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Simulation study on the critical adsorption and diffusion of polymer chains on heterogeneous surfaces with random adsorption sites.

Qing-Hui Yang, Hang-Kai Qi, Xiao Yang, Meng-Bo Luo,

The critical adsorption and diffusion of a linear polymer chain on a heterogeneous surface with randomly distributed adsorption sites are studied using dynamic Monte Carlo simulations. Results show that the critical fraction of the adsorption sites at which critical adsorption takes place decreases exponentially with the increasing polymer-surface attraction strength ... Read more >>

Soft Matter (Soft matter)
[2021, 17(4):1000-1007]

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The morphological effect of nanostructured hydroxyapatite coatings on the osteoinduction and osteogenic capacity of porous titanium.

Minxun Lu, Hongjie Chen, Bo Yuan, Yong Zhou, Li Min, Zhanwen Xiao, Xiao Yang, Xiangdong Zhu, Chongqi Tu, Xingdong Zhang,

Weak osteogenic activity affects the long-term fixation and lifespan of titanium (Ti) implants. Surface modification along with a built-in porous structure is a highly considerable approach to improve the osteoinduction and osseointegration capacity of Ti. Herein, the osteoinduction and osteogenic activities of electrochemically deposited (ED) nanoplate-like, nanorod-like and nanoneedle-like hydroxyapatite ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(47):24085-24099]

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Discriminative Multi-View Dynamic Image Fusion for Cross-View 3-D Action Recognition.

Yancheng Wang, Yang Xiao, Junyi Lu, Bo Tan, Zhiguo Cao, Zhenjun Zhang, Joey Tianyi Zhou,

Dramatic imaging viewpoint variation is the critical challenge toward action recognition for depth video. To address this, one feasible way is to enhance view-tolerance of visual feature, while still maintaining strong discriminative capacity. Multi-view dynamic image (MVDI) is the most recently proposed 3-D action representation manner that is able to ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2021, PP:]

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Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages.

Yang Xiao, Lingling Shu, Xiaoping Wu, Yang Liu, Lai Yee Cheong, Boya Liao, Xiaoyu Xiao, Ruby Lc Hoo, Zhiguang Zhou, Aimin Xu,

Both innate and adaptive immune cells are critical players in autoimmune destruction of insulin-producing β cells in type 1 diabetes. However, the early pathogenic events triggering the recruitment and activation of innate immune cells in islets remain obscure. Here we show that circulating fatty acid binding protein 4 (FABP4) level ... Read more >>

JCI Insight (JCI insight)
[2021, 6(7):]

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Clinical risk score for predicting invasive fungal disease after allogeneic hematopoietic stem cell transplantation: Analysis of the China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study.

Yuqian Sun, Jiong Hu, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang,

<h4>Background and objective</h4>Invasive fungal disease (IFD) is associated with a high mortality for patients with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed not only to develop a proven/probable IFD risk-scoring model but to identify high-risk populations that would benefit from anti-fungal prophylaxis.<h4>Methods</h4>Data from the China ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2021, :e13611]

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[Analysis of related factors of postoperative complications of Juvenile-onset recurrent respiratory papillomatosis].

Mengya Shen, Yang Xiao, Lijing Ma, Jun Wang,

<b>Objective:</b>To analyze the causes and related factors of postoperative complications of Juvenile-onset recurrent respiratory papillomatosis(JORRP). <b>Methods:</b>One hundred and seventy cases of JORRP who underwent surgical treatment in Beijing Tongren Hospital of Capital Medical University from 2017 to 2019 were followed up, and the types of complications, age of first operation, ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2021, 35(4):312-315]

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LRH-1 High Expression in the Ovarian Granulosa Cells of PCOS Patients

Xiao Yang, Qiumin Wang, Ying Wang, Tian Song, Yanjun Zheng, Wenqi Wang, Yuhua Shi,

Purpose: Polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine disorder with heterogeneity. There are also reports that liver receptor homolog 1 [LRH-1 or nuclear receptor subfamily 5 group A member 2 (NR5A2)] plays an important role in the reproductive system. But up to now, there ... Read more >>

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Investigation into the physical properties, antioxidant and antibacterial activity of Bletilla striata polysaccharide/chitosan membranes.

Yuan Li, Zihao Ma, Xiao Yang, Yuanping Gao, Yan Ren, Qingmiao Li, Yan Qu, Gongzhen Chen, Rui Zeng,

Traditional wound dressings and formulations, such as cream, gauze, cotton wool and gel, are disadvantaged by short residence time, poor leakage and air permeability, poor patient compliance, and the minimal preservation in wet environment. This study is purposed to develop new biodegradable, antioxidant, and antimicrobial membranes based on two natural ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, :]

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Low NLRP3 expression predicts a better prognosis of colorectal cancer.

Feng Shi, Bo Wei, Tian Lan, Yang Xiao, Xin Quan, Jun Chen, Chong Zhao, Jinhang Gao,

<h4>Background</h4>NOD-like receptor pyrin domain-3 (NLRP3) inflammasome activation is a double-edged sword in tumorigenesis. Whether NLRP3 is involved in the progression and prognosis of colorectal cancer (CRC) remains elucidated and is the focus of this study.<h4>Methods</h4>Immunohistochemistry (IHC) was applied on tissue microarray to determine the expression of NLRP3 in CRC patients. ... Read more >>

Biosci Rep (Bioscience reports)
[2021, :]

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Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.

Jianjun Fan, Yang Xiao, Matthias Quick, Yuwei Yang, Ziyi Sun, Jonathan A Javitch, Xiaoming Zhou,

The neurotransmitter:sodium symporter (NSS) homolog LeuT from Aquifex aeolicus has proven to be a valuable model for studying the transport mechanism of the NSS family. Crystal structures have captured LeuT in key conformations visited during the transport cycle, allowing for the construction of a nearly complete model of transport, with ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2021, :100609]

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RNAi-mediated silencing of Trichinella spiralis glutaminase results in reduced muscle larval infectivity.

Yuan Gao, Xiaoqing Meng, Xiao Yang, Shi Meng, Caixia Han, Xiaoyun Li, Shuang Wang, Wei Li, Mingxin Song,

Trichinella spiralis is an important foodborne parasitic nematode distributed worldwide that infects humans and animals. Glutaminase (GLS) is an important gene in the glutamine-dependent acid resistance (AR) system; however, its role in T. spiralis muscle larvae (ML) remains unclear. The present study aimed to characterize T. spiralis GLS (TsGLS) and ... Read more >>

Vet Res (Veterinary research)
[2021, 52(1):51]

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Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells.

Xiao Yang, Dong Fang, Ming Li, Jiayi Chen, Yuanbo Cheng, Jianming Luo,

BACKGROUND Enzymatically inactive chitinase-like protein CHI3L1 is overexpressed in diffuse large B cell lymphoma (DLBCL) patients with PD-L1 imbalance and promotes tumor progression in the microenvironment. Based on this, we investigated how CHI3L1 acts on the proliferation and apoptosis of DLBCL and whether there is a synergy of CHI3L1 in ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2021, 27:e929431]

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PXR mediates mifepristone-induced hepatomegaly in mice.

Xin-Peng Yao, Ting-Ying Jiao, Yi-Ming Jiang, Shi-Cheng Fan, Ying-Yuan Zhao, Xiao Yang, Yue Gao, Fei Li, Yan-Ying Zhou, Pan-Pan Chen, Min Huang, Hui-Chang Bi,

Mifepristone (Mif), an effective synthetic steroidal antiprogesterone drug, is widely used for medical abortion and pregnancy prevention. Due to its anti-glucocorticoid effect, high-dose Mif is also used to treat Cushing's syndrome. Mif was reported to active pregnane X receptor (PXR) in vitro and PXR can induce hepatomegaly via activation and ... Read more >>

Acta Pharmacol Sin (Acta pharmacologica Sinica)
[2021, :]

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Evaluation of lung involvement in COVID-19 pneumonia based on ultrasound images.

Zhaoyu Hu, Zhenhua Liu, Yijie Dong, Jianjian Liu, Bin Huang, Aihua Liu, Jingjing Huang, Xujuan Pu, Xia Shi, Jinhua Yu, Yang Xiao, Hui Zhang, Jianqiao Zhou,

<h4>Background</h4>Lung ultrasound (LUS) can be an important imaging tool for the diagnosis and assessment of lung involvement. Ultrasound sonograms have been confirmed to illustrate damage to a person's lungs, which means that the correct classification and scoring of a patient's sonogram can be used to assess lung involvement.<h4>Methods</h4>The purpose of ... Read more >>

Biomed Eng Online (Biomedical engineering online)
[2021, 20(1):27]

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Isolation and Identification of Antibacterial Bioactive Compounds From Bacillus megaterium L2.

Yudan Xie, Qiuju Peng, Yuyu Ji, Ailin Xie, Long Yang, Shuzhen Mu, Zhu Li, Tengxia He, Yang Xiao, Jinyi Zhao, Qinyu Zhang,

Bacterial metabolites exhibit a variety of biologically active compounds including antibacterial and antifungal activities. It is well known that <i>Bacillus</i> is considered to be a promising source of bioactive secondary metabolites. Most plant pathogens have an incredible ability to mutate and acquire resistance, causing major economic losses in the agricultural ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:645484]

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Increased 68Ga-FAPI Uptake in Chronic Cholecystitis and Degenerative Osteophyte.

Huipan Liu, Zan Chen, Xiao Yang, Wenhui Fu, Yue Chen,

<h4>Abstract</h4>68Ga-FAPI PET/CT has been used in the evaluation of a variety of malignancies. An increasing number of case studies on FAPI uptake in nonmalignant diseases is also gaining support and enthusiasm. We present a case of asymptomatic chronic cholecystitis and degenerative osteophyte detected incidentally by 68Ga-FAPI PET/CT. ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, :]

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Peripheral white blood cell counts mediated the associations of sleep duration with atherosclerotic cardiovascular disease risk: a cross-sectional study of middle-aged and older Chinese.

Xiaobing Feng, Dongming Wang, Ruyi Liang, Man Cheng, Limin Cao, Yang Xiao, Min Zhou, Meian He, Xiaomin Zhang, Jing Yuan, Weihong Chen,

<h4>Purpose</h4>To investigate the associations between sleep duration and atherosclerotic cardiovascular disease (ASCVD) risk and the potential mechanism.<h4>Methods</h4>Overall, 24,471 subjects without ASCVD were included from Dongfeng-Tongji (DFTJ) cohort. Data collection included questionnaires and general medical examinations. We used logistic regression models and generalized linear models to examine the associations between sleep ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2021, :]

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Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

Guimei Yu, Xiaowei Pan, Jingfang Hao, Lifang Shi, Yong Zhang, Jifeng Wang, Yang Xiao, Fuquan Yang, Jizhong Lou, Wenrui Chang, Alizée Malnoë, Mei Li,

Non-photochemical quenching (NPQ) plays an important role for phototrophs in decreasing photo-oxidative damage. qH is a sustained component of NPQ and depends on the plastid lipocalin (LCNP). A thylakoid membrane-anchored protein SUPPRESSOR OF QUENCHING1 (SOQ1) prevents qH formation by inhibiting LCNP. SOQ1 suppresses qH with its lumen-located C-terminal Trx-like and ... Read more >>

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Meningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report.

Chenyang Zhang, Kang Zhang, Bing Chen, Jiao Yin, Miaomiao Dong, Yixin Qin, Xiao Yang,

<h4>Background</h4>Neuromyelitis optica spectrum disorders (NMOSD), a group of autoimmune neurological diseases, involve the optic nerve, spinal cord, and brain. Meningitis is rarely reported as the primary clinical manifestation of both anti-aquaporin-4 (AQP4)/ anti-myelin oligodendrocyte glycoprotein (MOG) antibody-negative NMOSD (NMOSD<sup>neg</sup>).<h4>Case presentation</h4>A 30-year-old man initially presented with fever, headache, and neck stiffness. ... Read more >>

BMC Neurol (BMC neurology)
[2021, 21(1):109]

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Interplay between Pds5 and Rec8 in regulating chromosome axis length and crossover frequency.

Meihui Song, Binyuan Zhai, Xiao Yang, Taicong Tan, Ying Wang, Xuan Yang, Yingjin Tan, Tingting Chu, Yanding Cao, Yulong Song, Shunxin Wang, Liangran Zhang,

Meiotic chromosomes have a loop/axis architecture, with axis length determining crossover frequency. Meiosis-specific Pds5 depletion mutants have shorter chromosome axes and lower homologous chromosome pairing and recombination frequency. However, it is poorly understood how Pds5 coordinately regulates these processes. In this study, we show that only ~20% of wild-type level ... Read more >>

Sci Adv (Science advances)
[2021, 7(11):]

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Identification of hub genes associated with neutrophils infiltration in colorectal cancer.

Hao Su, Tianyi Cai, Sen Zhang, Xialin Yan, Leqi Zhou, Zirui He, Pei Xue, Jianwen Li, Minhua Zheng, Xiao Yang, Bo Feng,

Colorectal cancer (CRC) is the leading cause of cancer-related mortality in the world. Accumulating evidence indicate that tumour infiltrating immune cells participated in cancer progression. Among them, tumour infiltrating neutrophils (TINs) are reported to play crucial role in various cancers. In this study, we used CIBERSORTx, a digital cytometry tool ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, 25(7):3371-3380]

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Distribution and migration characteristics of dinitrotoluene sulfonates (DNTs) in typical TNT production sites: Effects and health risk assessment.

Wenchu Zhao, Xiao Yang, Aixi Feng, Xiulan Yan, Lingqing Wang, Tao Liang, Juan Liu, Huansong Ma, Yaoyu Zhou,

The production of 2,4,6-trinitrotoluene (TNT) produces a great deal of waste water, and dinitrotoluene sulfonates (DNTs) are the main pollutants in its waste. This paper presents a pilot investigation on the geochemical transformation of DNTs affected by historical wastewater spillage from a typical TNT production company in Northwest China. In ... Read more >>

J Environ Manage (Journal of environmental management)
[2021, 287:112342]

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INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion.

Shu Xian, Yan Zhang, Li Wang, Fang Yao, Jinli Ding, Yanqing Wang, Xiao Yang, Fangfang Dai, Tailang Yin, Yanxiang Cheng,

The INO80 complex, a SWI/SNF family chromatin remodeler, has regulatory effects on ESC self-renewal, somatic cell reprogramming and blastocyst development. However, the role of INO80 in regulating trophoblast cells and recurrent miscarriage (RM) remains elusive. To investigate the in vivo effects of Ino80 in embryo development, we disrupted Ino80 in ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, :]

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Pre-operative N-terminal pro-B-type natriuretic peptide for prediction of acute kidney injury after noncardiac surgery: A retrospective cohort study.

Bing-Cheng Zhao, Pei-Pei Zhuang, Shao-Hui Lei, Shi-Da Qiu, Xiao Yang, Cai Li, Wei-Feng Liu, Ke-Xuan Liu,

<h4>Background</h4>Acute kidney injury (AKI) is associated with poor outcomes after noncardiac surgery. Whether pre-operative N-terminal pro-B-type natriuretic peptide (NT-proBNP) predicts AKI after noncardiac surgery is unclear.<h4>Objective</h4>To investigate the predictive role of pre-operative NT-proBNP on postoperative AKI.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Nanfang Hospital, Southern Medical University, China.<h4>Patients</h4>Adult patients who had a serum creatinine and ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, :]

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Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution.

Huan Qi, Ming-Liang Ma, He-Wei Jiang, Jian-Ya Ling, Ling-Yun Chen, Hai-Nan Zhang, Dan-Yun Lai, Yang Li, Zi-Wen Guo, Chuan-Sheng Hu, Shu-Juan Guo, Qing-Feng Meng, Yan Ren, Xiao Yang, Wei Wang, Jie Zhou, Xiao-Dong Zhao, Hua Li, Sheng-Ce Tao,

Cell Mol Immunol (Cellular & molecular immunology)
[2021, 18(4):1067-1069]

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