Full Text Journal Articles by
Author Xiaohong Li

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A versatile fluorometric in situ hybridization method for the quantitation of hairpin conformations in DNA self-assembled monolayers.

Jiale He, Xiaochen Hu, Xiaoyi Gao, Chenchen Meng, Yunchao Li, Xiaohong Li, Louzhen Fan, Hua-Zhong Yu,

As the performance of hairpin DNA (hpDNA)-based biosensors is highly dependent on the yield of stem-loop (hairpin) conformations, we report herein a versatile fluorometric in situ hybridization protocol for examining hpDNA self-assembled monolayers (SAMs) on popularly used biochip substrates. Specifically, the ratio of fluorescence (FL) intensities of hpDNA SAMs (in ... Read more >>

Analyst (The Analyst)
[2020, 145(13):4522-4531]

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3D spheroids generated on carbon nanotube-functionalized fibrous scaffolds for drug metabolism and toxicity screening.

Jiaojun Wei, Jinfu Lu, Maohua Chen, Songzhi Xie, Tao Wang, Xiaohong Li,

The mechanical and electrical stimuli have a profound effect on the cellular behavior and function. In this study, a series of conductive nanofibrous scaffolds are developed by blend electrospinning of poly(styrene-co-maleic acid) (PSMA) and multiwalled-carbon nanotubes (CNTs), followed by grafting galactose as cell adhesion cues. When the mass ratios of ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 8(1):426-437]

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Janus micromotors for motion-capture-lighting of bacteria.

Long Zhao, Songzhi Xie, Yuan Liu, Qingjie Liu, Xiaojie Song, Xiaohong Li,

The rapid and sensitive identification of bacteria has long been a major challenge in quality control, environmental monitoring and food safety. In the current study, the "motion-capture-lighting" strategy is proposed via integration of motion-enhanced capture of bacteria and capture-induced fluorescence turn-on of micromotors. Compared with the commonly used microtubes and ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(38):17831-17840]

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Fluorescent fibrous mats assembled with self-propagating probes for visual sensing of hydrogen peroxide and choline.

Long Zhao, Zhanlin Zhang, Maohua Chen, Yuan Liu, Tao Wang, Xiaohong Li,

Challenges remain in the facile, rapid and sensitive detection of substances at ultralow levels. In the current study, visual sensors of hydrogen peroxide (H2O2) and choline are developed via the integration of an ultrafine fibrous substrate and self-propagating and aggregation-induced emission (AIE) probes. Self-immolative probes (SIPs) composed of phenylboronic acid ... Read more >>

Analyst (The Analyst)
[2019, 144(18):5624-5636]

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The value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as complementary diagnostic tools in the diagnosis of rheumatoid arthritis: A multicenter retrospective study.

Zihan Jin, Gaojun Cai, Ping Zhang, Xiaohong Li, Shuang Yao, Lin Zhuang, Min Ren, Qiang Wang, Xiaolong Yu,

BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have drawn attention in recent years as novel non-specific inflammatory markers; however, only a few studies have been conducted to investigate their value in RA. OBJECTIVE:To investigate the value of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) as complementary diagnostic ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, :e23569]

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Breastfeeding practice in China from 2013 to 2018: a study from a national dynamic follow-up surveillance

Leni Kang, Juan Liang, Chunhua He, Lei Miao, Xiaohong Li, Li Dai, Qi Li, Zheng Liu, Jun Zhu, Yanping Wang, Hanmin Liu,

Abstract Background Breastfeeding is important for the physical and psychological health of the mother and child. Basic data on breastfeeding practices in China are crucial for understanding how to advance health-related goals. Methods This was an observational study. We used data from the Under-5 Child Nutrition and ... Read more >>

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IgG Subclass Expression in Diabetic Nephropathy

Xuanli Tang, Xue Jiang, Feng Wan, Xiaohong Li, Ruchun Yang, Bin Zhu, Yayu Li, Haichun Yang,

Abstract Background: This study aimed to analyze the distribution of IgG subclasses in diabetic nephropathy (DN) and its association with clinico-pathological features. Methods: Forty DN cases were analyzed to identify IgG subclasses, as well as collagen IV α5, CD34, and KIM-1. Results: Both IgG and its subclasses showed a linear ... Read more >>

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Serum platelet-derived growth factor-BB levels as a potential biomarker in assessing the metabolic activity of lesions in alveolar echinococcosis patients

ying ke, Xiaojuan Bi, Ning Yang, Xiaohong Li, Wenmei Ma, Hui Liu, Hui Wang, Liang Li, Cheng Li, Yongde Qin, Tuerganaili Aji, Yingmei Shao, Guodong Lü, Renyong Lin,

Abstract Objective Alveolar echinococcosis (AE) is a chronic disease caused by the larval stage of Echinococcus multilocularis. Assessing the metabolic activity of AE lesions is critical to evaluate disease progression and survey treatment options. There is an urgent need to identify more rapid, convenient, and non-invasive clinical detection methods to ... Read more >>

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Copper-Catalyzed Defluorinative Hydroarylation of Alkenes with Polyfluoroarenes.

Xiaohong Li, Bin Fu, Qiao Zhang, Xiuping Yuan, Qian Zhang, Tao Xiong, Qian Zhang,

A catalytic  defluorinative hydroarylation of alkenes with polyfluoroarenes in the presence of dppbz-ligated Cu catalyst and silanes was presented for the first time. This method provides a straightforward and alternative avenue to synthetic important polyfluorinated arenes with readily available and bench-stable alkenes as latent nucleophiles, and therefore avoids conventional reliance on stoichiometric ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Correction to "Diuranium(IV) Carbide Cluster U2C2 Stabilized Inside Fullerene Cages".

Jiaxin Zhuang, Laura Abella, Dumitru-Claudiu Sergentu, Yang-Rong Yao, Meihe Jin, Wei Yang, Xingxing Zhang, Xiaomeng Li, Duo Zhang, Yiming Zhao, Xiaohong Li, Shuao Wang, Luis Echegoyen, Jochen Autschbach, Ning Chen,

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(35):15202]

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Response surface optimization of the water immersion extraction and macroporous resin purification processes of anhydrosafflor yellow B from Carthamus tinctorius L.

Peng Zhou, Yijia Fangma, Weifeng Jin, Zhan Jin, Xiaohong Li, Yu He,

In this study,based on a developed high performance liquid chromatographic quantitative method, the suitable extraction and purification conditions of anhydrosafflor yellow B (AHSYB) from safflower were determined by response surface methodology. The optimal water immersion extraction parameters were as follows: liquid to solid ratio of 22:1; extraction temperature of 75 ... Read more >>

J. Food Sci. (Journal of food science)
[2020, :]

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Upregulated neuregulin-1 protects against optic nerve injury by regulating the RhoA/cofilin/F-actin axis.

Qian Hao, Yan Zhang, Xiaohong Li, Lingling Liang, Hui Shi, Zhihua Cui, Wei Yang,

OBJECTIVE:In recent years, the roles of Neuregulin-1 (NRG-1) in optic nerve injury and retinal cells have been investigated. However, the molecular mechanism by which NRG-1 affects optic nerve injury remains elusive and merits deeper exploration. Hence, this study examined the specific function of NRG-1 in the RhoA/cofilin/F-actin axis in optic ... Read more >>

Life Sci. (Life sciences)
[2020, :118283]

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Quantitative evaluation of range and metabolic activity of hepatic alveolar echinococcosis lesion microenvironment using PET/CT and multi-site sampling method

Abudusalamu Aini, Maiweilidan Yimingjiang, Aimaiti Yasen, Bo Ran, Tiemin Jiang, Xiaohong Li, Jian Wang, Kasimu Aihaiti, Aisika Ainiwa, Aubuduaini Abulizi, Yingmei Shao, Tuerganaili Aji, Hao Wen,

Abstract Background: Alveolar echinococcosis (AE) lesion microenvironment (LME) is crucial site where parasite-host interactions happen and of great significance during surgery and obtaining liver samples for basic research targeting immunology. However, little is known about quantification of LME range and its’ metabolic activity regarding different lesion types. Methods: A prospective ... Read more >>

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Real-world survival outcomes of heavily pretreated patients with refractory HR+, HER2-metastatic breast cancer receiving single-agent chemotherapy-a comparison with MONARCH 1.

Hope S Rugo, Veronique Dieras, Javier Cortes, Debra Patt, Hans Wildiers, Joyce O'Shaughnessy, Esther Zamora, Denise A Yardley, Gebra Cuyun Carter, Kristin M Sheffield, Li Li, Valerie A M Andre, Xiaohong I Li, Martin Frenzel, Yu-Jing Huang, Maura N Dickler, Sara M Tolaney,

PURPOSE:In MONARCH 1 (NCT02102490), single-agent abemaciclib demonstrated promising efficacy activity and tolerability in a population of heavily pretreated women with refractory HR+, HER2- metastatic breast cancer (MBC). To help interpret these results and put in clinical context, we compared overall survival (OS) and duration of therapy (DoT) between MONARCH 1 ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2020, :]

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BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis.

Yan Shi, Yongqing Li, Yuequn Wang, Ping Zhu, Yu Chen, Heng Wang, Shusheng Yue, Xiaohui Xia, Jimei Chen, Zhigang Jiang, Chengbin Zhou, Wanwan Cai, Haiyun Yuan, Yueheng Wu, Yongqi Wan, Xiaohong Li, Xiaolan Zhu, Zuoqiong Zhou, Guo Dai, Fang Li, Xiaoyang Mo, Xiangli Ye, Xiongwei Fan, Jian Zhuang, Xiushan Wu, Wuzhou Yuan,

BVES is a transmembrane protein, our previous work demonstrated that single nucleotide mutations of BVES in tetralogy of fallot (TOF) patients cause a downregulation of BVES transcription. However, the relationship between BVES and the pathogenesis of TOF has not been determined. Here we reported our research results about the relationship between ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14167]

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Dominant atopy risk mutations identified by mouse forward genetic analysis.

Jeffrey A SoRelle, Zhe Chen, Jianhui Wang, Tao Yue, Jin Huk Choi, Kuan-Wen Wang, Xue Zhong, Sara Hildebrand, Jamie Russell, Lindsay Scott, Darui Xu, Xiaowei Zhan, Chun Hui Bu, Tao Wang, Mihwa Choi, Miao Tang, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Eva Marie Y Moresco, Bruce Beutler,

BACKGROUND:Atopy, the overall tendency to become sensitized to an allergen, is heritable but seldom ascribed to mutations within specific genes. Atopic individuals develop abnormally elevated IgE responses to immunization with potential allergens. To gain insight into the genetic causes of atopy, we carried out a forward genetic screen for atopy ... Read more >>

Allergy (Allergy)
[2020, :]

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Newborn hearing screening coverage and detection rates of hearing impairment across China from 2008-2016.

Xuelian Yuan, Kui Deng, Jun Zhu, Liangcheng Xiang, Yongna Yao, Qi Li, Xiaohong Li, Hanmin Liu,

BACKGROUND:Newborn hearing screening (NHS) can reduce the economic and social burden of hearing impairment. To track the progress of the goal set by the National Program of Action for Child Development (NPACD) and to estimate the detection rates of hearing impairment, the present study examined NHS coverage in 2008-2010 and ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):360]

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Low serum 25-hydroxyvitamin D levels are associated with perennial allergic rhinitis but not disease severity.

Yan Ma, Yehai Liu, Xiaohong Li, Jianxin Qiu, Ping Fang,

BACKGROUND:Vitamin D deficiency plays an essential role in allergic rhinitis(AR), but the role of vitamin D deficiency in perennial allergic rhinitis (pAR) remains unclear. Therefore, our study explored 25(OH)D levels in patients with pAR and healthy individuals in a single center in China for three years. METHODS:A total of 655 ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, :e23516]

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Density Functional Theory Study of NiFeCo Trinary Oxy-Hydroxides for an Efficient and Stable Oxygen Evolution Reaction Catalyst.

Habib Ullah, Adeline Loh, David P Trudgeon, Xiaohong Li,

NiOOH and its doped species are widely used as electrocatalysts for the oxygen evolution reaction (OER) in alkaline media. In this work, we carried out comprehensive density functional theory (DFT) simulations of Ni-based electrocatalysts for the OER by applying suitable dopants in β-NiOOH. A range of Fe and Co atoms ... Read more >>

ACS Omega (ACS omega)
[2020, 5(32):20517-20524]

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Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood.

Xiaoming Zhan, Xue Zhong, Jin Huk Choi, Lijing Su, Jianhui Wang, Evan Nair-Gill, Priscilla Anderton, Xiaohong Li, Miao Tang, Jamie Russell, Sara Ludwig, Thomas Gallagher, Bruce Beutler,

Adenosine monophosphate deaminase 3 (Ampd3) encodes the erythrocyte isoform of the adenosine monophosphate (AMP) deaminase gene family. Mutations in this gene have been reported in humans, leading to autosomal-recessive erythrocyte AMP deaminase deficiency. However, the mutation is considered clinically asymptomatic. Using N-ethyl-N-nitrosourea mutagenesis to find mutations that affect peripheral lymphocyte ... Read more >>

Blood Adv (Blood advances)
[2020, 4(15):3594-3605]

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Plasma Interleukin-37 is Elevated in Acute Ischemic Stroke Patients and Probably Associated With 3-month Functional Prognosis.

Feng Zhang, Tianrui Zhu, Heng Li, Yi He, Yuanyuan Zhang, Nana Huang, Guitao Zhang, Yanshuang Li, Dujuan Chang, Xiaohong Li,

Background:Interleukin-37 is a novel cytokine emerging as a natural suppressor of inflammatory responses. Inflammation and the immune response play important roles in acute ischemic stroke. This study aimed at evaluating the plasma levels and the association with 3-month outcomes of interleukin-37 in acute ischemic stroke patients. Patients and Methods:In total, ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2020, 15:1285-1294]

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Association between prepregnancy body mass index and risk of congenital heart defects in offspring: an ambispective observational study in China.

Xuelian Yuan, Zhen Liu, Jun Zhu, Ping Yu, Ying Deng, Xinlin Chen, Nana Li, Shengli Li, Shuihua Yang, Jun Li, Hanmin Liu, Xiaohong Li,

BACKGROUND:Congenital heart defects (CHDs) are the most common birth defect around the world. Maternal prepregnancy obesity has been proposed as a risk factor of CHDs, but the relationship of CHD risk with over- and underweight is controversial, especially because body mass index (BMI) distribution differs between Asia and the West. ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):444]

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Enhanced cell proliferation by electrical stimulation based on electroactive regenerated bacterial cellulose hydrogels.

Li Wang, Sanming Hu, Muhammad Wajid Ullah, Xiaohong Li, Zhijun Shi, Guang Yang,

Electric fields (EFs) have shown promising impact on wound healing, these alone are ineffective to stimulate the whole wound area. In this study, we developed a newly regenerated bacterial cellulose/polypyrrole/carbon nanotube (rBC/PPy/CNT) electroactive hydrogel through cellulose dissolution, and physical and chemical crosslinking method to enhance cell proliferation with EF for ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2020, 249:116829]

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microRNA-1906 protects cerebral ischemic injury through activating Janus kinase 2/signal transducer and activator of transcription 3 pathway in rats.

Xiunan Yu, Xiaohong Li,

This study aimed to investigate the effects of miR-1906 on cerebral ischemic injury and its underlying mechanisms. After 24 h of reperfusion, neurological deficit scores, brain water content and infarct volume were measured. Neuronal apoptosis was detected by using terminal dexynucleotidyl transferase-mediated dUTP nick end labeling assay. Hematoxylin-eosin staining was used ... Read more >>

Neuroreport (Neuroreport)
[2020, 31(12):871-878]

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Effects of Disability Type on the Association between Age and Non-Communicable Disease Risk Factors among Elderly Persons with Disabilities in Shanghai, China.

Xichen Wang, Mei Sun, Xiaohong Li, Jun Lu, Gang Chen,

Little is known about differences in the association between age and risk factors of non-communicable diseases (NCDs), according to the disability type in Chinese elderly persons with disabilities. Thus, we examined the effects of these differences in elderly persons with disabilities in Shanghai, China. We evaluated four NCD risk factors ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(15):]

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