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Late-onset Hearing Loss From Congenital Cytomegalovirus Infection After Newborn Period in a Highly Immune Population in China.

Chengbin Wang, Xiaolin Liu, Shiwen Wang, Wenqiang Zhang, Haiyan Wang, Wei Ma, Xiangxin Meng, Xingqu Xu, Zhan Li, Qiang Pan, Shuxia Zhang, Ping Wang, Qian Lin, Xiaofang Wang, Minal Amin, Sheila Dollard, Aiqiang Xu, Winnie Chung,

After following 141 children with likely asymptomatic congenital cytomegalovirus infection in a highly immune population in China, four children (2.8%) were found to have late-onset hearing loss. No maternal or childhood factors, except higher saliva cytomegalovirus viral load at birth (P = 0.03), were associated with increased risk of developing ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):70-73]

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TNFAIP3 ameliorates the degeneration of inflammatory human nucleus pulposus cells by inhibiting mTOR signaling and promoting autophagy.

Jie Chen, Yufei Ma, Zhijie Yang, Haiyang Lan, Guangliang Liu, Ye Zhang, Huiqiang Xia, Xiaofang Wang, Fei Han, Xiaolin Tu, Bo Liu,

Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degeneration. We hypothesize that TNFAIP3 ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(23):24242-24254]

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Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients

Jing Ma, xiaofei Ai, Jinhuan Wang, Limin Xing, Chen Tian, Hongliang Yang, Yong Yu, Haifeng Zhao, Xiaofang Wang, Zhigang Zhao, Yafei Wang, Zeng Cao,

<h4>Background: </h4> Chromosomal abnormalities play an important role in classification and prognostication of myelodysplastic syndromes (MDS) patients. However, more than 50% low risk MDS patients harbor a normal karyotype. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for the detection of cytogenetic aberrations in ... Read more >>

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Retraction Note: Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis.

Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A Silva, Xiaofang Wang, Ping Wang, Zhan Zhang,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):233]

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Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice.

Jun Xu, Xiaofang Wang, Jiaye Chen, Shengbo Chen, Zhijun Li, Hongbin Liu, Yang Bai, Fachao Zhi,

<b>Rationale:</b> Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD) due to their immunomodulatory and trophic functions. However, their efficacy is influenced by tissue origin, donator condition, isolation, and expansion methods. Here, we generated phenotypically uniform MSCs from human embryonic stem cells (T-MSCs) and explored ... Read more >>

Theranostics (Theranostics)
[2020, 10(26):12204-12222]

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Fetal double aortic arch: prenatal sonographic and postnatal computed tomography angiography features, associated abnormalities and clinical outcomes.

Qiao Guo, Yifan Kong, Shi Zeng, Jiawei Zhou, Xiaofang Wang, Quanliang Shang, Jia Zhou, Hongxia Yuan, Ling Wang, Lili Tong, Aijiao Yi, Qichang Zhou,

<h4>Background</h4>Fetal double aortic arch (DAA) malformation is a rare congenital heart disease with few reported cases in the literature. We aimed to investigate the characteristics of prenatal ultrasound and postnatal computed tomography angiography (CTA) of DAA and to describe the associated anomalies and clinical outcomes to improve prenatal diagnosis and ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):614]

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Fetal double aortic arch: prenatal sonographic and postnatal computed tomography angiography features, associated abnormalities and clinical outcomes

Qiao Guo, Yifan Kong, Shi Zeng, Jiawei Zhou, Xiaofang Wang, Quanliang Shang, Jia Zhou, Hongxia Yuan, Ling Wang, Lili Tong, Aijiao Yi, Qichang Zhou,

<h4>Background: </h4> Fetal double aortic arch (DAA) malformation is a rare congenital heart disease with few reported cases in the literature. We aimed to investigate the characteristics of prenatal ultrasound and postnatal computed tomography angiography (CTA) of DAA and to describe the associated anomalies and clinical outcomes to improve prenatal ... Read more >>

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Regulatory role and mechanism of the inhibition of the Mcl-1 pathway during apoptosis and polarization of H37Rv-infected macrophages.

Ling Han, Yang Lu, Xiaofang Wang, Shujun Zhang, Yingzi Wang, Fang Wu, Wanjiang Zhang, Xinmin Wang, Le Zhang,

<h4>Background</h4>Myeloid cell leukemia-1 (Mcl-1) plays an important role in the clearance of Mycobacterium tuberculosis (MTB) infection. It has the effect of anti-apoptosis, protecting macrophages that have engulfed pathogens and preventing pathogen clearance. Meanwhile, the MAPK signaling pathway plays a significant role in regulating Mcl-1 expression during tuberculosis infection. In the ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(42):e22438]

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The Globodera pallida Effector GpPDI1 Is a Functional Thioredoxin and Triggers Defense-Related Cell Death Independent of Its Enzymatic Activity.

Rachel Gross, Shan Zhang, Lihui Wei, Allan Caplan, Joseph Kuhl, Louise-Marie Dandurand, Xiaofang Wang, Fangming Xiao,

The plant-parasitic nematode Globodera pallida is an obligate biotroph that only reproduces on select species in the Solanum family. The establishment of the feeding site, the syncytium, involves secretion of effectors into the plant cell to combat the plant defense response and facilitate transformation of root cells into the syncytium. ... Read more >>

Phytopathology (Phytopathology)
[2020, 110(11):1838-1844]

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MicroRNA-26a Protects the Heart Against Hypertension-Induced Myocardial Fibrosis.

Wenqian Zhang, Qiaozhu Wang, Yanjing Feng, Xuegui Chen, Lijun Yang, Min Xu, Xiaofang Wang, Weicheng Li, Xiaolin Niu, Dengfeng Gao,

Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, and sudden death. In recent years, with the deepening of research, microRNAs have been found to have an important role in blood pressure control and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(18):e017970]

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Epidemiology of autosomal-dominant polycystic liver disease in Olmsted county.

Tatsuya Suwabe, Alanna M Chamberlain, Jill M Killian, Bernard F King, Adriana V Gregory, Charles D Madsen, Xiaofang Wang, Timothy L Kline, Fouad T Chebib, Marie C Hogan, Patrick S Kamath, Peter C Harris, Vicente E Torres,

<h4>Background & aims</h4>Isolated autosomal-dominant polycystic liver disease (ADPLD) is generally considered a rare disease. However, the frequency of truncating mutations to ADPLD genes in large, population sequencing databases is 1:496. With the increasing use of abdominal imaging, incidental detection of hepatic cysts and ADPLD has become more frequent. The present ... Read more >>

JHEP Rep (JHEP reports : innovation in hepatology)
[2020, 2(6):100166]

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Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18 and SARS-CoV-2-specific IgA

Wanyin Tao, Shu Zhu, Guorong Zhang, Xiaofang Wang, Meng Guo, Weihong Zeng, Zihao Xu, Lianxin Liu, Kaiguang Zhang, Yucai Wang, Xiaoling Ma, Zhengxu Chen, Tengchuan Jin, Jianping Weng,

The current global COVID-19 pandemic is caused by beta coronavirus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which already infected over 10 million and caused 500 thousand deaths by June 2020. Overproduction of cytokines triggered by COVID-19 infection, known as "cytokine storm", is a highly risk factor associated with disease severity. ... Read more >>

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Overexpression of microRNA-130a predicts adverse prognosis of primary gastrointestinal diffuse large B-cell lymphoma.

Leiyuan Chen, Yutian Kan, Xinyuan Wang, Peng Ge, Tingting Ding, Qiongli Zhai, Yafei Wang, Yong Yu, Xiaofang Wang, Zhigang Zhao, Hongliang Yang, Xianming Liu, Lanfang Li, Lihua Qiu, Huilai Zhang, Zhengzi Qian, Haifeng Zhao,

Primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) is a highly heterogeneous type of non-Hodgkin lymphoma. A number of studies have demonstrated that microRNA-130a (miR-130a) serves a role in the tumorigenesis and prognosis of numerous human tumors. However, to the best of our knowledge, the prognostic significance of miR-130a in PGI-DLBCL ... Read more >>

Oncol Lett (Oncology letters)
[2020, 20(4):93]

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Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm.

Chuang Guo, Bin Li, Huan Ma, Xiaofang Wang, Pengfei Cai, Qiaoni Yu, Lin Zhu, Liying Jin, Chen Jiang, Jingwen Fang, Qian Liu, Dandan Zong, Wen Zhang, Yichen Lu, Kun Li, Xuyuan Gao, Binqing Fu, Lianxin Liu, Xiaoling Ma, Jianping Weng, Haiming Wei, Tengchuan Jin, Jun Lin, Kun Qu,

Several studies show that the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of the immune cell composition of two severe-stage COVID-19 patients prior to and following tocilizumab-induced remission, we identify a monocyte subpopulation ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):3924]

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Lanthanide terbium complex: synthesis, electrochemiluminescence (ECL) performance, and sensing application.

Xia Xu, Xiangxiang Qin, Ling Wang, Xiaofang Wang, Jing Lu, Xia Qiu, Yinggui Zhu,

In this study, a new lanthanide terbium complex, Tb(pzda)3(NO3)3·nH2O, was synthesized by a hydrothermal method and characterized by Fourier transform infrared spectroscopy (FT-IR) and energy-dispersive X-ray spectroscopy (EDS). It was found that the as-synthesized Tb-complex exhibited good electrochemiluminescence (ECL) behavior in the presence of triethanolamine (TEOA) in a HAc-NaAc buffer ... Read more >>

Analyst (The Analyst)
[2019, 144(7):2359-2366]

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Identification of Prognostic Biomarkers and Correlation with Immune Infiltrates in Hepatocellular Carcinoma Based on a Competing Endogenous RNA Network

Zhangya Pu, Yuanyuan Zhu, Xiaofang Wang, Yun Zhong, Fang Peng, Yiya Zhang,

<h4>Background: </h4> Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Recently, competing endogenous RNAs (ceRNA) have revealed a significant role in the progression of HCC. Herein, we aimed to construct a ceRNA network to identify potential biomarkers and illustrate its correlation with immune infiltration in HCC. ... Read more >>

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FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.

Jingyi Wu, Ye Tian, Lu Han, Chao Liu, Tianyu Sun, Ling Li, Yanlei Yu, Bikash Lamichhane, Rena N D'Souza, Sarah E Millar, Robb Krumlauf, David M Ornitz, Jian Q Feng, Ophir Klein, Hu Zhao, Fuming Zhang, Robert J Linhardt, Xiaofang Wang,

<h4>Background</h4>The formation of supernumerary teeth is an excellent model for studying the molecular mechanisms that control stem/progenitor cell homeostasis needed to generate a renewable source of replacement cells and tissues. Although multiple growth factors and transcriptional factors have been associated with supernumerary tooth formation, the regulatory inputs of extracellular matrix ... Read more >>

BMC Biol (BMC biology)
[2020, 18(1):87]

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Exosomal PD-L1 Derived From Osteosarcoma is Associated With Pulmonary Metastasis for Patients With Osteosarcoma

Jun Wang, Hongliang Zhang, Xin Sun, Xiaofang Wang, Tingting Ren, Yi Huang, Ranxin Zhang, Bingxin Zheng, Wei Guo,

<h4>Background: </h4> Recent studies indicated that exosomal programmed death-ligand 1 (PD-L1) derived from cancers could induce immunosuppression and tumor pathogenesis. However, it is unclear how the exosome influences the osteosarcoma (OS) progression and whether PD-L1 also exists in serum exosomes (Sr-exosomes) of patients with osteosarcoma. Methods We examined serum ... Read more >>

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Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms.

Cong-Lin Liu, Xin Liu, Yunzhe Wang, Zhiyong Deng, Tianxiao Liu, Galina K Sukhova, Gregory R Wojtkiewicz, Rui Tang, Jin-Ying Zhang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Xiaofang Wang, Guo-Ping Shi,

IgE-mediated activation of Nhe1 (Na+-H+ exchanger-1) induces aortic cell extracellular acidification and promotes cell apoptosis. A pH-sensitive probe pHrodo identified acidic regions at positions of macrophage accumulation, IgE expression, and cell apoptosis in human and mouse abdominal aortic aneurysm (AAA) lesions. Ang II (angiotensin II)-induced AAA in Nhe1-insufficient Apoe-/-Nhe1+/- mice ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 76(1):87-100]

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IL-22 hinders antiviral T cell responses and exacerbates neurological disorders in ZIKV-infected immunocompetent neonatal mice

Yuejin Liang, Panpan Yi, Wenjuan Ru, Zuliang Jie, Hui Wang, Tamer Ghanayem, Xiaofang Wang, Edrous Alamer, Jinjun Liu, Haitao Hu, Lynn Soong, Jiyang Cai, Jiaren Sun,

<h4>Background: </h4> The Zika virus (ZIKV) outbreak that occurred in multiple countries was linked to increased risk of neurological disorders and congenital defects. However, host immunity and immune-mediated pathogenesis in ZIKV infection are not well understood. Interleukin-22 (IL-22) is a crucial cytokine for regulating host immunity in infectious diseases. Whether ... Read more >>

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Competition for iron drives phytopathogen control by natural rhizosphere microbiomes.

Shaohua Gu, Zhong Wei, Zhengying Shao, Ville-Petri Friman, Kehao Cao, Tianjie Yang, Jos Kramer, Xiaofang Wang, Mei Li, Xinlan Mei, Yangchun Xu, Qirong Shen, Rolf Kümmerli, Alexandre Jousset,

Plant pathogenic bacteria cause high crop and economic losses to human societies<sup>1-3</sup>. Infections by such pathogens are challenging to control as they often arise through complex interactions between plants, pathogens and the plant microbiome<sup>4,5</sup>. Experimental studies of this natural ecosystem at the microbiome-wide scale are rare, and consequently we have ... Read more >>

Nat Microbiol (Nature microbiology)
[2020, 5(8):1002-1010]

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Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling.

Caroline R Sussman, Xiaofang Wang, Fouad T Chebib, Vicente E Torres,

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disorder associated with polycystic liver disease (PLD) and other extrarenal manifestations, the most common monogenic cause of end-stage kidney disease, and a major burden for public health. Many studies have shown that alterations in G-protein and cAMP signaling play a central ... Read more >>

Cell Signal (Cellular signalling)
[2020, 72:109649]

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The role of SRGN in the survival and immune infiltrates of skin cutaneous melanoma (SKCM) and SKCM-metastasis patients.

Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li, Kun Zhang,

<h4>Background</h4>Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on immune infiltrates and whether it associates with survival of SKCM and SKCM-metastasis patients has not been explored.<h4>Methods</h4>We evaluated SRGN ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):378]

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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis.

Fang Dong, Sha Hao, Sen Zhang, Caiying Zhu, Hui Cheng, Zining Yang, Fiona K Hamey, Xiaofang Wang, Ai Gao, Fengjiao Wang, Yun Gao, Ji Dong, Chenchen Wang, Jinyong Wang, Yu Lan, Bing Liu, Hideo Ema, Fuchou Tang, Berthold Göttgens, Ping Zhu, Tao Cheng,

How transplanted haematopoietic stem cells (HSCs) behave soon after they reside in a preconditioned host has not been studied due to technical limitations. Here, using single-cell RNA sequencing, we first obtained the transcriptome-based classifications of 28 haematopoietic cell types. We then applied them in conjunction with functional assays to track ... Read more >>

Nat Cell Biol (Nature cell biology)
[2020, 22(6):630-639]

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Linear Response Theory for Decomposition Energies of Stokes Shift in Proteins.

Jirui Guo, Xiaofang Wang, Tanping Li, Zhiyi Wei,

In aqueous solution, fluorescence Stokes shift experiments monitor the relaxation of the solute-solvent interactions upon photon excitation of the solute chromophore. Linear response (LR) theory expects the identical dynamics between the Stokes shift and the system's spontaneous fluctuations. Whether this identity guarantees similar dynamics between the nonequilibrated and equilibrium processes ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2020, 124(17):3540-3547]

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