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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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In-Situ Generation of N-Heteroaromatic Polymers: Metal-Free Polymerization and Multiple Functionalities

YUBING HU, Neng Yan, XIAOLIN LIU, Lingyu Pei, Canbin Ye, Wen-Xiong Wang, Jacky Lam, Ben Zhong Tang,

The electron-deficient <i>N</i>-heteroaromatic polymers are crucial for the high-tech applications of organic materials, especially in the electronic and optoelectronic fields. Thus, the development of new polymerizations to afford adaptable electron donating-accepting scaffolds in <i>N</i>-heteroaromatic polymers is in high demand. Herein, metal-free multicomponent polymerizations of diynes, diamines and glyoxylates are successfully ... Read more >>

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Comparative Transcriptome Profiling of Ovary Tissue between Black Muscovy Duck and White Muscovy Duck with High- and Low-Egg Production.

Xiuyu Bao, Yiping Song, Tao Li, Shanshan Zhang, Lihua Huang, Shuya Zhang, Junting Cao, Xiaolin Liu, Jianqin Zhang,

The egg-laying rate is an important indicator for evaluating fertility of poultry. In order to better understand the laying mechanism of Muscovy ducks, gene expression profiles and pathways of ovarian tissues in high- and low-laying black (BH and BL) and white Muscovy ducks (WH and WL) during the peak production ... Read more >>

Genes (Basel) (Genes)
[2020, 12(1):]

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Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.

Qiong Xu, Mingke Liu, Fangcheng Zhang, Xiaolin Liu, Sisi Ling, Xuke Chen, Jielei Gu, Wenchao Ou, Shiming Liu, Ningning Liu,

Cardiac fibrosis, featuring abnormally elevated extracellular matrix accumulation, decreases tissue compliance, impairs cardiac function and accelerates heart failure. Mounting evidence suggests that the ubiquitin proteasome pathway is involved in cardiac fibrosis. In the present study, ubiquitin-specific protease 2 (USP2) was identified as a novel therapeutic target in cardiac fibrosis. Indeed, ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, :]

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Immune Thrombocytopenia Induced by Immune Checkpoint Inhibitors in Solid Cancer: Case Report and Literature Review.

Xiaolin Liu, Xiuju Liang, Jing Liang, Yan Li, Jun Wang,

Immune checkpoint inhibitors, including antibodies targeting programmed cell death protein-1 (PD-1) and its receptor programmed cell death ligand-1 (PD-L1), represent promising therapeutic strategies for advanced human malignancies. However, a subgroup of patients experiences various autoimmune toxicities, termed immune-related adverse events (irAEs), that occur as a result of on-target and off-tumor ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:530478]

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Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury.

Yiwei Xu, Jing Zhou, Cuicui Liu, Sheng Zhang, Fenglin Gao, Wenjing Guo, Xiumin Sun, Chi Zhang, Heying Li, Zilong Rao, Shuai Qiu, Qingtang Zhu, Xiaolin Liu, Xiaodong Guo, Zengwu Shao, Ying Bai, Xiao Zhang, Daping Quan,

The repair of spinal cord injury (SCI) highly relies on microenvironment remodeling and facilitating the recruitment and neuronal differentiation of endogenous stem/progenitor cells. Decellularized tissue matrices (DTMs) have shown their unique and beneficial characteristics in promoting neural tissue regeneration, especially those derived from the nervous system. Herein, we present a ... Read more >>

Biomaterials (Biomaterials)
[2020, 268:120596]

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Anti-mastitis SNV identification of NFκB1 in Chinese Holstein cows and the possible anti-inflammation role of NFκB1/p105 in bovine MECs.

Ling Chen, Rongfu Tian, Huilin Zhang, Xiaolin Liu,

NFκB1/p105 is the critical member of the NFκB family which can suppress inflammation, ageing, and cancer when p50/p50 homodimer is formed. Currently, the research about the role of NFκB1/p105 during cow mastitis is limited. Here, we analyzed the correlation of six single-nucleotide variants of the NFκB1 gene with somatic cell ... Read more >>

Acta Biochim Biophys Sin (Shanghai) (Acta biochimica et biophysica Sinica)
[2020, 52(11):1191-1201]

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A directly grown pristine Cu-CAT metal-organic framework as an anode material for high-energy sodium-ion capacitors.

Wan Zhou, Si Lv, Xiaolin Liu, Yuanyuan Li, Jinping Liu,

Copper-based metal-organic framework (Cu-CAT) nanowires are directly grown as an anode of sodium ion hybrid capacitors (SIHCs) for the first time. The uniform molecular pores provide a natural Na+ diffusion pathway and abundant accommodations for Na+ coordination to the C-O active sites, which greatly facilitate the kinetics balance with the ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(75):11207-11210]

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Facilitate Angiogenesis and Neurogenesis by Growth Factors Integrated Decellularized Matrix Hydrogel.

Rui Li, Jinghui Xu, Zilong Rao, Rongli Deng, Yiwei Xu, Shuai Qiu, Houqing Long, Qingtang Zhu, Xiaolin Liu, Ying Bai, Daping Quan,

Neurological functional recovery depends on the synergistic interaction between angiogenesis and neurogenesis after peripheral nerve injury (PNI). Decellularized nerve matrix hydrogels have drawn much attention and been considered as potential therapeutic biomaterials for neurovascularization, due to their intrinsic advantages in construction of a growth-permissive microenvironment, strong affinity to multiple growth ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2020, :]

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Dynamic Transcriptome Reveals the Mechanism of Liver Injury Caused by DHAV-3 Infection in Pekin Duck.

Junting Cao, Yunsheng Zhang, Ying Chen, Suyun Liang, Dapeng Liu, Wenlei Fan, Yaxi Xu, Hehe Liu, Zhengkui Zhou, Xiaolin Liu, Shuisheng Hou,

Duck hepatitis A virus 3 (DHAV-3) is a wild endemic virus, which seriously endangers the duck industry in China. The present study aims to elucidate the mechanism of duck resistance to DHAV-3 infection. Both resistant and susceptible ducks were challenged with DHAV-3 in this experiment. The histopathological features and serum ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:568565]

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USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36.

Xiaohong Xia, Tumei Hu, Jinchan He, Qiong Xu, Cuifu Yu, Xiaolin Liu, Zhenlong Shao, Yuning Liao, Hongbiao Huang, Ningning Liu,

Foam cell formation process is involved in the pathogenesis of atherosclerosis (AS). Activation of this biological process depends on lipid uptake by scavenger receptors, such as CD36, SR-A and SR-B1. Among these receptors, CD36 is the principal one because it dominates roughly 50% lipid uptake in monocytes. In this study, ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(22):22892-22905]

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ERα is a target for butein-induced growth suppression in breast cancer.

Chuyi Huang, Xiaohong Xia, Jinchan He, Yuan Liu, Zhenlong Shao, Tumei Hu, Cuifu Yu, Xiaolin Liu, Qiong Xu, Bin Liu, Ningning Liu, Yuning Liao, Hongbiao Huang,

Breast cancer (BCa) has the highest incidence and mortality among malignant diseases in female worldwide. BCa is frequently caused by estrogen receptor α (ERα), a ligand-dependent receptor that highly expressed in about 70% of breast tumors. Therefore, ERα has become a well-characterized and the most effective target for treating ERα-expressing ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2020, 10(11):3721-3736]

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Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs

Panlin Wang, Yanyan Sun, Yunlei Li, Jing Fan, Yunhe Zong, Adamu Mani Isa, Lei Shi, Yuanmei Wang, Aixin Ni, Pingzhuang Ge, Linlin Jiang, Shixiong Bian, Hui Ma, Zhengdong Yuan, Xiaolin Liu, Jilan Chen,

<h4>Background: </h4> Effect of monochromatic green light illumination on embryo development has been reported in chickens. The avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic development. However, the involvement of pineal gland in the light transduction process remains to be elucidated. In the ... Read more >>

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LncRNA HCG11/miR-26b-5p/QKI5 feedback loop reversed high glucose-induced proliferation and angiogenesis inhibition of HUVECs.

Jiao Du, Ruijuan Han, Yihua Li, Xiaolin Liu, Shurong Liu, Zhenyu Cai, Zhaolong Xu, Ya Li, Xuchun Yuan, Xiuhai Guo, Bin Lu, Kai Sun,

Acute coronary syndrome caused by the rupture of atherosclerotic plaques is one of the primary causes of cerebrovascular and cardiovascular events. Neovascularization within the plaque is closely associated with its stability. Long non-coding RNA (lncRNA) serves a crucial role in regulating vascular endothelial cells (VECs) proliferation and angiogenesis. In this ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, :]

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Catalyst-Free Polymerization with 100% Atom Economy: Facile Synthesis of Polysulfonates with Multifunctionalities

XIAOLIN LIU, Xin Liang, YUBING HU, Qing Qu, Dongming Liu, Haotian Bai, Anjun Qin, Jacky Lam, Ryan Tsz Kin Kwok, Lei Han, Ben Zhong Tang,

Catalyst-free spontaneous polymerization for the synthesis of halogen-rich polysulfonates at room temperature in air with 100% atom economy in high yields was developed. The resulting polymers possess various properties, including post-functionalization, extraordinarily high refractive index, visible photodegradation, photoacid generation, multi-color and 3D fluorescent photopatterning, and practical broad-spectrum antibacterial activity. ... Read more >>

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Esomeprazole overcomes paclitaxel-resistance and enhances anticancer effects of paclitaxel by inducing autophagy in A549/Taxol cells.

Zhaoshi Bai, Nianyang Ding, Jianjuan Ge, Yue Wang, Lei Wang, Nan Wu, Qing Wei, Silu Xu, Xiaolin Liu, Guoren Zhou,

Non-small-cell lung cancer (NSCLC) is one of the most common malignancies, and the occurrence of drug-resistance severely limits the efficacy of anticancer drugs in the treatment of NSCLC. Identification of new agents to reverse drug-resistance in NSCLC treatment is of great importance and urgency both clinically and scientifically. In the ... Read more >>

Cell Biol Int (Cell biology international)
[2021, 45(1):177-187]

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Comparative Transcriptome Profiling of Skeletal Muscle from Black Muscovy Duck at Different Growth Stages Using RNA-seq.

Zhigang Hu, Junting Cao, Guangyu Liu, Huilin Zhang, Xiaolin Liu,

In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to ... Read more >>

Genes (Basel) (Genes)
[2020, 11(10):]

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The complete mitochondrial genome of Inimicus japonicus and its phylogenetic analysis.

Weiye Li, Xiaolin Liu, Jingang Xu, Siyuan Li, Xiaolong Yin, Hulin Xie, Xiaolin Zhang,

The complete mitochondrial genome was sequenced from the marine teleost fish <i>Inimicus japonicus</i>. The genome sequence is 16,830 bp in size and has a base composition of A (29.25%), T (29.01%), C (20.7%), and G (21.03%). Moreover, 13 protein-coding genes (PCGs) encoded 3210 amino acids in total. The phylogenetic analysis showed ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[2020, 5(3):3537-3538]

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MicroRNAs are involved in the development and progression of gastric cancer.

Xiaolin Liu, Ruixia Ma, Bin Yi, Adam I Riker, Yaguang Xi,

MicroRNAs (miRNAs) are recognized as an essential component of the RNA family, exerting multiple and intricate biological functions, particularly in the process of tumorigenesis, proliferation, and metastatic progression. MiRNAs are altered in gastric cancer (GC), showing activity as both tumor suppressors and oncogenes, although their true roles have not been ... Read more >>

Acta Pharmacol Sin (Acta pharmacologica Sinica)
[2020, :]

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In Vitro and In Vivo Evaluation of SP94 Modified Liposomes Loaded with N-14NCTDA, a Norcantharimide Derivative for Hepatocellular Carcinoma-Targeting.

Ying Jiang, Xiaolin Liu, Xinyi Tan, Ye Hou, Wanxiao Sun, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang,

The purpose of this research is to develop a liposomal drug delivery system, which can selectively target hepatocellular carcinoma (HCC) to deliver the antitumor agent N-14NCTDA, a C<sub>14</sub> alkyl chain norcantharimide derivative of norcantharidin. N-14NCTDA-loaded liposomes were successfully prepared by lipid membrane hydration and extrusion methods. SP94, a targeting peptide ... Read more >>

AAPS PharmSciTech (AAPS PharmSciTech)
[2020, 21(7):277]

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Expression and analysis of ESR1, IGF-1, FSH, VLDLR, LRP, LH, PRLR genes in Pekin duck and Black Muscovy duck.

Guangyu Liu, Mingfei Zeng, Xingxing Li, Yu Rong, Zhigang Hu, Huilin Zhang, Xiaolin Liu,

In order to explore the influence of egg-laying regulatory genes on egg production in ducks at different laying stages, Pekin duck and Black Muscovy duck were used in this study, including early laying stage (20-30 weeks old), peak laying period (31-48 weeks old) and late laying stage (49-66 weeks old). Relative quantitative RT-PCR ... Read more >>

Gene (Gene)
[2021, 769:145183]

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Local Riluzole Release from a Thermosensitive Hydrogel Rescues Injured Motoneurons through Nerve Root Stumps in a Brachial Plexus Injury Rat Model.

Jintao Fang, Liang Li, Hong Zhai, Bengang Qin, Daping Quan, Enxian Shi, Menghai Zhu, Jiantao Yang, Xiaolin Liu, Liqiang Gu,

The C5-C6 nerve roots are usually spared from avulsion after brachial plexus injury (BPI) and can thus be used as donors for nerve repair. A BPI rat model with C5-C6 nerve root stumps has been established in our previous work. The aim of this study was to test whether riluzole ... Read more >>

Neurochem Res (Neurochemical research)
[2020, 45(11):2800-2813]

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Focus on the depressive symptoms in COVID-19 patients: Perspective based on a rapid meta-analysis.

Yongfeng Lao, Yanbiao Jiang, Xiao Luo, Xiaolin Liu,

Asian J Psychiatr (Asian journal of psychiatry)
[2020, 54:102421]

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Tricyclic 2-Aminopyridinium Derivatives with Aggregation-Induced Emission for Concomitant Bacterial Discrimination and Inhibition

Bingnan Wang, Haozhong Wu, Rong Hu, Xiaolin Liu, zhiyang liu, Zhiming Wang, Anjun Qin, Ben Zhong Tang,

The development of new ionic compounds with aggregation-induced emission (AIE) has been widely noticed. They can not only effectively solve the problem of aggregation-caused quenching (ACQ) encountered in conventional fluorescent dyes, but also exhibit promising applications in biological imaging, diagnosis and therapy, etc. However, such AIE system should be further ... Read more >>

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Effects of Calcium and Signal Sensing Systems on Azorhizobium caulinodans Biofilm Formation and Host Colonization.

Xiaolin Liu, Kaiye Zhang, Yanan Liu, Desheng Zou, Dandan Wang, Zhihong Xie,

Biofilm formation is important for establishing plants-microbe associations. The role of calcium on biofilm formation has been studied in many bacteria except rhizobia. In this study, we investigated the role of calcium for biofilm formation in <i>Azorhizobium caulindans</i>, which forms nodules in the stem and root of its host plant ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:563367]

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