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ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway.

Xiangqin Tian, Changye Sun, Xianwei Wang, Ketao Ma, Yuqiao Chang, Zhikun Guo, Junqiang Si,

Cardiac fibrosis is associated with most of heart diseases, but its molecular mechanism remains unclear. Anoctamin-1 (ANO1), a calcium-activated chloride channels (CaCCs) protein, plays a critical role in various pathophysiological processes. In the current study, we identified ANO1 expression in myocardial infarction (MI) model of rat and verified the role ... Read more >>

Cell Calcium (Cell calcium)
[2020, 92:102306]

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Innate-adaptive immunity interplay and redox regulation in immune response.

Lizhe Sun, Xianwei Wang, Jason Saredy, Zuyi Yuan, Xiaofeng Yang, Hong Wang,

Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue inflammation. The innate immune system is the front line of host defense in which innate immune cells are activated by danger signals, including pathogen- and danger-associated molecular pattern, and metabolite-associated danger signal. Innate immunity activation can ... Read more >>

Redox Biol (Redox biology)
[2020, 37:101759]

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Hydroquinone inhibits PRV infection in neurons in vitro and in vivo.

Linlin Fang, Yanni Gao, Min Lan, Ping Jiang, Juan Bai, Yufeng Li, XianWei Wang,

Pseudorabies virus (PRV) is a prevalent and endemic swine pathogen that causes significant economic losses in the global swine industry. Due to the emergence of PRV mutant strains in recent years, vaccines can't completely prevent and control PRV infection. Therefore, research and development of new vaccines and drugs with inhibitory ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2020, 250:108864]

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LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation.

Zhou Cai, Jianhua Huang, Junxiao Yang, Baihong Pan, Wei Wang, Yangyang Ou, Xianwei Wang, Pu Yang,

Abdominal aortic aneurysm (AAA) is a progressive chronic dilatation of the abdominal aorta without effective medical treatment. This study aims to clarify the potential of long non-coding RNA SENCR as a treatment target in AAA. Angiotensin II (Ang-II) was used to establish AAA mouse model as well as a cell ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways.

Lin Lv, Mingzhu Cao, Juan Bai, Ling Jin, Xianwei Wang, Yanni Gao, Xuewei Liu, Ping Jiang,

Pseudorabies virus (PRV), a porcine alphaherpesvirus, causes neurological disorders and reproductive failure in swine. It is capable of avoiding host antiviral responses, resulting in viral latency in infected animals. The mechanisms by which many PRV proteins help the virus to evade immune surveillance are poorly understood. In this study, we ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2020, 250:108860]

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ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes.

Yu Sun, Yifan Lu, Jason Saredy, Xianwei Wang, Charles Drummer Iv, Ying Shao, Fatma Saaoud, Keman Xu, Ming Liu, William Y Yang, Xiaohua Jiang, Hong Wang, Xiaofeng Yang,

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases, inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress, regulate metabolic pathways and initiate proliferation, inflammation and cell death responses remain poorly characterized. In this analytic review, we concluded that: 1) Based on different features ... Read more >>

Redox Biol (Redox biology)
[2020, :101696]

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Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis.

Weijia Cheng, Xiao Li, Dongling Liu, Chaochu Cui, Xianwei Wang,

Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this ... Read more >>

J. Cardiovasc. Pharmacol. Ther. (Journal of cardiovascular pharmacology and therapeutics)
[2020, :1074248420952233]

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Genetically modified rabies virus vector-based bovine ephemeral fever virus vaccine induces protective immune responses against BEFV and RABV in mice.

Wenwen Zheng, Zhongxin Zhao, Li Tian, Lele Liu, Tong Xu, Xianwei Wang, Hongbin He, Xianzhu Xia, Ye Zheng, Yurong Wei, Xuexing Zheng,

Bovine ephemeral fever (BEF), caused by the bovine ephemeral fever virus (BEFV), is associated with an acute febrile infection in cattle and widespread in tropical and subtropical areas, leading to great economic losses to cattle and milk industry. However, no efficacious BEF vaccine is currently available in China. Herein, we ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2020, :]

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Blood flow patterns regulate PCSK9 secretion via MyD88-mediated pro-inflammatory cytokines.

Shijie Liu, Xiaoyan Deng, Peng Zhang, Xianwei Wang, Yubo Fan, Sichang Zhou, Shengyu Mu, Jawahar L Mehta, Zufeng Ding,

AIMS:Blood flow patterns play an important role in the localization of atherosclerosis in the sense that low-flow state is pro-atherogenic, and helical flow is protective against atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism via low-density lipoprotein receptor (LDLr) degradation and is highly expressed in the atherosclerotic tissues. ... Read more >>

Cardiovasc. Res. (Cardiovascular research)
[2020, 116(10):1721-1732]

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Ecological risk assessment of wetland vegetation under projected climate scenarios in the Sanjiang Plain, China.

Jing Fu, Juan Liu, Xianwei Wang, Mengduo Zhang, Weiwei Chen, Bin Chen,

Wetland ecosystems have comprehensive ecological functions and are sensitive to climate change. Under climate change, wetlands plant community productivity and diversity may be affected. In previous studies of wetlands, the effects of climate change have been primarily investigated using field observations, factor-controlled experiments, and mechanism analyses. However, the ecological risks ... Read more >>

J Environ Manage (Journal of environmental management)
[2020, 273:111108]

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Liraglutide Attenuates Myocardial Fibrosis via Inhibition of AT1R-Mediated ROS Production in Hypertensive Mice.

Peng Chen, Fen Yang, Wenya Wang, Xiao Li, Dongling Liu, Yongxi Zhang, Guotian Yin, Fenghua Lv, Zhikun Guo, Jawahar L Mehta, Xianwei Wang,

BACKGROUND/AIMS:Glucagon-like peptide-1 receptor agonist liraglutide has been reported to exert cardioprotective effects, but its effect on cardiac fibrosis remains controversial. The aim of this study was to investigate the effects of liraglutide on cardiac fibrosis and potential mechanisms. METHODS:C57BL/6 mice (3-month old) were randomly divided into control, hypertension, and hypertension ... Read more >>

J. Cardiovasc. Pharmacol. Ther. (Journal of cardiovascular pharmacology and therapeutics)
[2020, :1074248420942007]

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Identification of linear B cell epitopes on VP1 and VP2 proteins of Senecavirus A (SVA) using monoclonal antibodies.

Hui Fan, Huixin Zhu, Shihai Li, Mengyu Shi, Erxuan Zhou, Xianwei Wang, Ping Jiang, Juan Bai,

Senecavirus A (SVA), previously called Seneca Valley virus, belongs to the family Picornaviridae, species Senecavirus A, in the Senecavirus genus, and can cause vesicular lesions in sows and acute death in piglets. In this study, recombinant VP1 and VP2 proteins were expressed in prokaryotic expression system and used to generate ... Read more >>

Vet. Microbiol. (Veterinary microbiology)
[2020, 247:108753]

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The association of gene rearrangement and lymphoma diagnosis: A prospective observational study.

Xiaoyan He, Pei Xu, Xianwei Wang, Shuming Jiang, Daoyin Gong, Ning Wu,

INTRODUCTION:To investigate the gene rearrangement and mutation of lymphoma biomarkers including (Immunoglobulin H (IgH), Immunoglobulin kappa (IGK), Immunoglobulin lambda (IGL), and TCR) in the lymphoma diagnosis. METHODS AND ANALYSIS:Paraffin tissue samples from 240 cases diagnosed as suspected lymphoma in the department of pathology, Deyang City People's Hospital from June 2020 ... Read more >>

(Medicine)
[2020, 99(24):e20733]

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Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model.

Weigang Cui, Chunli Sun, Yuqi Ma, Songtao Wang, Xianwei Wang, Yinghua Zhang,

Cognitive impairment and neuro‑inflammatory responses are the distinctive characteristics of Alzheimer's disease (AD). Tormentic acid (TA) is one of the major active components of Potentilla chinensis and has been demonstrated to have anti‑inflammatory properties. However, the potential effects of TA on neuro‑inflammatory responses and memory impairment in AD remain unknown. The ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 22(2):739-750]

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The Impact of Electron Correlation on Describing QM/MM Interactions in the Attendant Molecular Dynamics Simulations of CO in Myoglobin.

Xianwei Wang, Chenhui Lu, Maoyou Yang,

The impact of the dispersion and electron correlation effects on describing quantum mechanics/molecular mechanics (QM/MM) interactions in QM/MM molecular dynamics (MD) simulations was explored by performing a series of up to 2 ns QM/MM MD simulations on the B states of the myoglobin-carbon monoxide (MbCO) system. The results indicate that both ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8539]

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CD49a+CD49b+ NK cells induced by viral infection reflect an activated state of conventional NK cells.

Wenhan Li, Jing Zhou, Xianwei Wang, Yuzhang Wu, Lilin Ye, Haiming Wei, Rui Sun, Zhigang Tian, Hui Peng,

Natural killer (NK) cells are important innate effectors that play a pivotal role in the defense against tumors and infections and participate in regulating adaptive immunity. Recent studies have revealed phenotypic and functional heterogeneity of NK cells. Here, using murine models of acute and chronic lymphocytic choriomeningitis virus infection, we ... Read more >>

Sci China Life Sci (Science China. Life sciences)
[2020, :]

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Inhibition of encephalomyocarditis virus replication by shRNA targeting 1C and 2A genes in vitro and in vivo.

Juan Bai, Liang Li, Yanni Gao, Shihai Li, Huixin Zhu, Mengyu Shi, Hui Fan, XianWei Wang, Ping Jiang,

Encephalomyocarditis virus (EMCV) infects many mammalian species, causing myocarditis, encephalitis and reproductive disorders. The small interference RNA (siRNA) targeting to the virus has not been understood completely. Here, two out of six interference sequences were screened to inhibit significantly EMCV replication by using recombinant plasmids expressing small hairpin RNA (shRNA) ... Read more >>

Vet. Microbiol. (Veterinary microbiology)
[2020, 244:108664]

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Cholesterol 25-hydroxylase inhibits encephalomyocarditis virus replication through enzyme activity-dependent and independent mechanisms.

Shihai Li, Liang Li, Huixin Zhu, Mengyu Shi, Hui Fan, YanNi Gao, XianWei Wang, Ping Jiang, Juan Bai,

Cholesterol-25-hydroxylase (CH25 H) is a reticulum-associated membrane protein induced by an important interferon-stimulating gene (ISG) and can significantly inhibit some virus replication. But the effect of CH25H on encephalomyocarditis virus (EMCV) is still not clear. In this study, we found that EMCV infection increases significantly the endogenous CH25H expression in ... Read more >>

Vet. Microbiol. (Veterinary microbiology)
[2020, 245:108658]

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The combination between NCSTN gene copy number variation and growth traits in Chinese cattle.

Yu-Fei Yao, Shijie Lyu, Xianwei Wang, Zijing Zhang, Kaixing Qu, Jiawei Xu, Cuicui Cai, Zhiming Li, Jianliang Xie, Baorui Ru, Zejun Xu, Eryao Wang, Chuzhao Lei, Hong Chen, Bizhi Huang, Yongzhen Huang,

Copy number variation (CNV) has been used as an important source of phenotypic and genetic diversity in recent years. Nicastrin (NCSTN) gene is usually attached to human diseases such as Alzheimer's disease, and Acne inversa. However, there are no essays about the NCSTN gene combining with cattle breeds. In our ... Read more >>

Anim. Biotechnol. (Animal biotechnology)
[2020, :1-5]

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Associations of Aminotransferases with Adverse Outcomes after Acute Ischemic Stroke: Results from China National Stroke Registry

Lixia Zong, Xianwei Wang, Zixiao Li, Xingquan Zhao, Liping Liu, Hao Li, Xia Meng, Yilong Wang, Yong-Jun Wang,

Abstract Background The relationship between aminotransferases and cardiovascular outcomes has been inconsistent in previous studies. We aimed to investigate the association of aminotransferases with clinical outcomes after acute ischemic stroke (AIS) or transient ischemic attack (TIA). Methods 17,178 AIS or TIA patients with serum alanine aminotransferase (ALT) levels < 120 ... Read more >>

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Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance.

Chaochu Cui, Jianbo Yang, Xiao Li, Dongling Liu, Liwu Fu, Xianwei Wang,

Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs, DNAs and proteins, to regulate cell activities in physiology and pathology. Accumulating evidence indicates that circRNAs play ... Read more >>

Mol. Cancer (Molecular cancer)
[2020, 19(1):58]

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CDKN1B Mediates Apoptosis of Neuronal Cells and Inflammation Induced by Oxyhemoglobin via miR-502-5p After Subarachnoid Hemorrhage.

Dong Chen, Xianwei Wang, Jiaming Huang, Sifu Cui, Liqiang Zhang,

Subarachnoid hemorrhage is a common disease in the neural system, which causes high fatality rate. Therefore, it is necessary to figure out inner mechanisms of factors related to this disease. RT-qPCR was applied for measuring expressions of CDKN1B and miR-502-5p and other factors of apoptosis and inflammation. Cell viabilities were ... Read more >>

J. Mol. Neurosci. (Journal of molecular neuroscience : MN)
[2020, 70(7):1073-1080]

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Identification and characterization of linear B cell epitopes on the nucleocapsid protein of porcine epidemic diarrhea virus using monoclonal antibodies.

Xianwei Wang, Linlin Fang, Jing Zhan, Xiaoli Shi, Qianyu Liu, Qianqian Lu, Juan Bai, Yufeng Li, Ping Jiang,

The nucleocapsid (N) protein of porcine epidemic diarrhea virus (PEDV), the most important pathogen causing severe diarrhea in piglets, is a highly conserved structural protein. In this study, 5 monoclonal antibodies (McAbs) against the PEDV N-protein were prepared and identified. Three new epitopes, 56QIRWRMRRGERI67, 318GYAQIASLAPNVAALLFGGNVA VRE342 and 398HEEAIYDDV406, were firstly ... Read more >>

Virus Res (Virus research)
[2020, 281:197912]

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The Association of the Copy Number Variation of the MLLT10 Gene with Growth Traits of Chinese Cattle.

Peng Yang, Zijing Zhang, Jiawei Xu, Kaixing Qu, Shijie Lyv, Xianwei Wang, Cuicui Cai, Zhiming Li, Eryao Wang, Jianliang Xie, Baorui Ru, Zejun Xu, Chuzhao Lei, Hong Chen, Bizhi Huang, Yongzhen Huang,

Copy number variation is a part of genomic structural variation and has caused widespread concern. According to the results of high-throughput screening of the MLLT10 gene, we found that the copy number variation region of the MLLT10 gene was correlated with bovine growth traits. We aimed to detect the MLLT10 ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(2):]

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Copy number variation of CADM2 gene revealed its association with growth traits across Chinese Capra hircus (goat) populations.

Zijie Xu, Xianwei Wang, Zijing Zhang, Qingming An, Yifan Wen, Dahui Wang, Xian Liu, Zhiming Li, Shijie Lyu, Lijuan Li, Eryao Wang, Baorui Ru, Zejun Xu, Yongzhen Huang,

Copy number variations (CNVs) are the wide structural variations ranging from 50 bp to several Mb at genome which can affect gene expression and further impacting growth and development traits of livestock. Comparing with single nucleotide polymorphisms (SNPs), CNVs can better explain the genetic and phenotypic diversity, are increasingly important in ... Read more >>

Gene (Gene)
[2020, 741:144519]

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