruses overcome this restriction by accumulating mutations which allow them to adapt to a new host. Among the many factors which facilitate virus host adaptation, polymerase basic protein 2 (PB2) 627 plays an important role, although the underlying molecular mechanism ... Read more >>

FEBS J. (The FEBS journal)
[2019, 286(17):3389-3400]

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FAM98A promotes cancer progression in endometrial carcinoma.

Zenghui Li, Ning Li, Xiaomei Sun, Jing Wang,

To investigate the expression status of FAM98A and its potential involvement in endometrial carcinoma, the relative expression of FAM98A in clinical endometrial carcinoma tissues was analyzed by immunohistochemistry and real-time polymerase chain reaction. Endogenous FAM98A protein was determined by Western blotting. The overall survival was calculated by the Kaplan-Meier's analysis. ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2019, 459(1-2):131-139]

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Expression of CPEB1 gene affects the cycle of ovarian granulosa cells from adult and young goats

Jingwen Qu, Haiyan Guo, Dejun Ji, Yongjun Li, Xiaomei Sun, Qiang Wang, Xiuyuan Yin,

CPEB is considered as an RNA-binding protein first identified in Xenopus oocytes. Although CPEB1 was involved in the growth of oocyte, its role in goat follicular granulosa cell has not been fully elucidated. To clarify the functions of this gene in goat follicular granulosa cells, CPEB1-overexpressing vector and interference vector ... Read more >>

(Electronic Journal of Biotechnology.)
[2019, 39:74-81]

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MicroRNA-362 Inhibits Cell Proliferation and Invasion by Directly Targeting SIX1 in Colorectal Cancer.

Jin'e Wan, Jian Yang, Cuixia Qiao, Xiaomei Sun, Aiting Di, Lize Zhang, Dandan Wang, Gang Zhao,

PURPOSE:Colorectal cancer (CRC) is the third most common cancer in China and poses high morbidity and mortality. In recent years, increasing evidence has indicated that microRNAs played important functions in the occurrence and development of tumors. The purpose of this study was to identify the biological mechanisms of miR-362 in ... Read more >>

Yonsei Med. J. (Yonsei medical journal)
[2019, 60(5):414-422]

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Functional characterization of poplar NAC13 gene in salt tolerance

Xuemei Zhang, Boru Zhou, Kai Zhao, Tingbo Jiang, Wenjing Yao, Xiaomei Sun, Zihan Cheng,

Transcription factor (TF) genes play a critical role in plant abiotic and biotic stress responses. In this study, we cloned a poplar TF NAC13 gene (Potri.001G404100.1), which is significantly up-regulated to salt stress. Then we developed gene overexpression and antisense suppression constructions driven by CaMV35S, and successfully transferred them to ... Read more >>

Plant Sci. (Plant science : an international journal of experimental plant biology)
[2019, 281:1-8]

Cited: 2 times

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Characteristics of the tree shrew gut virome.

Linxia Chen, Wenpeng Gu, Chenxiu Liu, Wenguang Wang, Na Li, Yang Chen, Caixia Lu, Xiaomei Sun, Yuanyuan Han, Dexuan Kuang, Pinfen Tong, Jiejie Dai,

The tree shrew (Tupaia belangeri) has been proposed as an alternative laboratory animal to primates in biomedical research in recent years. However, characteristics of the tree shrew gut virome remain unclear. In this study, the metagenomic analysis method was used to identify the features of gut virome from fecal samples ... Read more >>

PLoS ONE (PloS one)
[2019, 14(2):e0212774]

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