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The Effect of Auricular Acupressure on Sleep Disturbance Among Patients With Leukemia: A Feasibility Study.

Xiao-Rong Liu, Nicole Rana, Ng-Shin Wong, Chabu James, Jue Lu, Xiao Xu,

Auricular acupressure (AA) is widely used in East Asia and Europe to manage patients with sleep disturbance. This feasibility study was performed to demonstrate the potential of AA for sleep disturbance in patients with leukemia. Thirty-two patients with leukemia with poor sleep quality received AA 3 times a day for ... Read more >>

Holist Nurs Pract (Holistic nursing practice)
[2020, 34(2):103-112]

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Comparison of High-Throughput Single-Cell RNA Sequencing Data Processing Pipelines

Mingxuan Gao, Mingyi Ling, Xinwei Tang, Shun Wang, Xu Xiao, Ying Qiao, Wenxian Yang, Rongshan Yu,

Abstract With the development of single-cell RNA sequencing (scRNA-seq) technology, it has become possible to perform large-scale transcript profiling for tens of thousands of cells in a single experiment. Many analysis pipelines have been developed for data generated from different high-throughput scRNA-seq platforms, bringing a new challenge to users to ... Read more >>

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Liposomal 9-Aminoacridine for Treatment of Ischemic Stroke: From Drug Discovery to Drug Delivery.

Haojie Wang, Xiao Xu, Xin Guan, Shiyang Shen, Xuechao Huang, Guoyin Kai, Shunyi Zhao, Wenchen Ruan, Luyong Zhang, Tao Pang, Ran Mo,

Neuroinflammation plays a pivotal part in the pathogenesis of stroke. Orphan nuclear receptor NR4A1 is involved in the inflammatory response of microglia and macrophages. In this study, we discovered an old drug, 9-aminoacridine (9-AA), as a novel NR4A1 activator from our in-house FDA-approved drug library, which exhibited anti-inflammatory activities through ... Read more >>

Nano Lett. (Nano letters)
[2020, :]

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Association of Oxytocin Rest During Labor Induction of Nulliparous Women With Mode of Delivery.

Molly McAdow, Xiao Xu, Heather Lipkind, Uma M Reddy, Jessica L Illuzzi,

OBJECTIVE:To evaluate the association between temporary cessation in oxytocin infusion (oxytocin rest) and mode of delivery in women undergoing induction of labor with a protracted latent phase. METHODS:We conducted a retrospective cohort analysis of nulliparous women with term, vertex, singleton gestations who were undergoing induction of labor with continuous oxytocin ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2020, :]

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A randomized, placebo-controlled crossover trial of a decaffeinated energy drink shows no significant acute effect on mental energy.

Alicia Garcia-Alvarez, Corbin A Cunningham, Byron Mui, Lia Penn, Erin M Spaulding, J Michael Oakes, Jasmin Divers, Stephanie L Dickinson, Xiao Xu, Lawrence J Cheskin,

BACKGROUND:"Energy drinks" are heavily marketed to the general public, across the age spectrum. The efficacy of decaffeinated energy drinks in enhancing subjective feelings of energy (s-energy) is controversial. OBJECTIVE:The authors sought to test the efficacy of the caffeine-free version of a popular energy drink compared with a placebo drink. METHODS:This ... Read more >>

Am. J. Clin. Nutr. (The American journal of clinical nutrition)
[2020, :]

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DNA methylation of SOCS1/2/3 predicts hepatocellular carcinoma recurrence after liver transplantation.

Zhentao Yang, Hai Zhu, Liang Zhang, Qiang Wei, Lin Zhou, Xiao Xu, Penghong Song, Jialin Liu, Haiyang Xie, Shusen Zheng,

DNA methylation status of SOCS1/SOCS2/SOCS3 is intensely involved in the development and progression of hepatocellular carcinoma (HCC). This study explored its prognostic value for HCC recurrence after liver transplantation (LT). Clinical data from 62 HCC patients who underwent LT at our centre were retrospectively collected. The SOCS1/2/3 methylation level were ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2020, :]

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Utility of Birth Certificate Data for Evaluating Hospital Variation in Admissions to NICUs.

Eman S Haidari, Henry C Lee, Jessica L Illuzzi, Haiqun Lin, Xiao Xu,

OBJECTIVES:Efforts to study potential overuse of NICU admissions and hospital variation in practice are often hindered by a lack of an appropriate data source. We examined the concordance of hospital-level NICU admission rates between birth certificate data and California Children's Services (CCS) data to inform the utility of birth certificate ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2020, 10(2):190-194]

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Systematic Review: Risk Prediction Models for Recurrence of Hepatocellular Carcinoma after Liver Transplantation.

Abdulahad Abdulrab Mohammed Al-Ameri, Xuyong Wei, Xue Wen, Qiang Wei, Haijun Guo, Shusen Zheng, Xiao Xu,

BACKGROUND:Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is a significant clinical problem associated with poor surgical outcomes. AIM:This study aims to summarize the current evidence on risk prediction models of HCC recurrence after LT. METHODS:PubMed and EMBASE were searched to May 25, 2019, for relevant articles. Studies originally ... Read more >>

Transpl. Int. (Transplant international : official journal of the European Society for Organ Transplantation)
[2020, :]

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Volume management as a key dimension of a high-quality PD prescription.

Angela Yee-Moon Wang, Jie Dong, Xiao Xu, Simon Davies,

BACKGROUND:Appropriate volume control is one of the key goals in a peritoneal dialysis (PD) prescription. As such it is an important component of the International Society of Peritoneal Dialysis (ISPD) guideline for "High-quality PD prescription" necessitating a review of the literature on volume management. The workgroup recognized the importance of ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, :896860819895365]

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Matching-Adjusted Comparison of Oral Corticosteroid Reduction in Asthma: Systematic Review of Biologics.

Arnaud Bourdin, Don Husereau, Nicolas Molinari, Sarowar Golam, Mohd Kashif Siddiqui, Leandro Lindner, Xiao Xu,

BACKGROUND:Oral corticosteroid (OCS) treatment for severe asthma is associated with substantial disease burden. Thus, OCS dosage reduction is desirable. Relative efficacy of biologics in reducing OCS treatment for severe, uncontrolled asthma is not fully characterised. OBJECTIVE:We performed matching-adjusted indirect comparison (MAIC) to assess the relative effects on OCS treatment reduction ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2020, :]

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Impacts of the Plateau Environment on the Gut Microbiota and Blood Clinical Indexes in Han and Tibetan Individuals.

Zhilong Jia, Xiaojing Zhao, Xiaoshuang Liu, Le Zhao, Qian Jia, Jinlong Shi, Xiao Xu, Lijun Hao, Zhenguo Xu, Qin Zhong, Kang Yu, Saijia Cui, Huining Chen, Jianying Guo, Xiang Li, Yang Han, Xinyu Song, Chenghui Zhao, Xiaochen Bo, Yaping Tian, Weidong Wang, Guotong Xie, Qiang Feng, Kunlun He,

The intestinal microbiota is significantly affected by the external environment, but our understanding of the effects of extreme environments such as plateaus is far from adequate. In this study, we systematically analyzed the variation in the intestinal microbiota and 76 blood clinical indexes among 393 healthy adults with different plateau ... Read more >>

mSystems (mSystems)
[2020, 5(1):]

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Therapeutic IDOL reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice.

Jie Gao, Russell Littman, Graciel Diamante, Xu Xiao, In Sook Ahn, Xia Yang, Tracy A Cole, Peter Tontonoz,

Brain lipoprotein receptors have been shown to regulate the metabolism of ApoE and β-amyloid (Aβ) and are potential therapeutic targets for Alzheimer's Disease (AD). Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brain lipoprotein receptors. Genetic ablation of Idol increases low-density lipoprotein receptor (LDLR) protein levels, ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2020, :]

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Holly polyphenols alleviate intestinal inflammation and alter microbiota composition in lipopolysaccharide-challenged pigs.

Xiao Xu, Hongwei Hua, Longmei Wang, Pengwei He, Lin Zhang, Qin Qin, Cheng Yu, Xiuying Wang, Guolong Zhang, Yulan Liu,

The effect of holly polyphenols (HP) on intestinal inflammation and microbiota composition was evaluated in a piglet model of lipopolysaccharide (LPS)-induced intestinal injury. A total of twenty-four piglets were used in a 2 × 2 factorial design including diet type and LPS challenge. After 16 d of feeding with a ... Read more >>

Br. J. Nutr. (The British journal of nutrition)
[2020, :1-11]

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Dense Breast Notification Laws, Education, and Women's Awareness and Knowledge of Breast Density: a Nationally Representative Survey.

Kelly A Kyanko, Jessica Hoag, Susan H Busch, Jenerius A Aminawung, Xiao Xu, Ilana B Richman, Cary P Gross,

BACKGROUND:To date, 38 states have enacted dense breast notification (DBN) laws mandating that mammogram reports include language informing women of risks related to dense breast tissue. OBJECTIVE:Nationally representative survey to assess the association between residing in a state with a DBN law and women's awareness and knowledge about breast density, ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2020, :]

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Glutamine synthetase promotes tumor invasion in hepatocellular carcinoma through mediating epithelial-mesenchymal transition.

Peng Liu, Di Lu, Abdulahad Al-Ameri, Xuyong Wei, Sunbin Ling, Jie Li, Hai Zhu, Haiyang Xie, Liming Zhu, Shusen Zheng, Xiao Xu,

AIM:Glutamine synthetase (GS) levels increase gradually with the development of hepatocellular carcinogenesis. In this study, we aimed to investigate the clinical significance of GS and the underlying mechanism of GS promoting hepatocellular carcinoma (HCC) invasion. METHODS:Serum concentration of GS and α-fetoprotein (AFP) in HCC patients, liver cirrhosis patients, and healthy ... Read more >>

Hepatol. Res. (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(2):246-257]

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Scrotal Tumoral Calcinosis: A Rare and Easily Misdiagnosed Situation.

Zhenhua Liu, Xiao Xu, Baoyue Liu,

Int. J. Surg. Pathol. (International journal of surgical pathology)
[2020, :1066896919900551]

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CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells.

Jian-Yong Zhuo, Di Lu, Zu-Yuan Lin, Bei-Ni Cen, Xu-Yong Wei, Hai-Yang Xie, Shu-Sen Zheng, Xiao Xu,

BACKGROUND:Liver cirrhosis results from many forms of chronic damage, characterized by accumulation of extracellular matrix. The present study aimed to explore a potential non-invasive biomarker and its mechanism in the progression of liver cirrhosis. METHODS:Gene Expression Omnibus (GEO) dataset (GSE15654, n = 216) was analyzed to screen genes associated with progression of ... Read more >>

HBPD INT (Hepatobiliary & pancreatic diseases international : HBPD INT)
[2020, :]

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Assessment of the Relationship Between the Coronary Venous and Arterial Systems Using 256-Slice Computed Tomography.

Wei Bai, Xiao Xu, Heng Ma, Lin Zhong, Haizhu Xie, Chunjuan Sun, Yinghong Shi, Kaili Che, Meijie Liu, Jun Yang,

OBJECTIVES:To investigate the coronary venous system (CVS) and its spatial relationship with coronary arteries by using 256-slice computed tomography (CT). METHODS:One hundred one patients underwent coronary CT angiography by using a 256-slice CT. In each patient, the CVS and its spatial relationship with coronary arteries were analyzed. We measured the ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2020, 44(1):1-6]

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Protein Profiles of Pretransplant Grafts Predict Early Allograft Dysfunction After Liver Transplantation From Donation After Circulatory Death.

Haiyang Xie, Liang Zhang, Danjing Guo, Zhentao Yang, Hai Zhu, Ke Zhou, Xiaowen Feng, Qiang Wei, Xiao Xu, Penghong Song, Xue Wen, Jianhui Li, Jialin Liu, Shusen Zheng,

BACKGROUND:Predicting the development of early allograft dysfunction (EAD) following liver transplantation (LT) remains challenging for transplant clinicians. The objectives of this study are to investigate the potential relationship between the protein profiles of pretransplant grafts and the onset of EAD, and then combine with clinical parameters to construct a mathematically ... Read more >>

Transplantation (Transplantation)
[2020, 104(1):79-89]

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An effective dual-factor modified 3D-printed PCL scaffold for bone defect repair.

Yan Li, Qian Li, Hongming Li, Xiao Xu, Xiaoming Fu, Jijia Pan, Hui Wang, Jerry Ying Hsi Fuh, Yanjie Bai, Shicheng Wei,

Numerous bioactive molecules produced in cells are involved in the process of bone formation. We consider that appropriate, simultaneous application of two types of bioactive molecules would accelerate the regeneration of tissues and organs. Therefore, we combined aspirin-loaded liposomes ([email protected]) and bone forming peptide-1 (BFP-1) on three dimensional-printed polycaprolactone (PCL) ... Read more >>

J. Biomed. Mater. Res. Part B Appl. Biomater. (Journal of biomedical materials research. Part B, Applied biomaterials)
[2020, :]

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OsmiR530 acts downstream of OsPIL15 to regulate grain yield in rice.

Wei Sun, Xiao Hui Xu, Yaping Li, Lixia Xie, Yanan He, Wen Li, Xingbo Lu, Hongwei Sun, Xianzhi Xie,

MicroRNAs (miRNAs) are a class of small noncoding RNAs that play important roles in plant growth and development as well as in stress responses. However, little is known about their regulatory functions affecting rice grain yield. We functionally characterized a novel miRNA in rice, OsmiR530, its target OsPL3, and its ... Read more >>

New Phytol. (The New phytologist)
[2019, :]

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Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer.

Xuan Deng, Sihan Li, Fanyang Kong, Haoyu Ruan, Xiao Xu, Xinju Zhang, Zhiyuan Wu, Lin Zhang, Ying Xu, Hong Yuan, Haixia Peng, Da Yang, Ming Guan,

We identified a novel long noncoding RNA (lncRNA) upregulated in colorectal cancer (CRC). We elucidated its role and clinical significance in CRC carcinogenesis. Methods: LncRNA candidates were identified using TCGA database. LncRNA expression profiles were studied by qRT-PCR and microarray in paired tumor and normal tissues. The independence of the ... Read more >>

Theranostics (Theranostics)
[2020, 10(1):265-280]

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Highly Intensified Molecular Oxygen Activation on [email protected] via a Metallic Bi-Coordinated Facet-Dependent Effect.

Xiao Xu, Nan Yang, Pei Wang, Shengyao Wang, Yonggang Xiang, Xiaohu Zhang, Xing Ding, Hao Chen,

Construction of the semimetal/semiconductor composite interface is widely used to promote the O2 molecule adsorption and charge transfer for boosting solar-driven molecular oxygen activation (MOA). Herein, a [email protected]O6 heterostructure is fabricated via a two-step wet chemical method as a typical photocatalyst to investigate the underlying mechanism of Bi-coordinated facet-dependent MOA ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(1):1867-1876]

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Timing in combination with radiotherapy and patterns of disease progression in non-small cell lung cancer treated with EGFR-TKI.

Yi Tang, Bing Xia, Ruifei Xie, Xiao Xu, Minna Zhang, Kan Wu, Bing Wang, Shenglin Ma,

OBJECTIVES:Tyrosine kinase inhibitor (TKI) has been the standard of care for advanced non-small cell lung cancers (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation, but these tumors invariably develop drug resistance. As progression most frequently advances in sites of original disease, our study sought to explore the time to response ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2020, 140:65-70]

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PRMT5 promotes epithelial-mesenchymal transition via EGFR-β-catenin axis in pancreatic cancer cells.

Lu Ge, Huizhi Wang, Xiao Xu, Zhengrong Zhou, Junbo He, Wanxin Peng, Fengyi Du, Youli Zhang, Aihua Gong, Min Xu,

Protein arginine methyltransferase 5 (PRMT5) has been implicated in the development and progression of human cancers. However, few studies reveal its role in epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. In this study, we find that PRMT5 is up-regulated in pancreatic cancer, and promotes proliferation, migration and invasion in pancreatic ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, 24(2):1969-1979]

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