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The authors reply.

Christopher Lai, Jean-Louis Teboul, Xavier Monnet,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1185-e1186]

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The authors reply.

Christopher Lai, Jean-Louis Teboul, Xavier Monnet,

Crit Care Med (Critical care medicine)
[2021, 49(10):e1046-e1047]

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Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial.

Florence Ader, Maude Bouscambert-Duchamp, Maya Hites, Nathan Peiffer-Smadja, Julien Poissy, Drifa Belhadi, Alpha Diallo, Minh-Patrick Lê, Gilles Peytavin, Thérèse Staub, Richard Greil, Jérémie Guedj, Jose-Artur Paiva, Dominique Costagliola, Yazdan Yazdanpanah, Charles Burdet, France Mentré, ,

<h4>Background</h4>The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator support.<h4>Methods</h4>DisCoVeRy was a phase 3, open-label, adaptive, multicentre, ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, :]

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Bioreactance reliably detects preload responsiveness by the end-expiratory occlusion test when averaging and refresh times are shortened.

Francesco Gavelli, Alexandra Beurton, Jean-Louis Teboul, Nello De Vita, Danila Azzolina, Rui Shi, Arthur Pavot, Xavier Monnet,

<h4>Background</h4>The end-expiratory occlusion (EEXPO) test detects preload responsiveness, but it is 15 s long and induces small changes in cardiac index (CI). It is doubtful whether the Starling bioreactance device, which averages CI over 24 s and refreshes the displayed value every 4 s (Starling-24.4), can detect the EEXPO-induced changes in CI (ΔCI). ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):133]

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Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock.

Imane Adda, Christopher Lai, Jean-Louis Teboul, Laurent Guerin, Francesco Gavelli, Xavier Monnet,

<h4>Background</h4>Through venous contraction, norepinephrine (NE) increases stressed blood volume and mean systemic pressure (Pms) and exerts a "fluid-like" effect. When both fluid and NE are administered, Pms may not only result from the sum of the effects of both drugs. Indeed, norepinephrine may enhance the effects of volume expansion: because fluid ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):302]

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Changes in pulse pressure variation to assess preload responsiveness in mechanically ventilated patients with spontaneous breathing activity: an observational study.

Olfa Hamzaoui, Rui Shi, Simone Carelli, Benjamin Sztrymf, Dominique Prat, Frederic Jacobs, Xavier Monnet, Corentin Gouëzel, Jean-Louis Teboul,

<h4>Background</h4>Pulse pressure variation (PPV) is not reliable in predicting preload responsiveness in patients receiving mechanical with spontaneous breathing (SB) activity. We hypothesised that an increase in PPV after a tidal volume (V<sub>T</sub>) challenge (TVC) or a decrease in PPV during passive leg raising (PLR) can predict preload responsiveness in such ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 127(4):532-538]

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Multidisciplinary approach for post-acute COVID-19 syndrome: time to break down the walls.

David Montani, Laurent Savale, Antoine Beurnier, Romain Colle, Nicolas Noël, Tài Pham, Xavier Monnet, Marc Humbert,

Eur Respir J (The European respiratory journal)
[2021, 58(1):]

Cited: 2 times

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Monocyte distribution width as a biomarker of resistance to corticosteroids in patients with sepsis: the MOCORSEP observational study.

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Intensive Care Med (Intensive care medicine)
[2021, 47(10):1161-1164]

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COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study.

Rui Shi, Christopher Lai, Jean-Louis Teboul, Martin Dres, Francesca Moretto, Nello De Vita, Tài Pham, Vincent Bonny, Julien Mayaux, Rosanna Vaschetto, Alexandra Beurton, Xavier Monnet,

<h4>Background</h4>In acute respiratory distress syndrome (ARDS), extravascular lung water index (EVLWi) and pulmonary vascular permeability index (PVPI) measured by transpulmonary thermodilution reflect the degree of lung injury. Whether EVLWi and PVPI are different between non-COVID-19 ARDS and the ARDS due to COVID-19 has never been reported. We aimed at comparing ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):186]

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Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study : Prognosis of COVID-19 elderly critically ill patients in the ICU.

Martin Dres, David Hajage, Said Lebbah, Antoine Kimmoun, Tai Pham, Gaëtan Béduneau, Alain Combes, Alain Mercat, Bertrand Guidet, Alexandre Demoule, Matthieu Schmidt, ,

<h4>Background</h4>The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis of the older patients (> 70 years old) with COVID-19 admitted in the intensive care unit (ICU).<h4>Methods</h4>Characteristics, management, and prognosis of critically ill old patients (> 70 years) were extracted ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):77]

Cited: 3 times

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Effects of Prone Positioning on Venous Return in Patients With Acute Respiratory Distress Syndrome.

Christopher Lai, Imane Adda, Jean-Louis Teboul, Romain Persichini, Francesco Gavelli, Laurent Guérin, Xavier Monnet,

<h4>Objectives</h4>To examine the effects of prone positioning on venous return and its determinants such as mean systemic pressure and venous return resistance in patients with acute respiratory distress syndrome.<h4>Design</h4>Prospective monocentric study.<h4>Settings</h4>A 25-bed medical ICU.<h4>Patients</h4>About 22 patients with mild-to-severe acute respiratory distress syndrome in whom prone positioning was decided.<h4>Interventions</h4>We obtained cardiac ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):781-789]

Cited: 1 time

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Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19.

, Luc Morin, Laurent Savale, Tài Pham, Romain Colle, Samy Figueiredo, Anatole Harrois, Matthieu Gasnier, Anne-Lise Lecoq, Olivier Meyrignac, Nicolas Noel, Elodie Baudry, Marie-France Bellin, Antoine Beurnier, Walid Choucha, Emmanuelle Corruble, Laurent Dortet, Isabelle Hardy-Leger, François Radiguer, Sabine Sportouch, Christiane Verny, Benjamin Wyplosz, Mohamad Zaidan, Laurent Becquemont, David Montani, Xavier Monnet,

<h4>Importance</h4>Little is known about long-term sequelae of COVID-19.<h4>Objective</h4>To describe the consequences at 4 months in patients hospitalized for COVID-19.<h4>Design, setting, and participants</h4>In a prospective uncontrolled cohort study, survivors of COVID-19 who had been hospitalized in a university hospital in France between March 1 and May 29, 2020, underwent a telephone ... Read more >>

JAMA (JAMA)
[2021, 325(15):1525-1534]

Cited: 33 times

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Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study.

Guillaume Lebreton, Matthieu Schmidt, Maharajah Ponnaiah, Thierry Folliguet, Marylou Para, Julien Guihaire, Emmanuel Lansac, Edouard Sage, Bernard Cholley, Bruno Mégarbane, Pierrick Cronier, Jonathan Zarka, Daniel Da Silva, Sebastien Besset, Tristan Morichau-Beauchant, Igor Lacombat, Nicolas Mongardon, Christian Richard, Jacques Duranteau, Charles Cerf, Gabriel Saiydoun, Romain Sonneville, Jean-Daniel Chiche, Patrick Nataf, Dan Longrois, Alain Combes, Pascal Leprince, ,

<h4>Background</h4>In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in the COVID-19 pandemic. We report ECMO network organisation and outcomes during the first wave of the pandemic.<h4>Methods</h4>In this multicentre cohort study, we present an analysis of all ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(8):851-862]

Cited: 9 times

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Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

Temistocle Taccheri, Francesco Gavelli, Jean-Louis Teboul, Rui Shi, Xavier Monnet,

<h4>Background</h4>In patients ventilated with tidal volume (Vt) < 8 mL/kg, pulse pressure variation (PPV) and, likely, the variation of distensibility of the inferior vena cava diameter (IVCDV) are unable to detect preload responsiveness. In this condition, passive leg raising (PLR) could be used, but it requires a measurement of cardiac output. The tidal ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):110]

Cited: 1 time

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Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial.

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<h4>Background</h4>Patients with COVID-19 pneumonia have an excess of inflammation and increased concentrations of cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients in hospital with mild-to-moderate COVID-19 pneumonia.<h4>Methods</h4>In this multicentre, open-label, Bayesian randomised clinical trial (CORIMUNO-ANA-1), nested within ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(3):295-304]

Cited: 37 times

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Changes in the Plethysmographic Perfusion Index During an End-Expiratory Occlusion Detect a Positive Passive Leg Raising Test.

Alexandra Beurton, Francesco Gavelli, Jean-Louis Teboul, Nello De Vita, Xavier Monnet,

<h4>Objectives</h4>The end-expiratory occlusion test for assessing preload responsiveness consists in interrupting mechanical ventilation for 15 seconds at end-expiration and measuring the cardiac index changes. The perfusion index is the ratio between the pulsatile and the nonpulsatile portions of the plethysmography signal and is, in part, determined by stroke volume. We ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(2):e151-e160]

Cited: 1 time

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Current use of inotropes in circulatory shock.

Thomas W L Scheeren, Jan Bakker, Thomas Kaufmann, Djillali Annane, Pierre Asfar, E Christiaan Boerma, Maurizio Cecconi, Michelle S Chew, Bernard Cholley, Maria Cronhjort, Daniel De Backer, Arnaldo Dubin, Martin W Dünser, Jacques Duranteau, Anthony C Gordon, Ludhmila A Hajjar, Olfa Hamzaoui, Glenn Hernandez, Vanina Kanoore Edul, Geert Koster, Giovanni Landoni, Marc Leone, Bruno Levy, Claude Martin, Alexandre Mebazaa, Xavier Monnet, Andrea Morelli, Didier Payen, Rupert M Pearse, Michael R Pinsky, Peter Radermacher, Daniel A Reuter, Yasser Sakr, Michael Sander, Bernd Saugel, Mervyn Singer, Pierre Squara, Antoine Vieillard-Baron, Philippe Vignon, Jean-Louis Vincent, Iwan C C van der Horst, Simon T Vistisen, Jean-Louis Teboul,

<h4>Background</h4>Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope therapy in the treatment of patients with circulatory shock.<h4>Methods</h4>From November 2016 to April 2017, an anonymous web-based survey on the use of ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):21]

Cited: 2 times

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Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial.

Olivier Hermine, Xavier Mariette, Pierre-Louis Tharaux, Matthieu Resche-Rigon, Raphaël Porcher, Philippe Ravaud, ,

<h4>Importance</h4>Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19).<h4>Objective</h4>To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia.<h4>Design, setting, and particpants</h4>This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating patients with COVID-19 and moderate or severe pneumonia requiring ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2021, 181(1):32-40]

Cited: 222 times

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Do Changes in Pulse Pressure Variation and Inferior Vena Cava Distensibility During Passive Leg Raising and Tidal Volume Challenge Detect Preload Responsiveness in Case of Low Tidal Volume Ventilation?

Temistocle Taccheri, Francesco Gavelli, Jean-Louis Teboul, Rui Shi, Xavier Monnet,

<h4>Background: </h4> In patients ventilated with tidal volume (Vt) <8 mL/kg, pulse pressure variation (PPV) and, likely, the distensibility of the inferior vena cava diameter (IVCV) are unable to detect preload responsiveness. In this condition, passive leg raising (PLR) could be used but it requires a measurement of cardiac output. ... Read more >>

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Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation.

Antoine Beurnier, Etienne-Marie Jutant, Mitja Jevnikar, Athénaïs Boucly, Jérémie Pichon, Mariana Preda, Marie Frank, Jérémy Laurent, Christian Richard, Xavier Monnet, Jacques Duranteau, Anatole Harrois, Marie-Camille Chaumais, Marie-France Bellin, Nicolas Noël, Sophie Bulifon, Xavier Jaïs, Florence Parent, Andrei Seferian, Laurent Savale, Olivier Sitbon, David Montani, Marc Humbert,

<h4>Background</h4>Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of patients with asthma to develop an exacerbation when they present with severe pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is unknown. The objective of this study was to investigate the characteristics and outcomes ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(5):]

Cited: 33 times

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Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study.

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<h4>Purpose</h4>To describe acute respiratory distress syndrome (ARDS) severity, ventilation management, and the outcomes of ICU patients with laboratory-confirmed COVID-19 and to determine risk factors of 90-day mortality post-ICU admission.<h4>Methods</h4>COVID-ICU is a multi-center, prospective cohort study conducted in 138 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, adjunctive interventions, ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(1):60-73]

Cited: 118 times

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Incidence and Outcome of Subclinical Acute Kidney Injury Using penKid in Critically Ill Patients.

François Dépret, Alexa Hollinger, Alain Cariou, Nicolas Deye, Antoine Vieillard-Baron, Marie-Céline Fournier, Samir Jaber, Charles Damoisel, Qin Lu, Xavier Monnet, Isabelle Rennuit, Michael Darmon, Marc Leone, Bertrand Guidet, Romain Sonneville, Philippe Montravers, Sébastien Pili-Floury, Jean-Yves Lefrant, Jacques Duranteau, Pierre-François Laterre, Nicolas Brechot, Haikel Oueslati, Bernard Cholley, Joachim Struck, Oliver Hartmann, Alexandre Mebazaa, Etienne Gayat, Matthieu Legrand,

<b>Rationale:</b> Subclinical acute kidney injury (sub-AKI) refers to patients with low serum creatinine but elevated alternative biomarkers of AKI. Its incidence and outcome in critically ill patients remain, however, largely unknown. Plasma proenkephalin A 119-159 (penKid) has been proposed as a sensitive biomarker of glomerular function.<b>Objectives:</b> In this ancillary study ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(6):822-829]

Cited: 7 times

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Volume Infusion Markedly Increases Femoral dP/dtmax in Fluid-Responsive Patients Only.

Sergi Vaquer, Denis Chemla, Jean-Louis Teboul, Umar Ahmad, Flora Cipriani, Joan Carles Oliva, Ana Ochagavia, Antonio Artigas, Francisco Baigorri, Xavier Monnet,

<h4>Objectives</h4>To evaluate the preload dependence of femoral maximal change in pressure over time (dP/dtmax) during volume expansion in preload dependent and independent critically ill patients.<h4>Design</h4>Retrospective database analysis.<h4>Setting</h4>Two adult polyvalent ICUs.<h4>Patients</h4>Twenty-five critically ill patients with acute circulatory failure.<h4>Interventions</h4>Thirty-five fluid infusions of 500 mL normal saline.<h4>Measurements and main results</h4>Changes in femoral dP/dtmax, systolic, ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(10):1487-1493]

Cited: 0 times

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Assessment of tissue oxygenation to personalize mean arterial pressure target in patients with septic shock.

Mathieu Jozwiak, Matthieu Chambaz, Pierre Sentenac, Xavier Monnet, Jean-Louis Teboul,

<h4>Objective</h4>To investigate whether assessment of tissue oxygenation could help personalizing the mean arterial pressure (MAP) target in patients with septic shock.<h4>Methods</h4>We prospectively measured near-infrared spectroscopy variables in 22 patients with septic shock receiving norepinephrine with a MAP>75 mmHg within the first six hours of intensive care unit (ICU) stay for patients ... Read more >>

Microvasc Res (Microvascular research)
[2020, 132:104068]

Cited: 0 times

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Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19.

Margot Combet, Arthur Pavot, Laurent Savale, Marc Humbert, Xavier Monnet,

Eur Respir J (The European respiratory journal)
[2020, 56(2):]

Cited: 10 times

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