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Tunable oligo-histidine self-assembled monolayer junction and charge transport by a pH modulated assembly.

Baili Li, Lixian Tian, Xuehao He, Xuan Ji, Hira Khalid, Chong Yue, Qinggang Liu, Xi Yu, Shengbin Lei, Wenping Hu,

Histidine works as an important mediator in the charge transport process through proteins via its conjugate side group. It can also stabilize a peptide's secondary structure through hydrogen bonding of the imidazole group. In this study, the conformation of the self-assembled monolayer (SAM) and the charge transport of the tailor-made ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(47):26058-26065]

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DNA methylation of AHCY may increase the risk of ischemic stroke.

Lei Zhao, Xiaosheng Chen, Shengjun Zhou, Zhiqing Lin, Xi Yu, Yi Huang,

Genetic factors play an important role in the pathogenesis of ischemic stroke. Of these, epigenetic modifications provide a new direction for the study of ischemic stroke pathogenesis. This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):471-476]

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Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) by PP1-Mediated Dephosphorylation Exerts Neurotoxicity in Pb-exposed neural cells.

Xiaozhen Gu, Xiyao Huang, Danyang Li, Nanxi Bi, Xi Yu, Hui-Li Wang,

Lead (Pb) is an environmental contaminant that primarily affects the central nervous system, particularly the developing brain. Recently, increasing evidence indicates the important roles of histone deacetylases (HDACs) in Pb-induced neurotoxicity. However, the precise molecular mechanisms involving HDAC4 remains unknown. The purpose of this study was to investigate the role ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition.

Conghui Liu, Yuwei Ren, Zaiyuan Li, Qi Hu, Lijuan Yin, Hengchao Wang, Xi Qiao, Yan Zhang, Longsheng Xing, Yu Xi, Fan Jiang, Sen Wang, Cong Huang, Bo Liu, Hangwei Liu, Fanghao Wan, Wanqiang Qian, Wei Fan,

Whole-genome duplication (WGD), contributing to evolutionary diversity and environmental adaptability, has been observed across a wide variety of eukaryotic groups, but not in molluscs. Molluscs are the second largest animal phylum in terms of species numbers, and among the organisms that have successfully adapted to the nonmarine realm through aquatic-terrestrial ... Read more >>

Mol Ecol Resour (Molecular ecology resources)
[2020, :]

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MFAP4 deficiency alleviates renal fibrosis through inhibition of NF-κB and TGF-β/Smad signaling pathways.

Zhou Pan, Kang Yang, Huibo Wang, Yusha Xiao, Ming Zhang, Xi Yu, Tao Xu, Tao Bai, Hengcheng Zhu,

Renal fibrosis, which is characterized by excessive extracellular matrix (ECM) accumulation in the renal tubulointerstitium, can lead to chronic kidney disease (CKD). The role of microfiber-associated protein 4 (MFAP4), which is an ECM protein that interacts with elastin and collagen, in renal fibrosis has not been investigated. The aim of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(11):14250-14263]

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Small RNA-seq analysis of extracellular vesicles from porcine uterine flushing fluids during peri-implantation.

Renwu Hua, Yueying Wang, Weisi Lian, Wenchao Li, Yu Xi, Songyi Xue, Tingting Kang, Minggang Lei,

The extracellular vesicles (EVs) of uterine flushing fluids (UFs) mediate intrauterine communication between conceptus and uterus in pigs. The small RNAs of UFs-EVs are widely recognized as important factors that influence embryonic implantation. However, small RNAs expression profiles of porcine UFs-EVs during peri-implantation are still unknown. In this study, cup-shaped ... Read more >>

Gene (Gene)
[2020, 766:145117]

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Mutation analysis of the cystic fibrosis transmembrane conductance regulator gene in Chinese congenital absence of vas deferens patients.

Shaoge Luo, Jiarong Feng, Yanan Zhang, Xiaojian Yang, Gongchao Ma, Tengfei Hu, Yu Xi, Xuchong Tu, Chunlin Wang, Hui Zhang, Zijun Zou, Yan Zhang,

To find the variant spectrum of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and evaluate its frequent variants in Chinese congenital absence of vas deferens (CAVD) patients. A total of 276 patients with azoospermia and CAVD (aged from 21 to 44 years old) were investigated from May 2013 to September ... Read more >>

Gene (Gene)
[2020, 765:145045]

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Global quantitative phosphoproteome reveals phosphorylation network of bovine lung tissue altered by Mycobacterium bovis.

Xi Yu, Chunfa Liu, Wenmin Yang, Andrea Stojkoska, Guangyu Cheng, Hongjun Yang, Ruichao Yue, Jie Wang, Yi Liao, Xin Sun, Xiangmei Zhou, Jianping Xie,

Bovine tuberculosis caused by Mycobacterium bovis remains a major cause of economic loss in cattle industries worldwide. However, the pathogenic mechanisms remain poorly understood. Post-translation modifications (PTM) such as phosphorylation play a crucial role in pathogenesis. While the change of transcriptome and proteome during the interaction between M. bovis and ... Read more >>

Microb Pathog (Microbial pathogenesis)
[2020, 147:104402]

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Photoluminescence spectral broadening, chirality transfer and amplification of chiral perovskite materials (R-X-p-mBZA)2PbBr4 (X = H, F, Cl, Br) regulated by van der Waals and halogen atoms interactions.

Chenyang Zhou, Ya Chu, Linlin Ma, Yingqian Zhong, Chao Wang, Yalan Liu, Haoyue Zhang, Beibei Wang, Xia Feng, Xi Yu, Xiaotao Zhang, Yan Sun, Xiaozeng Li, Guangjiu Zhao,

In this work, we introduced halogen-substituted chiral molecules as A-site cations to synthesize a series of novel organic-inorganic hybrid two-dimensional (2D) chiral perovskite materials (R-X-p-mBZA)2PbBr4 (X = H, F, Cl, Br; p: para-position; mBZA = α-methylbenzylamine) for the first time. This halogen-substituted cation strategy collectively solved problems of narrow emission, ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(30):17299-17305]

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Rejection of antimony in dyeing and printing wastewater by forward osmosis.

Lijun Meng, Minjie Wu, Haisheng Chen, Yu Xi, Manhong Huang, Xubiao Luo,

Wastewater containing heavy metal antimony (Sb) from textile and printing industry has high potential toxicity to environment and human health. In this study, forward osmosis (FO) technology was firstly used to remove Sb from both model Sb wastewater and real dyeing and printing wastewater. The evaluation of FO performance with ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 745:141015]

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Single-cell analysis of Schistosoma mansoni reveals a conserved genetic program controlling germline stem cell fate

Pengyang Li, Dania Nanes Sarfati, Yuan Xue, Xi Yu, Alexander Tarashansky, Stephen Quake, Bo Wang,

Abstract Schistosomes are parasitic flatworms causing one of the most prevalent infectious diseases from which millions of people are currently suffering. Their germline outputs many fertilized eggs, which are both the transmissible agents and the cause of the infection-associated pathology. Given its significance, the schistosome germline has been a research ... Read more >>

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Thermoconductive, Moisture-Permeable, and Superhydrophobic Nanofibrous Membranes with Interpenetrated Boron Nitride Network for Personal Cooling Fabrics.

Xi Yu, Yang Li, Xianfeng Wang, Yang Si, Jianyong Yu, Bin Ding,

Space cooling occupies a large portion of total building energy consumption, aggravating the energy crisis and restricting human sustainable development, thus an efficient and energy-saving personal cooling technology is in high demand. Recently, thermally conductive fillers, such as boron nitride (BN), are usually enriched to fibrous materials to construct thermal ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(28):32078-32089]

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Ideal Current-voltage Characteristics and Rectification Performance of Molecular Rectifier under Single Level based Tunneling and Hopping Transport

Xianneng Song, Xi Yu, Wenping Hu,

In this work, we systematically studied the rectifying properties of molecular junction based on asymmetric tunneling and hopping charge transport in a single electronic state model using Landauer formula and Marcus theory. We first analyzed the asymmetric I-V characteristics and revealed distinct physical origins of the rectification under the two ... Read more >>

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Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation.

Mindi He, Chao Zhou, Yonghui Lu, Ling Mao, Yu Xi, Xiang Mei, Xue Wang, Lei Zhang, Zhengping Yu, Zhou Zhou,

Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1α (HIF-1α). Melatonin has shown diverse anticancer properties for its reactive oxygen species- (ROS-) scavenging ability. Our aim was to explore how melatonin antagonized a nickel-induced increment in aerobic glycolysis. In ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:5406284]

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Development of magnetic solid phase extraction platform for the purification of bioactive γ-glutamyl peptides from garlic (Allium sativum)

Xi Yu, Cerise Yin Xin Lim, Bingxue Dong, Kunn Hadinoto,

A magnetic solid phase extraction (MSPE) platform was developed as an alternative to industrial chromatography for purification of bioactive gamma-glutamyl peptides from crude garlic extract. Core-shell C18-functionalized Fe₃O₄–SiO₂ nanoparticles were prepared and characterized for use as magnetic adsorbents. Key MSPE variables, i.e. (1) garlic extract's pH, (2) eluent type, (3) ... Read more >>

(Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire)
[2020, 127:Not Available]

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Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition.

Ming Li, Zheng Yen Phua, Yu Xi, Zhujun Xu, Samuel A Nyantakyi, Wei Li, Mary Jackson, Ming Wah Wong, Yulin Lam, Shu Sin Chng, Mei Lin Go, Thomas Dick,

Chemistry campaigns identified amphiphilic indolyl Mannich bases as novel membrane-permeabilizing antimycobacterials. Spiroketal analogs of this series showed increased potency, and the lead compound 1 displayed efficacy in a mouse model of tuberculosis. Yet the mechanism by which the spiroketal moiety accomplished the potency "jump" remained unknown. Consistent with its membrane-permeabilizing ... Read more >>

ACS Infect Dis (ACS infectious diseases)
[2020, 6(7):1882-1893]

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The prediction value of PI-RADS v2 score in high-grade Prostate Cancer: a multicenter retrospective study.

Song Chen, Yun Yang, Tianchen Peng, Xi Yu, Haiqing Deng, Zhongqiang Guo,

Background: To explore the prediction value of PI-RADS v2 in high-grade prostate cancer and establish a prediction model combined with related variables of prostate cancer. Material and Methods: A total of 316 patients with newly discovered prostate cancer at Zhongnan Hospital of Wuhan University and Renmin Hospital of Wuhan University ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(10):1366-1374]

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Probiotics supplementation improves hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes mellitus: An update of meta-analysis.

Tingting Liang, Lei Wu, Yu Xi, Ying Li, Xinqiang Xie, Congcong Fan, Lingshuang Yang, Shuanghong Yang, Xuefeng Chen, Jumei Zhang, Qingping Wu,

Background: Although many studies have shown that consumption of probiotics is relevant to diabetes, the effects of probiotics improves clinical outcomes in type 2 diabetes have yielded conflicting results. The aim of this meta-analysis was conducted to assess the effects of probiotics supplementation on glycemic, blood lipids, pressure and inflammatory ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2020, :1-19]

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Roles of Symbiotic Microorganisms in Arboviral Infection of Arthropod Vectors.

Chunhong Yin, Peng Sun, Xi Yu, Penghua Wang, Gong Cheng,

Arthropod vectors serve as native reservoirs and transmitters of hundreds of arboviruses. In arthropod vectors, symbiotic microorganisms residing in the gut lumen and/or hemocoelic tissues maintain complicated relationships with their host and influence multiple aspects of vector physiology. Recently, accumulating evidence has established an important role for symbiotic microorganisms in ... Read more >>

Trends Parasitol. (Trends in parasitology)
[2020, 36(7):607-615]

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Systematic Modulation of Charge Transport in Molecular Devices through Facile Control of Molecule-Electrode Coupling Using a Double Self-Assembled Monolayer Nanowire Junction.

Bin Han, Yao Li, Xuan Ji, Xianneng Song, Shuaishuai Ding, Baili Li, Hira Khalid, Yaogang Zhang, Xiaona Xu, Lixian Tian, Huanli Dong, Xi Yu, Wenping Hu,

We report a novel solid-state molecular device structure based on double self-assembled monolayers (D-SAM) incorporated into the suspended nanowire architecture to form a "Au|SAM-1||SAM-2|Au" junction. Using commercially available thiol molecules that are devoid of synthetic difficulty, we constructed a "Au|S-(CH2)6-ferrocene||SAM-2|Au" junction with various lengths and chemical structures of SAM-2 to ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(21):9708-9717]

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Multifactorial pathways facilitate resilience among kindergarteners at risk for dyslexia: A longitudinal behavioral and neuroimaging study.

Jennifer Zuk, Jade Dunstan, Elizabeth Norton, Xi Yu, Ola Ozernov-Palchik, Yingying Wang, Tiffany P Hogan, John D E Gabrieli, Nadine Gaab,

Recent efforts have focused on screening methods to identify children at risk for dyslexia as early as preschool/kindergarten. Unfortunately, while low sensitivity leads to under-identification of at-risk children, low specificity can lead to over-identification, resulting in inaccurate allocation of limited educational resources. The present study focused on children identified as ... Read more >>

Dev Sci (Developmental science)
[2020, :e12983]

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MiR-543 regulates myoblast proliferation and differentiation of C2C12 cells by targeting KLF6.

Tingting Kang, Wenkai Xing, Yu Xi, Kun Chen, Mengsi Zhan, Xiaoyin Tang, Yueying Wang, Ruirui Zhang, Minggang Lei,

MicroRNA-543 (miR-543) has been found to play a suppressive role in various human cancers in many studies, whereas the specific functions of miR-543 in muscle development remain poorly understood. Here, we found that the expression of miR-543 was high in skeletal muscle and increased during the differentiation of C2C12 cells. Overexpression of ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Astragaloside IV prophylactic administration relieves recurrent allergic atopic dermatitis

Jie Zheng, Xi Yu, Xiao Wei, Hongwei Fan, Min Hong,

Abstract BackgroundAtopic dermatitis (AD) is a common allergic inflammatory skin disease with high relapse rates and recurring severity. However, the underlying pathogenesis of AD recurrence is still unclear. Our previous study reported Astragaloside IV (AS-IV) administration in sensitization stage ameliorated the allergic inflammation of AD. In this study, we aimed ... Read more >>

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Detecting Abnormal Brain Regions in Schizophrenia Using Structural MRI via Machine Learning.

ZhiHong Chen, Tao Yan, ErLei Wang, Hong Jiang, YiQian Tang, Xi Yu, Jian Zhang, Chang Liu,

Utilizing neuroimaging and machine learning (ML) to differentiate schizophrenia (SZ) patients from normal controls (NCs) and for detecting abnormal brain regions in schizophrenia has several benefits and can provide a reference for the clinical diagnosis of schizophrenia. In this study, structural magnetic resonance images (sMRIs) from SZ patients and NCs ... Read more >>

Comput Intell Neurosci (Computational intelligence and neuroscience)
[2020, 2020:6405930]

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The predictive value of PI-RADS v2 score in high-grade prostate cancer: a multicenter retrospective study

Song Chen, Yun Yang, Tianchen Peng, Xi Yu, Haiqing Deng, Zhongqiang Guo,

Abstract The authors have withdrawn this preprint from Research Square ... Read more >>

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