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Author Xi Lei Zeng

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Use of Human Intestinal Enteroids to Evaluate Persistence of Infectious Human Norovirus in Seawater.

Marion Desdouits, David Polo, Cecile Le Mennec, Sofia Strubbia, Xi-Lei Zeng, Khalil Ettayebi, Robert L Atmar, Mary K Estes, Fran├žoise S Le Guyader,

Little data on the persistence of human norovirus infectivity are available to predict its transmissibility. Using human intestinal enteroids, we demonstrate that 2 human norovirus strains can remain infectious for several weeks in seawater. Such experiments can improve understanding of factors associated with norovirus survival in coastal waters and shellfish. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2022, 28(7):1475-1479]

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Variants in Interferon Lambda are Associated with Very Early Onset Inflammatory Bowel Disease

Jodie Ouahed, Achille Broggi, Abigail Glick, Robin Haring, Michael Field, Daniel Chinnapen, Michael Grey, Wayne Lencer, Steven Steiner, Evida Dennis-Heyward, Noah Shroyer, Zachary Criss, Shih-Ching Lin, Xi-Lei Zeng, Sue Crawford, Mary Estes, Jay Thiagarajah, Amalia Capilla, Whitney Scoon, Gustavo Mostoslavsky, Jason Spence, Christoph Klein, Aleixo Muise, Bruce Horwitz, Ivan Zanoni, Scott Snapper,

Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the intestine that affect children and adults. The etiology is multifactorial with the contribution of genetic, immune, microbial, and environmental risk factors with a substantial involvement of host:microbial cross-talk in the lumen. Whether and how antiviral responses contribute to IBD pathogenesis ... Read more >>

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