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Silver Mesoporous Silica Nanoparticles: Fabrication to Combination Therapies for Cancer and Infection.

Xuan He, Fangman Chen, Zhimin Chang, Kasim Waqar, Hanze Hu, Xiao Zheng, Yingshuai Wang, Wen-Fei Dong, Chao Yang,

The integration of silver nanoparticles (Ag NPs) with mesoporous silica nanoparticles (MSNs) protects the former from aggregation and promotes the controlled release of silver ions, resulting in therapeutic significance on cancer and infection. The unique size, shape, pore structure and silver distribution of silver mesoporous silica nanoparticles (Ag-MSNs) embellish them ... Read more >>

Chem Rec (Chemical record (New York, N.Y.))
[2022, :e202100287]

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Adverse childhood experiences in depression and the mediating role of multimorbidity in mid-late life: A nationwide longitudinal study.

Xiao Zheng, Chichen Zhang, Yuehua Cui, Yaqing Xue, Lei Shi, Yi Guo, Fang Dong,

<h4>Backgrounds</h4>Adverse childhood experiences are co-occurring factors of multimorbidity and depression in mid-late life, but the combined effect of ACEs and multimorbidity on depression over life has not been fully studied.<h4>Methods</h4>We used data from the China Health and Retirement Longitudinal Study which includes 4,440 middle-aged and older adults. Different types of ... Read more >>

J Affect Disord (Journal of affective disorders)
[2022, :]

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DeFusionNET: Defocus Blur Detection via Recurrently Fusing and Refining Discriminative Multi-Scale Deep Features.

Chang Tang, Xinwang Liu, Xiao Zheng, Wanqing Li, Jian Xiong, Lizhe Wang, Albert Y Zomaya, Antonella Longo,

Albeit great success has been achieved in image defocus blur detection, there are still several unsolved challenges, e.g., interference of background clutter, scale sensitivity and missing boundary details of blur regions. To deal with these issues, we propose a deep neural network which recurrently fuses and refines multi-scale deep features ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2022, 44(2):955-968]

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Application of transcriptomic analysis to unveil the toxicity mechanisms of fall armyworm response after exposure to sublethal chlorantraniliprole.

Lu Xu, Jun Zhao, Dejin Xu, Guangchun Xu, Zhongyan Gu, Zheng Xiao, Youssef Dewer, Yanan Zhang,

The anthranilic diamide insecticide chlorantraniliprole is highly effective against Lepidoptera pests, but the underlying mechanisms of toxic effects of chlorantraniliprole exposures for adapting to the chemical environment are poorly known in fall armyworm (FAW), Spodoptera frugiperda (J.E.Smith). FAW being one of the most pests of maize in Latin America, suddenly ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 230:113145]

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Impact of Multimorbidity on Symptoms of Depression, Anxiety, and Stress in Older Adults: Is There a Sex Difference?

Huang Lin, Shujuan Xiao, Lei Shi, Xiao Zheng, Yaqing Xue, Qilong Yun, Ping Ouyang, Dong Wang, Hong Zhu, Chichen Zhang,

<b>Introduction:</b> Multimorbidity has become a key issue in the health care sector globally, and it can also lead to psychological distress in older adults. This study aimed to assess the impact of multimorbidity on depression, anxiety, and stress symptoms and identify whether there is a sex difference in these associations. ... Read more >>

Front Psychol (Frontiers in psychology)
[2021, 12:762310]

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Polymerized Porin as a Novel Delivery Platform for Coronavirus Vaccine

Zhongqian Yang, Liangqun Hua, Mengli Yang, Weiran Li, Zhaoling Ren, Xiao Zheng, Haoqian Chen, Qiong Long, Hongmei Bai, Weiwei Hang, Yanbing Ma,

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), seriously threatens human life and health. The correct folding and polymerization of the receptor-binding domain (RBD) protein of coronavirus in Escherichia coli may reduce the cost of SARS-CoV-2 vaccines. Here, we designed this nanopore by using the ... Read more >>

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The association between sleep quality and psychological distress among older Chinese adults: a moderated mediation model.

Chichen Zhang, Shujuan Xiao, Huang Lin, Lei Shi, Xiao Zheng, Yaqing Xue, Fang Dong, Jiachi Zhang, Benli Xue,

<h4>Background</h4>Previous research has found a link between sleep quality and psychological distress. However, the underlying mechanisms of this connection have still not been well explored. The aim of this study was to examine the roles of activities of daily living (ADL), physical activity, and perceived social support in the link ... Read more >>

BMC Geriatr (BMC geriatrics)
[2022, 22(1):35]

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A New Prognostic and Therapeutic Immune-related Risk Signature of Colorectal Cancer

Yuan Li, Hao Huang, Jun Feng, Yulan Zhu, Tianwei Jiang, Bin Xu, Xiao Zheng, Lujun Chen,

<h4>Background: </h4> Although some advanced colorectal cancer (CRC) patients could select immunotherapy, but still most microsatellite stability (MSS) CRC patients did not respond. Our present study aims to set up a novel system for prognostic prediction and immunotherapeutic responsiveness for MSS CRC patients.MethodsUnivariable Cox regression survival analysis and least absolute ... Read more >>

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The relationship between activities of daily living and psychological distress among Chinese older adults: A serial multiple mediation model.

Shujuan Xiao, Lei Shi, Yaqing Xue, Xiao Zheng, Jiachi Zhang, Jinghui Chang, Huang Lin, Ruibin Zhang, Chichen Zhang,

<h4>Background</h4>Few studies have shed light on the mechanisms underlying the link between activities of daily living (ADL) and psychological distress. This study aimed to explore the multiple mediating roles of loneliness and sleep quality in this relationship among Chinese older adults.<h4>Methods</h4>A total of 3250 older adults completed the Barthel Index, ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 300:462-468]

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Nanofactory for metabolic and chemodynamic therapy: pro-tumor lactate trapping and anti-tumor ROS transition.

Ruiqing He, Jie Zang, Yuge Zhao, Ying Liu, Shuangrong Ruan, Xiao Zheng, Gaowei Chong, Dailin Xu, Yan Yang, Yushan Yang, Tingting Zhang, Jingjing Gu, Haiqing Dong, Yongyong Li,

Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in tumors holds great promise for the reversal of the immunosuppressive tumor microenvironment (TME). Herein, we report on a "lactate treatment plant" (i.e., nanofactory) that can dynamically trap pro-tumor lactate and in situ transformation into anti-tumor cytotoxic reactive oxygen ... Read more >>

J Nanobiotechnology (Journal of nanobiotechnology)
[2021, 19(1):426]

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Emerging targetome and signalome landscape of gut microbial metabolites.

Xiao Zheng, Xiaoying Cai, Haiping Hao,

The gut microbiome produces chemically diverse small molecules to interact with the host, conveying signals from the gut to the whole system. The microbial metabolites feature several unique modes of interaction with host targets, which fits well into the balanced and networked fashion of biological regulation. Hence, fully unveiling the ... Read more >>

Cell Metab (Cell metabolism)
[2022, 34(1):35-58]

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Identification of Cu(100)/Cu(111) Interfaces as Superior Active Sites for CO Dimerization During CO2 Electroreduction.

Zhi-Zheng Wu, Xiao-Long Zhang, Zhuang-Zhuang Niu, Fei-Yue Gao, Peng-Peng Yang, Li-Ping Chi, Lei Shi, Wen-Sen Wei, Ren Liu, Zhi Chen, Shaojin Hu, Xiao Zheng, Min-Rui Gao,

The electrosynthesis of valuable multicarbon chemicals using carbon dioxide (CO<sub>2</sub>) as a feedstock has substantially progressed recently but still faces considerable challenges. A major difficulty lines in the sluggish kinetics of forming carbon-carbon (C-C) bonds, especially in neutral media. We report here that oxide-derived copper crystals enclosed by six {100} ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2022, 144(1):259-269]

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Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation.

Chang Dai, Bin Kong, Tianyou Qin, Zheng Xiao, Jin Fang, Yang Gong, Jun Zhu, Qi Liu, Hui Fu, Hong Meng, Wei Shuai, He Huang,

Both long-term and short-term alcohol consumption can cause internal homeostasis imbalance, and they have been proved to be related to the initiation and development of atrial fibrillation (AF). Ferroptosis is an iron-dependent form of non-apoptotic oxidative death which also regulate the cell death homeostasis, but whether it involves in AF ... Read more >>

Toxicology (Toxicology)
[2022, 465:153055]

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A General Strategy to Immobilize Single-Atom Catalysts in Metal-Organic Frameworks for Enhanced Photocatalysis.

Jianfei Sui, Hang Liu, Shaojin Hu, Kang Sun, Gang Wan, Hua Zhou, Xiao Zheng, Hai-Long Jiang,

Single-atom catalysts (SACs) are witnessing rapid development due to their high activity and selectivity toward diverse reactions. However, it remains a grand challenge in the general synthesis of SACs, particularly featuring an identical chemical microenvironment and on the same support. Herein, a universal synthetic protocol is developed to immobilize SACs ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, :e2109203]

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Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction.

Zheng Xiao, Bin Kong, Jin Fang, Tianyou Qin, Chang Dai, Wei Shuai, He Huang,

Cardiac dysfunction is a common complication of sepsis, and is attributed to severe inflammatory responses. Ferroptosis is reported to be involved in sepsis-induced cardiac inflammation. Therefore, we speculated that ferrostatin-1 (Fer-1), a ferroptosis inhibitor, improves cardiac dysfunction caused by sepsis. An intraperitoneal injection of lipopolysaccharide (LPS) was performed to induce ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(2):9367-9376]

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Efficient degradation of bisphenol A with MoS2/BiVO4 hetero-nanoflower as a heterogenous peroxymonosulfate activator under visible-light irradiation.

Xiao Zheng, Xiaodong Zhang, Yanpeng Cai, Shan Zhao, Shuguang Wang,

Photocatalyst activated peroxymonosulfate (PMS) under visible-light irradiation to construct a photo-Fenton system has shown great application prospect for environmental remediation. In this study, MoS<sub>2</sub>/BiVO<sub>4</sub> heterojunction nanoflowers were successfully synthesized by hydrothermal method and used to activate PMS under visible-light to achieve highly efficient degradation of bisphenol A (BPA). The constructed ... Read more >>

Chemosphere (Chemosphere)
[2022, 289:133158]

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miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.

Hongxin Xu, Ying Cui, Xianwei Liu, Xiao Zheng, Jiaqing Liu, Xinxin Hu, Fuhua Gao, Xiaoyan Hu, Mei Li, Xiaoqing Wei, Ying Gao, Ying Zhao,

<h4>Background</h4>MicroRNA-1290 (miR-1290) has been reported to be involved in many diseases and play a key role during the development process. However, the role of miR-1290 in atherosclerosis (AS) is still unclear.<h4>Methods and results</h4>The current study showed that the expressions of miR-1290 were high in serum of patients with hyperlipidemia. The ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2021, :]

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Tetramethylpyrazine alleviates diabetes-induced high platelet response and endothelial adhesion via inhibiting NLRP3 inflammasome activation.

Haowen Zhang, Hanyu Chen, Xiang Wu, Tong Sun, Manlu Fan, Huaqin Tong, Yejin Zhu, Zhe Yin, Weixin Sun, Chao Zhang, Xiao Zheng, Xiaohu Chen,

<h4>Background</h4>The inflammatory state of diabetes promotes high platelet response and endothelial adhesion, which are the main risk factors for cardiovascular events. Tetramethylpyrazine (TMP) is an amide alkaloid isolated from the traditional Chinese medicine Rhizoma Ligustici Chuanxiong, which has been widely used in the clinical treatment of ischemic cardiovascular disease.<h4>Purpose</h4>This study ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2021, :153860]

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The value of phacoemulsification combined with vitreous injection in the treatment of cataract complicated with diabetic macular edema.

Jing Zhang, Zhulin Zhang, Xin Long, Xiao Zheng,

Minerva Surg (Minerva surgery)
[2021, :]

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CRSIPR-A-I: a webtool for the efficacy prediction of CRISPR activation and interference

Xiao Zheng, Jiajun Cui, Yixuan Wang, Jing Zhang, Chaochen Wang,

<h4>A bstract </h4> CRISPR-based gene activation (CRISPRa) or interference (CRISPRi) are powerful and easy-to-use approaches to modify the transcription of endogenous genes in eukaryotes. Successful CRISPRa/i requires sgRNA binding and alteration of local chromatin structure, hence largely depends on the original epigenetic status of the target. Consequently, the efficacy of ... Read more >>

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Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey.

Xue-Yan Zhang, Jun Li, Cai-Juan Li, Ying-Qi Lin, Chun-Hui Huang, Xiao Zheng, Xi-Chen Song, Zhu-Chi Tu, Xiao-Jiang Li, Sen Yan,

In vitro cultures of primary cortical neurons are widely used to investigate neuronal function. However, it has yet to be fully investigated whether there are significant differences in development and function between cultured rodent and primate cortical neurons, and whether these differences influence the utilization of cultured cortical neurons to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2446-2452]

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Prognostic Impact of Postoperative Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus: From the Results of NEOCRTEC5010, a Randomized Multicenter Study.

Xuefeng Leng, Wenwu He, Hong Yang, Yuping Chen, Chengchu Zhu, Wentao Fang, Zhentao Yu, Weimin Mao, Jiaqing Xiang, Zhijian Chen, Haihua Yang, Jiaming Wang, Qingsong Pang, Xiao Zheng, Hui Liu, Huanjun Yang, Tao Li, Xu Zhang, Qun Li, Geng Wang, Teng Mao, Xufeng Guo, Ting Lin, Mengzhong Liu, Jianhua Fu, Yongtao Han,

<h4>Objective</h4>To determine the prognostic impact of pathologic lymph node (LN) status and investigate risk factors of recurrence in esophageal squamous cell carcinoma (ESCC) patients with pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT).<h4>Summary background data</h4>There are no large-scale prospective study data regarding ypN status and recurrence after pCR in ESCC ... Read more >>

Ann Surg (Annals of surgery)
[2021, 274(6):e1022-e1029]

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HiCArch: A Deep Learning-based Hi-C Data Predictor

Xiao Zheng, Jinghua Wang, Chaochen Wang,

<h4>A bstract </h4> Hi-C sequencing analysis is one of the most popular methods to study three-dimensional (3D) genome structures, which affect the gene expression and other cellular activities by allowing distal regulations in spatial proximity. Hi-C sequencing analysis enhances understanding of chromatin functionality. However, due to the high cost of ... Read more >>

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Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections.

Xiao Zheng, Ling Xu, Maosen Ye, Tianle Gu, Yu-Lin Yao, Long-Bao Lv, Dandan Yu, Yong-Gang Yao,

DNA damage inducible transcript 3 (DDIT3, also known as CHOP) belongs to the CCAAT/enhancer-binding protein (C/EBP) family and plays an essential role in endoplasmic reticulum stress. Here, we characterized the potential role of the Chinese tree shrew (Tupaia belangeri chinensis) DDIT3 (tDDIT3) in viral infections. The tDDIT3 protein is highly ... Read more >>

Dev Comp Immunol (Developmental and comparative immunology)
[2022, 127:104307]

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Evaluation of the value of water retention service in the middle and upper reaches of Hunhe River based on SWAT Model.

Jing-Hong Liu, Xiao Zheng, Jun-Mei Fan, Lan-Lin Zhao,

The upper and middle reaches of the Hunhe River, with forest coverage rate up to 68%, is an important water source protection area in Liaoning Province. Based on the SWAT model and shadow engineering method, we aimed to estimate the function and service value of water retention in the upper ... Read more >>

Ying Yong Sheng Tai Xue Bao (Ying yong sheng tai xue bao = The journal of applied ecology)
[2021, 32(11):3905-3912]

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