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Author Xian Han

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Hugan tablets for the treatment of RUCAM based drug-induced liver injury: a propensity score matching analysis using a nationwide database.

Jing Li, Jianzhong Zhang, Xiaorong Xu, Weidong Fang, Shilin Qu, Feng Jin, Jie Zhou, Xian Han, Hafiz Khuram Raza, Xiaoyun Li, Yimin Mao,

<h4>Background</h4>Drug-induced liver injury (DILI) is a major clinical challenge with no specific therapeutic drugs available. It is crucial to develop new agents to improve the clinical outcome of patients with DILI. This study evaluated the efficacy and safety of Hugan tablets in DILI patients using a nationwide database.<h4>Research design and ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2021, :1-8]

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Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets.

Zongtao Lin, Xie Wang, Katelyn A Bustin, Kyosuke Shishikura, Nate R McKnight, Lin He, Radu M Suciu, Kai Hu, Xian Han, Mina Ahmadi, Erika J Olson, William H Parsons, Megan L Matthews,

Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a single type of nucleophilic amino acid to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electrophilic enzyme cofactors, transient intermediates, and labile regulatory modifications, but ABPP probes for such species are ... Read more >>

ACS Cent Sci (ACS central science)
[2021, 7(9):1524-1534]

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Exploring the efficacy and safety of polyene phosphatidylcholine for treatment of drug-induced liver injury using the Roussel Uclaf causality assessment method: a propensity score matching comparison.

Xiaohong Lei, Jianzhong Zhang, Qingling Xu, Jing Li, Yunsong Qian, Jing Zhang, Liangming Liu, Wei Zhong, Yongfeng Wang, Xian Han, Jieting Tang, Minde Zeng, Yimin Mao,

<b>Objective</b> In China, polyene phosphatidylcholine (PPC) is widely used to treat alanine aminotransferase (ALT) elevation associated with various liver diseases. Here, we assessed the efficacy and safety of PPC in treating drug-induced liver injury (DILI).<b>Methods</b> Data from a multicenter retrospective cohort study (DILI-R) were analyzed to compare PPC and magnesium ... Read more >>

J Int Med Res (The Journal of international medical research)
[2021, 49(8):3000605211039810]

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GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma.

Wang Zhang, Zhendong Liu, Binchao Liu, Miaomiao Jiang, Shi Yan, Xian Han, Hong Shen, Meng Na, Yanbiao Wang, Zhishuai Ren, Binfeng Liu, Zhenfeng Jiang, Yanzheng Gao, Zhiguo Lin,

<h4>Background</h4>Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5, which is part of the G-protein family, has been associated with different malignant tumors, though the role of GNG5 in glioma has not been studied. ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):297]

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Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Qiuyu Tang, Yuan Dong, Meng Bai, Yibing Zhu, Guanghua Liu,

<h4>Background</h4>Risk factors that predispose the development of severe community-acquired pneumonia (CAP) among pediatric CAP patients of different age ranges are yet to be identified.<h4>Methods</h4>We retrospectively analyzed pediatric in-patients (< 6 years old) diagnosed with CAP in our hospital. We subdivided patients into four age groups (< 6 months, 6 months-1 year, 1-2 years, and 2-6 years). Their medical ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2021, 47(1):100]

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GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma

Wang Zhang, Zhendong Liu, Binchao Liu, Miaomiao Jiang, Shi Yan, Xian Han, Hong Shen, Meng Na, Yanbiao Wang, Zhishuai Ren, Binfeng Liu, Yanzheng Gao, Zhenfeng Jiang, Zhiguo Lin,

<h4>Background: </h4> Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5 , which is part of the G-protein family, has been associated with different malignant tumors, though the role of GNG5 in glioma has ... Read more >>

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Risk factors associated with wheezing in severe pediatric community-acquired pneumonia: a retrospective study.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Xi Liu, Libo Xu, Guanghua Liu,

<h4>Background</h4>Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated with the development of wheezing pneumonia and its clinical features are not fully characterized, especially in children with severe pneumonia.<h4>Methods</h4>We retrospectively recruited 1434 pediatric patients diagnosed with severe pneumonia between April 2012 and September 2019 ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2021, :]

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Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I.

Wang Zhang, Haiyang Wang, Binchao Liu, Miaomiao Jiang, Yifei Gu, Shi Yan, Xian Han, Alicia Y Hou, Chongyang Tang, Zhenfeng Jiang, Hong Shen, Meng Na, Zhiguo Lin,

Hippocampal sclerosis (HS) is one of the most prevalent pathological types of temporal lobe epilepsy (TLE), and it significantly affects patient prognoses. The methylation of DNA plays an important role in the development of epilepsy. However, few studies have focused on HS subtypes to determine DNA methylation profiles in TLE. ... Read more >>

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2021, 71(9):1951-1966]

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GNG5 is a Novel Oncogene Associated with Poor Prognosis in Glioma Patients

Wang Zhang, Binchao Liu, Miaomiao Jiang, Shi Yan, Xian Han, Hong Shen, Meng Na, Zhenfeng Jiang, Zhiguo Lin,

<h4>Background: </h4> Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5 , which is part of the G-protein family, has been associated with different malignant tumors, though the role of GNG5 in glioma has ... Read more >>

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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.

Bing Bai, Xusheng Wang, Yuxin Li, Ping-Chung Chen, Kaiwen Yu, Kaushik Kumar Dey, Jay M Yarbro, Xian Han, Brianna M Lutz, Shuquan Rao, Yun Jiao, Jeffrey M Sifford, Jonghee Han, Minghui Wang, Haiyan Tan, Timothy I Shaw, Ji-Hoon Cho, Suiping Zhou, Hong Wang, Mingming Niu, Ariana Mancieri, Kaitlynn A Messler, Xiaojun Sun, Zhiping Wu, Vishwajeeth Pagala, Anthony A High, Wenjian Bi, Hui Zhang, Hongbo Chi, Vahram Haroutunian, Bin Zhang, Thomas G Beach, Gang Yu, Junmin Peng,

Neuron (Neuron)
[2020, 106(4):700]

Cited: 4 times

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Association between Radiotherapy and Anatomic Severity of Coronary Artery Disease: A Propensity Score Matching Comparison Among Adult-Onset Thoracic Cancer Survivors.

Shunying Hu, Hai Gao, Jianzhong Zhang, Xian Han, Qian Yang, Juan Zhang, Yundai Chen,

<h4>Objective</h4>To investigate the association between radiotherapy and anatomic severity of coronary artery disease (CAD) using the SYNTAX scores (SXscores) of coronary angiograms in adult-onset thoracic cancer survivors.<h4>Methods</h4>A total of 152 patients who previously had thoracic cancer and underwent coronary angiography between 2010 and 2016 were examined. Propensity score matching (PSM) ... Read more >>

Cardiology (Cardiology)
[2018, 140(4):239-246]

Cited: 1 time

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GOLPH3L is a Novel Prognostic Biomarker for Epithelial Ovarian Cancer.

Yanling Feng, Fan He, Huini Wu, He Huang, Lan Zhang, Xian Han, Jihong Liu,

<h4>Objective</h4>Golgi phosphoprotein 3 (GOLPH3) is a highly conserved membrane protein that is involved in a variety of cancers such as colorectal cancer, gastric cancer, ovarian cancer, and breast cancer. GOLPH3L is a paralog of GOLPH3. Although these proteins share a similar amino acid sequence, much less is known regarding the ... Read more >>

J Cancer (Journal of Cancer)
[2015, 6(9):893-900]

Cited: 12 times

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Analysis of linkage and linkage disequilibrium for syntenic STRs on 12 chromosomes.

Weiwei Wu, Honglei Hao, Qiuling Liu, Xian Han, Yeda Wu, Jianding Cheng, Dejian Lu,

The purpose of this study is to evaluate allelic association and linkage of 18 adjacent syntenic short tandem repeat (STR) pairs form out of 30 markers located on 12 different autosomes. Linkage disequilibrium was tested by using the unknown gametic phase genotypes and phased haplotypes from 290 unrelated individuals from ... Read more >>

Int J Legal Med (International journal of legal medicine)
[2014, 128(5):735-739]

Cited: 6 times

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SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma.

Shu-Mei Yan, Xian Han, Pei-Jin Han, He-Mu Chen, Li-Yun Huang, Yong Li,

Sirtuin-3 (SIRT3) protein is a member of Sirtuins family. It functions as a critical mitochondrial deacetylase, which is involved in a variety of diseases, such as cancer, cardiovascular disease and diabetes. However, its role in esophageal squamous cell carcinoma (ESCC) has never been investigated before. With the help of immunohistochemistry, ... Read more >>

Med Oncol (Medical oncology (Northwood, London, England))
[2014, 31(8):103]

Cited: 12 times

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