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Author Xiaobo Huang

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Hybrid Ni3S2-MoS2 nanowire arrays as a pH-universal catalyst for accelerating the hydrogen evolution reaction.

Xundi Gu, Shuangjie Zheng, Xiaobo Huang, Hefeng Yuan, Jinping Li, Manab Kundu, Xiaoguang Wang,

Hybrid Ni3S2-MoS2 NWAs/NF, hybrid Ni3S2-MoS2 nanowire arrays in situ grown on Ni foam via a two-step hydrothermal method, can achieve cathodic current densities of 10 mA cm-2 and 100 mA cm-2 at overpotentials of 99 mV and 260 mV in 1.0 M KOH and 111 mV and 194 mV in ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(16):2471-2474]

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Preliminary analysis of serum electrolytes and body mass index in patients with and without urolithiasis.

Zaixian Zhang, Qingquan Xu, Xiaobo Huang, Shihe Liu, Chuanyu Zhang,

OBJECTIVES:To compare body mass index (BMI); serum parameters; and urine parameters between patients with and without urolithiasis. METHODS:Data from 1164 patients admitted to our Department of Urology from January 2011 to July 2013 were retrospectively reviewed; 714 patients (age, 5-87 years; male:female ratio, 1.8:1) exhibited urolithiasis, and 450 patients (age, ... Read more >>

J. Int. Med. Res. (The Journal of international medical research)
[2020, 48(6):300060520925654]

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A novel protein chip for simultaneous detection of antibodies against four epidemic swine viruses in China.

Yue Wu, Xudan Wu, Jing Chen, Jingfei Hu, Xiaobo Huang, Bin Zhou,

BACKGROUND:At present, pig industry in China is faced with the complex situation of mixed infection caused by multiple pathogens. It is urgent to develop some new high-throughput molecular diagnosis assays to simultaneously detect pathogens or antibodies. Biochip array technology has made it possible to screen thousands of samples simultaneously; it ... Read more >>

BMC Vet. Res. (BMC veterinary research)
[2020, 16(1):162]

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The Cardiac Injury in Hospitalized Patients with Severe COVID-19 in Wuhan, China

Sen Lu, Hongli He, Rong an Liu, Yaqiu Wu, Lei Deng, Pin Wang, Weiwei Huang, Yong Peng, Hongwen Xiao, Gang Li, Xiaobo Huang,

Abstract Background: The Coronavirus disease 2019 (COVID-19) has caused a global pandemic since December 2019, while the date on the relationship between cardiac injury and mortality in patients with COVID-19 is limited. Methods: All consecutive lab-confirmed critically ill COVID-19 patients in intensive care unit of Wuhan Red Cross Hospital from ... Read more >>

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Favorable manipulation of macrophage/endothelial cell functionality and their cross-talk on silicon-doped titania nanotube arrays.

Long Bai, Yanlian Liu, Xiangyu Zhang, Xiaobo Huang, Xiaohong Yao, Ruiqiang Hang, Bin Tang, Yin Xiao,

Inflammatory reactions and the functionality of endothelial cells (ECs) on the surfaces of coronary stents are critical in the prevention of in-stent restenosis and subsequent neoatherosclerosis. However, the interactions between immune cells and ECs on modified coronary stent surfaces have long been underestimated. In the present study, silicon (Si)-doped titania ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(13):5920-5931]

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Ultrasound-Guided Minimally Invasive Percutaneous Nephrolithotomy is Effective in the Management of Pediatric Upper Ureteral and Renal Stones.

Yang Hong, Haiyun Ye, Bo Yang, Liulin Xiong, Lizhe An, Kai Ma, Mingrui Xia, Xiaobo Huang, Qingquan Xu,

Aim: To evaluate the outcome of ultrasound (US)-guided minimally invasive percutaneous nephrolithotomy (MPCNL) in the management of upper ureteral and renal stones in pediatric patients.Methods: We collected data of 112 pediatric patients who were admitted to the xxxx between March 2006 and December 2016 and treated by US-guided MPCNL. Our ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2020, :1-5]

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Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the Plateau area

Yu lei, xiaobo huang, silang bamu, yunping lan, jianli lu, fan zeng,

Abstract Background: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread throughout China, but the clinical characteristics of Tibetan patients living in the Qinghai-Tibetan plateau are unknown. We aimed to investigate the epidemiological, clinical, laboratory and radiological characteristics of these patients. Methods: We included 67 Tibetan patients with confirmed ... Read more >>

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The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database.

Jean-Louis Vincent, Andrew Ferguson, Peter Pickkers, Stephan M Jakob, Ulrich Jaschinski, Ghaleb A Almekhlafi, Marc Leone, Majid Mokhtari, Luis E Fontes, Philippe R Bauer, Yasser Sakr, ,

BACKGROUND:Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):171]

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Identification of SOCS family members with prognostic values in human ovarian cancer.

Mengqi Yang, Huanting Chen, Lin Zhou, Xiaobo Huang, Fengxi Su, Peng Wang,

BACKGROUND:Suppressor of cytokine signaling (SOCS) family proteins regulate cytokine responses through inhibition of multiple signaling pathways. The expression profiles and prognostic significance of SOCS members in ovarian cancer (OC) patients still remains unclear. Here, we aimed to provide a comprehensive understanding of the prognostic values of SOCS family members in ... Read more >>

Am J Transl Res (American journal of translational research)
[2020, 12(5):1824-1838]

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Rationale and study design for ablation of paroxysmal atrial fibrillation guided by ablation index: a multi-center, prospective randomized trial (PAF-AI trial).

Ruhong Jiang, Minglong Chen, Jie Fan, Fu Yi, Anli Tang, Xingpeng Liu, Wenqing Zhu, Shaowen Liu, Xiaobo Huang, Weizhu Ju, Xi Zhang, Jie Li, Jiangui He, Liang Shi, Genqing Zhou, Yuegang Wang, Chenyang Jiang,

BACKGROUND:Pulmonary vein isolation (PVI) has become the cornerstone of atrial fibrillation (AF) ablation, but long-term success rates remains suboptimal, due in large part to late PV reconnection and insufficient ostial substrate modification. OBJECTIVE:To evaluate whether ablation index (AI)-guided PVI with electrical isolation and quantified ostial substrate modification improves clinical outcomes ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2020, :]

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Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis.

Bin Xiao, Xiaobo Huang, Qian Wang, Yanchuan Wu,

Beta-asarone (β-Asarone), the major component of Acorus tatarinowii Rhizoma, has been proved to be muti-pharmacological activities including anti-inflammation, and which is effective in protecting the central nervous system. However, the effect of β-Asarone on myocardial ischemia-reperfusion (I/R) injury is not yet clear. This study used a rat model with 45 min ... Read more >>

Biol. Pharm. Bull. (Biological & pharmaceutical bulletin)
[2020, 43(7):1046-1051]

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A HGF‑derived peptide suppresses EMT in human lens epithelial cells via the TGF‑β/Smad and Akt/mTOR signaling pathways.

Xiaobo Huang, Yulan Wang, Pei Zhang, Haidong Zou,

Posterior capsule opacification (PCO) as a result of proliferation and fibrogenesis of lens epithelial cells (LECs) is the most frequent long‑term complication of modern cataract surgery. LECs may undergo epithelial‑mesenchymal transition (EMT) that resembles the morphological and molecular characteristics of PCO. A pre‑identified novel, hepatocyte growth factor (HGF)‑derived peptide H‑RN, was reported to exhibit ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 22(1):551-558]

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Thinning enhances ecosystem multifunctionality via increase of functional diversity in a Pinus yunnanensis natural secondary forest

Xiaobo Huang, Shuaifeng Li, Jianrong Su,

Abstract Background: The impacts of thinning on ecosystem multifunctionality (EMF) remain largely unexplored. In this study, we analyzed nine variables related to four ecosystem functions (nutrient cycling, soil carbon stocks, decomposition, and wood production) under five thinning intensities. We included a control group to evaluate the shift in EMF of ... Read more >>

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Liver damage in severe COVID-19 patients from Sichuan area

Tianlong Li, Chao Deng, Qing Du, Hong Chen, Sen Lu, Ruiming Yue, Yang Guo, Xiaobo Huang, Lingai Pan,

Abstract Background: COVID-19 has spread worldwide, which becomes a huge threat to human beings. Materials: Severe COVID-19 patients from Sichuan area admitted to department of critical care medicine in Chengdu Public Health Clinical Medical Center were retrospectively enrolled. The liver function during the ICU hospitalization were record and analyzed. Results: ... Read more >>

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Clinical and Imaging features in COVID-19 Patients: Analysis of Data from Patients in Non-pandemic areas

Shengkun Peng, Lingai Pan, Shaojin Zhang, Yalong Liu, Hua Zhang, Liming Tan, Yang Guo, Xiaobo Huang, Jie Zeng, Hong Pu,

Abstract Purpose To describe the imaging characteristics in COVID-19 Patients from non-pandemic regions to improve understanding of the disease. Methods We reviewed chest CT scans of 30 COVID-19 patients from three hospitals in Sichuan province, China. Results Typical CT manifestations include the involvement of multiple lobes, mostly in the peripheral ... Read more >>

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How to transform a general hospital into an "infectious disease hospital" during the epidemic of COVID-19.

Hongli He, Caiying Hu, Nian Xiong, Cheng Liu, Xiaobo Huang,

Crit Care (Critical care (London, England))
[2020, 24(1):145]

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Clinical and Imaging features of COVID-19 Patients: Analysis of Data from High-Altitude Areas.

Jie Zeng, Shengkun Peng, Yu Lei, Jianxin Huang, Yang Guo, Xiaoqin Zhang, Xiaobo Huang, Hong Pu, Lingai Pan, ,

J. Infect. (The Journal of infection)
[2020, 80(6):e34-e36]

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Metal-Free Facile Synthesis of Multisubstituted 1-Aminoisoquinoline Derivatives with Dual-State Emissions.

Xinyu Zhang, Yibin Zhou, Mengzhu Wang, Yating Chen, Yunbing Zhou, Wenxia Gao, Miaochang Liu, Xiaobo Huang, Huayue Wu,

Although isoquinoline is a good traditional fluorescent structural unit, most of its derivatives emit fluorescence in solution and a few of them can emit solid-state fluorescence as well. Herein, a series of multisubstituted 1-aminoisoquinoline derivatives were synthesized by a simple reaction of a readily available 4H-pyran derivative and secondary amines. ... Read more >>

Chem Asian J (Chemistry, an Asian journal)
[2020, 15(11):1692-1700]

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How to perform tracheal intubation for COVID-19 patients safely and effectively: Experience AND tips from Sichuan, China.

Jianxin Huang, Jie Zeng, Min Xie, Xiaobo Huang, Xinchuan Wei, Lingai Pan,

J Clin Anesth (Journal of clinical anesthesia)
[2020, 64:109800]

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Pirfenidone ameliorates the formation of choroidal neovascularization in mice.

Yueqi Bao, Lili Huang, Xiaobo Huang, Chuang Gao, Yu Chen, Liucheng Wu, Shunxing Zhu, Yu Song,

The formation and development of choroidal neovascularization (CNV) is accompanied by inflammation and fibrosis. Existing treatments are expensive and can cause irreversible complications. Pirfenidone (PFD) exerts anti‑inflammatory and anti‑fibrotic effects; however, its applications in the eye remain unclear. Male C57BL/6J mice (aged 6‑8 weeks) were used to explore whether PFD ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 21(5):2162-2170]

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Microultrasonic Probe Combined with Ultrasound-Guided Minipercutaneous Nephrolithotomy in the Treatment of Upper Ureteral and Renal Stones: A Consecutive Cohort Study.

LiuLin Xiong, XiaoBo Huang, XiongJun Ye, Liang Chen, Kai Ma, Jun Liu, Yang Hong, QingQuan Xu, Xiaofeng Wang,

Objectives: We conduct a study to assess the outcome of microultrasonic probe combined with ultrasound (US)-guided minipercutaneous nephrolithotomy (PCNL) for upper ureteral and renal stones. Patients and Methods: Data of 119 patients (123 kidney units) who underwent microultrasonic lithotripsy combined with mini-PCNL were retrospectively reviewed. The group included 96 men ... Read more >>

J. Endourol. (Journal of endourology)
[2020, 34(4):429-433]

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Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the Plateau area

Yu Lei, yunping lan, jianli lu, xiaobo huang, bamu silang, fan zeng,

Abstract Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread throughout China, but the clinical characteristics of Tibetan patients living in the Qinghai-Tibetan plateau are unknown. We aimed to investigate the epidemiological, clinical, laboratory and radiological characteristics of these patients. We included 67 Tibetan patients with confirmed SARS-CoV-2 infection. ... Read more >>

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Toward helical-shaped diradicaloids: cyclobutenyl o-quinodimethane-bridged indeno[1,2-b]fluorenes.

Shuhai Qiu, Chaoqiang Wang, Sheng Xie, Xiaobo Huang, Lanlan Chen, Yunhui Zhao, Zebing Zeng,

Open-shell diradicaloids have been intensively investigated recently due to their attractive and unique optical, electronic and magnetic properties. However, open-shell diradicaloids with non-planar conjugated frameworks are less studied, especially helical-shaped π systems. In this work, we synthesized tetraindeno-based singlet biradicals in a helical geometry, bridged by a curved cyclobutenyl o-quinodimethane ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2018, 54(81):11383-11386]

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How to face the novel coronavirus infection during the 2019-2020 epidemic: the experience of Sichuan Provincial People's Hospital.

Lingai Pan, Li Wang, Xiaobo Huang,

Intensive Care Med (Intensive Care Medicine)
[2020, 46(4):573-575]

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The Effects of Yuan-Zhi Decoction and Its Active Ingredients in Both In Vivo and In Vitro Models of Chronic Cerebral Hypoperfusion by Regulating the Levels of Aβ and Autophagy.

Yan Liu, Xiaobo Huang, Wenqiang Chen, Yujing Chen, Ningqun Wang, Xiling Wu,

Chronic cerebral hypoperfusion (CCH) is closely related to the occurrence of Alzheimer's disease (AD) in the elderly. CCH can induce overactivation of autophagy, which increases the deposition of amyloid-β (Aβ) plaques in the brain, eventually impairing the cognitive function. Yuan-Zhi decoction (YZD) is a traditional Chinese medicine (TCM) formulation that ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2020, 2020:6807879]

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