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Author Xiaoling Luo

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The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer.

Ting Deng, Qidan Huang, Ting Wan, Xiaoling Luo, Yanling Feng, He Huang, Jihong Liu,

<h4>Objective</h4>To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).<h4>Methods</h4>We conducted a retrospective review of patients with clinical stage I-II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Demographic features and ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e40]

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Ni-Catalyzed Borylation of Aryl Sulfoxides.

Mingming Huang, Zhu Wu, Johannes Krebs, Alexandra Friedrich, Xiaoling Luo, Stephen A Westcott, Udo Radius, Todd B Marder,

A nickel/N-heterocyclic carbene (NHC) catalytic system has been developed for the borylation of aryl sulfoxides with B2(neop)2 (neop = neopentyl glycolato). A wide range of aryl sulfoxides with different electronic and steric properties were converted into the corresponding arylboronic esters in good yields. The regioselective borylation of unsymmetric diaryl sulfoxides ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2021, :]

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Prognostic Value and Molecular Mechanisms of Proteasome 26S Subunit, Non-ATPase Family Genes for Pancreatic Ductal Adenocarcinoma Patients after Pancreaticoduodenectomy.

Caifu Zhou, Haixia Li, Xiao Han, Hongbing Pang, Manya Wu, Yanping Tang, Xiaoling Luo,

<b>Objective:</b> Pancreatic cancer (PC) is an extremely malignant tumor with similar morbidity and mortality and lack of an effective treatment. This study explored the prognostic value and molecular mechanisms of proteasome 26S subunit, non-ATPase (PSMD) family genes in pancreatic ductal adenocarcinoma (PDAC). <b>Methods:</b> Survival analyses were performed to elucidate the ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2021, :1-17]

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Corrigendum to "ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma".

TingAn Wang, HuaGe Zhong, YuZhou Qin, WeiYuan Wei, Zhao Li, MingWei Huang, XiaoLing Luo,

[This corrects the article DOI: 10.1155/2020/3575038.]. ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:3179693]

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A new recursive least squares-based learning algorithm for spiking neurons.

Yun Zhang, Hong Qu, Xiaoling Luo, Yi Chen, Yuchen Wang, Malu Zhang, Zefang Li,

Spiking neural networks (SNNs) are regarded as effective models for processing spatio-temporal information. However, their inherent complexity of temporal coding makes it an arduous task to put forward an effective supervised learning algorithm, which still puzzles researchers in this area. In this paper, we propose a Recursive Least Squares-Based Learning ... Read more >>

Neural Netw (Neural networks : the official journal of the International Neural Network Society)
[2021, 138:110-125]

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Novel Compound Heterozygous BBS2 and Homozygous MKKS Variants Detected in Chinese Families with Bardet-Biedl Syndrome.

Li Huang, Limei Sun, Zhirong Wang, Songshan Li, Chonglin Chen, Xiaoling Luo, Xiaoyan Ding,

<h4>Background</h4>Bardet-Biedl syndrome (BBS) is a rare multisystem developmental disorder. In this study, we report the genetic causes and clinical manifestations in two Chinese families with BBS.<h4>Materials and methods</h4>Two families were recruited in this study. Family A was a four-generation family with four affected and 15 unaffected members participating in the ... Read more >>

J Ophthalmol (Journal of ophthalmology)
[2021, 2021:6751857]

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Selective Esophagogastric Devascularization in the Modified Sugiura Procedure for Patients with Cirrhotic Hemorrhagic Portal Hypertension: A Randomized Controlled Trial.

Yawu Zhang, Lingyi Zhang, Mancai Wang, Xiaoling Luo, Zheyuan Wang, Gennian Wang, Xiaohu Guo, Fengxian Wei, Youcheng Zhang,

<h4>Aim</h4>Portal hypertension is a series of syndrome commonly seen with advanced cirrhosis, which seriously affects patient's quality of life and survival. This study was designed to access the efficacy and safety of selective esophagogastric devascularization in the modified Sugiura procedure for patients with cirrhotic hemorrhagic portal hypertension.<h4>Methods</h4>Sixty patients with hepatitis ... Read more >>

Can J Gastroenterol Hepatol (Canadian journal of gastroenterology & hepatology)
[2020, 2020:8839098]

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Clinical features of ocular toxocariasis: a comparison between ultra-wide-field and conventional camera imaging.

Songshan Li, Limei Sun, Chengxi Liu, Weiqing Wang, Sijian Huang, Ting Zhang, Chonglin Chen, Zhirong Wang, Liming Cao, Xiaoling Luo, Bilin Yu, Xiaoyan Ding,

<h4>Purpose</h4>The purpose of this study is to compare the lesion detection rates of ocular toxocariasis (OT) between ultra-wide-field scanning laser ophthalmoscopy (UWF-SLO) and conventional fundus photography (CFP), and to evaluate the potential diagnostic ability of UWF-SLO in OT.<h4>Methods</h4>A total of 56 patients with serological/immunological confirmed unilateral OT were enrolled. The ... Read more >>

Eye (Lond) (Eye (London, England))
[2020, :]

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Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma.

Joshua T Kowalczyk, Xiaolin Wan, Edjay R Hernandez, Ruibai Luo, Gaelyn C Lyons, Kelli M Wilson, Devorah C Gallardo, Kristine A Isanogle, Christina M Robinson, Arnulfo Mendoza, Christine M Heske, Jinqui-Qiu Chen, Xiaoling Luo, Alexander E Kelly, Simone Difilippantinio, Robert W Robey, Craig J Thomas, Dan L Sackett, Deborah K Morrison, Paul A Randazzo, Lisa M Miller Jenkins, Marielle E Yohe,

Relapsed pediatric rhabdomyosarcomas (RMS) and neuroblastomas (NBs) have a poor prognosis despite multimodality therapy. In addition, the current standard of care for these cancers includes vinca alkaloids that have severe toxicity profiles, further underscoring the need for novel therapies for these malignancies. Here, we show that the small-molecule rigosertib inhibits ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2021, 20(2):307-319]

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Activation of LncRNA FOXD2-AS1 by H3K27 acetylation regulates VEGF-A expression by sponging miR-205-5p in recurrent pterygium.

Yali Gao, Xiaoling Luo, Jun Zhang,

LncRNA FOXD2-AS1 is abnormally expressed in many diseases. However, the molecular mechanisms whereby FOXD2-AS1 is involved in recurrent pterygium remain unknown. Here, qRT-PCR was performed to quantify FOXD2-AS1 expression, while CCK-8, flow cytometer and neoplasm xenograft assays were used to investigate its function. Dual-luciferase reporter, RIP and RNA pull-down assays ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(24):14139-14151]

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[DNMT1 protein promotes retinoblastoma proliferation by silencing MEG3 gene].

Yali Gao, Xiaoling Luo, Ting Meng, Minjuan Zhu, Meiwen Tian, Xiaohe Lu,

<h4>Objective</h4>To investigate whether DNMT1 protein induces retinoblastoma proliferation by silencing MEG3 gene.<h4>Methods</h4>Two retinoblastoma cell lines (HXO-RB44 and SO-RB50) and a normal human retinal pigment epithelial (RPE) cell line were transfected with the plasmid pcDNA-DNMT1 or si-DNMT1 for up-regulating or interference of DNMT1 expression, and with pcDNA-MEG3 or si-MEG3 for up-regulating ... Read more >>

Nan Fang Yi Ke Da Xue Xue Bao (Nan fang yi ke da xue xue bao = Journal of Southern Medical University)
[2020, 40(9):1239-1245]

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ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION: Comparison Between Optical Coherence Tomography Angiography and Dye Angiography.

Songshan Li, Limei Sun, Xiujuan Zhao, Sijian Huang, Xiaoling Luo, Aiyuan Zhang, Chonglin Chen, Zhirong Wang, Chengxi Liu, Xiaoyan Ding,

<h4>Purpose</h4>This study aims to suggest a novel strategy for assessing the activity of myopic choroidal neovascularization (mCNV) based on optical coherence tomography angiography (OCTA) and to compare it with traditional fundus fluorescein angiography as the gold standard.<h4>Methods</h4>Macular OCTA images were obtained using RTVue XR Avanti with AngioVue. Morphologic features of ... Read more >>

Retina (Retina (Philadelphia, Pa.))
[2020, 40(9):1757-1764]

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Novel variants in familial exudative vitreoretinopathy patients with KIF11 mutations and the Genotype-Phenotype correlation.

Chonglin Chen, Limei Sun, Songshan Li, Li Huang, Ting Zhang, Zhirong Wang, Bilin Yu, Xiaoling Luo, Xiaoyan Ding,

Familial exudative vitreoretinopathy (FEVR) is an inherited disease characterized by abnormal development of retinal vasculature. KIF11 mutations were identified to be associated with FEVR in recent years. The purpose of this study was to investigate novel variants and describe associated ocular and extraocular phenotypes in FEVR patients with KIF11 mutations. ... Read more >>

Exp Eye Res (Experimental eye research)
[2020, 199:108165]

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Mutation Spectrum and De Novo Mutation Analysis in Stickler Syndrome Patients with High Myopia or Retinal Detachment.

Li Huang, Chonglin Chen, Zhirong Wang, Limei Sun, Songshan Li, Ting Zhang, Xiaoling Luo, Xiaoyan Ding,

Stickler syndrome is a connective tissue disorder that affects multiple systems, including the visual system. Seven genes were reported to cause Stickler syndrome in patients with different phenotypes. In this study, we aimed to evaluate the mutation features of the phenotypes of high myopia and retinal detachment. Forty-two probands diagnosed ... Read more >>

Genes (Basel) (Genes)
[2020, 11(8):]

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Clinical manifestation and genetic analysis in Chinese early onset X-linked retinoschisis.

Li Huang, Limei Sun, Zhirong Wang, Chonglin Chen, Panfeng Wang, Wenmin Sun, Xiaoling Luo, Xiaoyan Ding,

<h4>Background</h4>X-linked retinoschisis (XLRS) is one type of retinal dystrophy leading to the schisis of the neural retina and causing reduced visual acuity. The study aimed to investigate the clinical manifestations and retinoschisin 1 (RS1) mutations in Chinese patients with early onset XLRS.<h4>Methods</h4>Thirty-eight probands with early onset XLRS were recruited, comprehensive ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2020, 8(10):e1421]

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Ultra-wide-field scanning laser ophthalmoscopy and optical coherence tomography in FEVR: findings and its diagnostic ability.

Ting Zhang, Zhirong Wang, Limei Sun, Songshan Li, Li Huang, Chengxi Liu, Chonglin Chen, Xiaoling Luo, Bilin Yu, Xiaoyan Ding,

BACKGROUND/AIMS:To describe some novel vitreoretinal microstructural findings in patients with mild familial exudative vitreoretinopathy (FEVR) on ultra-wide-field scanning laser ophthalmoscopy (UWF-SLO) and UWF optical coherence tomography (UWF-OCT) and to evaluate their clinical significance. METHODS:A total of 32 patients and 32 healthy controls were studied. An additional independent 40 FEVR patients, ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2020, :]

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ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.

TingAn Wang, HuaGe Zhong, YuZhou Qin, WeiYuan Wei, Zhao Li, MingWei Huang, XiaoLing Luo,

Armadillo gene subfamily members (ARMCX1-6) are well-known to regulate protein-protein interaction involved in nuclear transport, cellular connection, and transcription activation. Moreover, ARMCX signals on cell pathways also implicated in carcinogenesis and tumor progression. However, little is known about the associations of the ARMCX subfamily members with gastric carcinoma. This study ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:3575038]

Cited: 1 time

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Copper-Catalyzed Synthesis of Stereodefined Cyclopropyl Bis(boronates) from Alkenes with CO as the C1 Source.

Fu-Peng Wu, Xiaoling Luo, Udo Radius, Todd B Marder, Xiao-Feng Wu,

A novel copper-catalyzed stereodefined procedure for the selective synthesis of cyclopropyl bis(boronates) from terminal alkenes has been developed. Various aliphatic alkenes were transformed into the desired bis(boronate ester)-substituted cyclopropanes in moderate to good yields. Synthetic transformations of the resulting cyclopropyl bis(boronates) demonstrate their utility. A possible reaction mechanism is proposed. ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(33):14074-14079]

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Sp1-mediated up-regulation of lnc00152 promotes invasion and metastasis of retinoblastoma cells via the miR-30d/SOX9/ZEB2 pathway.

Yali Gao, Xiaoling Luo, Jun Zhang,

<h4>Purpose</h4>Previously, we found that long non-coding RNA (lncRNA) MEG3 may act as a tumour suppressor in retinoblastoma. Overall, however, little is known about the role of lncRNAs in retinoblastoma. Here, we aimed to determine the expression and clinical significance of lnc00152 in retinoblastoma.<h4>Methods</h4>Lnc00152 and its downstream targets were selected using ... Read more >>

Cell Oncol (Dordr) (Cellular oncology (Dordrecht))
[2021, 44(1):61-76]

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LincRNA-ROR is activated by H3K27 acetylation and induces EMT in retinoblastoma by acting as a sponge of miR-32 to activate the Notch signaling pathway.

Yali Gao, Xiaoling Luo, Jun Zhang,

Recent studies have suggested that lincRNA-ROR is involved in the tumorigenesis of different types of cancers. However, the role of lincRNA-ROR in retinoblastoma has not been determined. We investigated lincRNA-ROR levels in 58 retinoblastoma and adjacent non-tumor tissues by quantitative reverse transcription PCR. Recurrence-free survival was analyzed using Cox regression ... Read more >>

Cancer Gene Ther (Cancer gene therapy)
[2021, 28(1-2):42-54]

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Risk Scoring System based on lncRNA Expression for Predicting Survival in Hepatocellular Carcinoma with Cirrhosis.

Jiaxiang Ye, Haixia Li, Jiazhang Wei, Yue Luo, Hongmei Liu, Jinyan Zhang, Xiaoling Luo,

<h4>Objective</h4>This study aims to explore the roles of long non-coding RNAs (lncRNAs) for predicting survival in hepatocellular carcinoma (HCC) patients with cirrhosis.<h4>Methods</h4>A set of lncRNAs differentially expressed between HCC patients with or without cirrhosis was identified using expression profiles of The Cancer Genome Atlas database, and these lncRNAs were screened ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(6):1787-1795]

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A new and spontaneous animal model for ankylosing spondylitis  is found in cynomolgus monkeys

Huanhuan JIA, Meili CHEN, Xiaoling LUO, Gang HOU, Ting LUO, Jin’e LIAO, Yongfeng LI, Wei CHEN, Jun CHEN, Qingnan LI, Kai Kei MIU, Ren Huang, Li LU,

<h4>Background: </h4> Ankylosing spondylitis (AS) is a progressive, disabling joint disease that affects millions worldwide. There is a lack of useful disease model to conduct comprehensive mechanistic studies. Non-human primate model is a potential spontaneous model for ankylosing spondylitis (AS). Methods A group of cynomolgus monkeys with abnormal joints ... Read more >>

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Developmental Changes in Retinal Microvasculature in Children: A Quantitative Analysis Using Optical Coherence Tomography Angiography.

Songshan Li, Xiao Yang, Mengke Li, Limei Sun, Xiujuan Zhao, Qiong Wang, Sijian Huang, Chonglin Chen, Zhirong Wang, Xiaoling Luo, Bilin Yu, Xiaoyan Ding,

<h4>Purpose</h4>To quantify the macular microvasculature in healthy children of various ages by using optical coherence tomography angiography (OCTA).<h4>Design</h4>Prospective cross-sectional study.<h4>Methods</h4>A total of 333 normal children from 4 to 16 years old were included. OCTA was performed on a 3- × 3-mm area centered on the macular region. Vascular density, perfusion density, ... Read more >>

Am J Ophthalmol (American journal of ophthalmology)
[2020, 219:231-239]

Cited: 1 time

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PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells.

Yanping Liu, Huajun Bai, Fengfeng Guo, Phung N Thai, Xiaoling Luo, Peng Zhang, Chunli Yang, Xueqin Feng, Dan Zhu, Jun Guo, Ping Liang, Zhice Xu, Huangtian Yang, Xiyuan Lu,

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in biomedical applications. However, the immature state of cardiomyocytes obtained using existing protocols limits the application of hPSC-CMs. Unlike adult cardiac myocytes, hPSC-CMs generate ATP through an immature metabolic pathway-aerobic glycolysis, instead of mitochondrial oxidative phosphorylation (OXPHOS). Hence, metabolic switching is ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(8):7411-7430]

Cited: 3 times

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Mechanism and molecular network of RBM8A-mediated regulation of oxaliplatin resistance in hepatocellular carcinoma via EMT

Yan Lin, Rong Liang, Jinyan Zhang, Zhihui Liu, Ziyu Liu, Qian Li, Xiaoling Luo, Yongqiang Li, Jiazhou Ye,

Epithelial-mesenchymal transition (EMT) has been shown to be closely associated with Oxaliplatin (OXA) resistance. Previous study found that RBM8A is highly expressed in HCC and induce EMT, suggesting that it may be involved in the regulation of OXA resistance in HCC. However, the accurate mechanism has not been concluded. In ... Read more >>

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