Full Text Journal Articles by
Author Xiao Po Zhang

Advertisement

Find full text journal articles








The gut microbiota confers the glucose-and lipid-lowering effect of Laurolitsine in db/db mice

Rui-qi Wang, Fang Zhang, Ya-nan Yang, Yin-feng Tan, Yong Zhang, Lin Dong, Ning Ma, Wei-ying Lu, Chong-ming Wu, Xiao-po Zhang,

<h4>Background: </h4> Modulations on gut microbiota by traditional Chinese medicines (TCMs) and their active components are emerging as potential therapeutic agents on diabetes. Litsea glutinosa is a TCM used in clinic to treat diabetes with alkaloids as the active constituents, and the Laurolitsine is the richest one. Purpose Based ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Simultaneous Measurement of Tadehaginoside and its Principal Metabolite in Rats by HPLC–MS/MS and its Application in Pharmacokinetics and Tissue Distribution Study

Cai-Yun Zhang, Ya-Ting Lu, Yin-Feng Tan, Lin Dong, Zhi-Heng Su, Xiao-Po Zhang,

<h4>Background: </h4> Tadehaginoside, an active ingredient isolated from Tadehagi triquetrum L., exhibited various biological activities. However, the pharmacokinetics and tissue-distribution which affects tadehaginoside’s therapeutic actions and application remain elusive.MethodsTo clarify the metabolism of tadehaginoside in vivo , a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established to detect the ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Synthesis and In Vitro Evaluation of Caffeoylquinic Acid Derivatives as Potential Hypolipidemic Agents.

Yu Tian, Xiao-Xue Cao, Hai Shang, Chong-Ming Wu, Xi Zhang, Peng Guo, Xiao-Po Zhang, Xu-Dong Xu,

A series of novel caffeoylquinic acid derivatives of chlorogenic acid have been designed and synthesized. Biological evaluation indicated that several synthesized derivatives exhibited moderate to good lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives <b>3d</b>, <b>3g</b>, <b>4c</b> and <b>4d</b> exhibited more potential lipid-lowering effect than ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(5):]

Cited: 1 time

View full text PDF listing >>



Soulieoside O, a new cyclolanostane triterpenoid glycoside from Souliea vaginata.

Hai-Feng Wu, Peng-Fei Li, Yin-Di Zhu, Xiao-Po Zhang, Guo-Xu Ma, Xu-Dong Xu, Yi-Lin Liu, Zheng-Hong Luo, Di-Zhao Chen, Qiong-Yu Zou, Zi-Jian Zhao,

A new cyclolanostane triterpenoid glycoside, soulieoside O (1), together with 25-O-acetylcimigenol-3-O-β-d-xylopyranoside (2) and cimigenol-3-O-β-d-xylopyranoside (3), was isolated from the rhizomes of Souliea vaginata. Their structures were characterized by spectroscopic analysis and chemical methods. The new compound showed moderate inhibitory activity against three human cancer cell lines with IC<sub>50</sub> values of ... Read more >>

J Asian Nat Prod Res (Journal of Asian natural products research)
[2017, 19(12):1177-1182]

Cited: 1 time

View full text PDF listing >>



A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius.

De-Li Chen, Xiao-Po Zhang, Guo-Xu Ma, Hai-Feng Wu, Jun-Shan Yang, Xu-Dong Xu,

A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its (1)H and (13)C NMR, (1)H-(1)H ... Read more >>

Nat Prod Res (Natural product research)
[2016, 30(5):565-569]

Cited: 1 time

View full text PDF listing >>



Four new phenolic acid with unusual bicycle [2.2.2] octane moiety from Clerodendranthus spicatus and their anti-inflammatory activity.

Guo-Xu Ma, Xiao-Po Zhang, Peng-Fei Li, Zhong-Hao Sun, Nai-Liang Zhu, Yin-Di Zhu, Jun-Shan Yang, De-Li Chen, Hai-Feng Wu, Xu-Dong Xu,

Four new phenolic acids, clerodens A-D (1-4) possessing an unusual bicycle [2.2.2] octane moiety were isolated from the whole plants of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD data. All isolates were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide ... Read more >>

Fitoterapia (Fitoterapia)
[2015, 105:61-65]

Cited: 3 times

View full text PDF listing >>



[Pandanus tectorius derived caffeoylquinic acids inhibit lipid accumulation in HepG2 hepatoma cells through regulation of gene expression involved in lipid metabolism].

Chong-ming Wu, Hong Luan, Shuai Wang, Xiao-po Zhang, Hai-tao Liu, Peng Guo,

The fruit of Pandanus tectorius (PTF) has a long history of use as a folk medicine to treat hyperlipidemia in Hainan province, South China. Our previous studies have shown that the n-butanol extract of PTF is rich in caffeoylquinic acids and has an adequate therapeutic effect on dyslipidemic animals induced ... Read more >>

Yao Xue Xue Bao (Yao xue xue bao = Acta pharmaceutica Sinica)
[2015, 50(3):278-283]

Cited: 1 time

View full text PDF listing >>



Differential systemic exposure to galangin after oral and intravenous administration to rats.

Feng Chen, Yin-Feng Tan, Hai-Long Li, Zhen-Miao Qin, Hong-Die Cai, Wei-Yong Lai, Xiao-Po Zhang, Yong-Hui Li, Wei-Wei Guan, You-Bin Li, Jun-Qing Zhang,

<h4>Background</h4>Galangin (3,5,7-trihydroxyflavone) is present in high concentrations in herbal medicine such as Alpinia officinarum Hance. Galangin shows multifaceted in vitro and in vivo biological activities. The number and position of hydroxyl groups in this molecule play an important role in these biological activities. However, these hydroxyl groups undergo glucuronidation and ... Read more >>

Chem Cent J (Chemistry Central journal)
[2015, 9:14]

Cited: 5 times

View full text PDF listing >>



Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation.

Min Wang, Xiang-bao Meng, Ying-li Yu, Gui-bo Sun, Xu-dong Xu, Xiao-po Zhang, Xi Dong, Jing-xue Ye, Hui-bo Xu, Yi-fan Sun, Xiao-bo Sun,

Endoplasmic reticulum (ER) stress-induced apoptosis has been suggested to contribute to myocardial ischemia-reperfusion (I/R) injury. Elatoside C is one of the major triterpenoid compounds isolated from Aralia elata that is known to be cardioprotective. However, its effects on I/R injury to cardiac myocytes have not been clarified. This study aimed ... Read more >>

Apoptosis (Apoptosis : an international journal on programmed cell death)
[2014, 19(12):1727-1735]

Cited: 31 times

View full text PDF listing >>



Norcassane- and cassane-type furanoditerpenoids from the seeds of Caesalpinia sappan.

Hai-Feng Wu, Yin-Di Zhu, Zhong-Hao Sun, Jing-Quan Yuan, Hua Wei, Xiao-Po Zhang, Yu Tian, Jun-Shan Yang, Guo-Xu Ma, Xu-Dong Xu,

Three novel furanoditerpenoids, norcaesalpinin J (1) featuring an unusual 20-norcassane hydroperoxide and phangininoxys B (2) and C (3) possessing cassane hemiketal skeletons, were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated by extensive spectroscopic methods. All isolates were evaluated for the cytotoxic activities on three human cancer ... Read more >>

Fitoterapia (Fitoterapia)
[2014, 98:22-26]

Cited: 5 times

View full text PDF listing >>



Novel dinorcassane- and cassane-type diterpenes from the seeds of Caesalpinia minax.

Hai-Feng Wu, Jing-Yi Hong, Zhong-Hao Sun, Jing-Quan Yuan, Hua Wei, Xiao-Po Zhang, Yu Tian, Ying-Di Zhu, Jun-Shan Yang, Guo-Xu Ma, Xu-Dong Xu,

Two novel diterpenes, norcaesalpinin I (1) featuring an unusual ring C-contracted dinorcassane and caesalpinin U (2) possessing a highly oxygenated furanocassane skeleton were isolated from the seeds of Caesalpinia minax. Their structures were determined by different spectroscopic methods. A plausible biosynthetic pathway of 1 was proposed. The cytotoxic activity of ... Read more >>

Fitoterapia (Fitoterapia)
[2014, 94:172-176]

Cited: 5 times

View full text PDF listing >>



A new ursane-type triterpene, cymosic acid from Rosa cymosa.

Xiao-Peng Wu, Xiao-Po Zhang, Guo-Xu Ma, Mo Han, Mu-Die Xu, Hai-Feng Wu, Xiao-Yan Huang, Zhen Huang, Jun-Shan Yang, Jing-Quan Yuan, Xu-Dong Xu, Xiao-Ming Zhong,

A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its ¹H and ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds ... Read more >>

J Asian Nat Prod Res (Journal of Asian natural products research)
[2014, 16(4):422-425]

Cited: 2 times

View full text PDF listing >>



Four new diterpenes from Aphanamixis polystachya.

Hai-Feng Wu, Xiao-Po Zhang, Ying Wang, Jing-Yi Zhang, Guo-Xu Ma, Yu Tian, Li-Zhen Wu, Shi-Lin Chen, Jun-Shan Yang, Xu-Dong Xu,

Four novel diterpenes possessing rare five-membered peroxide ring, aphanaperoxides E-H (1-4), were isolated from stem bark of Aphanamixis polystachya. Their structures including the absolute configuration were elucidated by spectroscopic data and CD analysis. The cytotoxicities of the isolated compounds against a panel of human cancer cell lines were evaluated. ... Read more >>

Fitoterapia (Fitoterapia)
[2013, 90:126-131]

Cited: 4 times

View full text PDF listing >>



A new sesquiterpene lactone from Sarcandra glabra.

Xiao-Ru Hu, Hai-Feng Wu, Xiao-Po Zhang, Jun-Shan Yang, Zhong Dai, Rui-Chao Lin, Xu-Dong Xu,

A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1-4 showed ... Read more >>

Nat Prod Res (Natural product research)
[2013, 27(13):1197-1201]

Cited: 4 times

View full text PDF listing >>



Characterization of aromatic glycosides in the extracts of Trollius species by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Li-Zhen Wu, Xiao-Po Zhang, Xu-Dong Xu, Qing-Xia Zheng, Jun-Shan Yang, Wan-Long Ding,

Ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC/ESI-Q-TOF MS/MS) was used to investigate the MS fragmentation behaviors of flavone C-glycosides present in the extracts of five Trollius species. In this study, the primary MS fragmentation pathways and key diagnostic fragment ions of flavone C-glycosides ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2013, 75:55-63]

Cited: 12 times

View full text PDF listing >>



Two new ent-3,4-seco-labdane diterpenoids from Callicarpa nudiflora.

Lin Dong, Xiao-Po Zhang, Ming-Sheng Liu, Yan-Mei Li, Jin-Hui Wang, Yi Wang,

Two new ent-3,4-seco-labdane diterpenoids, methylcallicarpate (1) and callicarpic acid (2), were isolated from the leaves of Callicarpa nudiflora Hook et Arn. Their structures and relative configurations were established by analysis of spectroscopic data. Their absolute configurations were assigned by the application of the CD technique for the first time among ... Read more >>

J Asian Nat Prod Res (Journal of Asian natural products research)
[2013, 15(1):30-34]

Cited: 5 times

View full text PDF listing >>



Two new drimane sesquiterpenoids from compound Changweikang and their inhibitory activity against nitric oxide production.

Ming-Sheng Liu, Chang Liu, Xiao-po Zhang, Lin Sheng, Jun-qing Zhang, Sheng-li Kang,

Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated ... Read more >>

Chem Pharm Bull (Tokyo) (Chemical & pharmaceutical bulletin)
[2010, 58(9):1224-1226]

Cited: 3 times

View full text PDF listing >>



Phenylpropionic acid derivates from the bark of Cerbera manghas.

Xiao Po Zhang, Ming Sheng Liu, Yue Hu Pei, Jun Qing Zhang, Sheng Li Kang,

Two new phenylpropionic acid derivates, cerberic acids A (1) and B (2), were isolated from the bark of Cerbera manghas. Their structures were established on the basis of spectroscopic methods including IR, ESI-FT-ICR-MS, 1D and 2D NMR. Primary bioassays showed that compound 1 possessed weak cytotoxic activity against HepG2, MCF-7, ... Read more >>

Fitoterapia (Fitoterapia)
[2010, 81(7):852-854]

Cited: 0 times

View full text PDF listing >>



Chemical constituents from the bark of Cerbera manghas.

Xiao-Po Zhang, Ming-Sheng Liu, Jun-Qing Zhang, Sheng-Li Kang, Yue-Hu Pei,

Two new compounds, 1,3-bis(m-carboxylphenyl)-propan-2-one (1) and 2-(m-carboxylphenyl)-3-(m-carboxylbenzyl) succinic acid (2), were isolated from the barks of Cerbera manghas, and their structures were established on the basis of spectroscopic methods. ... Read more >>

J Asian Nat Prod Res (Journal of Asian natural products research)
[2009, 11(1):75-78]

Cited: 0 times

View full text PDF listing >>





Advertisement


Disclaimer

1.0865 s