Full Text Journal Articles by
Author Xi Liu

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The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells.

Zhan-Long Li, Jia Mi, Lu Lu, Qing Luo, Xi Liu, Ya-Mei Yan, Bo Jin, You-Long Cao, Xiao-Xiong Zeng, Lin-Wu Ran,

Anthocyanins have been reported to have effective chemopreventive activity. Lycium ruthenicum Murray is rich in anthocyanins and exhibits many biological activities. The purpose of this study was to investigate the effects and possible biological mechanism of the main anthocyanin monomer (Pt3G) of Lycium ruthenicum Murray on prostate cancer DU-145 cells. ... Read more >>

Food Funct (Food & function)
[2021, 12(4):1818-1828]

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Novel aryltriazole acyclic C-azanucleosides as anticancer candidates.

Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, Ling Peng, Yi Xia,

Nucleoside analogues represent an important class of drug candidates. With the aim of searching for novel bioactive nucleosides, we developed an efficient synthetic way to construct a series of aryl 1,2,3-triazole acyclic C-azanucleosides via Huisgen 1,3-dipolar cycloaddition. The aryl 1,2,3-triazole motifs within these azanucleosides showed coplanar features, suggesting they could ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2020, 18(47):9689-9699]

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Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy.

Zequn Zhang, Xi Liu, Zhaolong Shen, Jun Quan, Changwei Lin, Xiaorong Li, Gui Hu,

Fibrotic diseases pose significant clinical challenges due to their broadness and complexity. Thus, a better understanding of fibrogenesis and the development of more effective treatments is imperative. Recent evidence suggests a significant antifibrotic potential of an endogenous glycoprotein, endostatin. While endostatin has been widely studied for its role as an ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):2051-2061]

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Understandings of mental health, disclosure, help-seeking and psychological adaptation among Asian international students studying in Scotland: a sequential multi-method study

Nicola Cogan, Yvonne Chin-Van Chau, Xi Liu, Steve Kelly, Tony Anderson, Colin Flynn, Patrick Corrigan,

<p>International students often face psychosocial, academic, financial and adaptation challenges within the Higher Education (HE) environment that may impact on their mental health. The current study explored the understandings and experiences of Asian international students (AISs) in terms of mental health, disclosure, help-seeking and adaptation specific to cultural relocation within ... Read more >>

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Carbon Hollow Tube-Confined Sb/Sb2S3 Nanorod Fragments as Highly Stable Anodes for Potassium-Ion Batteries.

Yuanji Wu, Jiefeng Zheng, Yong Tong, Xi Liu, Yingjuan Sun, Li Niu, Hongyan Li,

Potassium-ion batteries (PIBs) have attracted widespread attention in recent years due to their potential advantages such as low cost and high energy density. However, the large radius of K+ and the low potassium storage capacity of some electrode materials limit their development. Antimony (Sb)-based materials are considered to be promising ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.

Mei Yang, Jiaqi Li, Zhaoxia Huang, Heng Li, Yueming Wang, Xiaoli Wang, Sisi Kang, Xing Huang, Changwen Wu, Tong Liu, Zhenxing Jia, Junlang Liang, Xiaohui Yuan, Suhua He, Xiaoxue Chen, Zhechong Zhou, Qiuyue Chen, Siqi Liu, Jing Li, Huiwen Zheng, Xi Liu, Kenan Li, Xiaojun Yao, Bin Lang, Longding Liu, Hua-Xin Liao, Shoudeng Chen,

The emerging new lineages of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have marked a new phase of coronavirus disease 2019 (COVID-19). Understanding the recognition mechanisms of potent neutralizing monoclonal antibodies (NAbs) against the spike protein is pivotal for developing new vaccines and antibody drugs. Here, we isolated several monoclonal antibodies ... Read more >>

Microbiol Spectr (Microbiology spectrum)
[2021, :e0135221]

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UbiBrowser 2.0: a comprehensive resource for proteome-wide known and predicted ubiquitin ligase/deubiquitinase-substrate interactions in eukaryotic species.

Xun Wang, Yang Li, Mengqi He, Xiangren Kong, Peng Jiang, Xi Liu, Lihong Diao, Xinlei Zhang, Honglei Li, Xinping Ling, Simin Xia, Zhongyang Liu, Yuan Liu, Chun-Ping Cui, Yan Wang, Liujun Tang, Lingqiang Zhang, Fuchu He, Dong Li,

As an important post-translational modification, ubiquitination mediates ∼80% of protein degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the delicate balance between specific ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase-mediated deubiquitination. In 2017, we developed UbiBrowser 1.0, which is an integrated database for predicted human proteome-wide E3-substrate interactions. ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, :]

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Non-metabolic function of MTHFD2 activates CDK2 in bladder cancer.

Xi Liu, Shuangjie Liu, Chiyuan Piao, Zhe Zhang, Xiaotong Zhang, Yuanjun Jiang, Chuize Kong,

Bladder cancer is a common tumor with a high recurrence rate and high fatality rate, and its mechanism of occurrence and development remains unclear. Many proteins and metabolites reprogram at different stages of tumor development to support tumor cell growth. The moonlighting effect happens when a protein performs multiple functions ... Read more >>

Cancer Sci (Cancer science)
[2021, :]

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Plastidic Pyruvate Dehydrogenase Complex E1 Component Subunit Alpha1 Is Involved in Galactolipid Biosynthesis Required for Amyloplast Development in Rice.

Jie Lei, Xuan Teng, Yongfei Wang, Xiaokang Jiang, Huanhuan Zhao, Xiaoming Zheng, Yulong Ren, Hui Dong, Yunlong Wang, Erchao Duan, Yuanyan Zhang, Wenwei Zhang, Hang Yang, Xiaoli Chen, Rongbo Chen, Yu Zhang, Mingzhou Yu, Shanbin Xu, Xiuhao Bao, Pengcheng Zhang, Shijia Liu, Xi Liu, Yunlu Tian, Ling Jiang, Yihua Wang, Jianmin Wan,

Starch accounts for over 80% of the total dry weight in cereal endosperm and determines the kernel texture and nutritional quality. Amyloplasts, terminally differentiated plastids, are responsible for starch biosynthesis and storage. We screened a series of rice mutants with floury endosperm to clarify the mechanism underlying amyloplast development and ... Read more >>

Plant Biotechnol J (Plant biotechnology journal)
[2021, :]

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PSEA: A phenotypic similarity ensemble approach for prioritizes candidate genes to aid mendelian disease diagnosis

Zhonghua Wang, Lipei Liu, Chao Chen, Xi Liu, Fei Tang, Yixiang Zhang, Yunmei Chen, Yaoshen Wang, Jun Sun, Zhiyu Peng,

<h4>Motivation</h4> Next-generation sequencing (NGS) is increasingly applied to the molecular diagnosis of genetic disorders. However, challenges for the interpretation of NGS data remain given the massive number of variants produced by NGS. Careful assessment is required to identify the most likely disease-causing variants that best match the patients’ clinical phenotypes, ... Read more >>

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Technology status and trends of industrial wastewater treatment: A patent analysis.

Guozhu Mao, Yixin Han, Xi Liu, John Crittenden, Ning Huang, Umme Marium Ahmad,

Globally, 80% of wastewater, among which 28% came from industry, returned to the ecosystem without treatment or reuse. The discharge of industrial wastewater poses public health and environmental concerns. The necessity and urgency of industrial wastewater treatment (IWT) will bring great challenges to most countries. This paper conducted the patent ... Read more >>

Chemosphere (Chemosphere)
[2021, :132483]

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Genome-wide Identification, Characterization, and Function Analysis Uncovered Roles of Wheat TaLIM in Responding to Adverse Stress and TaLIM8-4D Function as a Susceptible Gene

Yiting Li, Xi Liu, Yongxin Xiao, Yong Wen, Xiaowen Han, Shuo Han, Lijun Yang, Yongxing Zhu, Junliang Yin, Yiqing Liu,

<h4>Background: </h4> The LIM ( L in-11, I sl-1 and M ec-3 domains) transcription factors play essential roles in regulating plant biological processes, including cytoskeletal organization, development of secondary cell wall, and cell differentiation. Despite their important roles, there lacks a fully understanding of LIMs in wheat. <h4>Results: </h4>: In ... Read more >>

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Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy.

Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Juan L Iovanna, Xiaoxuan Liu, Ling Peng, Yi Xia,

Novel nucleoside derivatives were developed using the strategy of "terminal N,N-dimethylation" to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(69):10014-10017]

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Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.

You Wang, Jinxian Yuan, Xinyuan Yu, Xi Liu, Changhong Tan, Yangmei Chen, Tao Xu,

Although many studies have explored the mechanism of epilepsy, it remains unclear and deserves further investigation. Vezatin has been reported to be a synaptic regulatory protein involved in regulating neuronal synaptic transmission (NST). However, the role of vezatin in epilepsy remains unknown. Therefore, the aims of this study are to ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(10):936]

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NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner.

Can Huang, Patricia Santofimia-Castaño, Xi Liu, Yi Xia, Ling Peng, Célia Gotorbe, Jose Luis Neira, Daolin Tang, Jacques Pouyssegur, Juan Iovanna,

Ferroptosis is an iron-dependent cell death characterized by the accumulation of hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents. The ferroptotic activity can be improved by inhibiting antioxidant factors ... Read more >>

Cell Death Discov (Cell death discovery)
[2021, 7(1):269]

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AutoCNV: a semiautomatic CNV interpretation system based on the 2019 ACMG/ClinGen Technical Standards for CNVs.

Chunna Fan, Zhonghua Wang, Yan Sun, Jun Sun, Xi Liu, Licheng Kang, Yingshuo Xu, Manqiu Yang, Wentao Dai, Lijie Song, Xiaoming Wei, Jiale Xiang, Hui Huang, Meizhen Zhou, Fanwei Zeng, Lin Huang, Zhengfeng Xu, Zhiyu Peng,

<h4>Background</h4>The American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen) presented technical standards for interpretation and reporting of constitutional copy-number variants in 2019 (the standards). Although ClinGen developed a web-based CNV classification calculator based on scoring metrics, it can only track and tally points that ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):721]

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Poly(ionic liquid)-Based Efficient and Robust Antiseptic Spray.

Xi Liu, Li Chang, Liying Peng, Rushui Bai, Yan Wei, Chuao Ma, Hongliang Liu,

Exploring efficient and robust antibacterial materials is crucially important for human health and ecological security. Compared with intrinsically antibacterial materials, materials modified with antibacterial agents either by chemical or physical modification can simultaneously maintain basic functions and antibacterial properties. In particular, physical modification with antiseptic sprays is quite suitable for ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis.

Kang-Bo Huang, Yi-Hui Pan, Guan-Nan Shu, Hao-Hua Yao, Xi Liu, Mi Zhou, Jin-Huan Wei, Zhen-Hua Chen, Jun Lu, Zi-Hao Feng, Wei Chen, Hui Han, Zhou-San Zheng, Jun-Hang Luo, Jia-Xing Zhang,

Sunitinib resistance is a major challenge in systemic therapy for renal cell carcinoma (RCC). The role of circular RNAs (circRNAs) in regulating sunitinib resistance of RCC is largely unknown. We established sunitinib-resistant RCC cell lines in vivo. Through RNA-sequencing, we identified circSNX6, whose expression is upregulated in sunitinib-resistant cells compared ... Read more >>

Cancer Lett (Cancer letters)
[2021, 523:121-134]

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Tibial Cortex Transverse Distraction Followed by Open Correction with Internal Fixation for Management of Foot and Ankle Deformity with Ulcers.

Ya-Xing Li, Xi Liu, Yu Chen, Ting-Jiang Gan, Bo-Quan Qin, Yi Ren, Hui Zhang,

<h4>Objective</h4>To assess the feasibility and results of tibial cortex transverse distraction (TCTD) followed by open correction with internal fixation (OCIF) for foot and ankle deformity with concurrent ulcers.<h4>Methods</h4>A retrospective analysis was conducted. Between 2010 and 2019, a two-stage management of TCTD followed by OCIF was performed in 13 patients (13 ... Read more >>

Orthop Surg (Orthopaedic surgery)
[2021, :]

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PerCEIVED: Perceptions of children's emotions in videos, evolving and dynamic task.

Amy G Halberstadt, Alison N Cooke, Courtney A Hagan, Xi Liu,

Researchers have been studying emotion recognition skill for over 100 years (Feleky, 1914), yet technological advances continue to allow for the creation of better measures. Interest in consistent inaccuracies (sometimes described as bias) has also emerged recently. To support research in both emotion recognition skill and bias, we first describe ... Read more >>

Emotion (Emotion (Washington, D.C.))
[2021, :]

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Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size.

Alessandro Bonfini, Adam J Dobson, David Duneau, Jonathan Revah, Xi Liu, Philip Houtz, Nicolas Buchon,

The gut is the primary interface between an animal and food, but how it adapts to qualitative dietary variation is poorly defined. We find that the <i>Drosophila</i> midgut plastically resizes following changes in dietary composition. A panel of nutrients collectively promote gut growth, which sugar opposes. Diet influences absolute and ... Read more >>

Elife (eLife)
[2021, 10:]

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Impact of BMI on Left Atrial Strain and Abnormal Atrioventricular Interaction in Patients With Type 2 Diabetes Mellitus: A Cardiac Magnetic Resonance Feature Tracking Study.

Meng-Ting Shen, Ying-Kun Guo, Xi Liu, Yan Ren, Li Jiang, Lin-Jun Xie, Yue Gao, Yi Zhang, Ming-Yan Deng, Yuan Li, Zhi-Gang Yang,

<h4>Background</h4>Type 2 diabetes mellitus (T2DM) and obesity often coexist and together contribute to left atrial (LA) functional abnormalities. However, little is known about the impact of body mass index (BMI) on LA strains measured using cardiac magnetic resonance feature tracking (MR-FT).<h4>Purpose</h4>To investigate the additive effect of BMI on LA functional ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2021, :]

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Effect Of A Tertiary A-level Hospital WeChat-Based Intervention On Medication Adherence And Risk Factor Control In Patients With Stable Coronary Artery Disease Compared With Traditional Community Hospital Follow-Up: A Multicenter, Prospective Study.

Boqun Shi, Xi Liu, Qiuting Dong, Yuxiu Yang, Zhongxing Cai, Haoyu Wang, Dong Yin, Hongjian Wang, Kefei Dou, Weihua Song,

<h4>Background</h4>In China, the main cause of mortality is a cardiac condition known as ischemic heart disease. Having cardiac rehabilitation and a secondary prevention program in place is a class IA recommendation for individuals with coronary artery disease. WeChat-based interventions seem to be feasible and efficient for the follow-up and management ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2021, :]

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Total Flavonoids of Litchi Seed Attenuate Prostate Cancer Progression Via Inhibiting AKT/mTOR and NF-kB Signaling Pathways.

Ming Chang, Dan Zhu, Yanjiang Chen, Weiquan Zhang, Xi Liu, Xiao-Lan Li, Zhiping Cheng, Zhiheng Su, Jian Zhang, Yi Lu, Hongwei Guo,

Litchi seeds have been traditionally used in Chinese herbal formula for urologic neoplasms including prostate cancer (PCa). However, the effective components of Litchi seeds and the mechanisms of their actions on PCa cell growth and metastasis remain unclear. In this study, we investigated the effects and molecular mechanisms of the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:758219]

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A deep-learning model for identifying fresh vertebral compression fractures on digital radiography.

Weijuan Chen, Xi Liu, Kunhua Li, Yin Luo, Shanwei Bai, Jiangfen Wu, Weidao Chen, Mengxing Dong, Dajing Guo,

<h4>Objectives</h4>To develop a deep-learning (DL) model for identifying fresh VCFs from digital radiography (DR), with magnetic resonance imaging (MRI) as the reference standard.<h4>Methods</h4>Patients with lumbar VCFs were retrospectively enrolled from January 2011 to May 2020. All patients underwent DR and MRI scanning. VCFs were categorized as fresh or old according ... Read more >>

Eur Radiol (European radiology)
[2021, :]

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