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Non-inferiority in cancer clinical trials was associated with more lenient margins and higher hypothesized outcome event rates.

Yazhou He, Chi Shu, Ting Li, Qingbin Wu, Ziqiang Wang, Xin Chen, Xia Shen,

<h4>Objective</h4>To identify potential bias in non-inferiority design of published cancer trials, and to provide suggestions for future practice.<h4>Study design and setting</h4>We systematically searched MEDLINE, Embase and CENTRAL databases (until April 17, 2020) to obtain non-inferiority phase III cancer trials and protocols. Distribution of essential characteristics and study design parameters was ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, 139:214-221]

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Improved Estimation of Phenotypic Correlations Using Summary Association Statistics.

Ting Li, Zheng Ning, Xia Shen,

Estimating the phenotypic correlations between complex traits and diseases based on their genome-wide association summary statistics has been a useful technique in genetic epidemiology and statistical genetics inference. Two state-of-the-art strategies, Z-score correlation across null-effect single nucleotide polymorphisms (SNPs) and LD score regression intercept, were widely applied to estimate phenotypic ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:665252]

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Esketamine may be an ideal substitute for ketamine during cochlear function measurement.

Yufeng Li, Xuehua Zhou, Xia Shen,

The mixture of ketamine and xylazine is widely used for the auditory brainstem response (ABR) measurement. Esketamine is twice as potent as ketamine. Our objective was to assess the influence of esketamine in mice undergoing cochlear function measurement including ABR and distortion product otoacoustic emission (DPOAE) measurement. C57Bl/6J mice were ... Read more >>

Braz J Med Biol Res (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas)
[2021, 54(11):e11503]

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Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis.

Guijun Liu, Ningning Wang, Cunzhen Zhang, Min Li, Xuxiao He, Chunzhao Yin, Qiaochu Tu, Xia Shen, Lili Zhang, Jingwen Lv, Yongqiang Wang, Huimin Jiang, Shiting Chen, Nan Li, Yongzhen Tao, Huiyong Yin,

<h4>Background and aims</h4>Insulin receptor (IR) transduces cell surface signal through phosphoinositide 3-kinase (PI3K)-AKT pathways or translocates to the nucleus and binds to the promoters to regulate genes associated with insulin actions, including de novo lipogenesis (DNL). Chronic activation of IR signaling drives malignant transformation, but the underlying mechanisms remain poorly ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, :]

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Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout.

Xia Shen, Can Wang, Ningning Liang, Zhen Liu, Xinde Li, Zheng-Jiang Zhu, Tony R Merriman, Nicola Dalbeth, Robert Terkeltaub, Changgui Li, Huiyong Yin,

<h4>Objective</h4>To systematically profile metabolic alterations and dysregulated metabolic pathways in hyperuricemia and gout, and to identify potential metabolite biomarkers to discriminate gout from asymptomatic hyperuricemia.<h4>Methods</h4>Serum samples from 330 participants, including 109 with gout, 102 with asymptomatic hyperuricemia, and 119 normouricemic controls, were analyzed by high-resolution mass spectrometry-based metabolomics. Multivariate principal ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2021, 73(9):1738-1748]

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BoDV-1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats.

Tian Tang, Yujie Guo, Xiaoyan Xu, Libo Zhao, Xia Shen, Lin Sun, Peng Xie,

Borna disease virus (BoDV-1) can infect the hippocampus and limbic lobes of newborn rodents, causing cognitive deficits and abnormal behavior. Studies have found that neuroinflammation caused by viral infection in early life can affect brain development and impair learning and memory function, revealing the important role of neuroinflammation in cognitive ... Read more >>

J Med Virol (Journal of medical virology)
[2021, 93(11):6163-6171]

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Targeted genetic screening in bacteria with a Cas12k-guided transposase.

Weizhong Chen, Ze-Hui Ren, Na Tang, Guoshi Chai, Hongyuan Zhang, Yifei Zhang, Jiacheng Ma, Zhaowei Wu, Xia Shen, Xingxu Huang, Guan-Zheng Luo, Quanjiang Ji,

Microbes employ sophisticated cellular networks encoded by complex genomes to rapidly adapt to changing environments. High-throughput genome engineering methods are valuable tools for functionally profiling genotype-phenotype relationships and understanding the complexity of cellular networks. However, current methods either rely on special homologous recombination systems and are thus applicable in only ... Read more >>

Cell Rep (Cell reports)
[2021, 36(9):109635]

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Cerebral Hemodynamic Responses to the Difficulty Level of Ambulatory Tasks in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis.

Jin P Lin, Hong S Feng, Hua Zhai, Xia Shen,

<i>Background</i>. Ambulatory tasks are the important components of balance training which effectively improve postural stability and functional activities in persons with Parkinson's disease (PD). The difficulty level of an ambulatory task is usually set in the form of attention, direction, speed, or amplitude requirement. <i>Objectives</i>. This study aimed to explore ... Read more >>

Neurorehabil Neural Repair (Neurorehabilitation and neural repair)
[2021, 35(9):755-768]

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Preoperative Psychological Burdens in Patients with Vestibular Schwannoma.

Yufeng Li, Guo Ran, Kaizheng Chen, Xia Shen,

<h4>Objective</h4>To assess preoperative psychological burden in patients with vestibular schwannoma (VS).<h4>Methods</h4>A total of 100 patients undergoing VS resection between September 2019 and June 2020 completed preoperative psychological screening. The Hospital Anxiety and Depression Scale (HADS) was applied the day before surgery, and a score >14 was considered clinically important. Univariate ... Read more >>

Ann Otol Rhinol Laryngol (The Annals of otology, rhinology, and laryngology)
[2021, :34894211018915]

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Total genetic contribution assessment across the human genome.

Ting Li, Zheng Ning, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Wenzheng Xu, Yipeng Wang, Kejun Ying, Yiwen Chen, Xia Shen,

Quantifying the overall magnitude of every single locus' genetic effect on the widely measured human phenome is of great challenge. We introduce a unified modelling technique that can consistently provide a total genetic contribution assessment (TGCA) of a gene or genetic variant without thresholding genetic association signals. Genome-wide TGCA in ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2845]

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Postoperative Delirium is Not Associated with Long-Term Decline in Activities of Daily Living or Mortality After Laryngectomy.

Yiru Wang, Weiwei Liu, Kaizheng Chen, Xia Shen,

<h4>Purpose</h4>To determine the relationships between postoperative delirium (POD) and postoperative activities of daily living (ADL) and mortality in patients undergoing laryngectomy. We hypothesized that POD would reduce postoperative ADL and increase postoperative mortality.<h4>Patients and methods</h4>The prospective study included older participants (age ≥65 y) undergoing total laryngectomy, partial laryngectomy, total laryngectomy ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2021, 16:823-831]

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Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese.

Shaofeng Huo, Liang Sun, Geng Zong, Xia Shen, He Zheng, Qianlu Jin, Huaixing Li, Huiyong Yin, Xu Lin,

Little is known about changes in plasma metabolome profiles during the oral glucose tolerance test (OGTT) in Chinese. We aimed to characterize plasma metabolomic profiles at 0 and 2 h of OGTT and their changes in individuals of different glycemic statuses. A total of 544 metabolites were detected at 0 ... Read more >>

Nutrients (Nutrients)
[2021, 13(5):]

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Establishing content validity for a composite activities-specific risk of falls scale:linkage between fear of falling and physical activity.

Jing X Wang, Lin Y Chen, Yan N Jiang, Ling Ni, Jie M Sheng, Xia Shen,

<h4>Background</h4>Fear of falling (FoF) and physical activity (PA) are important psychological and behavioral factors associated with falls. No instrument quantifies the link between these two factors to evaluate the risk of falls. We aimed to design a scale linking FoF with PA (Composite Activities-specific Risk of Falls Scale, CARFS) for ... Read more >>

BMC Geriatr (BMC geriatrics)
[2021, 21(1):275]

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Integrative analyses identify potential key genes and pathways in Keshan disease using whole-exome sequencing

Jichang Huang, Chenqing Zheng, Rong Luo, Mingjiang Liu, Qingquan Gu, Jinshu Li, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

Keshan disease (KD), an endemic heart disease with multifocal necrosis and replacement fibrosis of the myocardium,is still a nightmare situation for human health. However, molecular mechanism in the pathogenesis of KD remains unclear. Herein, blood samples were collected from 68 KD patients and 100 controls, and we systematically analyzed mutation ... Read more >>

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Nontrivial Replication of Loci Detected by Multi-Trait Methods.

Zheng Ning, Yakov A Tsepilov, Sodbo Zh Sharapov, Zhipeng Wang, Alexander K Grishenko, Xiao Feng, Masoud Shirali, Peter K Joshi, James F Wilson, Yudi Pawitan, Chris S Haley, Yurii S Aulchenko, Xia Shen,

The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. However, how to replicate these discovered pleiotropic loci has yet to ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:627989]

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B cell lymphoma with IRF4 rearrangement: A clinicopathological study of 13 cases.

Luting Zhou, Bin Gu, Xia Shen, Ouyang Binshen, Lei Dong, Jun Zhou, Hongmei Yi, Chaofu Wang,

Interferon regulatory factor 4 (IRF4) rearrangement is commonly detected in patients with a range of lymphoproliferative malignancies, including myelomas, large B cell lymphomas and low-grade B cell neoplasms. However, IRF4 rearrangement is generally a relatively rare finding in these latter two cancer types. In the present article, we describe and ... Read more >>

Pathol Int (Pathology international)
[2021, 71(3):183-190]

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Risk Factors for Acute Postoperative Sort Throat (POST) After Supraglottic Device Use 

Yanzhe Huang, Kaizheng Chen, Xia Shen,

<h4>Background: </h4> To identify risk factors for acute postoperative sort throat (POST) after general anesthesia using a supraglottic airway device (SAD) in adults undergoing elective tympanoplasty. <h4>Methods: </h4>. The medical records of 1424 adults who underwent elective tympanoplasty under general anesthesia using an SAD were reviewed retrospectively. Patients received one ... Read more >>

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Clostridium difficile toxin A and toxin B inhibit YAP in the colonic epithelial cells.

Jinglue Song, Xia Shen, Zhenyu Huang, Yun Liu, Long Cui, Xuewei Cui, Chen-Ying Liu,

Toxin A (TcdA) and toxin B (TcdB), the two exotoxins of Clostridium difficile, are main causal agents for the colonic epithelium damage in Clostridium difficile infection (CDI). The Hippo pathway is crucial for the control of tissue homeostasis and regeneration of intestines. However, the dysregulation of Hippo pathway in CDI ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(2):e22652]

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Improved estimation of phenotypic correlations using summary association statistics

Ting Li, Zheng Ning, Xia Shen,

Estimating the phenotypic correlations between complex traits and diseases based on their genome-wide association summary statistics has been a useful technique in genetic epidemiology and statistical genetics inference. Two state-of-the-art strategies, Z-score correlation across null-effect SNPs and LD score regression intercept, were widely applied to estimate phenotypic correlations. Here, we ... Read more >>

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Genetic mechanisms of critical illness in COVID-19.

Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D Bretherick, Konrad Rawlik, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alexandre C Pereira, Alessandra Renieri, , , , , , , Xia Shen, Chris P Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter J M Openshaw, Malcolm G Semple, Andrew Law, Veronique Vitart, James F Wilson, J Kenneth Baillie,

Host-mediated lung inflammation is present<sup>1</sup>, and drives mortality<sup>2</sup>, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development<sup>3</sup>. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in ... Read more >>

Nature (Nature)
[2021, 591(7848):92-98]

Cited: 179 times

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Muscovy duck reovirus promotes virus replication by inhibiting autophagy-lysosomal degradation pathway.

Minghui Li, Ping Yan, Xia Shen, Zhenni Liu, Quanxi Wang, Yifan Huang, Yijian Wu,

Autophagy plays a momentous role in cellular responses against pathogens. However, the influence of the autophagy machinery on Muscovy duck reovirus (MDRV) infection is not yet confirmed. In this study, it was shown that MDRV infection significantly increased the number of autophagy-like vesicles in DF-1 cells under electron microscope and ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 253:108945]

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Money matters: a multicenter cross-sectional study of depressive symptoms among the caregivers of children on peritoneal dialysis in Mainland China.

Rui Zhao, Ying Gu, Xia Shen, Xianying Mai, Cheng Zhou, Yufen Zhang, Yihui Zhai, Qian Shen, Hong Xu, Qing Zhou,

<h4>Background</h4>The caregivers of children on peritoneal dialysis face heavy care burdens and may have a high risk of depression. This study aimed to describe the prevalence and severity of depression and identify its related demographic and socioeconomic factors in the caregivers of children on peritoneal dialysis in China.<h4>Methods</h4>A multicenter cross-sectional ... Read more >>

BMC Nephrol (BMC nephrology)
[2020, 21(1):472]

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Genetic mechanisms of critical illness in Covid-19

Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew Bretherick, Konrad Rawlik, Nick Parkinson, Dorota Pasko, Susan Walker, Anne Richmond, Max Head Fourman, Clark Russell, Andrew Law, James Furniss, Elvina Gountouna, Nicola Wrobel, Loukas Moutsianas, Bo Wang, Alison Meynert, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Fiona Griffiths, Wilna Oosthuyzen, Graeme Grimes, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David Porteous, Caroline Hayward, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Xia Shen, Kathy Rowan, Angie Fawkes, Lee Murphy, Chris Ponting, Albert Tenesa, Mark Caulfield, Richard Scott, Peter J.M. Openshaw, Malcolm Semple, Veronique Vitart, James Wilson, Kenneth Baillie, , , ,

The subset of patients who develop critical illness in Covid-19 have extensive inflammation affecting the lungs 1 and are strikingly different from other patients: immunosuppressive therapy benefits critically-ill patients, but may harm some non-critical cases. 2 Since susceptibility to life-threatening infections and immune-mediated diseases are both strongly heritable traits, we ... Read more >>

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On "Translating COVID-19 Evidence to Maximize Physical Therapists' Impact and Public Health Response." Dean E, Jones A, Yu HP-M, Gosselink R, Skinner M. Phys Ther. 2020:100;1458-1464.

Jia Han, Xueqiang Wang, Xia Shen, Jia Hu, Xin Zhang, Xin Tang, Hong Wang, Qinglu Luo, Ying Jiang, Zheng Jiang, Lin Yang, Qi Zhang, Yiwen Bai, Xubo Wu,

Phys Ther (Physical therapy)
[2020, 100(10):1885-1886]

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Polyphenolic Proanthocyanidin-B2 suppresses proliferation of liver cancer cells and hepatocellular carcinogenesis through directly binding and inhibiting AKT activity.

Guijun Liu, Aimin Shi, Ningning Wang, Min Li, Xuxiao He, Chunzhao Yin, Qiaochu Tu, Xia Shen, Yongzhen Tao, Qiang Wang, Huiyong Yin,

The well-documented anticarcinogenic properties of natural polyphenolic proanthocyanidins (OPC) have been primarily attributed to their antioxidant and anti-inflammatory potency. Emerging evidence suggests that OPC may target canonical oncogenic pathways, including PI3K/AKT; however, the underlying mechanism and therapeutic potential remain elusive. Here we identify that proanthocyanidin B2 (OPC-B2) directly binds and ... Read more >>

Redox Biol (Redox biology)
[2020, 37:101701]

Cited: 5 times

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