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Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits.

David A Salisbury, David Casero, Zhengyi Zhang, Dan Wang, Jason Kim, Xiaohui Wu, Laurent Vergnes, Aashiq H Mirza, Paola Leon-Mimila, Kevin J Williams, Adriana Huertas-Vazquez, Samie R Jaffrey, Karen Reue, Jianjun Chen, Tamer Sallam,

Males and females exhibit striking differences in the prevalence of metabolic traits including hepatic steatosis, a key driver of cardiometabolic morbidity and mortality. RNA methylation is a widespread regulatory mechanism of transcript turnover. Here, we show that presence of the RNA modification N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) triages lipogenic transcripts for degradation and ... Read more >>

Nat Metab (Nature metabolism)
[2021, 3(7):940-953]

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An Ecological Comparison Study On The Causal Association Between Leptospirosis and Moyamoya Disease in Hubei, China, 2017-2019

Ma Zhiyang, Xiong Wang, Meifang Li, Da Zhou, Jianjian Zhang, Lu Ma, Xiang Li, Wei Wei, Xiaohui Wu, Xiangyan Chen, Keyao Zhou, Zenghui Huang, Jincao Chen,

<h4>Background: </h4> and Purpose The importance of environmental factors (especially leptospirosis) in moyamoya disease (MMD) has not been clarified. Here we investigated the epidemiological characteristics of MMD under perspective of ecology in Hubei province, China. <h4>Methods: </h4> We conducted a population-based study to describe the epidemiologic characteristics of MMD in ... Read more >>

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QuantifyPoly(A): reshaping alternative polyadenylation landscapes of eukaryotes with weighted density peak clustering.

Congting Ye, Danhui Zhao, Wenbin Ye, Xiaohui Wu, Guoli Ji, Qingshun Q Li, Juncheng Lin,

The dynamic choice of different polyadenylation sites in a gene is referred to as alternative polyadenylation, which functions in many important biological processes. Large-scale messenger RNA 3' end sequencing has revealed that cleavage sites for polyadenylation are presented with microheterogeneity. To date, the conventional determination of polyadenylation site clusters is ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, :]

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Integrating sulfur, iron(II), and fixed organic carbon for mixotrophic denitrification in a composite filter bed reactor for decentralized wastewater treatment: Performance and microbial community.

Xiejuan Lu, Yanlei Wan, Zhenxing Zhong, Bo Liu, Feixiang Zan, Fugang Zhang, Xiaohui Wu,

Decentralized wastewater treatment in rural areas is an imperative challenge around the world, particularly in developing countries. The composite filter bed reactor is viable for decentralized wastewater treatment, but its performance on nitrogen removal often fluctuates with the unstable influent characteristics and loadings. Here, a composite filter bed reactor integrating ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 795:148825]

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scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data.

Xiaohui Wu, Tao Liu, Congting Ye, Wenbin Ye, Guoli Ji,

Alternative polyadenylation (APA) generates diverse mRNA isoforms, which contributes to transcriptome diversity and gene expression regulation by affecting mRNA stability, translation and localization in cells. The rapid development of 3' tag-based single-cell RNA-sequencing (scRNA-seq) technologies, such as CEL-seq and 10x Genomics, has led to the emergence of computational methods for ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, 22(4):]

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Abnormal Fibrinogen Level as a Prognostic Indicator in Coronavirus Disease Patients: A Retrospective Cohort Study.

Wei Long, Jie Yang, Zhengwei Li, Jinpeng Li, Sichao Chen, Danyang Chen, Shipei Wang, Qianqian Li, Di Hu, Jianglong Huang, Wen Zeng, Liang Guo, Xiaohui Wu,

<b>Purpose:</b> The coronavirus disease (COVID-19) pandemic poses a global threat, and identification of its prognostic biomarkers could prove invaluable. Fibrinogen (FIB) could be one such indicator as coagulation and fibrinolysis abnormalities are common among COVID-19 patients. We examined the role of FIB levels in the prognosis of COVID-19. <b>Methods:</b> This ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:687220]

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Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues.

Xiaohui Wu, Xin Wang, Xiaobin Chen, Xiaowei Yang, Qian Ma, Guohua Xu, Lin Yu, Jiandong Ding,

It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues. Herein, we designed a novel macromolecular contrast agent with ultrahigh radiopacity (iodinate content > 50%) via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol) (PEG). A set of thermosensitive and biodegradable ... Read more >>

Bioact Mater (Bioactive materials)
[2021, 6(12):4717-4728]

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Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer's Disease.

Lin Zhu, Linlin Xu, Xiaohui Wu, Fei Deng, Rujiang Ma, Yang Liu, Fan Huang, Linqi Shi,

With the failure of various amyloid-β-targeted drugs for Alzheimer's disease (AD) in clinical trials, tau protein has gained growing attention as an alternative therapeutic target in recent years. The aggregation of tau exerts neurotoxicity, and its spreading in the brain is associated with increasing severity of clinical symptoms for AD ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(20):23328-23338]

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Hypothalamic-Pituitary-End-Organ Axes: Hormone Function in Female Patients with Major Depressive Disorder.

Yuncheng Zhu, Xiaohui Wu, Rubai Zhou, Oliver Sie, Zhiang Niu, Fang Wang, Yiru Fang,

Classic hypothalamic-pituitary-end-organ feedback loops - the hypothalamic-pituitary-adrenal axis (HPAA), hypothalamic-pituitary-thyroidal axis (HPTA), and hypothalamic-pituitary-gonadal axis (HPGA) - are associated with the neuroendocrine and immune systems in major depressive disorder (MDD). Female patients with MDD present with evident neuroendocrine and immunological changes. Glucocorticoid, thyroid hormone, and reproductive steroid levels fluctuate with ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2021, :]

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Epigenetic Age Acceleration Was Delayed in Schizophrenia.

Xiaohui Wu, Junping Ye, Zhongju Wang, Cunyou Zhao,

Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging hypothesis of schizophrenia has been proposed, the quantitative study of the disruption of the physiological trajectory caused by schizophrenia is inconclusive. In this study, we employed 3 "epigenetic clock" methods to quantify the ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2021, 47(3):803-811]

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Codonopsis Radix modulates water and electrolytes homeostasis in mice.

Shu Chen, Xiaohui Wu,

Codonopsis Radix is a traditional Chinese medicine best known for its effects in treating digestive, cardiovascular, immunological and hematopoitic diseases. It also appears in the traditional Chinese medical prescriptions against ascites. However, the physiological effect and molecular mechanism of Codonopsis Radix in water and electrolytes homeostasis have not been well ... Read more >>

Heliyon (Heliyon)
[2021, 7(4):e06735]

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Consumption of chilies and sweet peppers is associated with lower risk of sarcopenia in older adults.

Xuena Wang, Xiaohui Wu, Ge Meng, Shanshan Bian, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xingqi Cao, Huiping Li, Yunyun Liu, Xiaoyue Li, Kun Song, Kaijun Niu,

<h4>Background</h4>Sarcopenia is an aging-related loss of muscle mass and function, which induces numerous adverse outcomes. Capsaicin and capsiate, separately extracted from chilies and sweet peppers, have the potential to induce muscle hypertrophy via activation of transient receptor potential vanilloid 1. The present study aimed to investigate whether chili and sweet ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(6):9135-9142]

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Rosmarinic acid prevents refractory bacterial pneumonia through regulating Keap1/Nrf2-mediated autophagic pathway and mitochondrial oxidative stress.

Wei Zhang, Cheng Cheng, Zhou Sha, Changmai Chen, Chengtao Yu, Nianyin Lv, Peng Ji, Xiaohui Wu, Tonghui Ma, Haibo Cheng, Liyun Shi,

Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial pneumonia, featured with exuberant inflammatory cytokine production, extensive oxidative stress and tissue injury. The Keap1/Nrf2 system is the major apparatus essential for host defense against oxidative and electrophilic stresses of both exogenous and endogenous origins, representing a logical target for ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 168:247-257]

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Clinical features of the patients with major depressive disorder co-occurring insomnia and hypersomnia symptoms: a report of NSSD study.

Jie Zhao, Hongmei Liu, Zhiguo Wu, Yun Wang, Tongdan Cao, Dongbin Lyu, Qinte Huang, Zhenling Wu, Yuncheng Zhu, Xiaohui Wu, Jun Chen, Yong Wang, Yousong Su, Chen Zhang, Daihui Peng, Zezhi Li, Han Rong, Tiebang Liu, Yong Xia, Wu Hong, Yiru Fang,

<h4>Background</h4>The co-occurrence of insomnia and hypersomnia symptoms in patients with major depressive disorder (MDD) is associated with suicidal ideation and functional impairment. The relationship between sleep disturbances and clinical features and outcomes may not be adequately studied. In this study, we measured the functional impairments and clinical features of co-occurring ... Read more >>

Sleep Med (Sleep medicine)
[2021, 81:375-381]

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Comparing the Value of Cystatin C and Serum Creatinine for Evaluating the Renal Function and Predicting the Prognosis of COVID-19 Patients.

Sichao Chen, Jinpeng Li, Zeming Liu, Danyang Chen, Ling Zhou, Di Hu, Man Li, Wei Long, Yihui Huang, Jianglong Huang, Shipei Wang, Qianqian Li, Wen Zeng, Liang Guo, Xiaohui Wu,

<b>Background:</b> Coronavirus disease- (COVID-19-) related renal function abnormality is associated with poor prognosis. However, the clinical significance of dynamic changes in renal function indicators has not been studied, and no studies have evaluated the renal function in COVID-19 patients by cystatin C. <b>Objective:</b> This study aimed to evaluate the effect ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:587816]

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A Balance Between Capture and Release: How Nanochaperones Regulate Refolding of Thermally Denatured Proteins.

Feihe Ma, Xiaohui Wu, Ang Li, Linlin Xu, Yingli An, Linqi Shi,

Nanochaperones have been designed and used for regulating the (re)folding of proteins, treating protein misfolding-related diseases, and, more recently, in drug delivery. Despite various successes, a complete understanding of the working mechanisms remains elusive, which represents a challenge for the realization of their full potential. Here, we thoroughly investigated the ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, 60(19):10865-10870]

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GCSF As a Potential Molecular Target for Overall Survival of Hepatocellular Carcinoma.

Heng Cao, Peng Guo, Xiaohui Wu, Jiankun Li, Chenlong Ge, Shunxiang Wang,

<h4>Background</h4>Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of digestive tract in the world. Therefore, it is important to carry out studies on the molecular mechanisms of early diagnosis and treatment of HCC to reduce mortality.<h4>Methods</h4>Bioinformatic analysis was performed to explore the significant role of GCSF on ... Read more >>

Comb Chem High Throughput Screen (Combinatorial chemistry & high throughput screening)
[2021, :]

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Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice.

Lihong Tan, Minghui Yu, Yaxin Li, Shanshan Xue, Jing Chen, Yihui Zhai, Xiaoyan Fang, Jialu Liu, Jiaojiao Liu, Xiaohui Wu, Hong Xu, Qian Shen,

Congenital anomalies of the kidney and urinary tract (CAKUT) is a common birth defect and is the leading cause of end-stage renal disease in children. The etiology of CAKUT is complex and includes mainly genetic and environmental factors. However, these factors cannot fully explain the etiological mechanism of CAKUT. Recently, ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:594640]

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A Proteogenomic Atlas of Clear Cell Renal Cell Carcinoma in a Chinese Population

Chen Ding, Yuan-Yuan Qu, Jinwen Feng, Xiaohui Wu, Lin Bai, Wenhao Xu, Lingli Zhu, Yang Liu, Fujiang Xu, Xuan Zhang, Guojian Yang, Jiacheng Lv, Xiuping Chen, Guohai Shi, Hongkai Wang, Dalong Cao, Hang Xiang, Lingling Li, Subei Tan, Hualei Gan, Menghong Sun, Hailiang Zhang, Jian-Yuan Zhao, Dingwei Ye,

Renal cell carcinoma (RCC) is among the top 10 malignant carcinomas 1 . Clear cell (cc)RCC, accounting for ~ 75% of RCC cases, is an aggressive histological RCC subtype. In the last decade, large-scale multiomics studies have profoundly enhanced our understanding of this disease 2,3 . However, despite the differences of ... Read more >>

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Chaos Analysis of Urban Low-Carbon Traffic Based on Game Theory.

Xiaohui Wu, Ren He, Meiling He,

Developing urban low-carbon traffic is an effective measure to reduce traffic carbon emissions, which are important parts of greenhouse gas. In order to understand the development characteristics and regular patterns of urban low-carbon traffic, we present a game model that enables us to predict the possible range of travel mode ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(5):]

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Histone H3 methyltransferase Ezh2 promotes white adipocytes but inhibits brown and beige adipocyte differentiation in mice.

Xiaohui Wu, Jianqiang Li, Kaixuan Chang, Fan Yang, Zhen Jia, Cheng Sun, Qing Li, Yuqiao Xu,

Obesity is a disease characterized by imbalance between energy intake and expenditure, excessive energy store in white adipocytes, but brown and beige adipocytes consume energy to relieve obesity. In this study, we want to explore the role of the histone H3 methyltransferase Ezh2 in the differentiation of white, brown and ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2021, 1866(6):158901]

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High-normal thyroid function predicts incident non-alcoholic fatty liver disease among middle-aged and elderly euthyroid subjects.

Yeqing Gu, Xiaohui Wu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu,

<h4>Background</h4>Thyroid hormones (THs) influence hepatic lipid homeostasis through multiple pathways, suggesting that THs may predict the risk of non-alcoholic fatty liver disease (NAFLD). However, prospective studies on the association between THs levels and incident NAFLD in euthyroid subjects are limited. This prospective cohort study aimed to explore whether THs were ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, :]

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Association between consumption of edible seaweeds and newly diagnosed non-alcohol fatty liver disease: The TCLSIH Cohort Study.

Huiping Li, Yeqing Gu, Xiaohui Wu, Sabina Rayamajhi, Shanshan Bian, Qing Zhang, Ge Meng, Li Liu, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Amrish Thapa, Shaomei Sun, Xing Wang, Qiyu Jia, Kun Song, Kaijun Niu,

<h4>Background & aims</h4>Seaweeds are rich sources of anti-oxidants and anti-inflammatory properties, which are beneficial to non-alcoholic fatty liver disease (NAFLD). However, whether seaweed consumption is associated with NAFLD is unknown. We investigated the association of seaweed consumption with newly diagnosed NAFLD in a large-scale adult population.<h4>Methods</h4>This cross-sectional study involved 24 572 ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(2):311-320]

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Predictive Value of Thyroid Hormones for Incident Hyperuricemia in Euthyroid Subjects: The Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study.

Yeqing Gu, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Xiaohui Wu, Kaijun Niu,

<h4>Objective</h4>Thyroid hormones (THs) play an important role in both serum uric acid (SUA) excretion and purine nucleotide metabolism. Past research mainly focused on the relationships between thyroid dysfunction and hyperuricemia. Although most subjects at risk for hyperuricemia are euthyroid, few studies have investigated the predictive values of THs on incident ... Read more >>

Endocr Pract (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists)
[2021, 27(4):291-297]

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[Analysis of upper airway flow field between obstructive sleep apnea and normal children based on computational fluid dynamics].

Yufeng Guo, Lijun Su, Huikun Cai, Xingqiang Gao, Xiaohui Wu, Haoyang Xue,

<b>Objective:</b>In this study, the characteristics of the upper airway flow field were analyzed by using computational fluid dynamics(CFD). The study analyze the differences in the upper airway flow field between normal children and children with obstructive sleep apnea(OSA), and the pathological characteristics of children with OSA were elaborated from the ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2021, 35(2):141-146]

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