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Patterns of definitive radiotherapy practice for cervical cancer in South Korea: a survey endorsed by the Korean Radiation Oncology Group (KROG 20-06).

Nalee Kim, Won Park,

<h4>Objective</h4>The Korean Radiation Oncology Group conducted a nationwide questionnaire survey to evaluate the patterns of clinical practice for patients with cervical cancer receiving definitive radiation therapy (RT) in South Korea.<h4>Methods</h4>Practicing radiation oncologists from 93 centers in South Korea were administered a questionnaire survey via e-mail. The survey focused on demographic ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e43]

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Risk Factors and Patterns of Locoregional Recurrence After Radical Nephrectomy for Locally Advanced Renal Cell Carcinoma.

Gyu Sang Yoo, Won Park, Hongryull Pyo, Byong Chang Jeong, Hwang Gyun Jeon, Minyong Kang, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Byung Kwan Park, Chan Kyo Kim, Sung Yoon Park, Ghee Young Kwon,

<h4>Purpose</h4>We aimed to investigate the risk factors and patterns of locoregional recurrence (LRR) after radical nephrectomy (RN) in patients with locally advanced renal cell carcinoma (RCC).<h4>Materials and methods</h4>We retrospectively analyzed 245 patients who underwent RN for non-metastatic pathologic T3-4 RCC from January 2006 to January 2016. We analyzed the risk ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, :]

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Silk Fibroin Enhances Cytocompatibilty and Dimensional Stability of Alginate Hydrogels for Light-Based Three-Dimensional Bioprinting.

Eunu Kim, Ji Min Seok, Su Bin Bae, Su A Park, Won Ho Park,

Three-dimensional (3D) bioprinting is a technology under active study for use in tissue engineering and regenerative medicine. Bioink comprises cells and polymers and is the essential material for 3D bioprinting. The characteristics of the bioink affect its printability, gelation behavior, and cell compatibility. In this study, alginate derivatives were synthesized ... Read more >>

Biomacromolecules (Biomacromolecules)
[2021, :]

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Bioinspired Self-Healable Polyallylamine-Based Hydrogels for Wet Adhesion: Synergistic Contributions of Catechol-Amino Functionalities and Nanosilicate.

Jee Na Lee, Su Yeon Lee, Won Ho Park,

Recently, many studies have been reported on functional adhesives that are applicable in wet conditions as well as in air conditions. In this study, a novel polymer hydrogel that mimics the mussel foot proteins (Mfps) was designed as an adhesive that can adhere strongly to various substrates in wet conditions. ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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Effect of Waiting Time from Pathological Diagnosis to Definitive Concurrent Chemoradiation (CCRT) for Cervical Cancer on Overall Survival.

Kyoung Won Noh, Bomi Kim, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Won Kyung Cho, Won Park, Yoo-Young Lee,

<h4>Purpose</h4>This study aimed to evaluate the effect of waiting time, from diagnosis to initiation of definitive concurrent chemoradiation (CCRT), on overall survival in cervical cancer patients.<h4>Materials and methods</h4>Patients with cervical cancer who were treated with definitive CCRT between 2000 and 2017 were retrospectively reviewed. Time from initial pathological diagnosis to ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, :]

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Mortality and Morbidities according to Time of Birth in Extremely Low Birth Weight Infants.

Misun Yang, So Yoon Ahn, Heui Seung Jo, Se In Sung, Yun Sil Chang, Won Soon Park, ,

<h4>Background</h4>Although the overall quality of high-risk neonatal care has improved recently, there is still concern about a difference in the quality of care when comparing off-hour births and regular-hour births. Moreover, there are no data in Korea regarding the impact of time of birth on mortality and morbidities in preterm ... Read more >>

J Korean Med Sci (Journal of Korean medical science)
[2021, 36(13):e86]

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Efficacy and safety of brodalumab, an anti-IL17RA monoclonal antibody, in patients with axial spondyloarthritis: 16-week results from a randomised, placebo-controlled, phase 3 trial.

James Cheng-Chung Wei, Tae-Hwan Kim, Mitsumasa Kishimoto, Naoki Ogusu, Haeyoun Jeong, Shigeto Kobayashi, ,

<h4>Objective</h4>To investigate the efficacy and safety of brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, in patients with axial spondyloarthritis (axSpA).<h4>Methods</h4>In a multicentre, placebo-controlled phase 3 study (NCT02985983) conducted at 48 sites across Japan, Korea and Taiwan, patients with axSpA were randomised 1:1 to receive subcutaneous brodalumab 210 mg ... Read more >>

Ann Rheum Dis (Annals of the rheumatic diseases)
[2021, :]

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Nonintervention Is Not Noninferior to Oral Ibuprofen for Treatment of Patent Ductus Arteriosus-Reply.

Se In Sung, Myung Hee Lee, Won Soon Park,

JAMA Pediatr (JAMA pediatrics)
[2021, 175(4):430-431]

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Adjuvant radiotherapy for cervical cancer in South Korea: a radiation oncology survey of the Korean Radiation Oncology Group (KROG 20-06).

Nalee Kim, Won Park,

<h4>Objective</h4>Radiation therapy plays an important role in adjuvant treatment for surgically treated cervical cancer with adverse pathological findings. This was the first study to evaluate current practices of adjuvant radiation therapy among centres affiliated with the Korean Radiation Oncology Group.<h4>Methods</h4>A survey containing specific questions on the demographics in 2019, indications ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, :]

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Erratum to 'Mussel-inspired poly(γ-glutamic acid)/nanosilicate composite hydrogels with enhanced mechanical properties, tissue adhesive properties, and skin tissue regeneration' [Acta Biomaterialia 123 (2021) 254-262].

Min Hee Kim, Jeehee Lee, Jee Na Lee, Haeshin Lee, Won Ho Park,

Acta Biomater (Acta biomaterialia)
[2021, :]

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Effects of Aerobic and Resistance Exercise Training on Carotid Intima-Media Thickness in Abdominal Obese Women.

Do Kyung Kim, Jae Hwan Jee, Won Hah Park,

<b><i>Aims:</i></b> The purpose of this study was to investigate the effects of a 12-week aerobic and resistance training program on waist circumference (WC) and carotid intima-media thickness (CIMT) in abdominal obese middle-aged women. <b><i>Methods:</i></b> Subjects were 40 middle-aged women with abdominal obesity (WC >85 cm) but no specific diseases. Subjects were ... Read more >>

Metab Syndr Relat Disord (Metabolic syndrome and related disorders)
[2021, :]

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Longitudinal impact of postmastectomy radiotherapy on arm lymphedema in patients with breast cancer: An analysis of serial changes in arm volume measured by infrared optoelectronic volumetry.

Nalee Kim, Haeyoung Kim, Ji Hye Hwang, Won Park, Won Kyung Cho, Seung Mi Yeo, Hyebin Lee, Sei Kyung Lee,

<h4>Background and purpose</h4>This study was conducted to evaluate the longitudinal impact of postmastectomy radiation therapy (PMRT) on persistent severe lymphedema (PSL) using arm volume measurements by an infrared optoelectronic volumetry.<h4>Materials and methods</h4>Of the patients who underwent mastectomy between 2008 and 2016, we included 330 patients with secondary arm lymphedema. Percentage ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 158:167-174]

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The anti-diabetic drug alogliptin induces vasorelaxation via activation of Kv channels and SERCA pumps.

Hee Seok Jung, Mi Seon Seo, Jin Ryeol An, Ryeon Heo, Minji Kang, Eun-Taek Han, Hongzoo Park, Geehyun Song, Youn Kyoung Son, Won-Kyo Jung, Il-Whan Choi, Sung Hun Na, Won Sun Park,

In the present study, we investigated the vasorelaxant effects of alogliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, using phenylephrine (Phe)-induced pre-contracted aortic rings. Alogliptin induced vasorelaxation in a dose-dependent manner. Pre-treatment with the voltage-dependent K<sup>+</sup> (Kv) channel inhibitor 4-aminopyridine (4-AP) significantly decreased the vasorelaxant effect ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2021, 898:173991]

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Chitosan-Alginate-Pectin-coated Suspended-Liquid-Encapsulating (CAPSuLE) marbles for therapeutic agent storage and delivery.

Yoojin Kim, Seokmin Oh, Heehyung Lee, Dongsoo Lee, Mihyun Kim, Heung Soo Baek, Won Seok Park, Eunmi Kim, Jae-Hyung Jang,

Developing a cutting-edge system capable of ensuring long-lasting functionality of therapeutic agents and implementing diverse delivery modes is challenging. A quasi-spherical triple-layered capsule containing suspended liquid droplets and allowing multi-modal delivery of therapeutic agents in the aqueous phase was developed, primarily by adopting the core principles for creating liquid marbles. ... Read more >>

Biomater Sci (Biomaterials science)
[2021, 9(5):1639-1651]

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Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines.

Kyoung Sik Park, Madhuri Saindane, Eun Yeol Yang, TongYi Jin, Harikrishna Reddy Rallabandi, Alexander Heil, Sang Eun Nam, Young Bum Yoo, Jung-Hyun Yang, Jong Bin Kim, Seo-Young Park, Won Seo Park, Yeo-Kyu Youn,

<h4>Purpose</h4>Papillary thyroid cancer (PTC) has a high incidence of BRAF<sup>V600E</sup> mutation. The purpose of this study was to evaluate the potential relationship between thyroiditis and BRAF<sup>V600E</sup> mutation status in patients with PTC. We investigated how a selective inhibitor of BRAF<sup>V600E</sup> PLX4032 affects the proliferation and inflammatory cytokine levels of thyroid ... Read more >>

Ann Surg Treat Res (Annals of surgical treatment and research)
[2021, 100(3):127-136]

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First Report of Post-Harvest Tuber Rot of American Groundnut (Apios americana) Caused by Fusarium acuminatum.

Jin Cheon Park, Yeonghoon Lee, Eom-Ji Hwang, Da Eun Kwon, Won Park, Sun Kyeng Han, Narayan Chandra Paul,

Apios americana Medik, commonly known as American groundnut, is a leguminous perennial vine crop native to North America and is cultivated in Japan and Korea (Chu et al. 2019). Its tubers are edible and believed to be very nutritious, especially for women just after childbirth. The tubers also contain secondary ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA): Surgical Outcomes and Learning Curve.

Young Jun Chai, Sumin Chae, Moon Young Oh, Hyungju Kwon, Won Seo Park,

The transoral endoscopic thyroidectomy vestibular approach (TOETVA) has excellent cosmetic effects and its popularity is increasing worldwide. We present our experience with TOETVA and its short-term outcomes. This study included 110 consecutive patients who underwent TOETVA at a single institution between July 2016 and June 2020. We analyzed clinicopathologic data, ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(4):]

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The effects of tegaserod, a gastrokinetic agent, on voltage-gated K+ channels in rabbit coronary arterial smooth muscle cells.

Jin Ryeol An, Hee Seok Jung, Mi Seon Seo, Minji Kang, Ryeon Heo, Hongzoo Park, Geehyun Song, Won-Kyo Jung, Il-Whan Choi, Won Sun Park,

Tegaserod, a gastroprokinetic agent, is used to treat irritable bowel syndrome. Despite its extensive clinical use, little is known about the effects of tegaserod on vascular ion channels, especially K<sup>+</sup> channels. Therefore, we examined the effects of tegaserod on voltage-gated K<sup>+</sup> (Kv) channels in rabbit coronary arterial smooth muscle cells ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2021, 48(5):748-756]

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Internal Mammary Node Irradiation in Node-Positive Breast Cancer Treated with Mastectomy and Taxane-Based Chemotherapy

Won Kyung Cho, Jee Suk Chang, Seung Gyu Park, Nalee Kim, Doo Ho Choi, Haeyoung Kim, Yong Bae Kim, Won Park, Chang Ok Suh,

Purpose: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. <h4>Methods: </h4> and Materials: We ... Read more >>

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Altmetric Attention Score: Evaluating the Social Media Impact of Burn Research.

Michelle A Richardson, Won Park, Scott R Echternacht, Derek E Bell,

Traditional measures of scholarly impact (i.e., impact factor, citation rate) do not account for the role of social media in knowledge dissemination. The Altmetric Attention Score (AAS) tracks the online sharing activity of articles on platforms such as Twitter and Facebook. All 285 original scientific articles published in Journal of ... Read more >>

J Burn Care Res (Journal of burn care & research : official publication of the American Burn Association)
[2021, :]

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Dual-crosslinked, self-healing and thermo-responsive methylcellulose/chitosan oligomer copolymer hydrogels.

Yong Ho Yeo, Won Ho Park,

Self-healing, thermo-responsive hydrogels have received increasing attention for tissue engineering, drug delivery, and cosmetic applications. Here, a thermo-responsive hydrogel with self-healing properties was prepared from methylcellulose (MC) and a water-soluble chitosan oligomer (CHI-O). First, dialdehyde methylcellulose (DAMC) derivative was synthesized from MC via periodate oxidation, and its rheological behavior was ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2021, 258:117705]

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Corrigendum to "Nod 1, a CARD protein, enhances pro-interleukin-1 beta processing through the interaction with pro-caspase-1" [Biochem. Biophys. Res. Commun. 299(4) (2002) 652-8].

Nam Jin Yoo, Won Sang Park, Su Young Kim, John C Reed, Seong Gon Son, Jung Young Lee, Sug Hyung Lee,

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 543:97]

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Characteristics of Advance Care Planning Interventions Across Dementia Stages: A Systematic Review.

Hyejin Kim, Jeonghyun Cho, Won Seok Park, Sang Suk Kim,

<h4>Purpose</h4>Little is known regarding how advance care planning (ACP) interventions change with the progression of dementia. Thus, the primary purpose of this systematic review is to compare characteristics of ACP interventions across dementia stages. We also identify the role of nurses in implementing ACP interventions for persons with dementia and ... Read more >>

J Nurs Scholarsh (Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing)
[2021, 53(2):180-188]

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Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study.

Seung Yeun Chung, Jee Suk Chang, Kyung Hwan Shin, Jin Ho Kim, Won Park, Haeyoung Kim, Kyubo Kim, Ik Jae Lee, Won Sup Yoon, Jihye Cha, Kyu-Chan Lee, Jin Hee Kim, Jin Hwa Choi, Sung-Ja Ahn, Boram Ha, Sun Young Lee, Dong Soo Lee, Jeongshim Lee, Sei One Shin, Sea-Won Lee, Jinhyun Choi, Mi Young Kim, Yeon Joo Kim, Jung Ho Im, Chang-Ok Suh, Yong Bae Kim,

<h4>Purpose</h4>Emerging data suggest that higher radiation doses in post-mastectomy radiotherapy may be associated with an increased risk of reconstruction complications. This study aimed to validate previous findings regarding the impact of radiation dose on complications among women with breast cancer using a multi-center dataset.<h4>Methods</h4>Fifteen institutions participated, and women with breast ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2021, 56:7-13]

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Mussel-inspired poly(γ-gl utamic acid)/nanosilicate composite hydrogels with enhanced mechanical properties, tissue adhesive properties, and skin tissue regeneration.

Min Hee Kim, Jeehee Lee, Jee Na Lee, Haeshin Lee, Won Ho Park,

It was demonstrated herein that the adhesive property of catechol-functionalized nanocomposite hydrogel can be enhanced by tuning the cohesive strength due to the secondary crosslinking between catechol and synthetic bioactive nanosilicate, viz. Laponite (LP). The nanocomposite hydrogel consists of the natural anionic poly(γ-glutamic acid) (γ-PGA), which was functionalized with catechol ... Read more >>

Acta Biomater (Acta biomaterialia)
[2021, 123:254-262]

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