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The two-component signal transduction system and its regulation in Candida albicans.

Biaoyou Liao, Xingchen Ye, Xi Chen, Yujie Zhou, Lei Cheng, Xuedong Zhou, Biao Ren,

<i>Candida albicans</i>, which can cause superficial and life-threatening systemic infections, is the most common opportunistic fungal pathogen in the human microbiome. The two-component system is one of the most important <i>C. albicans</i> signal transduction pathways, regulating the response to oxidative and osmotic stresses, adhesion, morphogenesis, cell wall synthesis, virulence, drug ... Read more >>

Virulence (Virulence)
[2021, 12(1):1884-1899]

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Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer.

Mei-Feng Yang, Xing-Xing Long, Hong-Sai Hu, Yu-Ling Bin, Xuan-Ming Chen, Ben-Hua Wu, Quan-Zhou Peng, Li-Sheng Wang, Jun Yao, De-Feng Li,

Synaptotagmins (SYTs), constitute a family of 17 membrane-trafficking protein, palying crucial roles in the development and progression of human cancers. However, only very few studies have investigated the expression profile and prognostic values of SYTs family members in gastric cancer (GC). Therefore, we comprehensively evaluated the expression, methylation, prognosis and ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3550-3565]

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Taxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways.

Chuanbo Ding, Yingchun Zhao, Xueyan Chen, Yinan Zheng, Wencong Liu, Xinglong Liu,

<h4>Context</h4>Taxifolin (TAX) has effective anti-inflammatory, antioxidant and hepatoprotective activities, but its potential mechanism has not been revealed.<h4>Objective</h4>To evaluate the potential protective effect of TAX on acute alcohol-induced liver injury in mice.<h4>Materials and methods</h4>Alcoholic liver injury model was established by oral alcohol in mice, and randomly distributed in five groups (<i>n</i> = 10): ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):868-879]

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Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation.

Shuqi He, Wu Zhang, Xian Li, Junjie Wang, Xufeng Chen, Yu Chen, Renfa Lai,

Oral squamous cell carcinoma (OSCC) is the most common tumor of the oral cavity. Studies have shown that exosomal miRNAs from cancer cells play an important role in mediating the cellular environment. The objective was to investigate the effect of OSCC-derived exosomes microRNA-221 (miR-221) in OSCC. We used quantitative real-time ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2164-2174]

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Correlation and integration of circulating miRNA and peripheral whole blood gene expression profiles in patients with venous thromboembolism.

Xiaonan Chen, Jun Cao, Zi Ge, Zhijie Xia,

The main aim of this work was to evaluate differential expression and biological functions of circulating miRNA and whole peripheral blood (PB) genes in patients affected by venous thromboembolism (VTE) and in healthy subjects. Circulating miRNA sequences and PB expression profiles were obtained from GEO datasets. Ten miRNAs with the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2352-2363]

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Predictive value of sub classification of focal segmental glomerular sclerosis in Oxford classification of IgA nephropathy.

Fang Yu, Xuejing Zhu, Shuguang Yuan, Xiaojun Chen, Zheng Li, Zhong Qu, Hong Liu, Lin Sun, Fuyou Liu,

<h4>Background</h4>The Oxford classification of IgA nephropathy (IgAN) was revised in 2016 which lacked sufficient evidence for prognostic value of subclassification of focal segmental glomerular sclerosis (S lesion), and the proper proportion of S lesion for subclassification remains undetermined.<h4>Aim</h4>This study aimed to explore the predictive value of the new subclassification of ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):587-595]

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A united risk model of 11 immune‑related gene pairs and clinical stage for prediction of overall survival in clear cell renal cell carcinoma patients.

Zijia Tao, Enchong Zhang, Lei Li, Jianyi Zheng, Yiqiao Zhao, Xiaonan Chen,

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Currently, we lack effective risk models for the prognosis of ccRCC patients. Given the significant role of cancer immunity in ccRCC, we aimed to establish a novel united risk model including clinical stage and immune-related gene ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4259-4277]

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Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in rats.

Tao Sun, Bing Zhang, Qing-Jing Ru, Xiao-Mei Chen, Bo-Dong Lv,

<h4>Context</h4>Glucagon-like peptide 1 (GLP-1) and α-tocopheryl quinone can promote the growth of intestinal flora and affect the pathogenesis of non-alcoholic steatohepatitis (NASH).<h4>Objective</h4>This study determines the molecular mechanism of the effect of tocopheryl quinone in the treatment of high cholesterol and cholate diet (HFCC)-induced NASH.<h4>Materials and methods</h4>Thirty-two male Sprague Dawley (SD) ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):723-731]

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Pinocembrin ameliorates arrhythmias in rats with chronic ischaemic heart failure.

Yan Guo, Cui Zhang, Tianxin Ye, Xiuhuan Chen, Xin Liu, Xiaoli Chen, Yazhou Sun, Chuan Qu, Jinjun Liang, Shaobo Shi, Bo Yang,

<h4>Objective</h4>Ventricular arrhythmias (VAs) are a common complication of chronic ischaemic heart failure (CIHF). The purpose of this study is to investigate the efficacy of pinocembrin in a rat model of VAs induced by CIHF and further examine the possible mechanism.<h4>Methods</h4>Rats were subjected to ligation of left anterior descending coronary artery ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):830-840]

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Tensile mechanical analysis of anisotropy and velocity dependence of the spinal cord white matter: a biomechanical study.

Norihiro Nishida, Itsuo Sakuramoto, Yoshihiro Fujii, Rudolf Yoga Hutama, Fei Jiang, Junji Ohgi, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Xian Chen, Takashi Sakai,

In spinal cord injuries, external forces from various directions occur at various velocities. Therefore, it is important to physically evaluate whether the spinal cord is susceptible to damage and an increase in internal stress for external forces. We hypothesized that the spinal cord has mechanical features that vary under stress ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2557-2562]

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A real time image-guided reposition system for the loosed bone graft in orthognathic surgery.

Xiaojun Chen, Yang Li, Lu Xu, Yi Sun, Constantinus Politis, Xiaoyi Jiang,

In traditional orthognathic surgery, the dental splint technique is typically used to assist surgeons to reposition the maxilla or mandible. However, the design and manufacturing of dental splints is time-consuming and labor-intensive, and the templates may not applicable for some complicated cases due to the anatomic intricacies in the maxillofacial ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):1-8]

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High ultrafiltration rate induced intradialytic hypotension is a predictor for cardiac remodeling: a 5-year cohort study.

Jinbo Yu, Xiaohong Chen, Yang Li, Yaqiong Wang, Zhonghua Liu, Bo Shen, Jie Teng, Jianzhou Zou, Xiaoqiang Ding,

<h4>Background</h4>Intradialytic-hypotension (IDH) is a common complication of hemodialysis. High ultrafiltration rate (UFR) might lead to IDH. However, the relationships between UFR, IDH, and cardiac remodeling among hemodialysis patients in the long-term have not been deeply explored.<h4>Methods</h4>This retrospective cohort study collected clinical and echocardiographic data. Patients were enrolled from 1 January ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):40-48]

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A pilot exploration with Posiphen to normalize amyloid precursor protein in Down syndrome.

Xu-Qiao Chen,

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2420-2421]

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Weighted gene co-expression network analysis (WGCNA) to explore genes responsive to Streptococcus oralis biofilm and immune infiltration analysis in human gingival fibroblasts cells.

Xia Chen, Jianfeng Ma,

The correlation between oral bacteria and dental implants failure has been reported. However, the effect and mechanism of bacteria during dental implants is unclear. In this study, we explored key genes and candidate gene clusters in human gingival fibroblasts (HGF) cells in response to <i>Streptococcus oralis</i> biofilm through weighted gene ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1054-1065]

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Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis.

Kun Zhang, Lifu Wang, Zhongcheng Liu, Bin Geng, Yuanjun Teng, Xuening Liu, Qiong Yi, Dechen Yu, Xiangyi Chen, Dacheng Zhao, Yayi Xia,

Articular cartilage consists of an extracellular matrix including many proteins as well as embedded chondrocytes. Articular cartilage formation and function are influenced by mechanical forces. Hind limb unloading or simulated microgravity causes articular cartilage loss, suggesting the importance of the healthy mechanical environment in articular cartilage homeostasis and implying a ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):339-359]

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Epidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China.

Xiu Chen, Chunwei Qin, Rongfeng Chen, Yunxuan Huang, Yuexiang Xu, Qiao Tang, Xianjun Liang, Bing Peng, Yi Shao, Yao Yang, Jie Chen, Xinwei Wang, Liufang Wen, Bingyu Liang, Li Ye, Xionglin Qin, Junjun Jiang, Hao Liang,

The HIV/AIDS prevalence in female sex workers (FSWs) and elderly male clients is increasing in Guangxi, China, but the transmission relationship between them remains unclear. This study aims to illuminate the transmission network between FSWs and elderly male clients using molecular epidemiological analyses. Phylogenetic analysis indicated that CRF01_AE was the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):384-395]

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Clinical significance and potential molecular mechanism of miRNA-222-3p in metastatic prostate cancer.

Yu Sun, Gang Chen, Juan He, Zhi-Guang Huang, Sheng-Hua Li, Yuan-Ping Yang, Lu-Yang Zhong, Shu-Fan Ji, Ying Huang, Xin-Hua Chen, Mao-Lin He, Hao Wu,

The clinical significance and underlying molecular mechanism of miRNA-222-3p in metastatic prostate cancer (MPCa) remain unclear. The present study used a large number of cases (n = 1,502) based on miRNA chip and miRNA sequencing datasets to evaluate the expression and diagnostic potential of miRNA-222-3p in MPCa. We applied a variety of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):325-340]

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Antithrombotic effects of Huanglian Jiedu decoction in a rat model of ischaemia-reperfusion-induced cerebral stroke.

Huan Liu, Xiaoyan Chen, Yanling Liu, Chunjuan Fang, Shaofen Chen,

<h4>Context</h4>Huanglian Jiedu Decoction (HLJJD) has a variety of pharmacological activities, such as anti-inflammatory and neuroprotection against ischaemic brain injury.<h4>Objectives</h4>This <i>ex vivo</i> study explores its antithrombosis activity and inhibition of platelet aggregation.<h4>Material and methods</h4>To study the antithrombosis activity of HLJJD <i>ex vivo</i>, saline, or HLJDD (100, 200, and 500 mg/kg) was treated ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):823-827]

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Mixed chimerism after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia.

Yuling Zhang, Yumiao Li, Liangliang Wu, Ming Zhou, Caixia Wang, Wenjian Mo, Xiaowei Chen, Shilin Xu, Ruiqing Zhou, Shunqing Wang, Yuping Zhang,

A retrospective study on 287 patients with SAA who underwent allo-HSCT between October 2012 and January 2020 was conducted to explore the outcomes, risk factors and treatment options for MC. Among 287 AA patients who excluded Fanconi anemia (FA), Congenital dyskeratosis (DKC), Paroxysmal nocturnal hemoglobinuria (PNH), etc.112 underwent matched sibling ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):435-443]

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Outcomes and risk management in type B aortic dissection patients with acute kidney injury: a concise review.

Xiaolan Chen, Ming Bai, Shiren Sun, Xiangmei Chen,

<h4>Purpose</h4>Type B aortic dissection is a rare but life-threatening disease. Thoracic endovascular aortic repair (TEVAR) was widely used for Type B aortic dissection patients in the last decade due to the lower mortality and morbidity compared with open chest surgical repair (OCSR). AKI in type B aortic dissection is a ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):585-596]

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HOTAIR suppresses PTEN via DNMT3b and confers drug resistance in acute myeloid leukemia.

Wei Zhou, Shilin Xu, Xiaowei Chen, Caixia Wang,

<h4>Objective</h4>HOTAIR has been well reported to be involved in the drug resistance of many diseases. This study aims to explore the possible implication of HOTAIR in doxorubicin (ADM) resistance in acute myeloid leukemia (AML).<h4>Methods</h4>Expressions of HOTAIR and PTEN in bone marrows of patient with newly diagnosed AML and relapsed/refractory AML ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):170-178]

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Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia.

Xiao Chen, Han Zhu, Chun Qiao, Sishu Zhao, Lu Liu, Yan Wang, Huimin Jin, Sixuan Qian, Yujie Wu,

<h4>Objectives</h4>The study aims to understand geneome diversification and complexity that developed in Acute myeloid leukemia (AML).<h4>Methods</h4>Next-generation sequencing (NGS) was used to identify the genetic profiles of 22 genes relevant to hematological malignancy in 204 patients with de novo non-M3 AML.<h4>Results</h4>At time of initial diagnosis, at least one mutation was identified ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):111-122]

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Pro-inflammatory cytokines as potential predictors for intradialytic hypotension.

Jinbo Yu, Xiaohong Chen, Yang Li, Yaqiong Wang, Xuesen Cao, Zhonghua Liu, Bo Shen, Jianzhou Zou, Xiaoqiang Ding,

<h4>Background</h4>Intradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, the association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate the potential role of pro-inflammatory cytokines in IDH.<h4>Methods</h4>MHD patients starting ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):198-205]

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δ-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis.

Mei Shi, Xiuyun Chen, Hui Li, Lixia Zheng,

Preeclampsia (PE) is a severe medical disorder during pregnancy and there has been controversy about the effects of vitamin E on PE. This research intended to explore if δ-tocotrienol (δ-TT), an isomer of vitamin E, could impact PE. Preeclamptic and normal placentas were obtained and total RNA was extracted. The ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1861-1873]

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Microwave irradiation alters the rheological properties and molecular structure of hull-less barley starch

Xiaojing Chen, Yi Liu, Zekun Xu, Chuangchuang Zhang, Xingxun Liu, Zhongquan Sui, Harold Corke,

Hull-less barley kernels and their isolated starches were irradiated under different microwave conditions (power 640, 720, and 800 W, time 60, 120 and 180 s) and changes in rheological properties and molecular structures were studied. Steady shear rheological results showed that, as the microwave energy input increased, K values decreased and n ... Read more >>

(Food hydrocolloids.)
[2021, 120:Not Available]

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