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Molecular pathways underlying tissue injuries in the bladder with ketamine cystitis.

Xiang Xie, Jiayu Liang, Run Huang, Chuang Luo, Jiali Yang, Hongming Xing, Le Zhou, Han Qiao, Erti Ergu, Huan Chen,

Ketamine cystitis (KC) is a chronic bladder inflammation leading to urinary urgency, frequency, and pain. The pathogenesis of KC is complicated and involves multiple tissue injuries in the bladder. Recent studies indicated that urothelium disruption, lamina propria fibrosis and inflammation, microvascular injury, neuropathological alterations, and bladder smooth muscle (BSM) abnormalities ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21703]

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Polymorphisms of rs2483205 and rs562556 in the PCSK9 gene are associated with coronary artery disease and cardiovascular risk factors.

Min-Tao Gai, Dilare Adi, Xiao-Cui Chen, Fen Liu, Xiang Xie, Yi-Ning Yang, Xiao-Ming Gao, Xiang Ma, Zhen-Yan Fu, Yi-Tong Ma, Bang-Dang Chen,

PCSK9 plays a crucial role in lipid metabolism. This case-control study explored the associations of novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene with coronary artery disease (CAD) (≥ 1 coronary artery stenosis ≥ 50%) and its risk factors in the Han population in Xinjiang, China. Four tag SNPs (rs11583680, rs2483205, rs2495477 ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11450]

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Correction to: Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.

Dilare Adi, Jialin Abuzhalihan, Jing Tao, Yun Wu, Ying-Hong Wang, Fen Liu, Yi-Ning Yang, Xiang Ma, Xiao-Mei Li, Xiang Xie, Zhen-Yan Fu, Yi-Tong Ma,

Hereditas (Hereditas)
[2021, 158(1):19]

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Inhibiting mTOR enhanced Cardiac STAT3 Phosphorylation at Site Ser 727 and Attenuated Myocardial Ischemia Reperfusion Injury in Diabetic Rats

Xiang Xie, Zhongbao Zhao, Danyong Liu, Dengwen Zhang, Yi He, Liangqing Zhang, Han Lin, Sheng Wang, Zhengyuan Xia,

<h4>Background: </h4> Reduced levels of myocardial STAT3 activity in diabetic hearts may contribute to the increased susceptibility to ischemia-reperfusion injury (I/RI). The protein mammalian target of rapamycin (mTOR) can regulate metabolism and cell processes and plays major roles in the dynamics of I/RI. However, the role of mTOR in regulation ... Read more >>

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Long-term dual antiplatelet-induced intestinal injury resulting in translocation of intestinal bacteria into blood circulation increased the incidence of adverse events after PCI in patients with coronary artery disease.

Ying-Ying Zheng, Ting-Ting Wu, Qian-Qian Guo, You Chen, Xiang Ma, Yi-Tong Ma, Jin-Ying Zhang, Xiang Xie,

<h4>Background and aims</h4>The present study aimed to investigate the efficacy and safety of long-term (>18 months) dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).<h4>Methods</h4>A total of 3205 coronary artery disease (CAD) patients after PCI from CORFCHD-PCI, a retrospective cohort study (Identifier: ChiCTR-ORC-16010153), were divided into two groups: monotherapy of ... Read more >>

Atherosclerosis (Atherosclerosis)
[2021, 328:1-10]

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Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention.

You Chen, Min Han, Ying-Ying Zheng, Feng Zhu, Aikebai Aisan, Tunike Maheshati, Yi-Tong Ma, Xiang Xie,

<h4>Background</h4>Coronary heart disease (CHD) is caused by the blockage or spasm of coronary arteries. Evidence shows that liver disease is related to CHD. However, the correlation between the Model for End-Stage Liver Disease (MELD) score and outcomes in patients after percutaneous coronary intervention (PCI) was unclear.<h4>Method</h4>A retrospective cohort study involved ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2021, 2021:6401092]

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Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.

Dilare Adi, Jialin Abuzhalihan, Jing Tao, Yun Wu, Ying-Hong Wang, Fen Liu, Yi-Ning Yang, Xiang Ma, Xiao-Mei Li, Xiang Xie, Zhen-Yan Fu, Yi-Tong Ma,

<h4>Background</h4>Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang.<h4>Methods</h4>We designed two independent case-control studies. The first one included in the Han population (448 ... Read more >>

Hereditas (Hereditas)
[2021, 158(1):12]

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Molecular mechanisms of voiding dysfunction in a novel mouse model of acute urinary retention.

Xiang Xie, Huan Chen, Lanlan Zhang, Daniel Chan, Warren G Hill, Mark L Zeidel, Weiqun Yu,

Acute urinary retention (AUR) is a common urological emergency and affects a significant patient population. The inability to eliminate urine may lead to permanent damage to the bladder's structure and functioning. However, we know little about the underlying molecular sequelae to the urine retention. To closely mirror the potential high ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(4):e21447]

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Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China.

Jing Ming, Xian Wei, Min Han, Dilare Adi, Jialin Abuzhalihan, Yong-Tao Wang, Yi-Ning Yang, Xiao-Mei Li, Xiang Xie, Zhen-Yan Fu, Min-Tao Gai, Yi-Tong Ma,

Dyslipidemia is one of the main risk factors for coronary heart disease (CHD). The E3 ubiquitin ligase which is encoded by the ring finger protein 145 (RNF145) gene is very important in the mediation of cholesterol synthesis and effectively treats hypercholesterolemia. Thus, the purpose of the present research is to ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):5969]

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Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining.

Haiyan Zhang, Yongfei Xie, Zhi Hu, Hong Yu, Xiang Xie, Yingchun Ye, Wenfeng Xu, Siji Nian, Qing Yuan,

<b>Background:</b> Sialic acid-binding immunoglobulin-type lectin (SIGLEC) family members are involved in regulating immune-cell activation, proliferation, and apoptosis, and they play an important role in tumor development. However, their expression and correlation with immune molecules in lung adenocarcinoma (LUAD) remain unclear. <b>Methods:</b> We utilized Gene Expression Profiling Interactive Analysis, Kaplan-Meier analysis, ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:608113]

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A Retrospective Study of Double Eyelid Surgery for Sunken Upper Eyelid in Chinese.

Xiang Xie, Yang An, Hongyu Xue, Hongbin Xie, Jianfang Zhao, Dong Li,

<h4>Objective</h4>The aim of this study was to explore the effective technique of double eyelid surgery for mild, moderate, and severe sunken upper eyelid in Chinese.<h4>Methods</h4>According to the degree of the sunken upper eyelid, different procedures were performed. For mild sunken upper eyelid, the key technique was named eyelid volume redistribution ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2021, 86(3S Suppl 2):S253-S258]

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Study On The Application Value of Thromboelastic Graph in The Condition Assessment of Patients With Acute Myocardial Infarction

Kaiyang Wang, Yunjie Teng, Tingting Wu, Yitong Ma, Xiang Xie,

<h4>Background: </h4> To explore the application value of thromboelastic graph (TEG) in the assessment of patients with acute myocardial infarction (AMI). <h4>Results: </h4>: 1.R time (min), K time (min) and LY30(%) in the STEMI group were lower than those in the NSTEMI group, and the differences were statistically significant ( ... Read more >>

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Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predictor of long-term adverse outcomes in patients who underwent percutaneous coronary intervention: a retrospective cohort study.

Ying Pan, Jian Zhang, Ting-Ting Wu, Xian-Geng Hou, Yi Yang, Xiang Ma, Yi-Tong Ma, Ying-Ying Zheng, Xiang Xie,

BACKGROUND:Previous studies suggested that baseline white blood cell count and apolipoprotein A1 levels were associated with clinical outcomes in patients with coronary heart disease (CAD) who underwent percutaneous coronary intervention (PCI). However, the ratio of baseline white blood cell count-to-apolipoprotein A1 level (WAR) and CAD after PCI have not been ... Read more >>

Lipids Health Dis (Lipids in health and disease)
[2020, 19(1):43]

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Temperature-robust and ratiometric G-quadruplex proximate DNAzyme assay for robustly monitoring of uranium pollution and its microbial biosorbents screening.

Yuchuan Yang, Hao Yang, Yi Wan, Wenhu Zhou, Sha Deng, Yao He, Guiping He, Xiang Xie, Ruijie Deng,

Uranium pollution in environment and food chain is a serious threat to public security and human health. Herein, we proposed a temperature-robust, ratiometric, and label-free bioassay based on G-quadruplex proximate DNAzyme (G4DNAzyme), accommodating us to precisely monitor uranium pollution and biosorption. The proximity of split G-quadruplex probes was proposed to ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2021, 413:125383]

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Polymorphisms of rs2483205 and rs562556 in Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene are Associated With Coronary Artery Disease

Min-Tao Gai, Dilare Adi, Xiao-Cui Chen, Fen Liu, Xiang Xie, Yi-Ning Yang, Xiao-Ming Gao, Xiang Ma, Zhen-Yan Fu, Yi-Tong Ma, Bang-dang Chen,

PCSK9 plays a pivotal role in lipid metabolism. The present study is to explore the potential novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene which is associated with coronary artery disease (CAD) in the Han population who lived in Xinjiang, China. We conducted a case-control study and genotyped four ... Read more >>

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[House dust mite extract activates EphA2-STAT3/p38 MAPK signaling pathway in airway epithelial cells to mediate airway inflammation].

Guoping Huang, Qing Yuan, Yingchun Ye, Hong Yu, Xiang Xie, Wenfeng Xu, Siji Nian,

Objective To investigate the effect of ephrin type-A receptor 2 (EphA2) on the expression of inflammatory cytokines in airway epithelial cells induced by house dust mite extract (HDM) and the underlying mechanism. Methods The cell model of EphA2 knockdown was established by transfection of EphA2 siRNA into airway cell line ... Read more >>

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology)
[2021, 37(1):31-38]

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Fasting blood glucose to HDL-C ratio as a novel predictor of clinical outcomes in non-diabetic patients after PCI.

Qian-Qian Guo, Ying-Ying Zheng, Jun-Nan Tang, Ting-Ting Wu, Xu-Ming Yang, Zeng-Lei Zhang, Jian-Chao Zhang, Yi Yang, Xian-Geng Hou, Meng-Die Cheng, Feng-Hua Song, Zhi-Yu Liu, Kai Wang, Li-Zhu Jiang, Lei Fan, Xiao-Ting Yue, Yan Bai, Xin-Ya Dai, Ru-Jie Zheng, Xiang Xie, Jin-Ying Zhang,

Background The present study was to assess the prognostic value of fasting blood glucose to high-density lipoprotein cholesterol ratio (GHR) in non-diabetic patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Methods and results A total of 6645 non-diabetic patients from two independent cohorts, the CORFCHD-PCI study (n=4282) ... Read more >>

Biosci Rep (Bioscience reports)
[2020, 40(12):]

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A Novel ABC Score Predicts Mortality in Non-ST-Segment Elevation Acute Coronary Syndrome Patients Who underwent Percutaneous Coronary Intervention.

Ying-Ying Zheng, Ting-Ting Wu, Ying Gao, Qian-Qian Guo, Yan-Yan Ma, Jian-Chao Zhang, Yi-Li Xun, Ding-Yu Wang, Ying Pan, Meng-Die Cheng, Feng-Hua Song, Zhi-Yu Liu, Kai Wang, Li-Zhu Jiang, Lei Fan, Xiao-Ting Yue, Yan Bai, Zeng-Lei Zhang, Xin-Ya Dai, Ru-Jie Zheng, You Chen, Xiang Ma, Yi-Tong Ma, Jin-Ying Zhang, Xiang Xie,

<h4>Objective</h4> In the present study, we aimed to establish a novel score to predict long-term mortality of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients who underwent percutaneous coronary intervention (PCI).<h4>Methods</h4> A total of 2,174 NSTE-ACS patients from the CORFCHD-ZZ study were enrolled as the derivation cohort. The validation cohort including 1,808 NSTE-ACS ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, 121(3):297-308]

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Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population.

Zhiqiang Han, Huaming Sheng, Qiuzhi Gao, Yu Fan, Xiang Xie,

In recent years, increasing evidence has implicated the importance of mutations in the <i>MTHFR</i> gene in the risk of gastric cancer risk. A single nucleotide polymorphism (SNP) in the <i>MTHFR</i> gene (rs1801133) may serve a critical role in gastric cancer. A hospital-based case-controlled study was performed to assess the risk ... Read more >>

Biomed Rep (Biomedical reports)
[2021, 14(1):14]

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A new isolation device for shortening gene flow distance in small-scale transgenic maize breeding.

Lili Zhang, Shanshan Huo, Yang Cao, Xiang Xie, Yanhua Tan, Yuliang Zhang, Hui Zhao, Pingping He, Jingyuan Guo, Qiyu Xia, Xia Zhou, Huan Long, Anping Guo,

The transmission of pollen is the main cause of maize gene flow. Under the compulsory labeling system for genetically modified (GM) products in China, isolation measures are crucial. At present, there is no effective isolation device for preventing and controlling the short-range flow of GM maize pollen. The purposes of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15733]

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Cardiac Shock Wave Therapy for Coronary Heart Disease: an Updated Meta-analysis.

Hai-Tao Yang, Xiang Xie, Xian-Geng Hou, Wen-Juan Xiu, Ting-Ting Wu,

<h4>Introduction</h4>The aim of this article is to study the efficacy and safety of cardiac shock wave therapy (CSWT) in the treatment of coronary heart disease (CAD).<h4>Methods</h4>A comprehensive search of electronic databases and a manual search of conference papers and abstracts were performed until September 30, 2018. The studies using RevMan ... Read more >>

Braz J Cardiovasc Surg (Brazilian journal of cardiovascular surgery)
[2020, 35(5):741-756]

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Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats.

Jingjin Liu, Xiang Xie, Dan Yan, Yongshun Wang, Hongbin Yuan, Yin Cai, Jierong Luo, Aimin Xu, Yu Huang, Chi Wai Cheung, Michael G Irwin, Zhengyuan Xia,

Vascular complications from diabetes often result in poor outcomes for patients, even after optimized interventions. Forkhead box protein O1 (FoxO1) is a key regulator of cellular metabolism and plays an important role in vessel formation and maturation. Alterations of FoxO1 occur in the cardiovascular system in diabetes, yet the role ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(23):13727-13738]

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Homotherapy for heteropathy active components and mechanisms of Qiang-Huo-Sheng-Shi decoction for treatment of rheumatoid arthritis and osteoarthritis.

Yuan-Yuan Shi, Ying-Qi Li, Xiang Xie, Yu-Ting Zhou, Qian Zhang, Jia-Lin Yu, Ping Li, Na Mi, Fei Li,

Qiang-Huo-Sheng-Shi decoction (QHSSD), a classic traditional Chinese herbal formula, which has been reported to be effective in rheumatoid arthritis (RA) and osteoarthritis (OA). However, the concurrent targeting mechanism of how the aforementioned formula is valid in the two distinct diseases OA and RA, which represents the homotherapy-for-heteropathy principle in traditional ... Read more >>

Comput Biol Chem (Computational biology and chemistry)
[2020, 89:107397]

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Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology.

Huan Chen, David H Vandorpe, Xiang Xie, Seth L Alper, Mark L Zeidel, Weiqun Yu,

The general anesthetic ketamine has been repurposed by physicians as an anti-depressant and by the public as a recreational drug. However, ketamine use can cause extensive pathological changes, including ketamine cystitis. The mechanisms of ketamine's anti-depressant and adverse effects remain poorly understood. Here we present evidence that ketamine is an ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4328]

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Correlation Between 25-Hydroxy-Vitamin D and Parkinson's Disease: A Case-Control Study

Ming Xia, Wenjuan Xiu, Xuliang Wang, Tingting Wu, Yingying Zheng, Yitong Ma, Xiang Xie, Qingjiu Zhou,

<h4>Background: </h4> Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25- hydroxy vitamin D (25(OH)D) concentrations than controls. whether the research in other regions findings are generalizable to China populations remains untested in other studies. In this case-control study we examined the Correlation between 25-hydroxy-vitamin ... Read more >>

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