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Author Xiao Yu Hou

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Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission.

Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou,

Neuronal activity regulates spatial distribution of the SUMOylation system in cytosolic and dendritic sites, which has been implicated in learning, memory, and underlying synaptic structural and functional remodeling in the hippocampus. However, the functional target proteins for activated small ubiquitin-like modifiers (SUMOs) and downstream molecular consequences behind long-term potentiation (LTP) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21769]

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Cyclin G2 promotes the formation of smooth muscle cells derived foam cells in atherosclerosis via PP2A/NF-κB/LOX-1 pathway.

Di Zhang, Jin-Lan Gao, Chen-Yang Zhao, Dan-Ning Wang, Xue-Sha Xing, Xiao-Yu Hou, Shu-Sen Wang, Qi Liu, Yang Luo,

<h4>Background</h4>To investigate the role and underlying mechanism of cyclin G2 (G2-type cyclin) in the formation of vascular smooth muscle cells (VSMCs) derived foam cells.<h4>Methods</h4>The levels of α-SMA (alpha-SM-actin), p-NF-κB (phosphorylation nuclear transcription factors kappa B), and LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) were measured by immunohistochemistry and western blotting. The ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(6):446]

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MLK3 Is Associated With Poor Prognosis in Patients With Glioblastomas and Actin Cytoskeleton Remodeling in Glioblastoma Cells.

Yan Zhu, Jin-Min Sun, Zi-Chen Sun, Feng-Jiao Chen, Yong-Ping Wu, Xiao-Yu Hou,

Mixed lineage kinase 3 (MLK3) has been implicated in human melanoma and breast cancers. However, the clinical significance of MLK3 in human gliomas and the underlying cellular and molecular mechanisms remain unclear. We found that MLK3 proteins were highly expressed in high-grade human glioma specimens and especially prevalent in primary ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:600762]

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Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling.

Cai-Ping Du, Mei Wang, Chi Geng, Bin Hu, Li Meng, Yan Xu, Bao Cheng, Nan Wang, Qiu-Ju Zhu, Xiao-Yu Hou,

Aims: Neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) signaling have been implicated in learning, memory, and underlying long-lasting synaptic plasticity. In this study, we aimed at detecting whether nNOS is a target protein of SUMOylation in the hippocampus and its contributions to hippocampal long-term potentiation (LTP) of synaptic ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2020, 32(1):18-34]

Cited: 4 times

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A Brief Ischemic Postconditioning Protects Against Amyloid-β Peptide Neurotoxicity by Downregulating MLK3-MKK3/6-P38MAPK Signal in Rat Hippocampus.

Hui Li, Xiao-Bing Luo, Yan Xu, Xiao-Yu Hou,

<h4>Background</h4>Oligomeric amyloid-β peptide (Aβ) is associated with dysfunctional neuronal networks and neuronal loss in the development of Alzheimer's disease (AD). Ischemic postconditioning protects against post-ischemic excitotoxicity, oxidative stress, and inflammatory process that have also been implicated in the pathogenesis of AD. Evaluating the roles of ischemic postconditioning in oligomeric Aβ-induced ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2019, 71(2):671-684]

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Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia.

Gui-Ying Yao, Qian Zhu, Jing Xia, Feng-Jiao Chen, Ming Huang, Jing Liu, Ting-Ting Zhou, Jian-Feng Wei, Gui-Yun Cui, Kui-Yang Zheng, Xiao-Yu Hou,

Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that the expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1 subfield after global ischemia. Ischemic postconditioning restored VDACs to physiological ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(10):1033]

Cited: 5 times

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Arginine vasopressin antagonizes the effects of prostaglandin E2 on the spontaneous activity of warm-sensitive and temperature-insensitive neurons in the medial preoptic area in rats.

Jian-Hui Xu, Xiao-Yu Hou, Yu Tang, Rong Luo, Jie Zhang, Chang Liu, Yong-Lu Yang,

Arginine vasopressin (AVP) plays an important role in thermoregulation and antipyresis. We have demonstrated that AVP could change the spontaneous activity of thermosensitive and temperature insensitive neurons in the preoptic area. However, whether AVP influences the effects of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) on the spontaneous activity of neurons in the medial ... Read more >>

Neurosci Lett (Neuroscience letters)
[2018, 662:59-64]

Cited: 1 time

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A simply prepared small-diameter artificial blood vessel that promotes in situ endothelialization.

Hong-Feng Guo, Wei-Wei Dai, De-Hui Qian, Zhe-Xue Qin, Yan Lei, Xiao-Yu Hou, Can Wen,

Synthetic grafts are of limited use in small-diameter vessels (Φ<6mm) due to the poor patency rate. The inability of such grafts to achieve early endothelialization together with the compliance mismatch between the grafts and the native vessels promote thrombosis, which eventually leads to graft occlusion. In the current study, stromal ... Read more >>

Acta Biomater (Acta biomaterialia)
[2017, 54:107-116]

Cited: 5 times

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Improving endothelialization by the combined application of polyethylene glycol coated cerium oxide nanoparticles and VEGF in electrospun polyurethane scaffolds.

Wei-Wei Dai, Hong-Feng Guo, De-Hui Qian, Zhe-Xue Qin, Yan Lei, Xiao-Yu Hou, Can Wen,

Synthetic small-diameter vascular grafts are of limited use mainly due to the lack of endothelial cells (ECs), which inhibit intraluminal thrombosis and intimal hyperplasia. Grafts loaded with homing factors for circulating endothelial progenitor cells (EPCs) have the potential to achieve in situ endothelialization. In view of the important role that ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2017, 5(5):1053-1061]

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Oligomeric amyloid-β peptide disrupts olfactory information output by impairment of local inhibitory circuits in rat olfactory bulb.

Bin Hu, Chi Geng, Xiao-Yu Hou,

Although early olfactory dysfunction has been found in patients with Alzheimer's disease, the underlying mechanisms remain unclear. In this study, we investigated whether and how oligomeric amyloid-β peptide (Aβ) affects the responses of mitral cells (MCs). We found that oligomeric Aβ1-42 increased spontaneous and evoked firing rates but decreased the ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2017, 51:113-121]

Cited: 8 times

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Origin of the Different Reactivity of the Triatomic Anions HMoN- and ZrNH- toward Alkane: Compositions of the Active Orbitals.

Ji-Chuang Hu, Lin-Lin Xu, Xiao-Yu Hou, Hai-Fang Li, Jia-Bi Ma, Sheng-Gui He,

The reactivity of the triatomic anions HMoN<sup>-</sup> and ZrNH<sup>-</sup> toward alkanes was investigated by means of mass spectrometry in conjunction with density functional theory calculations. HMoN<sup>-</sup> can activate C-H bond of ethane with the liberation of ethene and hydrogen molecules, and the generation of hydrogen molecules is the major reaction ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2016, 120(39):7786-7791]

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PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway.

Xiao-Hui Yin, Jing-Zhi Yan, Guo Yang, Li Chen, Xiao-Feng Xu, Xi-Ping Hong, Shi-Liang Wu, Xiao-Yu Hou, GuangYi Zhang,

Respecting the selective inhibition of peptides on protein-protein interactions, they might become potent methods in ischemic stroke therapy. In this study, we investigated the effect of PDZ1 inhibitor peptide on ischemic neuron apoptosis and the relative mechanism. Results showed that PDZ1 inhibitor peptide, which significantly disrupted GluK2-PSD-95 interaction, efficiently protected ... Read more >>

Brain Res (Brain research)
[2016, 1637:64-70]

Cited: 4 times

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Involvement of P38MAPK activation by NMDA receptors and non-NMDA receptors in amyloid-β peptide-induced neuronal loss in rat hippocampal CA1 and CA3 subfields.

Yan Xu, Da-Hong Cao, Gui-Mei Wu, Xiao-Yu Hou,

Oligomeric amyloid-β peptide (Aβ) has been found to be associated with the pathogenesis of Alzheimer's disease (AD). Numerous studies have reported Aβ neurotoxicity, but the underlying molecular mechanisms remain to be fully illuminated. In the present study, we investigated the Aβ-induced activation and regulation of P38MAPKs in rat hippocampus in ... Read more >>

Neurosci Res (Neuroscience research)
[2014, 85:51-57]

Cited: 10 times

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Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia.

Qiu-Ju Zhu, Fan-Shu Kong, Hao Xu, Yi Wang, Cai-Ping Du, Chang-Cheng Sun, Yong Liu, Ting Li, Xiao-Yu Hou,

Although kainate receptors play important roles in ischemic stroke, the molecular mechanisms underlying postischemic regulation of kainate receptors remain unclear. In this study we demonstrate that Src family kinases contribute to the potentiation of kainate receptor function. Brain ischemia and reperfusion induce rapid and sustained phosphorylation of the kainate receptor ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(38):13990-13995]

Cited: 4 times

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The upregulation of NR2A-containing N-methyl-D-aspartate receptor function by tyrosine phosphorylation of postsynaptic density 95 via facilitating Src/proline-rich tyrosine kinase 2 activation.

Chao Zhao, Cai-Ping Du, Yan Peng, Zhen Xu, Chang-Cheng Sun, Yong Liu, Xiao-Yu Hou,

The activation of postsynaptic N-methyl-D-aspartate (NMDA) receptors is required for long-term potentiation (LTP) of synaptic transmission. Postsynaptic density 95 (PSD-95) serves as a scaffold protein that tethers NMDA receptor subunits, kinases, and signal molecules. Our previous study proves that PSD-95 is a substrate of Src/Fyn and identifies Y523 on PSD-95 ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2015, 51(2):500-511]

Cited: 8 times

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MLK3-MKK3/6-P38MAPK cascades following N-methyl-D-aspartate receptor activation contributes to amyloid-β peptide-induced apoptosis in SH-SY5Y cells.

Fang Zhou, Yan Xu, Xiao-Yu Hou,

Amyloid-β peptide (Aβ) has been implicated in the development of Alzheimer's disease (AD), but the underlying molecular mechanisms remain unclear. The present study explores the proapoptosis signaling evoked by N-methyl-D-aspartate (NMDA) receptors in Aβ neurotoxicity. Oligomeric Aβ25-35 incubation resulted in significant apoptosis of neuronal SH-SY5Y cells. Preadministration of the potent ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2014, 92(6):808-817]

Cited: 13 times

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Neuroprotection of ischemic postconditioning by downregulating the postsynaptic signaling mediated by kainate receptors.

Jing Liu, Qin Xu, Hui Wang, Ran Wang, Xiao-Yu Hou,

<h4>Background and purpose</h4>Ischemic postconditioning, a brief episode of ischemia after a prolonged ischemic insult, has been found to reduce the delayed neuronal loss after stroke. However, the mechanisms underlying such endogenous neuroprotective strategy remain obscure. In this study, we try to explore the excitatory postsynaptic signal events associated with neuroprotective ... Read more >>

Stroke (Stroke)
[2013, 44(7):2031-2035]

Cited: 14 times

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Waste intercostal neurovascular bundles used for microsurgical skills training: beneficial inspiration?

Deng-Jin Jiang, Xiao-Yu Hou, Ai-Jun Yang, Yan Lei, Yang-Jun Lan,

J Reconstr Microsurg (Journal of reconstructive microsurgery)
[2013, 29(3):211-212]

Cited: 0 times

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Cost-effective framework for basic surgical skills training.

Deng-Jin Jiang, Chan Wen, Ai-Jun Yang, Zhi-Li Zhu, Yan Lei, Yang-Jun Lan, Qing-Yuan Huang, Xiao-Yu Hou,

<h4>Background</h4>The importance of basic surgical skills is entirely agreed among surgical educators. However, restricted by ethical issues, finance etc, the basic surgical skills training is increasingly challenged. Increasing cost gives an impetus to the development of cost-effective training models to meet the trainees' acquisition of basic surgical skills. In this ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2013, 83(6):472-476]

Cited: 1 time

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Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-β peptide treatment.

Cai-Ping Du, Ran Tan, Xiao-Yu Hou,

<h4>Aims</h4>Src family protein tyrosine kinases (SrcPTKs) have been implicated in the pathogenesis of brain ischemia and Alzheimer's disease (AD). In this study, we investigated whether Src and Fyn kinases, two major members of SrcPTKs in the brain, have distinct roles in the oxygen and glucose deprivation (OGD) and amyloid-β peptide ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2012, 18(9):754-761]

Cited: 22 times

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SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation.

Qiu-Ju Zhu, Yan Xu, Cai-Ping Du, Xiao-Yu Hou,

Protein SUMOylation has been implicated in the pathogenesis of ischemic stroke. However, the underlying mechanisms remain unclear. Here, we found that global brain ischemia evokes a sustained elevation of GluK2 SUMOylation in the rat hippocampal CA1 region. Over-expression of wild-type GluK2, but not SUMOylation-deficient mutant, significantly increased the activity of ... Read more >>

FEBS Lett (FEBS letters)
[2012, 586(9):1259-1264]

Cited: 12 times

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Depolarization induces NR2A tyrosine phosphorylation and neuronal apoptosis.

Yong Liu, Jing-Zhi Yan, Ying-Hui Gu, Wei Wang, Yan-Yan Zong, Xiao-Yu Hou, Guang-Yi Zhang,

<h4>Background</h4>Cytosol Ca2+ overload plays a vital role in ischemic neuronal damage, which is largely contributed by the Ca2+ influx through L-type voltage-gated calcium channels (L-VGCCs) and N-methyl-D-aspartate (NMDA) type glutamate receptors. In this article, L-VGCCs were activated by depolarization to investigate the cross-talk between NMDA receptors and L-VGCCs.<h4>Methods</h4>Depolarization was induced ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2011, 38(6):880-886]

Cited: 0 times

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Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6.PSD-95.MLK3 pathway.

Shu-Qun Hu, Jie Zhu, Dong-Sheng Pei, Yan-Yan Zong, Jing-Zhi Yan, Xiao-Yu Hou, Guang-Yi Zhang,

Recent studies have shown that kainate (KA) receptors are involved in neuronal cell death induced by seizure, which is mediated by the GluR6.PSD-95.MLK3 signaling module and subsequent JNK activation. In our previous studies, we demonstrated the neuroprotective role of a GluR6 c-terminus containing peptide against KA or cerebral ischemia-induced excitotoxicity ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2009, 87(16):3626-3638]

Cited: 7 times

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[Analysis of genetic diversity and biological functional site of HIV-1 gp120 from a patient with AIDS dementia complex].

Yu-Fen Yan, Li Zhao, Zhi-Yu Wang, Michael S McGrath, Xiao-Yu Hou, Xiao-Min Zheng, Yan-Yan Song, Yao-Ping, Hong-Ling Wen, Gui-Ting Wang, Hong-Zhi Xu,

To explore the relationship between the genetic diversity and biological functional site of human immunodeficiency virus HIV-1 gp120 and the pathogenesis of AIDS dementia complex (ADC), the full length sequences of gp120 gene was amplified with PCR from genomic DNA which was extracted from lymphoid and different brain department (periaortic ... Read more >>

Bing Du Xue Bao (Bing du xue bao = Chinese journal of virology)
[2009, 25(3):166-172]

Cited: 0 times

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Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield.

Gui-Mei Wu, Xiao-Yu Hou,

Amyloid-beta peptide (Abeta) plays a causal role in the pathogenesis of Alzheimer's disease (AD). To elucidate the mechanisms underlying the over-activation of NMDA receptors in AD, we investigated the alteration of NR2A tyrosine phosphorylation after intracerebroventricular infusion of Abeta25-35 oligomers. Abeta25-35 treatment resulted in the elevated tyrosine phosphorylation of NR2A ... Read more >>

Brain Res (Brain research)
[2010, 1343:186-193]

Cited: 10 times

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