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Author Xiao Xu

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A Time-Phased Machine Learning Model for Real-Time Prediction of Sepsis in Critical Care.

Xiang Li, Xiao Xu, Fei Xie, Xian Xu, Yuyao Sun, Xiaoshuang Liu, Xiaoyu Jia, Yanni Kang, Lixin Xie, Fei Wang, Guotong Xie,

OBJECTIVES:As a life-threatening condition, sepsis is one of the major public health issues worldwide. Early prediction can improve sepsis outcomes with appropriate interventions. With the PhysioNet/Computing in Cardiology Challenge 2019, we aimed to develop and validate a machine learning algorithm with high prediction performance and clinical interpretability for prediction of ... Read more >>

Crit. Care Med. (Critical care medicine)
[2020, 48(10):e884-e888]

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Salinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma.

Jianguo Wang, Jianyong Zhuo, Yaoye Tao, Shengjun Xu, Zun Chen, Fan Yang, Qinghong Ke, Haiyang Xie, Shusen Zheng, Hangxiang Wang, Xiao Xu,

Background:There is currently no effective treatment for advanced hepatocellular carcinoma (HCC), and chemotherapy has little effect on long-term survival of HCC patients, largely due to the cancer stem cell (CSC) chemoresistance of HCC. Methods:We constructed a small-molecule nanometer-sized prodrug (nanoprodrug) loaded with salinomycin (SAL) for the treatment of HCC. SAL ... Read more >>

Int J Nanomedicine (International journal of nanomedicine)
[2020, 15:6839-6854]

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Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.

Alessandra Ferrari, Cuiwen He, John Paul Kennelly, Jaspreet Sandhu, Xu Xiao, Xun Chi, Haibo Jiang, Stephen G Young, Peter Tontonoz,

Recent studies have demonstrated the existence of a discrete pool of cholesterol in the plasma membranes (PM) of mammalian cells-referred to as the accessible cholesterol pool-that can be detected by the binding of modified versions of bacterial cytolysins (e.g., anthrolysin O). When the amount of accessible cholesterol in the PM ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2020, 40(19):]

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The ongoing trends of patient-derived xenograft models in oncology.

Jianyong Zhuo, Renyi Su, Winyen Tan, Zhengxing Lian, Di Lu, Xiao Xu,

Cancer Commun (Lond) (Cancer communications (London, England))
[2020, :]

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Intravoxel Incoherent Motion Magnetic Resonance Imaging for Assessing Parotid Gland Tumors: Correlation and Comparison with Arterial Spin Labeling Imaging.

Gao Ma, Xiao Quan Xu, Liu Ning Zhu, Jia Suo Jiang, Guo Yi Su, Hao Hu, Shou Shan Bu, Fei Yun Wu,

OBJECTIVE:To compare and correlate the findings of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging and arterial spin labeling (ASL) imaging in characterizing parotid gland tumors. MATERIALS AND METHODS:We retrospectively reviewed 56 patients with parotid gland tumors evaluated by MR imaging. The true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and ... Read more >>

Korean J Radiol (Korean journal of radiology)
[2020, :]

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A Multi-Cell Hybrid Approach to Elevate the Energy Absorption of Micro-Lattice Materials.

Lijun Xiao, Xiao Xu, Weidong Song, Menglei Hu,

Multi-cell hybrid micro-lattice materials, in which the stretching dominated octet cells were adopted as the strengthen phase while the bending dominated body centered cubic (BCC) lattice was chosen as the soft matrix, were proposed to achieve superior mechanical properties and energy absorption performance. Both stochastic and symmetric distribution of octet ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2020, 13(18):]

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KVarPredDB: A Database for Predicting Pathogenicity of Missense Sequence Variants of Keratin Genes Associated With Genodermatoses

Santasree Banerjee, Yuyi Ying, Lu Lu, Lizhen Xu, Qiang Zhao, Hao Wu, Ruiqi Li, Xiao Xu, Hua Yu, Dante Neculai, Yongmei Xi, Fan Yang, Jiale Qin, Chen Li,

Abstract Background: Germline variants of ten keratin genes ( K1, K2, K5, K6A, K6B, K9, K10, K14, K16 and K17 ) have been reported for causing different types of genodermatoses with an autosomal dominant mode of inheritance. Among all the variants of these ten keratin genes, most of them are ... Read more >>

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The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina.

Jialan Lyu, Yuchen Chen, Weiwei Yang, Ting Guo, Xiao Xu, Yongmei Xi, Xiaohang Yang, Wanzhong Ge,

Increasing evidence suggests that miRNAs play important regulatory roles in the nervous system. However, the molecular mechanisms of how specific miRNAs affect neuronal development and functions remain less well understood. In the present study, we provide evidence that the conserved microRNA miR-210 regulates lipid metabolism and prevents neurodegeneration in the ... Read more >>

Cell Death Differ. (Cell death and differentiation)
[2020, :]

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PNPLA3 I148M is involved in the variability in anti-NAFLD response to exenatide.

Yunzhi Chen, Xuemei Yan, Xiao Xu, Shuhua Yuan, Fen Xu, Hua Liang,

PURPOSE:GLP-1 receptor agonists, such as exenatide, have been proven to attenuate nonalcoholic fatty liver disease (NAFLD) in vivo and in vitro. However, the efficiency of exenatide had interindividual differences. PNPLA3 is a major susceptibility gene for NAFLD and its I148M polymorphism increases the risk of all disorders of the NAFLD ... Read more >>

Endocrine (Endocrine)
[2020, :]

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Target-oriented delivery of self-assembled immunosuppressant cocktails prolongs allogeneic orthotopic liver transplant survival.

Haiyang Xie, Hai Zhu, Ke Zhou, Jianqin Wan, Liang Zhang, Zhentao Yang, Liqian Zhou, Xiaona Chen, Xiao Xu, Shusen Zheng, Hangxiang Wang,

Organ transplantation remains the gold standard therapeutic option for patients with end-stage organ failure. However, there have been few improvements in the management of post-transplant immunosuppression. As the long-term use of immunosuppressive agents (ISAs) may result in off-target systemic toxicity and complications, minimizing the ISA dosage while preserving the pharmacological ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2020, 328:237-250]

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Effect of intimal flap motion on flow in acute type B aortic dissection by using fluid-structure interaction.

Mei Yan Chong, Boram Gu, Bee Ting Chan, Zhi Chao Ong, Xiao Yun Xu, Einly Lim,

A monolithic, fully coupled fluid-structure interaction (FSI) computational framework was developed to account for dissection flap motion in acute type B aortic dissection (TBAD). Analysis of results included wall deformation, pressure, flow, wall shear stress (WSS), von Mises stress and comparison of hemodynamics between rigid wall and FSI models. Our ... Read more >>

Int J Numer Method Biomed Eng (International journal for numerical methods in biomedical engineering)
[2020, :e3399]

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A robust 11-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts.

Jiaxing Lin, Jieping Yang, Xiao Xu, Yutao Wang, Meng Yu, Yuyan Zhu,

Background:Bladder cancer is the tenth most common cancer globally, but existing biomarkers and prognostic models are limited. Method:In this study, we used four bladder cancer cohorts from The Cancer Genome Atlas and Gene Expression Omnibus databases to perform univariate Cox regression analysis to identify common prognostic genes. We used the ... Read more >>

Cancer Cell Int. (Cancer cell international)
[2020, 20:402]

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Differential impact of non-pharmaceutical public health interventions on COVID-19 epidemics in the United States

Xiaoshuang Liu, Xiao Xu, Guanqiao Li, Xian Xu, Yuyao Sun, Fei Wang, Xuanling Shi, Xiang Li, Guotong Xie, Linqi Zhang,

Abstract The widespread pandemic of novel coronavirus disease 2019 (COVID-19) poses an unprecedented global health crisis. In the United States (US), different state governments have adopted various combinations of non-pharmaceutical public health interventions (NPIs) to mitigate the epidemic from February to April, 2020. Quantitative assessment on the effectiveness of NPIs ... Read more >>

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Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.

Xiaoqing Wang, Xiao Xu, Guoqiang Jiang, Cuili Zhang, Likun Liu, Jian Kang, Jing Wang, Lawrence Owusu, Liye Zhou, Lin Zhang, Weiling Li,

Dihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, the therapeutic benefits and underlying mechanisms of DHTS on ovarian cancer remain uncertain. In this study, we demonstrated the cytocidal effects of DHTS on ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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Multi-omics Analysis at Serum Proteomic and Metabolomic Levels Reveals Mechanisms of Moxibustion for a Mouse Model of Ankylosing Spondylitis

Xiao Xu, Ting Liu, Rong-Yun Wang, Ya-Nan Shi, Jing-ming Xu, Wen Mao, Feng-qin Wu, Hong-yuan Wang, Zhi-Ling Sun, Qiu-hua Sun,

Abstract Background: Moxibustion is widely used in ameliorating symptoms of ankylosing spondylitis (AS). The aim of this study was to identify the potential molecular profiles of moxibustion on relieving AS mice through incorporating ultra-high-performance liquid chromatography quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF/MS) based metabolomics approach and data independent acquisition-mass spectrometry ... Read more >>

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Long Noncoding RNA LINC01485 Promotes Tumor Growth and Migration via Inhibiting EGFR Ubiquitination and Activating EGFR/Akt Signaling in Gastric Cancer.

Jianping Zhou, Lulu Wu, Weiling Li, Xiao Xu, Feng Ju, Shao Yu, Jianfeng Guo, Gang Li, Jun Shi, Sujun Zhou,

Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gastric cancer. Materials and Methods:Microarray and computational analysis ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:8413-8425]

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Hospital variation in admissions to neonatal intensive care units by diagnosis severity and category.

Eman S Haidari, Henry C Lee, Jessica L Illuzzi, Ciaran S Phibbs, Haiqun Lin, Xiao Xu,

OBJECTIVE:To examine interhospital variation in admissions to neonatal intensive care units (NICU) and reasons for the variation. STUDY DESIGN:2010-2012 linked birth certificate and hospital discharge data from 35 hospitals in California on live births at 35-42 weeks gestation and ≥1500 g birth weight were used. Hospital variation in NICU admission rates ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, :]

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Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment.

Li Duan, Yujie Liang, Xiao Xu, Yin Xiao, Daping Wang,

Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at maintaining cartilage integrity have attracted considerable attention in the OA research field. Recently, a series of studies have suggested dual functions of microRNA-140 (miR-140) ... Read more >>

Arthritis Res. Ther. (Arthritis research & therapy)
[2020, 22(1):194]

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The Acer truncatum genome provides insights into the nervonic acid biosynthesis.

Qiuyue Ma, Tianlin Sun, Shushun Li, Jing Wen, Lu Zhu, Tongming Yin, Kunyuan Yan, Xiao Xu, Shuxian Li, Jianfeng Mao, Ya-Nan Wang, Shuangxia Jin, Xing Zhao, Qianzhong Li,

Acer truncatum (purpleblow maple) is a woody tree species that produces seeds with high levels of valuable fatty acids (especially nervonic acid). However, the lack of a complete genome sequence has limited both basic and applied research on A. truncatum. We describe a high-quality draft genome assembly comprising 633.28 Mb ... Read more >>

Plant J. (The Plant journal : for cell and molecular biology)
[2020, :]

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A robust eleven-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts

Jiaxing Lin, Jieping Yang, Xiao Xu, Yutao Wang, Meng Yu, Yuyan Zhu,

Abstract Background: Bladder cancer is the tenth most common cancer globally, but existing biomarkers and prognostic models are limited. Method: In this study, we used four bladder cancer cohorts from The Cancer Genome Atlas and Gene Expression Omnibus databases to perform univariate Cox regression analysis to identify common prognostic genes. ... Read more >>

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No intrauterine vertical transmission in pregnancy with COVID-19: A case report.

Yantian Lv, Binbin Gu, Ying Chen, Siming Hu, Ting Ruan, Guopeng Xu, Jian Ding, Xiao Xu, Xinghua Shen,

The coronavirus disease 2019 (COVID-19) has been a worldwide pandemic diseases, nearly 400,000 people died at now. The data of status of pregnant women and neonates after infection of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is limited. We report a case of pregnant woman in her third trimester with ... Read more >>

J. Infect. Chemother. (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2020, :]

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Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy.

Yujie Liang, Xiao Xu, Xingfu Li, Jianyi Xiong, Biquan Li, Li Duan, Daping Wang, Jiang Xia,

Targeted delivery to the diseased cell or tissue is the key to the successful clinical use of nucleic acid drugs. In particular, delivery of microRNA-140 (miRNA-140, miR-140) into chondrocytes across the dense, nonvascular extracellular matrix of cartilage remains a major challenge. Here, we report the chondrocyte-targeting exosomes as vehicles for ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(33):36938-36947]

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MicroRNA expression profiling in an ovariectomized rat model of postmenopausal osteoporosis before and after estrogen treatment.

Xiao Xu, Peng Zhang, Xingfu Li, Yujie Liang, Kan Ouyang, Jianyi Xiong, Daping Wang, Li Duan,

Postmenopausal osteoporosis (PMOP) is a common disease that seriously threatens human health. Estrogen deficiency plays an essential role in the pathogenesis of PMOP. MicroRNAs (miRNAs) are involved in the development and progression of PMOP. Therefore, identification of miRNAs in PMOP due to estrogen deficiency may contribute to earlier diagnosis and ... Read more >>

Am J Transl Res (American journal of translational research)
[2020, 12(8):4251-4263]

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Iron-based superelastic alloys with near-constant critical stress temperature dependence.

Ji Xia, Yuki Noguchi, Xiao Xu, Takumi Odaira, Yuta Kimura, Makoto Nagasako, Toshihiro Omori, Ryosuke Kainuma,

Shape memory alloys recover their original shape after deformation, making them useful for a variety of specialized applications. Superelastic behavior begins at the critical stress, which tends to increase with increasing temperature for metal shape memory alloys. Temperature dependence is a common feature that often restricts the use of metal ... Read more >>

Science (Science (New York, N.Y.))
[2020, 369(6505):855-858]

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The Role of Ischemia/Reperfusion Injury in Early Hepatic Allograft Dysfunction.

Junbin Zhou, Jian Chen, Qiang Wei, Kourosh Saeb-Parsy, Xiao Xu,

Liver transplantation (LT) is the only available curative treatment for patients with end-stage liver disease. Early allograft dysfunction (EAD) is a life-threatening complication of LT and is thought to be mediated in large part through ischemia/reperfusion injury (IRI). However, the underlying mechanisms linking IRI and EAD after LT are poorly ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2020, 26(8):1034-1048]

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